• Acidic amino acid residues Asp32, Glu251, and Asp367 in the transmembrane region of NorM are conserved in one of the clusters of the MATE family. (elsevierpure.com)
  • In this study, we investigated the role(s) of acidic amino acid residues Asp32, Glu251, and Asp367 in the transmembrane region of NorM by site-directed mutagenesis. (elsevierpure.com)
  • They are ANTIPORTERS that exchange vesicular PROTONS for cytoplasmic NEUROTRANSMITTER and play an essential role in regulating neurotransmission. (uams.edu)
  • Since carriers are much more closely related, at least mechanistically, to symporters and antiporters than to channels, they are the type of uniporter emphasized in this volume. (biologists.com)
  • Nelson and Lill, 1994 ) the decision as to whether they are symporters or antiporters depends upon the direction of translocation, relative to that of the primary driving ion, of the substrate of greatest physiological importance. (biologists.com)
  • 2021) as well as in human antiporter NHA2 (Vélazquez et al. (cas.cz)
  • Analysis of a full-length CAX1 clone suggested that the CAX1 open reading frame contains an additional 36 amino acids at the N terminus that were not found in the original clone identified by suppression of yeast (Saccharomyces cerevisiae) vacuolar Ca2+ transport mutants. (manchester.ac.uk)
  • The structure and function of the cadaverine-lysine antiporter, CadB (2.A.3.2.2), and the putrescine-ornithine antiporter, PotE (2.A.3.2.1), in E. coli have been evaluated using model structures based on the crystal structure of AdiC (2.A.3.2.5), an agmatine-arginine antiporter. (tcdb.org)
  • have presented the crystal structure of apo-ApcT, a proton-coupled broad-specificity amino acid transporter, at 2.35 Å resolution. (tcdb.org)
  • however, minor alterations in the 36-amino acid region restored Ca2+/H+ transport. (manchester.ac.uk)
  • NorM is a member of the multidrug and toxic compound extrusion (MATE) family and functions as a Na + /multidrug antiporter in Vibrio parahaemolyticus, although the underlying mechanism of the Na + /multidrug antiport is unknown. (elsevierpure.com)
  • Sequence analysis suggests that a 36-amino acid N-terminal regulatory domain may be present in all Arabidopsis CAX-like genes. (manchester.ac.uk)
  • As an example, Wood and colleagues (pp. 2695-2710) present the sialic acid gene repressor NanR (PDB-6WFG), where cryo-EM revealed the DNA-binding mode. (silverchair.com)
  • In the case of exchangers (also referred to antiporters ), the driving and driven species move in opposite directions across the membrane. (physiologyweb.com)
  • System xc- is a plasma membrane amino acid antiporter, of mainly glial origin, that couples the import of cystine with the export of glutamate. (vub.be)
  • Although it was originally identified only in cells expressing a mutant RAS oncogene, ferroptosis has also been found in normal cells following treatment by small molecules (e.g., erastin and RSL3) or drugs (e.g., sulfasalazine, sorafenib, and artesunate), which target antioxidant enzyme systems, especially the amino acid antiporter system x c − and the glutathione peroxidase GPX4. (elsevierpure.com)
  • Although it was originally identified only in cells expressing a mutant RAS oncogene, ferroptosis has also been found in normal cells following treatment by small molecules (e.g., erastin and RSL3) or drugs (e.g., sulfasalazine, sorafenib, and artesunate), which target antioxidant enzyme systems, especially the amino acid antiporter system xc− and the glutathione peroxidase GPX4. (elsevierpure.com)
  • In that case, such 'antiporters' (as we now call them) were considered to be essential if mitochondria were to express a membrane potential, negative inside the organelle, for over the long term cytosolic Na + and K + would inevitably accumulate, driven inwards by the electrical potential and, unless some mechanism were available for cation extrusion, swelling and lysis would be just as inevitable. (biologists.com)