Amino Acid SubstitutionEvolution, MolecularBase SequenceAmino Acid SequenceMolecular Sequence DataAmino AcidsSequence Homology, Amino AcidMutationMutagenesis, Site-DirectedSequence AlignmentPhylogenyCloning, MolecularModels, MolecularEscherichia coliStructure-Activity RelationshipBinding SitesPoint MutationProtein ConformationKineticsCodonGenetic VariationProtein Structure, TertiaryMutation, MissenseSequence Homology, Nucleic AcidRecombinant ProteinsSequence Analysis, DNAProtein Structure, SecondaryMutagenesisBacterial ProteinsProtein BindingDNA Mutational AnalysisConserved SequenceSpecies SpecificityDNASubstrate SpecificityAmino Acid MotifsSelection, GeneticCell LineDNA PrimersPeptide FragmentsPlasmidsAlaninePolymerase Chain ReactionDNA, ComplementaryAllelesPeptidesProteinsRestriction MappingLeucineEnzyme StabilityRecombinant Fusion ProteinsAmino Acids, EssentialBiological EvolutionAspartic AcidGenes, BacterialCysteineModels, GeneticPolymorphism, GeneticGenesPhenotypeAmino Acid Transport SystemsSaccharomyces cerevisiaeArginineProtein EngineeringValineEscherichia coli ProteinsViral ProteinsCatalysisCattlePhenylalanineElectrophoresis, Polyacrylamide GelTemperatureExonsMutant ProteinsSuppression, GeneticTransfectionEpitopesSequence Analysis, ProteinGlycineDNA, BacterialHistidineMolecular WeightChordataMacromolecular SubstancesChromatography, High Pressure LiquidGenetic CodeTrypsinLysineGenetic Complementation TestLikelihood FunctionsAlcohol DehydrogenaseMembrane ProteinsCatalytic DomainCrystallography, X-RayThermodynamicsCircular DichroismProlineProtein FoldingIsoleucineAmino Acids, Aromatic