Chemicals and DrugsPhenomena and Processes
AmidinesThioamidesBenzamidinesPalladiumMolecular Structure
DerivativesCyclic amidineArylReactMoietyAnalogsInhibitorAmidesInhibitionFunctional groupCompoundMedicinal ChemistryReactionTherapeuticClassGroupTypeResearchEffectsFormGuanidinesSynthesisGuanidineCyclicAmitrazComplexesInsecticideFormamidineSubstituentsAmideOxoacidsBenzamidineOrganicStructuralFormation
Derivatives1
  • Heterocyclic amidine derivatives have been synthesized by condensation of 2-cyanopyrazine, 4-cyanopyridine and 2-cyanopyridine with furfurylamine, histamine, 1-(3-aminopropyl)imidazole, 4-picolylamine, 2-picolylamine, and tryptamine respectively, in the presence of sodium methoxide as well as via microwave irradiation in good yields. (csircentral.net)
Cyclic amidine2
  • Imidazolines contain a cyclic amidine. (wikipedia.org)
  • Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. (ntu.edu.sg)
Aryl1
  • This disclosure relates to aryl amidines of Formula I and their use as fungicides. (sumobrain.com)
React2
  • Among others they react with amines giving amidines as the products. (springer.com)
  • Amidines react with diphenylamine-2,2'-dicarbonyl chloride to yield polyheterocycles. (heterocycles.jp)
Moiety3
  • b) DFMO enhances the polyamine uptake system in tumor cells, increasing the entry of tetracyclic amidines bearing a putrescine moiety as well as their accessibility to final DNA-binding sites. (curehunter.com)
  • The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. (springer.com)
  • Moreover, the amidine group may be a perfect linker unit that could connect two pharmacophores, e.g., the sulfanilamide moiety and the pyridine or pyrazine system. (springer.com)
Analogs2
  • The present disclosure provides a group of amidine analogs and their pharmaceutically acceptable salts that are useful for treating a bacterial or fungal infection. (sumobrain.com)
  • Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. (expasy.org)
Inhibitor4
  • A hydrogen bond unique to Ser190 protease-arylamidine complexes between O gamma(Ser190) and the inhibitor amidine confers an intrinsic preference for such inhibitors toward Ser190 proteases over Ala190 counterparts. (rcsb.org)
  • Here, we used Cl-amidine, a selective inhibitor of NETs to investigate the role of NETs in neural damage after TBI. (biomedcentral.com)
  • Cl-amidine, 2′3′-cGAMP (an activator of stimulating Interferon genes (STING)), C-176 (a selective STING inhibitor), and Kira6 [a selectively phosphorylated inositol-requiring enzyme-1 alpha [IRE1α] inhibitor] were administrated to explore the mechanism by which NETs promote neuroinflammation and neuronal apoptosis after TBI. (biomedcentral.com)
  • NETs inhibitor Cl-amidine treatment improved short-term neurological functions, reduced cerebral lesion volume, reduced brain edema, and restored cerebral blood flow (CBF) after TBI. (biomedcentral.com)
Amides1
  • Dimethylformamide acetal reacts with primary amines to give amidines: Me2NC(H)(OMe)2 + RNH2 → Me2NC=NHR + 2 MeOH Amidines are much more basic than amides and are among the strongest uncharged/unionized bases. (wikipedia.org)
Inhibition1
  • Altogether, we are the first to demonstrate that NETs inhibition with Cl-amidine ameliorated neuroinflammation, neuronal apoptosis, and neurological deficits via STING-dependent IRE1α/ASK1/JNK signaling pathway after TBI. (biomedcentral.com)
Functional group2
  • Amidines are organic compounds with the functional group RC(NR)NR2, where the R groups can be the same or different. (wikipedia.org)
  • The amidine functional group is an important structural element of compounds with established pharmacological activity. (springer.com)
Compound3
  • Treatment of the resulting compound with ammonia then completes the conversion to the amidine. (wikipedia.org)
  • Provided in the present invention are an amidine derivative compound as represented by formula I, and a preparation method therefor and the use thereof. (sumobrain.com)
  • The amidine derivative compound of the present invention has Nav1.8 selective inhibi. (sumobrain.com)
Medicinal Chemistry1
  • 5 Amidines and Guanidines in Medicinal Chemistry. (wikipedia.org)
Reaction1
  • Examples of amidines include: DBU diminazene benzamidine Pentamidine Paranyline A common route to primary amidines is the Pinner reaction. (wikipedia.org)
Therapeutic1
  • Thus, Cl-amidine treatment may provide a promising therapeutic approach for the early management of TBI. (biomedcentral.com)
Class1
Group1
  • The −OH group is replaced by an −NH2 group and the =O group is replaced by =NR, giving amidines the general structure RnE(=NR)NR2. (wikipedia.org)
Type3
  • Carboxamidines are frequently referred to simply as amidines, as they are the most commonly encountered type of amidine in organic chemistry. (wikipedia.org)
  • This study reports an effective amidine-type n-dopant of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) that can universally dope electron acceptors, including PC61BM, N2200, and ITIC, by mixing the dopant with the acceptors in organic solvents or exposing the acceptor films in the dopant vapor. (researcher-app.com)
  • An effective solution-processed amidine-type n-dopant of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), which can universally dope electron acceptor materials, including PC61BM, N2200, and ITIC, is reported. (researcher-app.com)
Research1
  • The programme of research that constitutes AMIDiNe will address the increasingly problematic management of electrical load on distribution networks as the UK transitions to a low carbon energy system. (amidine.net)
Effects1
  • In addition, Cl-amidine exerted neuroprotective effects by attenuating BBB disruption, inhibiting immune cell infiltration, and alleviating neuronal death after TBI. (biomedcentral.com)
Form1
  • The oxoacid from which an amidine is derived must be of the form RnE(=O)OH, where R is a substituent. (wikipedia.org)
Guanidines1
  • 5 Amidines and Guanidines in Medicinal Chemistry. (wikipedia.org)
Synthesis2
  • Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives. (wikigenes.org)
  • Yibiao Li and colleagues, Wuyi University, Jiangmen, China, have developed an annulation reaction synthesis of halogenated imidazoles from 1,1-dibromoalkenes and amidines. (chemistryviews.org)
Guanidine2
  • A breakthrough in the development of nonpeptidomimetic BACE1 inhibitors was the identification of amidine- and guanidine-containing small molecules. (simulations-plus.com)
  • To establish the rates and mechanisms of decomposition of guanidine and amidine derivatives in aqueous solution and the rate enhancements produced by the corresponding enzymes, we examined their rates of reaction at elevated temperatures and used the Arrhenius equation to extrapolate the results to room temperature. (annexpublishers.co)
Cyclic1
Amitraz1
  • Amitraz is an amidine acaricide and insecticide. (herts.ac.uk)
Complexes3
  • In order to minimize the steric hindrance in the second coordination sphere of complexes 8a , b , the value of the C1−N1−P1 bond angle of the amidine moiety widened from 119−122° in 7a , b to 133°, which corresponds to a dramatic change in the geometry of the N -phosphino amidine ligands. (figshare.com)
  • 2. A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation. (nih.gov)
  • 5. Chemistry and biological activity of platinum amidine complexes. (nih.gov)
Insecticide1
  • An amidine acaricide and insecticide for use in top fruit, ornamentals and some vegetables. (herts.ac.uk)
Formamidine1
Substituents1
  • Several drug or drug candidates feature amidine substituents. (wikipedia.org)
Amide1
  • Ta[MeC(N i Pr) 2 ](NMe 2 ) 3 Cl has also been synthesized through the aminolysis of Ta(NMe 2 ) 4 Cl [tantalum amide chloride] with a diisopropyl amidine. (tennessee.edu)
Oxoacids1
Benzamidine1
  • Examples of amidines include: DBU diminazene benzamidine Pentamidine Paranyline A common route to primary amidines is the Pinner reaction. (wikipedia.org)
Organic2
  • Amidines are organic compounds with the functional group RC(NR)NR2, where the R groups can be the same or different. (wikipedia.org)
  • Carboxamidines are frequently referred to simply as amidines, as they are the most commonly encountered type of amidine in organic chemistry. (wikipedia.org)
Structural1
  • The amidine structural motif within each core forms a bidentate interaction with a different aspartic acid of the catalytic diad. (rcsb.org)
Formation2
  • Cl-amidine treatment inhibited NZM NET formation in vivo and significantly altered circulating autoantibody profiles and complement levels while reducing glomerular IgG deposition. (nih.gov)
  • Hydralazine, but not procainamide, induced significant release of hydrogen peroxide in PMNs, and NET formation was inhibited by DPI and BB-Cl-amidine. (nih.gov)