• A pregnant woman taking amikacin with another aminoglycoside has a possibility of causing congenital deafness in her child. (wikipedia.org)
  • Amikacin is an aminoglycoside antibiotic that is used to treat serious gram-negative bacterial infections. (wedgewoodpharmacy.com)
  • Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
  • When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
  • Extensively drug resistant-tuberculosis is defined as multidrug-resistant tuberculosis that is also resistant to any one of the fluoroquinolones and to at least one of three injectable second-line antibiotics (amikacin, capreomycin or kanamycin). (who.int)
  • Extensively drug-resistant (XDR) tuberculosis is defined as disease caused by Mycobacterium tuberculosis with resistance to at least isoniazid and rifampicin, any fluoroquinolone, and at least one of three injectable second-line drugs (amikacin, capreomycin, or kanamycin). (nih.gov)
  • capreomycin, or kanamycin. (cdc.gov)
  • MDR-TB that is also resistant to any one of the fluoroquinolones and to at least one of three injectable second-line medicines (amikacin, capreomycin or kanamycin).6 MDR-TB and XDR-TB are principally a result of inadequate or poorly administered treatment regimens. (who.int)
  • Amikacin liposome inhalation suspension is the first drug approved under the US limited population pathway for antibacterial and antifungal drugs (LPAD pathway). (wikipedia.org)
  • The US Food and Drug Administration (FDA) granted the application for amikacin liposome inhalation suspension fast track, breakthrough therapy, priority review, and qualified infectious disease product (QIDP) designations. (wikipedia.org)
  • The FDA granted approval of Arikayce to Insmed, Inc. The safety and efficacy of amikacin liposome inhalation suspension, an inhaled treatment taken through a nebulizer, was demonstrated in a randomized, controlled clinical trial where patients were assigned to one of two treatment groups. (wikipedia.org)
  • One group of patients received amikacin liposome inhalation suspension plus a background multi-drug antibacterial regimen, while the other treatment group received a background multi-drug antibacterial regimen alone. (wikipedia.org)
  • By the sixth month of treatment, 29 percent of patients treated with amikacin liposome inhalation suspension had no growth of mycobacteria in their sputum cultures for three consecutive months compared to 9 percent of patients who were not treated with amikacin liposome inhalation suspension. (wikipedia.org)
  • Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection. (wikipedia.org)
  • The second-line injectable drugs are amikacin, kanamycin, and capreomycin. (cdc.gov)
  • Amikacin trough levels of more than 10 mcg/mL have been associated with significant ototoxicity and nephrotoxicity. (medscape.com)
  • Although a reported 130 medications can produce ototoxicity, some are seldom seen by the average retail pharmacist (e.g., ethacrynic acid, dihydrostreptomycin, kanamycin, sisomycin). (medscape.com)
  • Our study of different scientific research also indicates that Amikacin does not cause any serious side effects in breastfeeding mothers. (drlact.com)
  • Amikacin should be used in smaller doses in the elderly, who often have age-related decreases in kidney function, and children, whose kidneys are not fully developed yet. (wikipedia.org)
  • The mechanism of action for amikacin is through disruption of the bacterial cell wall, irreversible binding of the 30S ribosomal subunit, and inhibition of bacterial protein synthesis. (wedgewoodpharmacy.com)
  • The bactericidal properties of amikacin are concentration dependent and there is significant bactericidal activity even after drug concentrations are below the minimum inhibitory concentration (MIC). (wedgewoodpharmacy.com)
  • DrLact safety Score for Amikacin is 1 out of 8 which is considered Safe as per our analyses. (drlact.com)
  • Because there is little variability in the milk amikacin levels during multiple daily dose regimens, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. (drlact.com)
  • [ 8 ] In one study, pharmacokinetic dosing with maintenance of trough levels below 1 mcg/mL significantly reduced the incidence of nephropathy with amikacin. (medscape.com)
  • Immunoassay techniques are the preferred methods of measurement of serum amikacin levels and produce comparable results with other testing techniques such as gas chromatography and microbiological assays. (medscape.com)
  • Serum amikacin levels are used to guide therapy to ensure adequate but not excessive levels. (medscape.com)
  • Amikacin works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to produce proteins. (wikipedia.org)