Animal Use AlternativesDisease Models, AnimalAlzheimer DiseaseModels, AnimalMutation, MissenseMutationPoint MutationAmino Acid SubstitutionTrypsin Inhibitor, Kazal PancreaticPedigreeAmyloid beta-PeptidesHeterozygoteFrameshift MutationMolecular Sequence DataDNA Mutational AnalysisPancreatitis, AlcoholicBase SequenceParkinson DiseaseAmino Acid SequenceGerm-Line MutationMutagenesis, Site-DirectedPhenotypeGenotypeAllelesAmyloid beta-Protein PrecursorGenetic Predisposition to DiseaseHomozygoteSerineJewsPolymerase Chain ReactionBraintau ProteinsGenetic TestingMice, TransgenicCell LineProtein Structure, TertiaryAge of OnsetNeurofibrillary TanglesModels, MolecularGait AtaxiaProtein BindingMutagenesisMutation RatePlaque, AmyloidGaucher DiseaseSequence Analysis, DNAGene FrequencyExonsGlycineGlucosylceramidaseBinding SitesProtein-Serine-Threonine KinasesDNA PrimersPresenilin-1Recombinant ProteinsMice, Inbred C57BLDrug Resistance, ViralSequence Homology, Amino AcidApolipoprotein E4Insecticide ResistanceDNA-Binding ProteinsProtein ConformationPolymorphism, Single-Stranded ConformationalChromosome MappingModels, GeneticRomaniaDNANeurofibrilsPeptide FragmentsNeuronsDementiaCarbamatesNeurodegenerative DiseasesTransfectionAmyloid Precursor Protein SecretasesCOS CellsCysteineCodon, NonsenseKineticsAmyloidSequence AlignmentGenetic LinkagePolymorphism, Restriction Fragment LengthCognition DisordersProtein Structure, SecondaryModels, BiologicalHuntington DiseaseMembrane ProteinsHaplotypesGenes, RecessiveNerve Tissue ProteinsCells, CulturedMice, KnockoutAtrophyCercopithecus aethiopsStructure-Activity RelationshipSequence DeletionGenes, DominantGene DeletionNeuropsychological Tests