NeomycinGentamicinStreptomycinAminoglycosidesAminoglycosideOfloxacinCapreomycin or kanamycinInjectable second-lineAntibioticsLiposome inhalation suspensionGram-positiveDrugsOtotoxicitySystemicChemicallyBreast milkInfectionsInfantsBreastfeeding mothersDosesIrreversibleConcentrationsAgentsSafetyLevelsProduceIncreaseActivity
Neomycin2
- Similarly, a potentiating effect of chlorpromazine on kanamycin, gentamicin and neomycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. (springer.com)
- amikacin and neomycin PO both increase nephrotoxicity and/or ototoxicity. (medscape.com)
Gentamicin6
- aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin etc. (mydr.com.au)
- A synergistic effect of this extract on gentamicin and kanamycin was demonstrated. (springer.com)
- Amikacin and gentamicin are the most commonly used in veterinary medicine. (wedgewoodpharmacy.com)
- Amikacin has a broader spectrum of activity than some of the other members of this group and is often used for bacterial infections resistant to gentamicin. (wedgewoodpharmacy.com)
- Amikacin is generally preferred over gentamicin for systemic use in neonatal foals. (wedgewoodpharmacy.com)
- Whether tobramycin is less nephrotoxic than either gentamicin or amikacin when used clinically is controversial. (elephantcare.org)
Streptomycin4
- However, the following antituberculosis drugs are contraindicated in pregnant women - Streptomycin, Kanamycin, Amikacin, Capreomycin and Fluoroquinolones (Ciprofloxacin / Ofloxacin). (ndtv.com)
- The latest evidence from individual patient data meta-analyses of 50 observational studies published since 2009 indicates that kanamycin and capreomycin are inferior and should be replaced by amikacin (or streptomycin, if susceptible) or, even better, by oral agents such as bedaquiline [ 13 , 14 ]. (ersjournals.com)
- Kanamycin or amikacin is the first choice of an injectable agent, given the high rates of streptomycin resistance in drug-resistant TB. (boneandspine.com)
- [ 5 ] Babies have suffered congenital deafness when their mothers took kanamycin or streptomycin during pregnancy. (medscape.com)
Aminoglycosides6
- There are some gram-positive Staphyloccus that are sensitive to amikacin although generally the aminoglycosides are combined with other antibiotics when both gram-negative and gram-positive bacteria are present. (wedgewoodpharmacy.com)
- Amikacin and other aminoglycosides are eliminated via the kidney and can be nephrotoxic. (wedgewoodpharmacy.com)
- Amikacin and other aminoglycosides are commonly used in ophthalmic preparations to treat corneal ulcers. (wedgewoodpharmacy.com)
- Newborn infants apparently absorb small amounts of other aminoglycosides, but serum levels with typical three times daily dosages are far below those attained when treating newborn infections and systemic effects of amikacin are unlikely. (drlact.com)
- Amikacin (I) is one of the most effective aminoglycosides. (epharmacognosy.com)
- Amikacin, like other aminoglycosides, can be given in multiple daily doses (conventional) or once-daily dose (pulse). (medscape.com)
Aminoglycoside4
- A pregnant woman taking amikacin with another aminoglycoside has a possibility of causing congenital deafness in her child. (wikipedia.org)
- Amikacin is an aminoglycoside antibiotic that is used to treat serious gram-negative bacterial infections. (wedgewoodpharmacy.com)
- Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
- When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
Ofloxacin2
- DST of second-line drugs (ofloxacin, amikacin, kanamycin, capreomycin) was performed on isolates from MDR-TB cases to identify pre-XDR and XDR cases. (who.int)
- Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. (who.int)
Capreomycin or kanamycin4
- Extensively drug resistant-tuberculosis is defined as multidrug-resistant tuberculosis that is also resistant to any one of the fluoroquinolones and to at least one of three injectable second-line antibiotics (amikacin, capreomycin or kanamycin). (who.int)
- Extensively drug-resistant (XDR) tuberculosis is defined as disease caused by Mycobacterium tuberculosis with resistance to at least isoniazid and rifampicin, any fluoroquinolone, and at least one of three injectable second-line drugs (amikacin, capreomycin, or kanamycin). (nih.gov)
- capreomycin, or kanamycin. (cdc.gov)
- MDR-TB that is also resistant to any one of the fluoroquinolones and to at least one of three injectable second-line medicines (amikacin, capreomycin or kanamycin).6 MDR-TB and XDR-TB are principally a result of inadequate or poorly administered treatment regimens. (who.int)
Injectable second-line2
- In this type the bacteria causing tuberculosis is resistant to isoniazid, rifampin, any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, capreomycin). (centerhears.com)
- Extensively drug-resistant TB (XDR TB) is a rare type of MDR TB that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin). (boneandspine.com)
Antibiotics1
- Amikacin may be combined with other antibiotics to provide coverage for gram positive bacteria. (wedgewoodpharmacy.com)
Liposome inhalation suspension5
- Amikacin liposome inhalation suspension is the first drug approved under the US limited population pathway for antibacterial and antifungal drugs (LPAD pathway). (wikipedia.org)
- The US Food and Drug Administration (FDA) granted the application for amikacin liposome inhalation suspension fast track, breakthrough therapy, priority review, and qualified infectious disease product (QIDP) designations. (wikipedia.org)
- The FDA granted approval of Arikayce to Insmed, Inc. The safety and efficacy of amikacin liposome inhalation suspension, an inhaled treatment taken through a nebulizer, was demonstrated in a randomized, controlled clinical trial where patients were assigned to one of two treatment groups. (wikipedia.org)
- One group of patients received amikacin liposome inhalation suspension plus a background multi-drug antibacterial regimen, while the other treatment group received a background multi-drug antibacterial regimen alone. (wikipedia.org)
- By the sixth month of treatment, 29 percent of patients treated with amikacin liposome inhalation suspension had no growth of mycobacteria in their sputum cultures for three consecutive months compared to 9 percent of patients who were not treated with amikacin liposome inhalation suspension. (wikipedia.org)
Gram-positive1
- The only Gram-positive bacteria that amikacin strongly affects are Staphylococcus and Nocardia. (wikipedia.org)
Drugs2
- Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection. (wikipedia.org)
- The second-line injectable drugs are amikacin, kanamycin, and capreomycin. (cdc.gov)
Ototoxicity2
- Amikacin trough levels of more than 10 mcg/mL have been associated with significant ototoxicity and nephrotoxicity. (medscape.com)
- Although a reported 130 medications can produce ototoxicity, some are seldom seen by the average retail pharmacist (e.g., ethacrynic acid, dihydrostreptomycin, kanamycin, sisomycin). (medscape.com)
Systemic1
- Systemic amikacin is used to treat serious gram-negative infections. (wedgewoodpharmacy.com)
Chemically1
- It may be produced chemically from Kanamycin (II) but this route is rather expensive and not cost-effective. (epharmacognosy.com)
Breast milk2
- While it is known to cross the placenta, amikacin is only partially secreted in breast milk. (wikipedia.org)
- Does Amikacin extracts into breast milk? (drlact.com)
Infections3
- Amikacin is an antibiotic medication used for a number of bacterial infections. (wikipedia.org)
- Amikacin is frequently used in topical otic-preparations to treat susceptible bacterial infections (most commonly Pseudomonas Aeruginosa). (wedgewoodpharmacy.com)
- [ 6 ] In critically ill patients with serious gram-negative infections, higher loading doses and closer monitoring of amikacin levels are required to achieve a peak-to-MIC ratio of greater than 8-10. (medscape.com)
Infants3
- In general, amikacin should be avoided in infants. (wikipedia.org)
- Does Amikacin has any long term or short term side effects on infants? (drlact.com)
- Older infants would be expected to absorb even less amikacin. (drlact.com)
Breastfeeding mothers1
- Our study of different scientific research also indicates that Amikacin does not cause any serious side effects in breastfeeding mothers. (drlact.com)
Doses1
- Amikacin should be used in smaller doses in the elderly, who often have age-related decreases in kidney function, and children, whose kidneys are not fully developed yet. (wikipedia.org)
Irreversible1
- The mechanism of action for amikacin is through disruption of the bacterial cell wall, irreversible binding of the 30S ribosomal subunit, and inhibition of bacterial protein synthesis. (wedgewoodpharmacy.com)
Concentrations1
- The bactericidal properties of amikacin are concentration dependent and there is significant bactericidal activity even after drug concentrations are below the minimum inhibitory concentration (MIC). (wedgewoodpharmacy.com)
Safety1
- DrLact safety Score for Amikacin is 1 out of 8 which is considered Safe as per our analyses. (drlact.com)
Levels4
- Because there is little variability in the milk amikacin levels during multiple daily dose regimens, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. (drlact.com)
- [ 8 ] In one study, pharmacokinetic dosing with maintenance of trough levels below 1 mcg/mL significantly reduced the incidence of nephropathy with amikacin. (medscape.com)
- Immunoassay techniques are the preferred methods of measurement of serum amikacin levels and produce comparable results with other testing techniques such as gas chromatography and microbiological assays. (medscape.com)
- Serum amikacin levels are used to guide therapy to ensure adequate but not excessive levels. (medscape.com)
Produce1
- Amikacin works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to produce proteins. (wikipedia.org)
Increase1
- Proper cleaning of the ear will increase the effectiveness of topical treatments with amikacin. (wedgewoodpharmacy.com)
Activity2
- Amikacin has no activity against fungi, or most anaerobic bacteria. (wedgewoodpharmacy.com)
- KANAMYCIN MONOSULFATE, From Streptomyces kanamycetikus Crystalline, Activity: Approx. (alna-bioscience.com)