Amino AcidsProtein PrecursorsAmino Acid SequenceMolecular Sequence DataAmyloid beta-Protein PrecursorCloning, MolecularBase SequenceAmyloid Precursor Protein SecretasesDNASequence Homology, Amino AcidHexosaminesAspartic Acid EndopeptidasesAmyloid beta-PeptidesAlzheimer DiseaseAmino Acid SubstitutionEscherichia coliKineticsPresenilin-1EndopeptidasesN-Acetylneuraminic AcidProtein Processing, Post-TranslationalNeuraminic Acids3-Oxoacyl-(Acyl-Carrier-Protein) SynthasePeptide FragmentsMutationValineRNA, MessengerChromatography, High Pressure LiquidCholic AcidsCarbon RadioisotopesCarbon IsotopesProtein Structure, TertiaryCells, CulturedMembrane ProteinsCell LineSequence AlignmentNucleosidesRecombinant ProteinsBinding SitesAmino Acids, EssentialFatty AcidsEnzyme PrecursorsAmino Acid MotifsProtein BindingDNA, ComplementaryAmino Acid Transport SystemsStreptomycesRNAMutagenesis, Site-DirectedPeptidesNucleic Acid PrecursorsBrainMolecular WeightTritiumMice, TransgenicRecombinant Fusion ProteinsLiverMolecular StructureProtein Sorting SignalsProtein ConformationBile Acids and SaltsPlaque, AmyloidSubstrate SpecificityChromatography, GasSequence Homology, Nucleic AcidElectrophoresis, Polyacrylamide GelNeuronsPresenilin-2Biological TransportModels, MolecularTransfectionLeucineStructure-Activity RelationshipAmyloidProtein BiosynthesisProtease NexinsBacterial ProteinsPlasmidsRestriction MappingProtein TransportCarrier ProteinsPresenilinsNerve Tissue ProteinsAmino Acids, AromaticDNA PrimersProteinsAmino Acids, Branched-ChainSaccharomyces cerevisiaeCricetinaeAmino Acids, SulfurCell MembranePlant ProteinsChloroplastsGene ExpressionMitochondriaTranscription, GeneticProtein Structure, SecondaryMembrane Transport ProteinsPhylogenyCHO Cells