Amino acid domain found protein domain. Medical search. Frequent questions

Nucleic Acids Res. (nih.gov)

We compared the S protein structures of MERS-CoV, SARS-CoV, and SARS-CoV-2 viruses and identified the residues like C526, C383, and N468 located in equivalent positions of these viruses have effects on S protein structure. (frontiersin.org)
repeat families are found in the conserved residues that form the hydrophobic domain core. (cellsignal.com)
SEB consists of 239 amino acid residues and has a molecular weight of 28 kd. (medscape.com)
By analyzing its amino acid sequence, RCC1 was found to consist of seven homologous repeats of 51-68 amino acid residues, which were later shown to adopt a seven-bladed beta-propeller fold. (nih.gov)
The interface between MTERF4 and NSUN4 contains evolutionarily conserved polar and hydrophobic amino acids, and mutations that change these residues completely disrupt complex formation. (rcsb.org)
A hydrophobic surface patch is created by motif residues that are highly conserved among a variety of proteins from diverse eukaryotic species. (embl-heidelberg.de)
A gene was identified (1229 bp) with a putative open reading frame (204 bp) encoding a 67-amino-acid protein exhibiting several characteristic features of MT proteins, including 16 cysteine residues (24%) and only one aromatic residue. (portlandpress.com)
Although the protein sequence showed high identity with plant and invertebrate MTs, it contained a unique 'linker ' region (14 amino acid residues) between the two putative metal-binding domains which contained no cysteine residues. (portlandpress.com)
Complete amino acid sequence consisted of 229 residues, including a FReD in the N-terminal. (bvsalud.org)
The current view of protein folding and stability is largely based on SAXS and DLS data13-16 and the extensive exposure of hydropho- a generic structural classification into native (N), compact dena- bic residues suggested by the finding that the heat capacity of the tured or molten globule (MG), and unfolded or denatured (D) MG state is midway between that of the N and D states7 have been conformational states1-10. (lu.se)

Mutations in the three SHANK genes encoding for postsynaptic scaffolding proteins have been shown to represent risk factors for autism spectrum disorders and other neurodevelopmental disorders. (nature.com)
The goal of the present investigation is to examine the effects of missense mutations in the MERS-CoV S protein on protein stability and binding affinity with DPP4 to provide insight that is useful in developing vaccines to prevent coronavirus infection. (frontiersin.org)
We utilized a saturation mutagenesis approach to simulate all possible mutations in the MERS-CoV full-length S, S Receptor Binding Domain (RBD) and DPP4. (frontiersin.org)
We investigated the effects of MERS-CoV S protein viral mutations on protein stability and binding affinity. (frontiersin.org)
In addition, we studied all DPP4 mutations and found the functional substitution R336T weakens both DPP4 protein stability and S-DPP4 binding affinity. (frontiersin.org)
These findings provide further information on how mutations in coronavirus S proteins effect protein function. (frontiersin.org)
We also detected in 4 asthenospermic patients a double novels mutations, the first was found in COXII gene (m.8021 G/A) that was absent in normospermic infertile men. (nih.gov)
In sites with an epithelial component, e.g. the skin epidermis or conjunctiva of the eye, activating BRAF mutations are frequently found. (ubc.ca)
Truncating RAD21 variants are shown above, and missense mutations and in-frame deletions are shown below the protein representation. (springer.com)
These mutations alter the structure or disrupt the production of the pro-α1(VII) chain protein, which affects the production of type VII collagen. (medlineplus.gov)
In many cases, these mutations alter a part of type VII collagen known as the triple helical domain. (medlineplus.gov)
Mutations that substitute other amino acids for glycine in this region can disrupt the triple-stranded structure of type VII collagen. (medlineplus.gov)
Although they are most commonly associated with DDEB, mutations that substitute glycine amino acids in the triple helical domain can also cause RDEB. (medlineplus.gov)
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl CpG binding protein 2 ( MeCP2 ) gene. (neurology.org)
The authors found 17 novel mutations, including a complex gene rearrangement found in one individual involving two deletions and a duplication. (neurology.org)
Studies examining the relationship between mutation type, X-inactivation status, and severity of clinical presentation found significant differences in clinical presentation between different types of mutations. (neurology.org)
Mutations in the amino-terminus were significantly correlated with a more severe clinical presentation compared with mutations closer to the carboxyl-terminus of MeCP2. (neurology.org)
Skewed X-inactivation patterns were found in two asymptomatic carriers of MeCP2 mutations and six girls diagnosed with either atypical or classical RTT. (neurology.org)
More than 95% of individuals with RTT have mutations in methyl-CpG-binding protein 2 (MECP2), whose protein product modulates gene transcription. (bmj.com)
Results In general agreement with previous studies, we found that particular mutations, such as p.Arg133Cys, p.Arg294X, p.Arg306Cys, 3° truncations and other point mutations, were relatively less severe in both typical and atypical RTT. (bmj.com)
Fewer than 10 mutations in the EDARADD gene have been found to cause hypohidrotic ectodermal dysplasia, the most common form of ectodermal dysplasia. (medlineplus.gov)
Most of the EDARADD gene mutations associated with hypohidrotic ectodermal dysplasia change single protein building blocks (amino acids) in the receptor protein. (medlineplus.gov)
Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)
X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)

There are several leucine-rich nuclear export signals in the amino acid sequence of the protein. (wikipedia.org)
As a sub-objective, since PDE10A transcript variants were reported strictly through analyses of bovine genomic sequence, we also wanted to determine the nucleotide and amino acid sequences by experimental evidence. (plos.org)
The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
repeats vary more in length, amino acid sequence and 3D-structure. (cellsignal.com)
Amino-acid sequence and structure comparison suggested that the enzyme belongs to a group of enzymes classified as archaeal Holliday junction-resolving enzymes, which are typically divalent metal ion-binding dimers that are able to cleave X-shaped dsDNA-Holliday junctions (Hjs). (iucr.org)

So far, common variants in the SHANK1 gene were reported to be associated with reduced auditory working memory in SCZ 36 and a rare de novo loss-of-function mutation affecting SHANK1 was recently found in a large-scale exome-sequencing study. (nature.com)
This mutation substituting the Isoleucine at position 146 to Valine in a conserved amino acid in the transmembrane functional domain of the protein. (nih.gov)
A) this mutation was found in homoplasmic state and was absent in normospermic patients. (nih.gov)
Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
This mutation has been found to be present in all sublines of C57BL/6N and in C57BL/6ByJ, but not in any C57BL/6J subline. (jax.org)
To understand the impact of this species-specific variation at position 60, the authors constructed two versions of the human CARD8 protein in which the human-specific mutation was replaced with the amino acid found in other primates (S60 or L60 instead of F60). (fredhutch.org)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
To the best of our knowledge, this is the first study to show that a novel mutation (p.Glu1389AspfsX16) causing the truncation of the PIKFYVE protein causes fleck corneal dystrophy in the Japanese population. (molvis.org)
Accession C0001 Systematic name Allele 1 and 2: g.1044G>A, c.396G>A, p.G111S Original code 25-year-old man Description Allele 1 and 2: point mutation in the exon 2 leading to an Description amino acid change in the IG-V domain Date 10-Oct-2002 (Rel. (lu.se)

In particular, upstream open reading frames (uORFs) are segments of 5′UTR mRNA sequences that can initiate and terminate translation upstream of protein-coding start codons. (nature.com)
Specific uORFs are known to control protein expression by tuning translation rates of downstream protein-coding sequences, and potential uORFs have been identified in ~50% of all human protein-coding genes 1 , 2 . (nature.com)
Using the allele frequency spectrum of SNVs from 71,702 whole genome sequences in gnomAD, we find that SNVs introducing new stop codons, or creating stronger translation termination signals in uORFs are under strong selective constraints within 5′UTRs. (nature.com)
The predicted structures of the Gimap proteins show common sequences and motifs, such as GTP-binding domains in the N-terminal half, but with differing C-terminal ends [ 2 , 3 ]. (hindawi.com)
This model represents a family of small (about 115 amino acids) uncharacterized proteins with N-terminal signal sequences, found exclusively in Gram-positive organisms. (nih.gov)
Using mass spectrometry, a laboratory technique that breaks down a substance into its individual components, the researchers analyzed the makeup of the TLA and found two peptide sequences that match up to key segments of the protein protocadherin-15 in humans, mice, and chickens, suggesting that the two proteins are evolutionarily comparable. (sciencedaily.com)
The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. (embl-heidelberg.de)
This extended linker is larger than the tripeptide found in archetypal vertebrate MTs, but does not conform either with the 40-amino-acid linkers commonly found in plant MT sequences. (portlandpress.com)
The lectin showed affinity only for the glycoproteins fetuin, asialofetuin, mucin type III, and bovine submaxillary mucin type I. The complete amino acid sequences of two isoforms of ALL, named ALL-a and ALL-b, were determined by a combination of Edman degradation and overlapped peptides sequenced by tandem mass spectrometry. (bvsalud.org)

This study goal was to find a baseline which could be used to help identify diseased tissue and look at genes with tissue specific expression and how those can be used as markers for detecting diseased and injured tissue in organs. (wikipedia.org)
This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. (nih.gov)
Of note, the genes encoding these effectors and immunity proteins are widely distributed in Salmonella genomes, suggesting a relevant role in interbacterial competition and virulence. (frontiersin.org)
As several synaptic proteins like neurexins and neuroligins are interaction partners of the SHANKs and associate with both disorders, the question arises if variants in the SHANK genes themselves can be associated with SCZ. (nature.com)
Our results suggest translation disrupting mechanisms relating uORF variation to reduced protein expression, and demonstrate that translation at uORFs is genetically constrained in 50% of human genes. (nature.com)
Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
Loss of function-variants in cohesin genes including RAD21 were found in individuals with holoprosencephaly of whom some demonstrated CdLS features as well (Kruszka et al. (springer.com)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
8 The MeCP2 protein, initially characterized by its ability to bind single methylated CG nucleotides, 9 plays a significant role in the transcriptional silencing of genes. (neurology.org)
The major part of his production relates to variations ranging from protein engineering to effects and mechanisms of variations in protein structures, genes and diseases. (lu.se)
The S gene is one of the structural genes of the virus which encodes for a protein that sits on the surface of the SARS CoV-2 virus. (who.int)

CCDC 169 was found not to have housekeeping gene type expression. (wikipedia.org)

A key component in the virulence of MERS-CoV is the Spike (S) protein, which binds with the host membrane receptor dipeptidyl peptidase 4 (DPP4). (frontiersin.org)
[ 13 ] The toxin binds directly to the major histocompatability complex (MHC) class II proteins on target cells, subsequently stimulating the proliferation of large numbers of T lymphocytes. (medscape.com)
Additional experiments using western blot analysis, a technique that identifies individual proteins in a substance by separating them from one another by mass and testing how they react to certain antibodies, demonstrated that the antibody that recognizes protocadherin-15 in mice also binds to the TLA. (sciencedaily.com)
It was identified in the human intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two tandem PPPGHR segments within the cytoplasmic region of CD2. (embl-heidelberg.de)
Thus this paper describes, for the first time, an MT gene identified from macroalgae which is induced by copper exposure and whose encoded protein product binds cadmium and copper. (portlandpress.com)
Like other ets-related proteins it binds to consensus sites in DNA through a 85 amino acid ets domain in the carboxyl region of the protein. (bdbiosciences.com)
In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)
Lead also binds to metallothionein, a sulfhydryl-rich protein, but does not appear to displace cadmium or zinc. (cdc.gov)

It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)
From these studies, the emerging picture is that the RLD is a versatile domain which may perform many different functions, including guanine nucleotide exchange on small GTP-binding proteins, enzyme inhibition or interaction with proteins and lipids. (nih.gov)

N amino acid substitution. (cdc.gov)
N substitution are also found in amphibian IRF3 but not in amphibian IRF7. (cdc.gov)
N substitution in IRF3 DPHK is again found in cetaceans such as whales and dolphins as well as in marsupials. (cdc.gov)
Gimap4 and Gimap1 each had one amino acid substitution of unlikely significance for lymphopenia. (hindawi.com)
Indeed, they found that substitution of F60 prevents HIV from cleaving CARD8. (fredhutch.org)

H untington, E longation Factor 3, PR65/ A , T OR) is found in the four diverse eukaryotic proteins for which the domain is named. (cellsignal.com)

By numerous specific protein-protein interactions, SHANKs are either directly or indirectly linked to other structural proteins, cell adhesion molecules, receptors, ion channels and to actin-interacting proteins at the postsynaptic density. (nature.com)

These findings shed new light on hydrophobic stabilization of proteins. (lu.se)
Whereas the N state has been character- taken to imply that hundreds of water molecules penetrate the MG ized at high resolution, many aspects of the D and MG states are protein (except for a relatively small hydrophobic core)5,7,8,17-19. (lu.se)

Click through the PLOS taxonomy to find articles in your field. (plos.org)

There are two low identity paralogs and two hypothetical protein paralogs found through the sequencing of the human genome. (wikipedia.org)

For -lactalbu- min, only water molecules conserved in the human and baboon structures are shown (the structure of the bovine protein has not been reported). (lu.se)

As we show here, these RCC1 superfamily proteins can be subdivided in five subgroups based on structural criteria. (nih.gov)
In recent years, a number of studies have been published regarding the functions of RCC1 superfamily proteins. (nih.gov)
Here, we review the available structural and functional data on RCC1 superfamily members, paying special attention to the human proteins and their involvement in disease. (nih.gov)
also known as ZIP kinase and DLK) is a 52 kDa member of the CAMK Ser/Thr kinase family, protein kinase superfamily of enzymes. (rndsystems.com)

TDP-43 pathology includes cytoplasmic aggregates of the normally nuclear protein. (alzforum.org)
TDP-43 is known to modify mRNAs, so it was no surprise to see components of the heterogenous nuclear ribonuclear (hnRNP) protein complex, as well as other RNA-binding proteins. (alzforum.org)
The interaction is most likely an early event" in disease, Ling speculated, leading up to later stages where TDP-43 and FUS, normally nuclear proteins, are mislocalized and aggregated in the cytoplasm. (alzforum.org)
These attachment sites are linked to actin-bundles that surround the nucleus via an Ndj1-Mps3-Csm4 protein bridge that spans the inner and outer nuclear membranes. (biorxiv.org)
KMT2A gene consists of 37 exons encoding a 3969 amino-acid nuclear protein with a molecular weight of nearly 431 kDa. (atlasgeneticsoncology.org)

An overall 55% homology exists between human and bacterial HSP60 that can even reach 72% at certain domains of the 573-amino-acid-long molecule ( 18 ). (spandidos-publications.com)
The RAF Proto Oncogene Serine, Threonine Protein Kinase (Proto Oncogene c RAF or RAF1 or EC 2.7.11.1) pipeline drugs market research report provides comprehensive information on the RAF Proto Oncogene Serine/Threonine Protein Kinase (Proto Oncogene c RAF or RAF1 or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. (globaldata.com)
The viral S gene is important as it codes for the Spike protein which is the molecule that makes contact with, and allows entry of the virus into susceptible host cells, causing infection. (who.int)

FLNA gene consists of 48 exons encoding a 2647 amino-acid protein with a molecular weight of 280739 Da. (atlasgeneticsoncology.org)
The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)

These results provide a resource of 600 human proteins containing effectors and demonstrate a scalable strategy for assigning functions to protein domains. (stanford.edu)

motifs of Protein Phosphatase 2A PR65/A subunit. (cellsignal.com)
MTERF4 is composed of structurally repeated MTERF-motifs that form a nucleic acid binding domain. (rcsb.org)

Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)
In patients with the group A variant, sphingomyelin and other lipids are stored in the brain in increased amounts, a finding consistent with the neuronopathic features, whereas in patients with the group B form, the nervous tissue does not appear to store sphingomyelin. (medscape.com)

The HIV-1 protease directly cleaves between amino acids at positions 59-60. (fredhutch.org)
The LC selectively cleaves a disease that is contracted by ingestion of food containing the neuronal proteins required for acetylcholine release. (cdc.gov)
Of the serotypes, only one, BoNT/C, administration of therapeutic immunoglobulin product and is most cleaves more than one specific protein. (cdc.gov)

To find clues to the protein's normal role, the scientists isolated the wild-type protein, with its associated hangers-on, and used mass spectrometry to identify the partners. (alzforum.org)

While some effector proteins specifically target bacterial or eukaryotic cells, others can target both types of cells (trans-kingdom effectors). (frontiersin.org)

Members of this protein family are ABC transporter permease proteins associated with urea transport and metabolism. (nih.gov)
The SHANK protein family is composed of three multidomain scaffolding proteins residing at the postsynaptic density of excitatory glutamatergic synapses. (nature.com)
This family of proteins is found in eukaryotes. (embl.de)
Proteins in this family are typically between 115 and 196 amino acids in length. (embl.de)
Recently, it was reported that the caspase recruitment domain family member 8 (CARD8), an inflammasome sensor, plays a role in detecting HIV-1 infection. (fredhutch.org)
We recently showed that a member of the mitochondrial transcription termination factor (MTERF) family of proteins, MTERF4, recruits NSUN4, a 5-methylcytosine RNA methyltransferase, to the large ribosomal subunit in a process crucial for mitochondrial ribosome biogenesis. (rcsb.org)
This study provides a molecular explanation for MTERF4-dependent recruitment of NSUN4 to ribosomal RNA and suggests a unique mechanism by which other members of the large MTERF-family of proteins can regulate ribosomal biogenesis. (rcsb.org)
Cytosine C5 methylation is an important epigenetic control mechanism in a wide array of eukaryotic organisms and generally carried out by proteins of the C-5 DNA methyltransferase family (DNMTs). (mdpi.com)
Collagens are a family of proteins that strengthen and support connective tissues, such as skin, bone, tendons, and ligaments, throughout the body. (medlineplus.gov)

Two recent papers address these questions, focusing on TDP-43's stability and protein-protein interactions. (alzforum.org)
Ling plans to examine TDP-43 stability and protein-protein interactions in neurons and patient-derived cells. (alzforum.org)
The hydration of nonnative states is central to protein folding and stability but has been probed mainly by indirect methods. (lu.se)
Considering the widely acknowledged Accordingly, theoretical models of the MG state invariably invoke importance of protein-solvent interactions for stability and fold- a substantial internal hydration20-22. (lu.se)

Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)

Searches for similarity found that ELL was very close to putative proteins from Strongylocentrotus purpuratus. (bvsalud.org)

The protein is found to be over expressed in the testis of humans. (wikipedia.org)
Transmembrane protein 53 , or TMEM53 , is a protein that is encoded on chromosome 1 in humans. (wn.com)
Transmembrane protein 131 (TMEM131) is a protein that is encoded by the TMEM131 gene in humans. (wn.com)
Protocadherin-15 is a protein made by a gene that causes one form of type 1 Usher syndrome, the most common cause of deaf-blindness in humans. (sciencedaily.com)
In humans, phenylalanine is found at both positions and this cleavage site is unique to human CARD8. (fredhutch.org)

RAF proto-oncogene serine/threonine-protein kinase or proto-oncogene c-RAF is an enzyme encoded by the RAF1 gene. (globaldata.com)

We show that uORF variants introducing new stop codons, or strengthening existing stop codons, are under strong negative selection comparable to protein-coding missense variants. (nature.com)
Using these variants, we map and validate gene-disease associations in two independent biobanks containing exome sequencing from 10,900 and 32,268 individuals, respectively, and elucidate their impact on protein expression in human cells. (nature.com)
We evaluated consequences of 12 intragenic variants by protein modelling and molecular dynamic studies. (springer.com)
Careful phenotyping is essential in interpreting consequences of RAD21 variants, and protein modeling and dynamics can be helpful in determining pathogenicity. (springer.com)
Variants for which protein modelling is available, are marked in bold. (springer.com)
ClinVar variants which are reported in the ClinVar database and could be investigated for pathogeneity with protein modelling (see supplementary Table S6). (springer.com)
RAD21 variants are found in a minority of CdLS patients. (springer.com)

This deletion causes a frame shift and a premature stop codon that truncates the transmembrane and cytoplasmic domain of the protein after amino acid 1207. (jax.org)

High throughput measurements of direct activation domain-coactivator interactions. (stanford.edu)
Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions. (embl-heidelberg.de)

In animals, lead has been shown to alter a number of neurotransmitter systems including dopamine, norepinephrine, serotonin, and gamma- aminobutyric acid systems (ATSDR 1999). (cdc.gov)

domain consists of repeats of two anti-parallel α-helices and two turns arranged about a common axis. (cellsignal.com)
The CARD8 protein consists of two domains: FIIND (N terminus) and CARD (C terminus), the FIIND domain is cleaved during HIV infection, allowing the free CARD domain to trigger cell death and promote inflammatory responses. (fredhutch.org)
The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)

Proteins crucial for the respiratory chain are translated by the mitochondrial ribosome. (rcsb.org)

Some C-terminal regions are consistent with transmembrane domains as in the case of Gimap1 and Gimap5, while others, as in Gimap9 and Gimap4, predict coiled coil domains [ 3 , 14 ]. (hindawi.com)
The TMEM131 protein contains three domains of unknown function 3651 (DUF3651) and two transmembrane domains . (wn.com)

A transmembrane protein (TP) is a type of membrane protein spanning the entirety of the biological membrane to which it is permanently attached . (wn.com)

There is evidence that the protein is retained in the nucleus. (wikipedia.org)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)

C13orf38 is a protein found in the thirteenth chromosome with an open reading frame number 38. (wikipedia.org)
Lasp1 (LIM and SH3 domain protein 1), localized on chromosome 17q11-21.3, was first identified in 1995 [ 1 ]. (oncotarget.com)

Thus, the architecture of the GYF domain may be widely used in protein-protein associations. (embl-heidelberg.de)
2016). In addition, Vihinen has introduced widely followed guidelines, recommendations and policies, he has founded a new sub-discipline of immunome, and introduced systematics to biological prediction methods and their assessment. (lu.se)

Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
Human DAPK3 is 454 amino acids (aa) in length and contains one protein kinase domain (aa 134‑275) and a C-terminal Leu-zipper motif (aa 427‑441) that mediates homo- and hetero-dimerization. (rndsystems.com)

CARD8 is a cytosolic protein that forms part of the immune system and is activated during viral infection. (fredhutch.org)
The galectin lattice (i) regulates flow of receptors and solute transporters to coated-pit endocytosis and/or caveolin domains, and (ii) promotes turnover of cell-cell contacts such as immune synapses and focal adhesion complexes. (gr.jp)
The S protein, due to its exposure on the outside of the virus is also one of the parts of the virus that is recognised as foreign by the immune system. (who.int)

2011). Filamin A is an actin crosslinking phosphoprotein of the peripheral cytoplasm and interacts with Pho proteins. (atlasgeneticsoncology.org)
The EDARADD protein interacts with another protein, called the ectodysplasin A receptor, which is produced from the EDAR gene. (medlineplus.gov)

Additionally, in a clinical study, a strong positive correlation was found between high levels of soluble HSP60 and the risk of CAD ( 21 ). (spandidos-publications.com)

The results show that nonnative proteins are more structured and less solvent exposed than commonly believed. (lu.se)

In Jurkat T cells, over-expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor. (embl-heidelberg.de)
The activity of the receptor is mediated by G proteins that stimulate adenylate cyclase. (globaldata.com)
The EDARADD protein acts as an adapter, which means it assists the ectodysplasin A receptor in triggering chemical signals within cells. (medlineplus.gov)
These changes occur in or near the death domain, preventing the EDARADD protein from interacting effectively with the ectodysplasin A receptor. (medlineplus.gov)
The heavy chain is responsible for both receptor some species of the genus Clostridium, in particular, Clostridium binding via its C-terminal (CT) binding domain [4,5] (HC) and botulinum, C. butyricum, C. baratii, and C. argentinense. (cdc.gov)

The SH3 domain is a 60 amino acids segment shared by diverse structural and signaling proteins [ 6 ]. (oncotarget.com)

This is a PFAM domain. (embl.de)

Homologs were found mostly in primates. (wikipedia.org)

A protein associated with a disorder that causes deafness and blindness in people may be a key to unraveling one of the foremost mysteries of how we hear, says a study in the June 28 issue of the Journal of Neuroscience. (sciencedaily.com)

Pandemics of influenza A occur when a major change occurs in the proteins of circulating strains of the virus. (cdc.gov)
ALL is a protein with antibacterial potential, when in association with ampicillin and oxacillin the lectin potentiates its antibiotic effect, included Methicillin-resistant Staphylococcus strains. (bvsalud.org)

repeats are found in proteins involved in translation including eIF4Gs, p97/DAP5, Paip-1, GCN1 and FRAP/mTOR. (cellsignal.com)

In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17-aa motif (GPY[orF]xxxxM[orV]xxWxxx GYF), also found in several yeast and Caenorhabditis elegans proteins of unknown function. (embl-heidelberg.de)
The opacities were relatively dominant at the peripheral region of the cornea, yet were found throughout the entire cornea. (molvis.org)
This translocation brings the 5' region of the EWS gene into conjunction with the 3' region of the Fli-1 gene encoding the ets-DNA binding domain. (bdbiosciences.com)
It contains an N-terminal LIM domain and a C-terminal SRC homology region 3 (SH3) domain [ 2 - 4 ]. (oncotarget.com)
These fibrils are found in a region known as the epidermal basement membrane zone, which is a two-layer membrane located between the top layer of skin, called the epidermis, and an underlying layer called the dermis. (medlineplus.gov)
This interaction occurs at a region called the death domain that is present in both proteins. (medlineplus.gov)

7 The Rett gene was recently identified as the methyl CpG binding protein 2 ( MeCP2 ) gene. (neurology.org)

They pulse-labeled growing cells with radioactive methionine and cysteine to tag newly translated proteins, then followed TDP-43 radioactivity over time. (alzforum.org)

This protein is part of a signaling pathway that plays an important role in development before birth. (medlineplus.gov)

This finding suggests that both subunits of the protein complex likely contribute to RNA recognition. (rcsb.org)
The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)

The Type VI Secretion System (T6SS) is a multiprotein device that has emerged as an important fitness and virulence factor for many Gram-negative bacteria through the injection of effector proteins into prokaryotic or eukaryotic cells via a contractile mechanism. (frontiersin.org)
The second study, posted online in the Journal of Biological Chemistry on June 16, suggests one possible mechanism by which TDP-43 might bind other proteins. (alzforum.org)
Proviral infection at the "site of the highest degree" was thought to be the mechanism of carcinogenesis, giving the first name to the gene found along this pathway as INT1. (chemdiv.com)

Anatomy10

Organisms13

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes84

Disciplines and Occupations1

Information Science11

Health Care1

Nucleic Aci1

Residues10

Mutations24

Sequence5

Mutation10

Sequences9

Genes11

Housekeeping gene1

Binds8

Nucleotide2

Substitution5

Eukaryotic proteins1

Structural proteins1

Hydrophobic2

Taxonomy1

Hypothetical protein1

Structures1

Superfamily4

Nuclear5

Molecule3

Molecular weight2

Human proteins1

Motifs2

Lipids2

Cleaves3

Mass spectrometry1

Effectors1

Family9

Stability4

Isoforms1

Putative1

Humans5

Enzyme1

Variants7

Cytoplasmic1

Interactions2

19991

Consists3

Mitochondrial1

Transmembrane domains2

Spanning the entirety1

Nucleus2

Chromosome2

Widely2

Kinase3

Immune3

Interacts2

Soluble1

Commonly1

Receptor5

Segment1

PFAM1

Primates1

Disorder1

Strains2

Repeats1

Region7

MeCP21

Cysteine1

Signaling pathway1

Subunits2

Mechanism3