The use of tert -butyl hydroperoxide as an oxidant and an inexpensive and air stable copper catalyst enables a simple and efficient protocol for the oxidative amidation of commercially affordable alcohols to Weinreb amides in very good yields. (organic-chemistry.org)
Amide bonds were synthesized by an oxidative amidation in the presence of dibromoisocyanuric acid (DBI). (ewha.ac.kr)
The team's method wholly avoids the need for a precious metal catalyst and involves a visible-light-driven oxidative amidation of the requisite C-H bond. (chemistryviews.org)
Oxidative amidation is facilitated by a commercially available organic oxidant (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) and proceeds under very mild conditions for an array of structurally diverse substrates. (uconn.edu)
Synthesis5
Copper- and Palladium-Catalyzed Amidation Reactions for the Synthesis of Substituted Imidazo[4,5-c]pyridines. (acs.org)
Now, intramolecular C-H amidation of dioxazolones via biocatalytic nitrene transfer enables the synthesis of enantioenriched lactams with various ring sizes. (nature.com)
We have reported a transition-metal-free phenanthridinone synthesis using an organophotocatalyst," the team states, "This is the first method of phenanthridinone synthesis that progresses via a direct C-H amidation without using a transition metal under visible-light irradiation, and the reaction proceeds under mild conditions at low cost. (chemistryviews.org)
Catalytic direct amidation reactions have been the focus of considerable recent research effort, due to the widespread use of amide formation processes in pharmaceutical synthesis. (chemrxiv.org)
Synthesis of cytimidine through a one-pot copper-mediated amidation cascade. (tamu.edu)
Aldehydes1
Rh(iii)-Catalyzed ortho-C-H amidation of ketones and aldehydes under cooperative metal organocatalysis has been utilized for synthesizing various ortho-amidocarbonyl analogs, and the reaction for the aldehyde proceeds at ambient temperature. (iisc.ac.in)
Amides1
A group of researchers working on Dr. Reddy's has published now a paper showing the application of this boric acid amidation for the preparation of several API-related amides with excellent yield and purity. (galchimia.com)
Intramolecular5
We report the Pd(II)-catalyzed, bidentate directing group (BDG)-assisted arylation and successive arylation/intramolecular amidation of γ-C(sp 3 )-H bonds. (researcher-app.com)
These compounds were then used as substrates to investigate the arylation and successive arylation/intramolecular amidation of the γ-C(sp 3 )-H bonds. (researcher-app.com)
Prolonging the reaction period to 48-70 h led to successive γ-C(sp 3 )-H arylation/intramolecular amidation and the construction of both C-C and C-N bonds. (researcher-app.com)
Intramolecular amidation is often used to construct the main backbone of the molecule, the lactam group, and then a costly metal catalyst is required to complete the preparation of the phenanthridinone. (chemistryviews.org)
In 2018, an intramolecular C-H bond amidation of biphenyl using an expensive iridium-containing photocatalyst was reported [2]. (chemistryviews.org)
Catalytic5
However, the vast majority of catalytic amidations are performed in non-polar solvents (aromatic hydrocarbons, ethers) which are typically undesirable from a sustainability perspective, and are often poor at solubilising polar carboxylic acid and amine substrates. (chemrxiv.org)
As a consequence, most catalytic amidation protocols are unsuccessful when applied to polar and/or functionalised substrates of the kind commonly used in medicinal chemistry. (chemrxiv.org)
In this paper we report a practical and useful catalytic direct amidation reaction using tert-butyl acetate as the reaction solvent. (chemrxiv.org)
3. Catalytic direct dehydrative amidation by a novel B3NO2 heterocyclic catalyst. (caltech.edu)
We are proud to offer a number of products used in catalytic amidation technology. (sigmaaldrich.com)
Carboxylic Acids3
Triarylsilanols are reported as the first silicon-centred molecular catalysts for direct amidation of carboxylic acids with amines as identified after a screen of silanols, silanediols, disiloxanediols and incompletely condensed silsesquioxanes as potential homogeneous catalysts. (imperial.ac.uk)
Methyltrimethoxysilane [MTM, CH3Si(OMe)3] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. (imperial.ac.uk)
Ammonia-borane as a catalyst for the direct amidation of carboxylic acids published in Organic Letters. (purdue.edu)
Fatty acids1
Ceramides are formed by keratinocytes by amidation of sphingoid bases such as phytosphingosine with fatty acids. (cosmeticsandtoiletries.com)
Reaction4
An amidation reaction was scaled up to 100 mmol and proceeded with excellent yield and efficency, with a measured process mass intensity of 8. (chemrxiv.org)
The aniline derivative 3,5-bis(trifluoromethyl)aniline promotes the amidation reaction via a transient imine directing group. (iisc.ac.in)
The second involves simple product crystallization from the reaction mixture providing a low process mass intensity direct amidation protocol. (imperial.ac.uk)
The reaction involved grafting 12- aminododecanoic acid to the inherent carboxylic acid groups on the film, followed by amidation of the grafted amino acid. (4spe.org)
Reactions1
Despite being one of the most frequently carried out chemical reactions in industry, there is currently no amidation protocol that is regarded as safe, high yielding, environmentally friendly and inexpensive. (imperial.ac.uk)
Catalyst1
An eco-friendly, easy amidation using boric acid as the catalyst was developed by Tang et al . (galchimia.com)
Amide1
Conversion of film carboxylic acid groups to primary amide groups was also conducted to compare the impact of direct surface amidation. (4spe.org)
Amine2
The direct amidation of a carboxylic acid with an amine is viewed as an inherently good solution for developing such a protocol. (imperial.ac.uk)
This review covers the methods published to April 2021 for silicon reagent mediated direct amidation of a carboxylic acid with an amine. (imperial.ac.uk)
Direct2
Since the 1960s, there has been a gradual development in the use of silicon reagents for direct amidation. (imperial.ac.uk)
This review also covers the use of polymeric SiO2 to promote direct amidation. (imperial.ac.uk)
Compounds1
Four different types of low methoxyl pectins (LMPs) were prepared via amidation and methylesterification to investigate the release of 14 aroma compounds from different pectin gel systems at different calcium concentration. (ewha.ac.kr)
Mild1
Herein, we describe a mild and efficient method for the site-selective amidation of unsaturated enones with electrophilic N-centered radicals as a key intermediate. (ceon.pl)
Research1
Research teams have homed in on the essential amidation of the carbon-hydrogen bond to make phenanthridinones with varying degrees of success. (chemistryviews.org)
Efficient1
The efficient amidation agent is dioxazolone. (iisc.ac.in)
Method1
This boric acid-catalyzed amidation method seems promising. (galchimia.com)
Defective2
We identified and treated five patients (one male, four females) from four families with defective bile acid amidation due to a genetically confirmed deficiency in bile acid CoA:amino acid N-acyl transferase (BAAT) with the conjugated bile acid, glycocholic acid (GCA). (nih.gov)
The biochemical profile was consistent with defective bile acid amidation. (medscape.com)
Peptide3
Scholars@Duke publication: Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. (duke.edu)
Amidation plays an important role in peptidesand peptide hormones. (protpi.ch)
The 11-residue peptide that is without amidation. (nih.gov)
Carboxylic1
Serotonin was linked by amidation to the carboxylic acid groups of a series of structurally diverse NSAIDs. (nih.gov)
Bile4
Bile acid amidation defects were predicted to present with fat/fat soluble vitamin malabsorption with minimal cholestasis. (nih.gov)
Based on a study of 10 pediatric patients, genetic defects that disrupt bile acid amidation cause fat-soluble vitamin deficiency and growth failure, indicating the importance of bile acid conjugation in lipid absorption. (medscape.com)
Two enzymes catalyze the reactions leading to bile acid amidation. (medscape.com)
In 1997, we first described in a preliminary report a defect in bile acid amidation in a 14-year-old boy with fat malabsorption and fat-soluble vitamin deficiency. (medscape.com)
Sequence1
A key bis-amide precursor to the bis-oxazole was formed in a chemoselective one-pot, bis-amidation sequence without the use of amino or carboxyl protecting groups. (fu-berlin.de)
Chemistry1
Our experts will discuss the greener solvents and greener reagents that are trending in popular fields of chemistry including amidation and catalysis. (imcdgroup.com)
Modifications2
Many conotoxins are also highly modified with posttranslational modifications such as proline hydroxylation, glutamic acid gamma-carboxylation, tyrosine sulfation and C-terminal amidation, amongst others. (rcsb.org)
Here we synthesised a set of twelve conotoxin variants bearing posttranslational modifications in the form of native sulfotyrosine and C-terminal amidation and show that these two modifications in combination increase their activity at nicotinic acetylcholine receptors and binding to soluble acetylcholine binding proteins, respectively. (rcsb.org)
Study1
Circular dichroism (CD) and molecular dynamic (MD) simulations were used to study the effects of amidation on the interaction of antimicrobial peptides (AMPs) with lipid bilayers. (lincoln.ac.uk)
Presence2
Sulfonamidyl (hetero)arenes can be synthesized by a C(sp 2 )-H amidation with bench-stable amidyl-iminophenylacetic acids in the presence of a hypervalent iodine reagent. (organic-chemistry.org)
The stereochemical retention under amidation conditions was studied in detail in the presence of difference bases and via other control experiments, evidencing the possibility to reduce racemization using pyridine as base. (bvsalud.org)