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  • sequence similarity
  • This peptide has not shown a high percentage of sequence similarity with other toxins selective for the same family of K+ channels α-KTx and may be classified in a new group among the related Kv blocker. (wikipedia.org)
  • tumor
  • Our results introduce a strategy to identify peptide nanoparticles that can effectively reduce tumor volumes when administered to in in vivo mice models. (rsc.org)
  • Analysis of insert sequences of tumor-homing peptide clones showed several motifs, indicating nonrandom accumulation of clones in human tumors. (aacrjournals.org)
  • The peptide was able to home to tumor tissues, but in contrast to standard RGD (Arginylglycylaspartic acid) peptides, also spread much more extensively into extravascular tumor tissue. (wikipedia.org)
  • The iRGD peptide homes and penetrates tumors through a 3-step process: First, the RGD sequence motif mediates binding to αVβ3 and αVβ5 integrins that are expressed on tumor endothelial cells. (wikipedia.org)
  • hydrolysis
  • 175Cyclization of the ene-iminium ion derived from the (R)-2-phenylglycinol derivative (42) gives optically-pure 4-substituted pipecolic acids after routine deprotection and hydrolysis ~ t a g e s . '79 Radical cyclization (Ph3SnH-AIBN) of N-allyl-N-Boc-L-serine lactone gives 4-alkyl- and 4,4-di-alkylprolines. (kuryer-if.info)
  • The existence of this seventh catalytic type of proteases, in which the peptide bond cleavage occurs by self-processing instead of hydrolysis, was demonstrated with the discovery of the crystal structure of the self-cleaving precursor of the Tsh autotransporter from E. coli. (wikipedia.org)
  • mitochondria
  • A target peptide is a short (3-70 amino acids long) peptide chain that directs the transport of a protein to a specific region in the cell, including the nucleus, mitochondria, endoplasmic reticulum (ER), chloroplast, apoplast, peroxisome and plasma membrane. (wikipedia.org)