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Alzheimer DiseaseAmyloid beta-PeptidesPathologytau ProteinsNeurofibrillary TanglesAmyloid beta-Protein PrecursorPlaque, AmyloidBrainPathology, ClinicalPathology, SurgicalApolipoprotein E4NeurofibrilsDementiaPresenilin-1Amyloid Precursor Protein SecretasesAmyloidCognition DisordersAtrophyNeuropsychological TestsDementia, VascularMice, TransgenicDisease Models, AnimalApolipoproteins EPeptide FragmentsMild Cognitive ImpairmentMagnetic Resonance ImagingAgingHippocampusLewy Body DiseaseNeuronsPresenilin-2AutopsyCognitionAspartic Acid EndopeptidasesPathology Department, HospitalMental Status ScheduleTauopathiesAge of OnsetNerve DegenerationCerebral CortexCerebral Amyloid AngiopathyMemory DisordersAniline CompoundsMemantineCholinesterase InhibitorsPresenilinsNeurodegenerative DiseasesBrain ChemistryLewy BodiesDisease ProgressionPathology, OralProtease NexinsLongitudinal StudiesNational Institute on Aging (U.S.)Biological MarkersPositron-Emission TomographySubstantia InnominataDown SyndromeImmunohistochemistryNerve Tissue ProteinsAmyloidogenic ProteinsMutationNeuropil ThreadsThiazolesGenetic Predisposition to DiseaseMice, Inbred C57BLCase-Control StudiesParkinson DiseaseFrontotemporal DementiaPathology, MolecularPhenylcarbamatesTemporal LobeIndansGenotypePathology, VeterinaryMicrogliaProdromal SymptomsClioquinolNootropic AgentsFrontotemporal Lobar DegenerationCohort StudiesTelepathologyTime FactorsReference ValuesTacrineMemoryAmyloidosisPhosphorylationMolecular Sequence Dataalpha-SynucleinAmnesiaAstrocytesRisk FactorsImage Processing, Computer-AssistedSeverity of Illness IndexModels, BiologicalAge FactorsGliosisAphasia, Primary ProgressiveCells, Cultured