Amino acid fatty acid synthase type ii. Medical search. Frequent questions

This enzyme helps break down certain protein building blocks (amino acids), fat building blocks (fatty acids), and cholesterol. (medlineplus.gov)
MeCbl is also a cofactor, but for an enzyme known as methionine synthase. (medlineplus.gov)
This enzyme converts the amino acid homocysteine to another amino acid, methionine. (medlineplus.gov)
Summary of studies investigating the roles of the carboxy- and the amino terminal domains of the soluble epoxide hydrolase enzyme. (frontiersin.org)
eg PKU - without this enzyme an amino acid (called phenylalanine) rises to harmful levels and can lead to developmental delay. (nsu.govt.nz)
AHL profiles were broader than previously reported, correlated with a reduction in the intracellular concentrations of several metabolites, and were more pronounced in the E. coli strain producing the LasI synthase than the RhlI enzyme. (nottingham.ac.uk)
Moreover, an intermediate-enzyme adduct with a NOS-covalent linkage was observed in the later site, where it acts as a two-scissile-bond linkage facilitating nucleophilic addition and cofactor-free decarboxylation. (hokudai.ac.jp)
When an enzyme has multiple substrates, inhibitors can show different types of inhibition depending on which substrate is considered. (tpca-1inhibitor.com)
A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule. (ucsf.edu)
A desaturase (XcnN) and a saccharopine dehydrogenase-like enzyme (XcnM) are essential for this unusual transformation via two new identified intermediates and the catalytic reaction is regulated by the response regulator OmpR. (uni-frankfurt.de)
in intra and extracellular fluid,ketone bodies,THFA, name the enzyme involved in synthesis of thymine (thymidylate synthase). (kemunited.com)
Acute porphyria attacks are brought about by uncontrolled upregulation of the ALA synthase enzyme. (medscape.com)

The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
Through removing the genes encoding the AHL synthases, RhlI and LasI from the complex hierarchical system of P. aeruginosa by expressing them in the heterologous host, Escherichia coli, this study has measured the influence of AHL production upon bacterial metabolism. (nottingham.ac.uk)
Moreover, complete profiling of P. aeruginosa PA01 AHL synthase mutants is unravelling the interrelationship between metabolism and cell-to-cell communication in P. aeruginosa. (nottingham.ac.uk)
Community-level differences in functional potential were driven by enrichment of genes associated with carbon and nitrogen fixation in non-disinfected systems and γ-aminobutyrate metabolism in disinfected systems likely associated with the recycling of amino acids. (biomedcentral.com)
Disorders of fat metabolism result in the unavailability of free fatty acids and ketones as alternative fuels. (medscape.com)
This study establishes the biochemical function of LACC1 in humans/mice and its role in bridging inducible nitric oxide synthase and polyamine metabolism in inflammatory macrophages. (yale.edu)
Diarrhea-predominant IBS (IBS-D) demonstrated shifts in the metatranscriptome and metabolome including increased bile acids, polyamines, succinate pathway intermediates (malate, fumarate), and transcripts involved in fructose, mannose, and polyol metabolism compared to constipation-predominant IBS (IBS-C). A classifier incorporating metabolites and gene-normalized transcripts differentiated IBS-D from IBS-C with high accuracy (AUC 0.86). (biomedcentral.com)
Transcriptome sequencing revealed that all homologs induced the same general patterns with a drastic shift in gene expression profiles of leaves from that of a typical source tissue to a source-limited sink-like tissue: Transcripts encoding enzymes for plastid uptake and metabolism of phosphoenolpyruvate, fatty acid and oil biosynthesis were up-regulated, as were also transcripts encoding starch degradation. (biomedcentral.com)
L-methylmalonyl-CoA mutase converts L-methylmalonyl-CoA to succinyl-CoA in the metabolism of propionate, a short-chain fatty acid [ 2 ]. (nih.gov)
The formation of propionyl CoA in human metabolism is derived from many sources, chiefly catabolism of a number of essential amino acids (isoleucine, valine, threonine, methionine). (medscape.com)

Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. (thermofisher.com)
We hypothesize that AI-2 production was significantly reduced since it also requires AMC metabolites for its synthesis. (nottingham.ac.uk)
Further investigations by Smith concluded that aspirin and indomethacin inhibited synthesis by specifically blocking oxygenation of arachidonic acid. (medscape.com)
Hypoglycemia associated with elevated insulin levels makes certain disorders unlikely, such as defects in gluconeogenesis, free fatty acid synthesis and ketogenesis, growth hormone deficiency, and cortisol deficiency. (medscape.com)
A non-targeted metabolomics approach was used to reconstruct the metabolic pathways for the synthesis of oxylipins, derived from roughanic, linoleic, α-linolenic, and arachidonic acid in wild type, the oxylipin-deficient mutants of Ppaos1 and Ppaos2 , the mutants of Ppdes being deficient in all fatty acids harboring a Δ 6 -double bond and the C20-fatty acid-deficient mutants of Ppelo . (frontiersin.org)
2001) shows a pleiotropic loss of all ATP synthase subunits, but a specific reduction in the rate of synthesis of subunit IV (Lemaire and Wollman, 1989b). (rehabsociety.org.hk)
Moreover, transcripts representing fatty acid degradation were up-regulated indicating that fatty acids might be degraded to feed the increased need to channel carbons into fatty acid synthesis creating a futile cycle. (biomedcentral.com)
To be available for TAG synthesis, carbons from sucrose must first be converted to pyruvate through cytosolic or plastidic glycolytic pathways and at some point be imported into the plastid to yield acetyl-coenzyme A (CoA) which feeds fatty acid (FA) synthesis with carbon backbones. (biomedcentral.com)
It also stimulates glycogen synthesis by inhibiting glycogen synthase kinase 3 (GSK3) and activating glycogen synthase. (alliedacademies.org)
When activated, AMPK phosphorylates and inhibits enzymes involved in ATP-consuming processes, such as fatty acid synthesis (e.g., acetyl-CoA carboxylase, ACC) and protein synthesis (e.g., mammalian target of rapamycin, mTOR). (alliedacademies.org)

Because both of these cofactors are missing, the enzymes that require them (methylmalonyl CoA mutase and methionine synthase) do not function normally. (medlineplus.gov)
For example, in an environment rich in amino acids, cells do not expend energy for making amino acid biosynthetic enzymes. (go.jp)
However, if the environment becomes depleted of amino acids (nutritional downshift), cells will be exposed to a lack of both the amino acid biosynthetic enzymes and the amino acids required to make these enzymes. (go.jp)
Once amino acid biosynthetic enzymes start to accumulate, the cell is able to produce its own amino acids, and a new growth phase begins. (go.jp)
The plant C18 fatty acids, linoleic acid and linolenic acid, can be converted by the enzymes a -dioxygenase, 9- or 13-lipoxygenase, giving rise to a multitude of oxylipins. (gerli.com)
Vitamin B12 functions as a cofactor for two enzymes, methionine synthase and L-methylmalonyl-CoA mutase [ 1-3 , 5 ]. (nih.gov)
Conversely, it activates enzymes involved in ATP-generating processes, such as fatty acid oxidation (e.g., carnitine palmitoyltransferase 1, CPT1) and glucose uptake (e.g., translocation of GLUT4). (alliedacademies.org)

The MMADHC gene provides instructions for making a protein that helps convert vitamin B12 (also called cobalamin) into one of two molecules, adenosylcobalamin (AdoCbl) or methylcobalamin (MeCbl). (medlineplus.gov)
STK11/LKB1 encodes a 433 amino acid ubiquitously expressed protein with a central catalytic domain and regulatory N- and C-terminal domains. (medscape.com)
Fatty acid synthase is a multifunctional protein. (thermofisher.com)
Site-directed mutagenesis of key catalytic residues in the QSSM synthases was performed to directly prove that the effects observed were due to the function of the synthases, and not the production of a heterologous protein. (nottingham.ac.uk)
Neurological and developmental problems are especially severe in individuals with cblX type, in part due to disruption of the activity of other genes normally regulated by the HCF-1 protein. (medlineplus.gov)
The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
Lysosomal release of amino acids at ER three-way junctions regulates transmembrane and secretory protein mRNA translation. (janelia.org)
The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)
more protein) chlstrol ki 2 forms? (kemunited.com)

Methionine synthase catalyzes the conversion of homocysteine to the essential amino acid methionine [ 1 , 2 ]. (nih.gov)

A group of these diseases are due to defects of mitochondrial carriers, a family of proteins named solute carrier family 25 (SLC25), that transport a variety of solutes such as the reagents of ATP synthase (ATP, ADP, and phosphate), tricarboxylic acid cycle intermediates, cofactors, amino acids, and carnitine esters of fatty acids. (nih.gov)
If the enzymatic defects are in the initial steps of the metabolic cascade, early metabolic intermediates will accumulate (ie, aminolevulinic acid [ALA] and porphobilinogen [PBG]), which are responsible for attacks of neurologic dysfunction. (medscape.com)

Hepatic steatosis, inflammatory cell infiltration, and hepatocyte ballooning in the liver and increased hepatic mRNA expression of fatty acid synthase and glycerol-3-phosphate acyltransferase were observed in the MSG-treated mice. (biomedcentral.com)
Secretome mRNA translation near lysosomes was enhanced during amino acid deprivation. (janelia.org)

Among the human lipoxygenases, ALOXE3 is most closely (54% identity) related in amino acid sequence to ALOX12B. (wikipedia.org)
Furthermore, using sequence analysis of human genomic DNA, researchers concluded that the amino acids important for catalysis by COX-1 are conserved and are equally important for catalysis by COX-2. (medscape.com)
Glucose and several amino acids stimulate insulin secretion under physiologic conditions, and the sequence of events leading to insulin secretion is well delineated. (medscape.com)
The cytochrome b6f complex occupies a central position in the sequence of photosynthetic electron transport carriers, oxidizing plastoquinol (PQH 2) and providing the electron transfer connection between the two reaction center complexes, PS II and PS I, to which H + transfer is coupled, thus contributing to the trans-membrane. (rehabsociety.org.hk)

Examples of diseases, due to mitochondrial carrier mutations are: combined D-2- and L-2-hydroxyglutaric aciduria, carnitine-acylcarnitine carrier deficiency, hyperornithinemia-hyperammonemia-homocitrillinuria (HHH) syndrome, early infantile epileptic encephalopathy type 3, Amish microcephaly, aspartate/glutamate isoform 1 deficiency, congenital sideroblastic anemia, Fontaine progeroid syndrome, and citrullinemia type II. (nih.gov)
The cutoff between normal vitamin B12 levels and deficiency varies by method and laboratory, but most laboratories define subnormal serum or plasma values as those lower than 200 or 250 pg/mL (148 or 185 pmol/L) [ 2 ]. (nih.gov)
Levels of serum methylmalonic acid (MMA), a vitamin B12-associated metabolite, are the most sensitive markers of vitamin B12 status, and an MMA level greater than 0.271 micromol/L suggests vitamin B12 deficiency [ 6-8 ]. (nih.gov)

Accumulation of the 3-carbon fatty acyl-CoA within the mitochondrion leads to decreased free CoA for other reactions, which is alleviated by conversion of propionyl CoA to propionyl-carnitine. (medscape.com)

In Escherichia coli , amino acid starvation leads to the accumulation of an unusual molecule, polyphosphate (polyP), a linear polymer of many hundreds of orthophosphate residues. (go.jp)
Grisemycin, salinipeptin, and cypemycin belong to the linaridin class of ribosomally synthesized and posttranslationally modified peptides that contain multiple dehydrobutyrine and D-amino acid residues. (hokudai.ac.jp)
The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)
It differs from most FeS clusters in that two of the amino acid residues that This proton gradient across the thylakoid membrane creates a power, i.e. (rehabsociety.org.hk)

This study describes new gamma-lactam and related metabolites at the intersection of colibactin and fatty acid biosynthesis, establishing a new form of "cross-talk" between secondary polyketide and primary fatty acid pathways. (yale.edu)
Several classes of structurally diverse secondary metabolites with a broad spectrum of bioactivities (e.g. antibacterial, insecticidal, antifungal) are known from different Xenorhabdus and Photorhabdus strains and are produced by nonribosomal peptide synthetases (NRPS) and the fatty acid synthase (FAS)-related polyketide synthases (PKS) or even hybrids thereof. (uni-frankfurt.de)

As a result, certain amino acids, fatty acids, and cholesterol are not broken down and homocysteine cannot be converted to methionine. (medlineplus.gov)

Importantly, the amino acid diversity of EMAs is distributed throughout the length of the proteins. (biomedcentral.com)
To solve this dilemma, cells must use their own proteins as sources of amino acids in response to the nutritional downshift. (go.jp)
They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)
Amino acids are the building blocks that our bodies use to make proteins. (rxlist.com)
Altogether, these findings uncover a novel coordination between ER and lysosomes, in which local release of amino acids and other factors from ER-associated lysosomes patterns and regulates translation of mRNAs encoding secretory and membrane proteins. (janelia.org)
Depending on the length of their fatty acid chains and their degree of saturation, SL species have a strong impact on biophysical membrane parameters such as fluidity or rigidity and curvature, and on interaction with membrane proteins and/or cytoskeletal components, and membrane compartmentalization. (encyclopedia.pub)

Production of these QS signal molecules (QSSMs) requires precursors including fatty acids, S-adenosyl-L-methionine (SAM) and aromatic amino acids. (nottingham.ac.uk)

By 1964, after recognition of this basic structure, Bergstrom and colleagues successfully synthesized series 2 prostaglandins from arachidonic acid using sheep seminal fluid. (medscape.com)
Their distinct biosynthetic activity includes an endoperoxidase synthase reaction that oxygenates and cyclizes polyunsaturated fatty acid precursors (eg, arachidonic acid) to form prostaglandin G 2 (PGG2), and a peroxidase reaction that converts PGG2 to prostaglandin H 2 (PGH2), as shown below. (medscape.com)
Cyclooxygenase conversion of arachidonic acid into prostaglandin H2 (PGH2). (medscape.com)

18(2): e0281772, 2023. (bvsalud.org)
Sci Adv. 2023 Aug 2;9(31):eadi1359. (ucsf.edu)

2, 3, 4] Mutations in at least 11 genes that play a role in regulating beta-cell insulin secretion have been implicated in the pathogenesis of HI. (medscape.com)

However, we previously demonstrated that the grisemycin (grm) cluster contained cryptic dehydratase and epimerase genes by heterologous expression of this biosynthetic gene cluster in Streptomyces lividans and proposed that two genes (grmH and grmL) with unknown functions catalyze dehydration and epimerization reactions. (hokudai.ac.jp)
During this work, xenocoumacin 1 (XCN 1) and 2 (XCN 2), the major antimicrobial compounds produced by Xenorhabdus nematophila and their corresponding biosynthetic gene cluster were identified and studied in detail. (uni-frankfurt.de)

Multiple congenital anomalies in two boys with mutation in HCFC1 and cobalamin disorder. (medlineplus.gov)

FOS increased not only the fecal concentrations of n-butyric acid (0.04 ± 0.01 vs. 0.38 ± 0.14 mg/g, P = 0.02), propionic acid (0.09 ± 0.03 vs. 0.42 ± 0.16 mg/g, P = 0.02), and acetic acid (0.65 ± 0.16 vs. 1.48 ± 0.29 mg/g, P = 0.03) but also the serum concentration of propionic acid (3.9 ± 0.5 vs. 8.2 ± 0.5 μmol/L, P = 0.001). (biomedcentral.com)
Studies suggest that the underlying cause of the hyperammonemia is the inhibition of N -acetylglutamate synthase (NAGS) activity by free propionic acid. (medscape.com)

Although acetoxy derivatives of the 3,13- and 2,13-dienes showed almost the same mass spectra, the alcohols were distinguished by comparing the relative intensities of [M−18] + at m ⁄ z 248, indicating direct differentiation of the two positional isomers without derivatization. (go.jp)
A major class of oxylipins are the circular derivatives to which 12-oxo-phytodienoic acid (OPDA) and its metabolite jasmonic acid (JA) belong. (frontiersin.org)
As source of oxylipins, linoleic acid (18:2n-6) can be transformed into 9- and 13-derivatives (HODE, hydroxy-octadecadienoic acids). (gerli.com)

rather, it possess hepoxilin synthase (i.e. hydroperoxy isomerase) activity - that is, it converts hydroperoxy-containing PUFAs to hepoxilin-like epoxyalcohol products. (wikipedia.org)
ALOX12B metabolizes the LA in EOS to its 9R-hydroperoxy derivative which ALOXE3 then converts to three ceramide-esterified products: a) 9R,10R-trans-epoxide,13R-hydroxy-10E-octadecenoic acid, b) 9-keto-10E,12Z-octadecadienoic acid, and c) 9R,10R-trans-epoxy-13-keto-11E-octadecenoic acid. (wikipedia.org)
This pathway converts a C3 metabolite to two acetyl-CoA by fixation of one additional CO2 equivalent, or assimilates glyoxylate, a photorespiration intermediate, to produce acetyl-CoA without net carbon loss. (osti.gov)

Other sources of propionyl CoA include odd chain-length fatty acids and the side chain of cholesterol, although these probably contribute very little in relation to the amino acid sources. (medscape.com)
beta cholesterol k achy kaam bhi bta do folic acid coenzyme,schillings test,b12 coenzymes,y pernicious anaemia involves neurod egeneration,glutamine functions? (kemunited.com)

Two decades later, the prostaglandins were deduced to be a family of related compounds that contain 20-carbon polyunsaturated fatty acids with a cyclopentane ring, as depicted below. (medscape.com)
These regio-specific enzymatic reactions between oxygen and polyunsaturated fatty acids formed new compounds, named oxylipins, which are most frequently with the S-configuration (5-HpETE, 12-HpETE or 15-HpETE). (gerli.com)

This study presents a novel quantitative approach, based on proteotypic peptides, to determine the absolute concentration of apo(a) from two microliters of plasma and qualified according to guideline requirements for targeted proteomics assays. (bvsalud.org)
Furthermore, we demonstrated that GrmH/GrmL complex accepted salinipeptin and cypemycin precursor peptides, which possess three additional amino acids. (hokudai.ac.jp)

[ 2 ] With the exception of congenital erythropoietic porphyria (CEP), which is autosomal recessive, all other porphyrias are inherited as autosomal dominant disorders. (medscape.com)

In a pilot randomized controlled trial of the Mediterranean diet (MedDiet) and MET, whose participants were characterized by different components of metabolic syndrome, we tested the effect of MET on serum levels of B 12 , holo transcobalamin II (holo-TC-II), and methylmalonic acid (MMA). (mdpi.com)
Diagnostic criteria include plasma glucose levels less than 3 mmol/L with detectable serum insulin and C-peptide, low serum ketone bodies, and low serum fatty acids. (medscape.com)

Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. (biomedcentral.com)
Among the various forms of NAFLD, non-alcoholic steatohepatitis (NASH) involves hepatic inflammation and fibrosis, which can lead to cirrhosis, and the reported five-year cumulative incidence of liver cancer among patients with cirrhosis is 20% in Japan [ 2 ]. (biomedcentral.com)

Variants in the MMADHC gene can cause methylmalonic acidemia with homocystinuria, cblD type, which is one form of a condition that has features of both of the two conditions described above. (medlineplus.gov)
Several HCFC1 gene variants (also known as mutations) have been identified in people with methylmalonic acidemia with homocystinuria, cblX type, which is one form of a disorder that causes developmental delay, eye defects, neurological problems, and blood abnormalities. (medlineplus.gov)
These individuals have delayed development and other neurological problems but do not show other features of methylmalonic acidemia with homocystinuria, cblX type (described above). (medlineplus.gov)

After a few hours of fasting, insulin levels fall, and increased lipolysis creates free fatty acids and glycerol. (medscape.com)

One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by attaching glucuronic acid to them in the liver and then excreting the complex in the bile. (medindex.am)
releasing large amounts of free fatty acids (FFA) affecting the liver and muscle. (thepmc.org)

In turn, PGH2 is converted to biologically active products (ie, prostaglandin E 2 [PGE2]) by individual synthase and reductase reactions. (medscape.com)

Since N -acetylglutamate (NAG) is the allosteric activator of carbamoylphosphate synthase, the entry step into the urea cycle, decreased ureagenesis occurs with accumulation of free ammonia. (medscape.com)

It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N-terminal domain exhibits phosphatase activity. (frontiersin.org)

Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)

Linoleic acid is the most abundant fatty acid in the skin epidermis, being present mainly esterified to the omega-hydroxyl residue of amide-linked omega-hydroxylated very long chain fatty acids (VLCFAs) in a unique class of ceramides termed esterified omega-hydroxyacyl-sphingosine (EOS). (wikipedia.org)

This gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOX12B and ALOX15B. (wikipedia.org)
This gene plays a role in the conversion of vitamin B12 into one of two molecules, adenosylcobalamin (AdoCbl) or methylcobalamin (MeCbl). (medlineplus.gov)
The defect may be present at either of 2 different gene loci. (medscape.com)

[ 2 , 15 ] This may give the lesion the appearance of pseudoinvasion, because some of the epithelial cells, usually from benign glands, are surrounded by the smooth muscle (the lack of dysplasia in the polyps help to differentiate pseudoinvasion from malignancy). (medscape.com)
Bacillary cells and stichocytes are distinctive cell types found only in clade I nematodes 5 and are located in the slender anterior part of the adult whipworm that is burrowed within the intestinal epithelium. (nature.com)
While many cell types have a primary cilium, little is known about primary cilia in the brain, where they are less accessible than cilia on cultured cells or epithelial tissues and protrude from cell bodies into a deep, dense network of glial and neuronal processes. (janelia.org)
The HETE are found in many types of cells from invertebrates to humans. (gerli.com)
Open up in another windows Fig.?2 Cells react to SUV4-20 inhibition immediately and recover rapidly after removal of SUV4-20 inhibitor. (researchensemble.com)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

The microbiome associated with healthy individuals of the red seaweed Laurencia dendroidea can fix nitrogen and provide relevant amino acids and vitamins to the seaweed ( 3 ). (asm.org)

He localized the biologic activity to a fraction of lipid soluble acids that he termed "prostaglandin," hypothesizing that these substances originate in the prostate gland. (medscape.com)
Desaturation of the fatty acids in glycerolipids is catalyzed by acyl-lipid desaturase (Murata and Wada, 1995). (rehabsociety.org.hk)

Low adiponectin is predictive of the future development of type II diabetes and coronary artery disease. (thepmc.org)
3.structure n function of heparin 4.jakob disease 5.what are modified aminoacids ?example? (kemunited.com)

Roles of neuroactive amino acids in ammonia neurotoxicity. (cdc.gov)

Evidence suggests that COX-1 and COX-2 are similar in structure and function but that they exist as 2 distinct enzymatic entities. (medscape.com)
X-ray crystallography was used to investigate this complex enzymatic process, which showed Orf1 has two substrate-binding sites that sit 13.5 Å apart unlike canonical FAD-dependent oxidoreductases. (hokudai.ac.jp)
An essential structural element of the C20-fatty acid for the enzymatic insertion of molecular oxygen is the 1,4-pentadiene with the concomitant rearrangement of the double bond to form a 1,3-conjugated diene which absorbs strongly around 236 nm. (gerli.com)

Modification of amino acids. (kemunited.com)

The microbial community associated with seaweeds tends to be species specific and different from that associated with seawater ( 2 ). (asm.org)
Genome-level analyses for a subset of phylogenetically-related microorganisms suggests that disinfection selects for microorganisms capable of using fatty acids, presumably from microbial decay products, via the glyoxylate cycle. (biomedcentral.com)

We then implement the pathway in a photosynthetic organism Synechococcus elongates PCC7942, and show that it increases the intracellular acetyl-CoA pool and enhances bicarbonate assimilation by roughly 2-fold. (osti.gov)

However, two others forms, hydroxycobalamin and cyanocobalamin, become biologically active after they are converted to methylcobalamin or 5-deoxyadenosylcobalamin [ 1-3 ]. (nih.gov)

IBS is currently defined by symptom criteria, including recurrent abdominal pain associated with altered bowel habits in the absence of detectable anatomic, inflammatory, or biochemical pathology [ 2 ]. (biomedcentral.com)

1987. Ammonia emissions and their role in acid deposition. (cdc.gov)

Increased free fatty acids result in production of ketones, and the brain is able to metabolize ketones as an alternative source of fuel. (medscape.com)
In muscles, nutritional glucose cannot be taken up because of this insulin resistance from the elevated levels of circulating free fatty acids. (thepmc.org)
Computation of absolute binding free energies for noncovalent inhibitors with SARS-CoV-2 main protease. (ucsf.edu)

The seeds of the chia plant are rich in fiber, polyunsaturated fatty acids, and alpha-linolenic acid, a type of essential fatty acid. (mskcc.org)
Essential amino acids. (kemunited.com)

Anatomy1

Chemicals and Drugs15

Phenomena and Processes2

Information Science2

Enzyme12

Metabolism10

Synthesis10

Enzymes7

Protein10

Methionine synthase1

Intermediates2

MRNA2

Sequence4

Deficiency3

Carnitine1

Residues4

Polyketide2

Homocysteine1

Proteins6

Aromatic1

Arachidonic acid3

20232

Insulin secretion1

Biosynthetic2

Cobalamin1

Propionic acid2

Derivatives3

Converts3

Cholesterol2

Compounds2

Peptides2

Disorders1

Serum2

Hepatic2

Homocystinuria3

Glycerol1

Liver2

Reductase1

Accumulation1

Catalytic1

Genes2

Linoleic acid1

Gene3

Cells6

Vitamins1

Lipid2

Disease2

Roles1

Enzymatic3

Modification1

Microbial2

Pathway1

Biologically active1

Inflammatory1

Deposition1

Free3

Essential2