• Lycorine is the most widespread and abundant of the Amaryllidaceae alkaloids. (imperial.ac.uk)
  • We also show that the alkaloid lycorine is able to differentiate between cells containing defective mitochondrial DNA (mit-) and those lacking mitochondrial DNA completely (rho0). (nih.gov)
  • The Barbados Lily belongs to the Amaryllidaceae family and is toxic due to lycorine and other alkaloids. (embracepetinsurance.com)
  • Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. (bvsalud.org)
  • Lycorine, a major alkaloid found in many Amaryllidaceae species, has been shown to have FIGURE 1 - Chemical structure of lycorine. (bvsalud.org)
  • Considering that narcissus are a rich source of alkaloids (see Chapter 6, this volume), it is not surprising that the genus has figured in herbal medicine . (alpfmedical.info)
  • The Amaryllidaceae alkaloids are produced by species of Amaryllidaceae including Narcissus spp. (frontiersin.org)
  • Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. (sigmaaldrich.com)
  • Glycosides of benzodioxole-indole alkaloid 6-hydroxy-galanthindole having axial chirality were isolated from Narcissus. (cas.cz)
  • Amaryllidaceae are known as ornamental plants, furthermore some species of this family contain galanthamine, an acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, and other alkaloids with interesting pharmacological activity. (scielo.br)
  • This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. (mdpi.com)
  • To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. (mdpi.com)
  • Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. (unibas.ch)
  • Isoquinoline alkaloids from three Madagascan Crinum (Amaryllidaceae) species. (kew.org)
  • However, several plant species producing diverse classes of alkaloids, coumarins, terpenes, and polyphenols have been assessed for their anti-AChE activity, becoming potential candidates for new anti-AD drugs. (frontiersin.org)
  • Established immunoassays for quantitation of Colchicine, which is a water soluble alkaloid with cytotoxic activity, present in several species of Liliaceae . (rutgers.edu)
  • Greek gála "milk", ánthos "flower") is a small genus of approximately 20 species of bulbous perennial herbaceous plants in the family Amaryllidaceae . (wikipedia.org)
  • This review deals with mechanism and physiological activity of conjugated imine and iminium species, including those in the alkaloid category. (scirp.org)
  • Larger in stature than most other species of Amaryllidaceae, most crinums are suitable as landscape plants in or near water features while most of the smaller species can be successfully cultivated even in a small garden. (toptropicals.com)
  • 2004). Since the alkaloids are highly toxic, use of Crinum species is not recommended for the novice, as a large dose could easily be fatal. (toptropicals.com)
  • Each plant species produces a different mixture of alkaloids due to differential expression of the required biosynthetic enzymes, which have their own substrate specificity [ 17 ]. (biomedcentral.com)
  • Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. (medchemexpress.com)
  • Abstract Galanthamine is an Amaryllidaceae -derived acetylcholinesterase inhibitor used to treat memory impairment in Alzheimer's disease and vascular dementia . (bvsalud.org)
  • ChemInform Abstract: Oxidative Friedel,Crafts Reaction and Its Application to the Total Syntheses of Amaryllidaceae Alkaloids. (academicconcepts.net)
  • The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). (mdpi.com)
  • Described herein is the chemoenzymatic total synthesis of several Amaryllidaceae constituents and their unnatural C-I analogues. (brocku.ca)
  • Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents fromNarcissusandGalanthussp. (mcmaster.ca)
  • The limited supply of some Amaryllidaceae alkaloids and diversity of biological activities make the biosynthesis of Amaryllidaceae alkaloids a topic of interest for biotechnology. (frontiersin.org)
  • Six new monoterpenoid indole alkaloids from the aerial part of Gelsemium elegans . (jnu.edu.cn)
  • The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. (mdpi.com)
  • was analyzed by GC/MS. Seven known compounds, belonging to five structural types of Amaryllidaceae alkaloids, were identified. (scielo.br)
  • To explore the mode of action of these alkaloids derivatives, we tested their capacity to inhibit protein synthesis, compared their pharmacological profile with 80 anticancer compounds on 16 tumor cell lines (oncoprofile.16) and explored their impact on major cellular functions such as cellular integrity, cell cycle, topoisomerases inhibition, DNA damage and synthesis. (aacrjournals.org)
  • From the bulbs of Zephyranthes robusta Baker (Amaryllidaceae), seven known compounds, belonging to four structural types of Amaryllidaceae alkaloids, were identified and quantified by GC-MS. The alkaloid extract from the bulbs showed promising acetylcholinesterase and butyrylcholinesterase inhibitory activities against HuAChE (IC50 = 35.9 ± 3.5 μg/mL) and HuBuChE (IC50 = 190.9 ± 8.2 μg/mL). (cas.cz)
  • Analysis by GC/MS of the extracts from leaves of P. microphyllum and P. mucronatum detected 51 different compounds, such as alkaloids, diterpenes, triterpenes, sterols, alcohols, aldehydes, fatty acids and hydrocarbons. (scielo.br)
  • Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms. (wikipedia.org)
  • [3] Some synthetic compounds of similar structure may also be termed alkaloids. (wikipedia.org)
  • The boundary between alkaloids and other nitrogen-containing natural compounds is not clear-cut. (wikipedia.org)
  • [16] Compounds like amino acid peptides , proteins , nucleotides , nucleic acid , amines , and antibiotics are usually not called alkaloids. (wikipedia.org)
  • [2] Natural compounds containing nitrogen in the exocyclic position ( mescaline , serotonin , dopamine , etc.) are usually classified as amines rather than as alkaloids. (wikipedia.org)
  • These include several total syntheses of morphine alkaloids, total synthesis of Amaryllidaceae alkaloids and their medicinally useful derivatives, and approaches to other, highly oxygenated compounds such as xylosmin, tetrodotoxin, and idesolide. (msvu.ca)
  • 2] Natural compounds containing nitrogen in the exocyclic position (mescaline, serotonin, dopamine, etc.) are usually attributed to amines rather than alkaloids. (scribd.com)
  • 2011). In addition to evaluating the antimicrobial compounds such as Amaryllidaceae alkaloids, which activity, it is also important to investigate the effects of are used in the drug industry. (bvsalud.org)
  • This thesis describes the chemoenzymatic synthesis of three morphine alkaloids. (brocku.ca)
  • The present studies describe, as a primary goal, our recent progess toward the synthesis of morphine alkaloids from aromatic precursors. (brocku.ca)
  • The present study describes for the first time, the isolation of 6-hydroxycrinamine, a crinine alkaloid, from the methanol extract of the bulbs of Boophane disticha. (csir.co.za)
  • [email protected]#To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata. (bvsalud.org)
  • Cytotoxic and antimalarial amaryllidaceae alkaloids from the bulbs of Lycoris radiata. (sigmaaldrich.com)
  • Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants. (strath.ac.uk)
  • Kilgore M, Holland CK, Jez JM, Kutchan TM (2016) Identification of a noroxomaritidine reductase with Amaryllidaceae alkaloid biosynthesis-related activities. (wustl.edu)
  • Extracts from plants containing toxic alkaloids, such as aconitine and tubocurarine , were used since antiquity for poisoning arrows. (wikipedia.org)
  • A collection of 79 extracts of Amaryllidaceae plants were screened against T. cruzi . (biomedcentral.com)
  • Gorer & J.H.Harvey, S. candida extracts and alkaloids of S. clusiana , S. lutea and the B. Mathew & T. Baytop (endemic to Turkey), and S. anti-acetylcholinesterase and antioxidant activities of clusiana (Ker Gawl. (bvsalud.org)
  • Here, we evaluated the effects of galanthamine and two others Amaryllidaceae acetylcholinesterase inhibitors (haemanthamine and tazettine) analyzed by gas chromatography-mass spectrometry and identified by comparing their mass fragmentation patterns with literature and database NIST vs.2.0 on the agonist responses of brain nicotinic acetylcholine receptors α7, α3β4, (α4)2(β2)3 and (α4)3(β2)2. (bvsalud.org)
  • Specific examples of alkaloids derived from (10b R ,4a S )-noroxomaritidine include haemanthamine, maritidine, vittatine, and pretazettine. (frontiersin.org)
  • Abdel-Halim OB, Morikawa T, Ando S, Matsuda H, Yoshikawa M (2004) New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense . (springer.com)
  • Hippeastrum is a genus in the family Amaryllidaceae ( subfamily Amaryllidoideae , tribe Hippeastreae , and subtribe Hippeastrineae ). (wikipedia.org)
  • Wagner J, Pham HL, Doepke W (1996) Alkaloids from Hippeastrum equestre Herb. (springer.com)
  • The alkaloids of the Amaryllidaceae : the isolation and structures of two new alkaloids from Haemanthus natalensis and Nerine krigeii and contributions to the chemistry of coccinine : the absolute configuration of alkaloids based on the 5:10b-Ethanpohenanthridine nucleus. (ukzn.ac.za)
  • The alkaloids of the Amaryllidaceae : the isolation of the alkaloids of Boophone disticha Herb. (ukzn.ac.za)
  • Two new alkaloids from Crinum asiaticum var. (springer.com)
  • Ochi M, Otsuki H, Nagano K (1976) The structure of hamayne, a new alkaloid from Crinum asiaticum L. var. (springer.com)
  • Crinum is a fascinating genus of the large and equally captivating Amaryllidaceae family. (toptropicals.com)
  • The Amaryllidaceae family is well known for its pharmacologically active alkaloids. (mdpi.com)
  • The Amarylidaceae genus of plant has a venerable history in relation to the development of organic chemistry as the result of being the source of a wide range of highly bio-active natural products and also because speculation about the biosynthesis of various alkaloids from these plants led to the first postulation of oxidative phenolic coupling as a major mechanism of structural diversity in nature. (imperial.ac.uk)
  • Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. (sigmaaldrich.com)
  • A Russian pharmacologist first isolated the plant alkaloid galantamine from Galanthus woronowii in the early 1950s and characterized its reversible physiological effects on muscle as an acetylcholinesterase inhibitor. (naturalproductsinsider.com)
  • While the first patented synthetic pathway for galantamine was developed in 1996-two years after the passage of the U.S. Dietary Supplement Health and Education Act of 1994 (DSHEA)-the alkaloid was being isolated from the snowdrop ( Galanthus spp. (naturalproductsinsider.com)
  • Alkaloid profiling of Galanthus woronowii Losinsk. (ege.edu.tr)
  • 1963. The vinca alkaloids: a new class of oncolytic agents. (scielo.br)
  • Alternative extraction of alkaloid anticarcinogens from Brazilian "vinca rosea" using Ion Exchange chromatography. (scielo.br)
  • [25] these are called vinca alkaloids . (wikipedia.org)
  • Alkaloids pancratistatin and narciclasine, isolated from Amaryllidaceae, have been shown to present antitumor activity on preclinical models, including melanoma. (aacrjournals.org)
  • Plants of the Amaryllidaceae family are well-known for their ornamental value but also for the alkaloids they produce. (scielo.br)
  • Alkaloids are produced by a large variety of organisms including bacteria , fungi , plants , and animals . (wikipedia.org)
  • Alkaloid-containing plants have been used by humans since ancient times for therapeutic and recreational purposes. (wikipedia.org)
  • 11.Artem Kireev (2005): Synthesis and Comparative Biological Evaluation of Structurally Simplified Analogues of Selected Amaryllydaceae Alkaloids with Potent Anticancer and Antiviral Activities. (nmt.edu)
  • 2006), as well as other alkaloids with interesting pharmacological activities: antimalarial, antiviral and antiproliferative (Campbell et al. (scielo.br)
  • Galantamine, or galanthamine as it was originally termed, is an alkaloid constituent contained in multiple members of the Amaryllidaceae family. (naturalproductsinsider.com)
  • Members of the monocot subfamily Amaryllidoideae present a unique type of alkaloids, the norbelladine alkaloids, which are 4-methylcatechol derivatives combined with tyrosine. (wikipedia.org)
  • In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. (unibas.ch)
  • Alkaloids from all major structural classes of Amaryllidaceae alkaloids have biological activities. (frontiersin.org)
  • Alkaloids constitute positive roles in ameliorating pathophysiology of these illnesses by functioning as muscarinic and adenosine receptors agonists, anti-oxidant, anti-amyloid and MAO inhibitors, acetylcholinestrase and butyrylcholinesterase inhibitor, inhibitor of α-synuclein aggregation, dopaminergic and nicotine agonist, and NMDA antagonist. (ijbs.com)
  • A unifying mechanistic approach involving ET-ROS-OS is applied to synthetic drugs and alkaloids in the imineiminium category in relation to both beneficial and adverse effects. (scirp.org)
  • Boophane disticha of the family Amaryllidaceae is used traditionally by the indigenous people of southern Africa in the treatment of several neurological disorders. (csir.co.za)
  • They are found in the Amaryllidaceae (LILIACEAE) plant family. (bvsalud.org)
  • DeAngelis GG, Wildman WC (1969) Identification of Amaryllidaceae alkaloids utilizing ORD and CD spectroscopy. (springer.com)
  • Amaryllidaceae: fuente potencial de alcaloides. (uptc.edu.co)
  • In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus [email protected]*[email protected]#One new homolycorine-type alkaloid 2α-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2α-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6α-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained. (bvsalud.org)
  • Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg·mL-1 and CC50 values of 14.37, 4.79, and 80.12 μg·mL-1, respectively. (bvsalud.org)
  • Analogues of Marine Guanidine Alkaloids are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania ( L .) infantum Intracellular Amastigotes" Martins, L. F. et al. (uci.edu)
  • The chemical structures of these alkaloids are very variable as well as their pharmacological properties. (scielo.br)
  • Amaryllidaceae alkaloids (AAs) are a large group of plant-specialized metabolites displaying an array of biological and pharmacological properties. (springer.com)
  • Galanthamine is an Amaryllidaceae alkaloid used to treat the symptoms of Alzheimer's disease. (jove.com)
  • The present article reviews the potential efficacy of plant-derived alkaloids, which possess potential therapeutic effects against several NDDs including Alzheimer's disease (AD), Huntington disease (HD), Parkinson's disease (PD), Epilepsy, Schizophrenia, and stroke. (ijbs.com)
  • Galanthamine, is the most known Amaryllidaceae alkaloid, which is currently being prescribed for the treatment of mild to moderate Alzheimer's disease (AD) due to its anti-acetylcholinesterase activity. (usda.gov)