• This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
  • 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
  • Blood iron is affected by diet, and abnormally high or low iron levels are linked with age-related conditions such as Parkinson's disease, liver disease, and a reduction in the body's ability to fight infection in older age. (genengnews.com)
  • Lipoxygenase (LOX) activity has been implicated in neurodegenerative disorders such as Alzheimer's disease, but its effects in Parkinson's disease (PD) pathogenesis are less understood. (sri.com)
  • Our research aims to pinpoint how specific classes of transposable elements have contributed to the evolution of human neuronal gene expression networks and understand how these changes may relate to human's increased susceptibility to neurodevelopmental disorders such as Autism and Schizophrenia and human neurodegenerative diseases such as Alzheimer's and Parkinson's disease. (uva.nl)
  • Scientists have averted the onset of neurodegenerative disease in fruit flies by administering medication to flies genetically predisposed to a disorder akin to Parkinson's disease. (scienceblog.com)
  • Parkinson's disease is the second most common human neurodegenerative disorder, characterized by tremors, postural rigidity and progressive deterioration of dopaminergic neurons in specific areas of the brain. (scienceblog.com)
  • Like humans, Drosophila melanogaster experiences neuronal loss upon expression of a-synuclein, a protein implicated in the onset of Parkinson's disease in both species. (scienceblog.com)
  • Medications now prescribed to people with Parkinson's disease, such as levodopa, bromocriptine and deprenyl, relieve symptoms by rescuing neurons compromised by the disease," said Bonini, Penn professor of biology and investigator with the Howard Hughes Medical Institute. (scienceblog.com)
  • Geldanamycin and its derivatives warrant further exploration as cytoprotective agents for the treatment of neurodegenerative diseases involving a-synuclein toxicity, including Parkinson's disease. (scienceblog.com)
  • We then discuss the contribution of microbiota in CNS and pathogenesis of CNS disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), and gliomas. (biomedcentral.com)
  • While Parkinson's disease (PD) does not have any obvious Tau aggregation in the brain, it has been genetically associated with Tau. (psp.org)
  • Traumatic injuries are the leading cause of disability, and moreover are associated with elevated risk of developing cognitive impairments and neurodegenerative diseases (ND) such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). (purdue.edu)
  • Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
  • This blog entry reports on recent research which documents the importance of glial pathology as a general underlying factor in essentially all age related neurodegenerative diseases including Alzheimer's Disease, Parkinson's Disease, advanced spinal degeneration, ALS, multiple sclerosis, and several retinal diseases. (anti-agingfirewalls.com)
  • Lipidomic techniques continue to provide evidence for their association in neurological diseases, including Parkinson's disease (PD) and Lewy body disease (LBD). (mdpi.com)
  • Many studies associate microbial dysbiosis with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Multiple sclerosis (MS), and Amyotrophic lateral sclerosis (ALS). (biomed.news)
  • 15,000 individuals including Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS), frontotemporal dementia, and Parkinson's Disease supports the Environmental Neuroscience theme. (upenn.edu)
  • Homozygosity for the more common haplotype H1 is associated with an increased risk for several tauopathies, but also for the synucleinopathy Parkinson's disease (PD). (biomedcentral.com)
  • Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease (AD). (biomedcentral.com)
  • Journal of Parkinson's Disease. (lu.se)
  • In the biological part because of the different susceptibility of both sexes to some developmental disorders such as autism -four times more frequent in males than in females-, and also to psychiatric diseases and neurodegenerative disorders such as Alzheimer's disease, with a higher ratio in females. (mappingignorance.org)
  • Dr. Costantino Iadecola's ground-breaking research in neurology, including developing the concept of the 'neurovascular unit' to better understand the causes of stroke and dementia and opening more possible methods of treatment, makes him a true leader at the forefront of his field, significantly impacting how we think about prevention, diagnosis and treatment of neurovascular and neurodegenerative diseases," said Association President Donald M. Lloyd-Jones, M.D., Sc.M., FAHA. (heart.org)
  • His research demonstrates a relationship between innate immunity and the deleterious effects of hypertension on neurovascular regulation and cognitive function and found that high-salt diets cause dementia through the Alzheimer protein tau, bridging the age-old gap between neurovascular and neurodegenerative diseases. (heart.org)
  • Exposome research tries to reverse the paradigm of â nature versus nurtureâ and adopt one defined by complex and dynamic interactions between DNA sequence, epigenetic DNA modifications, gene expression and environmental factors that all combine to influence disease phenotypes. (aiche.org)
  • Gene-environment interaction models have utility in unmasking the impact of specific cellular pathways in toxicity that may not be observed using a solely genetic or toxicant disease model alone. (sri.com)
  • Genetic factors should be considered when investigating risk factors for atypical scrapie because some mutations of the prnp gene, which codes for prion protein (PrP), modify the risk for this disease ( 2 , 18 , 19 ). (cdc.gov)
  • Because all described genotypes of the prnp gene confer susceptibility to sheep, a purely genetic origin is unlikely but a confounding effect could occur. (cdc.gov)
  • The sub-haplotypes associated with PD or PSP are different from each other, suggesting that different versions of MAPT and Tau can increase risk for different Tauopathies, which could explain why several very different diseases can associated with the same gene. (psp.org)
  • The scientists sequenced every gene in 93 family members and discovered 18 genes newly linked to the disease. (blogspot.com)
  • Moreover, the combination of gene modification and directed differentiation of ESCs provides perfect tool for disease modelling and drug discovery. (benthamscience.com)
  • In the first study Alison Goate of Washington University and her colleagues identified a region on chromosome 10 that appears to contain a risk factor and concluded that the Alzheimer's susceptibility gene in this region could be as influential as the apolipoprotein E (APOE) gene on chromosome 19. (scientificamerican.com)
  • Our empirical study on the AHBA and ADNI data shows the promise of the approach, and the resulting AD gene discoveries provide valuable information for better understanding biological pathways from transcriptomic signatures to intermediate brain traits and to phenotypic disease outcomes. (biomedcentral.com)
  • The Philadelphia Lung Cancer Study on Gene Environment Interactions (Plus-Gene), a three-center study of non-small cell lung cancer and controls, and the Asbestos Exposure Cohort which will include individuals from the Philadelphia Insulators and Asbestos Workers Union who have undergone a chest CT for evaluation of asbestos-associated pulmonary disease and have provided a blood sample supports the Environmental Exposures & Cancer theme. (upenn.edu)
  • In families with familial ALS, there's a 50 percent chance each offspring will inherit the gene mutation, which could cause them to develop the disease. (dailymail.co.uk)
  • Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 ( Uchl1 ), a gene involved in brain function and neurodegenerative diseases 11 . (nature.com)
  • Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)
  • By investigating these complex interactions, researchers strive to unravel the intricate mechanisms underlying the aging process and identify strategies to delay or prevent age-related diseases. (eumag.org)
  • By studying individuals like Mr. Johnson who exhibit exceptional health outcomes despite their old age, researchers can uncover valuable insights into protective mechanisms against age-related diseases such as Alzheimer's or cardiovascular conditions. (eumag.org)
  • Some biochemical mechanisms for these diseases could be similar. (cdc.gov)
  • This concept inspired new research on mechanisms that regulate cerebral perfusion and on how their failure causes brain diseases. (heart.org)
  • Researchers are thus scrambling to identify risk factors for this neurodegenerative disorder and understand the biological mechanisms by which the disease unfolds, in hopes that this information will lead to improved treatment and prevention. (scientificamerican.com)
  • Therefore, JPND will launch a call for multidisciplinary proposals to perform network analyses across such diseases and to elucidate the underlying mechanisms involved. (neurodegenerationresearch.eu)
  • That same blog entry also cites publications arguing that, t o a considerable extent, aging-related neurodegenerative diseases appear to depend on the same underlying mechanisms. (anti-agingfirewalls.com)
  • We are seeking highly motivated postdoctoral fellow candidates to join the laboratory of Brett McCray, MD, PhD, at the University of Michigan to lead studies elucidating mechanisms of hereditary neuromuscular disease. (fellowshipbard.com)
  • In collaboration with Dr. McCray and other members of the laboratory, the fellow will contribute to the design, management, coordination, and implementation of in vitro and in vivo studies focused on defining mechanisms of disease pathogenesis. (fellowshipbard.com)
  • TheHastings Lab is a basic science and translational research lab looking for people to join the team that are interested in investigating mechanisms of disease and devising therapeutic strategies based on these mechanisms as potential disease treatments. (fellowshipbard.com)
  • The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. (iospress.com)
  • However, these genes can not account for the overall inheritance of susceptibility to POAG pathogenesis. (molvis.org)
  • Genetic association studies aimed at defining susceptibility to POAG may provide important insights into the pathogenesis of POAG. (molvis.org)
  • We review recent results that enable pathological staging of AD with neuroimaging and fluid-based biomarkers, with a particular emphasis on the role of amyloid, tau and neuroinflammation in disease pathogenesis. (cdc.gov)
  • One of the most critical factors determining our susceptibility to neurological diseases is neuroinflammation, or inflammation affecting our nervous system. (seniordirectory.com)
  • What troubles me, however, is that many of these advances don't address the single most important aging related problem we face today: neurological diseases. (sentientdevelopments.com)
  • That we are facing a looming epidemic of neurological diseases shouldn't really come as a surprise to anyone. (sentientdevelopments.com)
  • The chances of acquiring a neurological disease like Alzheimer's increases exponentially after the age of 65, and it is estimated that within the next 50 years approximately 30% of the population will be aged 65 years or older. (sentientdevelopments.com)
  • In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. (biomedcentral.com)
  • In this section, we discuss the interplay between resident microbiota and key immunological signaling, and implications of their relationship in CNS development and neurological diseases. (biomedcentral.com)
  • However, nowadays our understanding of catatonia has evolved to recognize it as neuropsychiatric syndrome that can arise from diverse etiological factors ranging from neurological to systemic diseases. (bvsalud.org)
  • Human biomonitoring samples have been analysed for identifying metabolomics and transcriptomics fingerprints, while they have also been mapped jointly into metabolic pathways, for identifying the perturbated pathways that are mostly associated with neurodegenerative diseases. (aiche.org)
  • Our research suggests that toxic tau may spread across different brain regions through direct neuronal connections, much like infectious diseases may spread to different cities through different transportation pathways. (sciencedaily.com)
  • In conclusion, our comprehensive investigation employing both rat and hiPSC models uncovers plausible molecular pathways connecting SCI to neurodegenerative diseases, providing insights into the enduring consequences of these injuries on affected patients. (purdue.edu)
  • There is clinical, genetic and biochemical evidence that similar molecular pathways are relevant in different neurodegenerative and other chronic diseases. (neurodegenerationresearch.eu)
  • Yes, age-associated diseases such as cancer and cardiovascular disease are clearly bad, but the most devastating of these involve the nervous system-diseases like Alzheimer's and Parkinson's. (sentientdevelopments.com)
  • The spread is restricted during normal aging, but in Alzheimer's disease the spread may be facilitated by beta-amyloid, and likely leads to widespread neuronal death and eventually dementia," says lead author Jacob Vogel from McGill University. (sciencedaily.com)
  • Maybe we need to think about these less as individual diseases and more as collective problems of neuronal susceptibility. (blogspot.com)
  • The neuronal injuries associated with Alzheimer disease have several similarities with the optic nerve changes often seen with POAG. (molvis.org)
  • Atypical scrapie could be a spontaneous disease influenced by genetic and metabolic factors. (cdc.gov)
  • For example, we know that patients with Alzheimer's disease tend to have metabolic problems, Mutlu said. (neurosciencenews.com)
  • Although, an overall comparative analysis of microbes and their metabolic involvement in these diseases is still lacking. (biomed.news)
  • The functional analysis of these dysbiotic microbes showed several potential metabolic links which can be involved in the altered microbiome-gut-brain axis in neurodegenerative diseases. (biomed.news)
  • Our study provides a comprehensive catalog of potential dysbiotic microbes and their metabolic involvement in neurodegenerative disorders, including AD, PD, MS, and ALS. (biomed.news)
  • Obesity, as a metabolic disease, manifests the excessive fat accumulation and increased body weight. (hindawi.com)
  • IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)
  • Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)
  • His discovery of the cerebrovascular effects of the amyloid-beta peptide and tau established that neurovascular dysfunction is an early biomarker for Alzheimer's disease. (heart.org)
  • Specifically, we utilized genotype and phenotype data from n = 931 individuals collected under the auspices of the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study to perform a total of 19 separate GWAS analyses. (uni-luebeck.de)
  • «Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases» has been accepted for publication in Alzheimer's & Dementia . (neurodegenerationresearch.eu)
  • In a groundbreaking study that holds the promise of transforming our understanding of Alzheimer's disease, neuroscience researchers from Wayne State University have unveiled the remarkable potential of blood-based neurofilament light (NfL) levels as a predictive biomarker for the likelihood and rate of neurodegeneration progression within the confines of this debilitating condition. (thebrighterside.news)
  • As Damoiseaux explicates, 'The cross-sectional literature indicates that blood NfL shows great promise as a monitoring biomarker to indicate the severity of neurodegeneration in Alzheimer's disease. (thebrighterside.news)
  • Moreover, this biomarker holds potential as a harbinger of change in those at a higher risk of developing Alzheimer's disease due to factors such as the APOE ε4 allele or increased Aβ load. (thebrighterside.news)
  • From the article: ' AD-Detect Test for Alzheimer Disease is the first blood test available for consumers to purchase that measures a biomarker linked to the most common form of dementia. (cdc.gov)
  • Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that occurs when a person's immune system attacks healthy cells in the body. (medicaldaily.com)
  • This includes using genetic and genomic approaches to identify susceptibility in DNA as well as genome-wide association studies and whole genome/exome sequencing in families affected by disease. (psp.org)
  • AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. (uni-luebeck.de)
  • Targeted genetic analyses, genome-wide association studies, and imaging genetic analyses have been performed to detect AD risk and protective genes and have successfully identified dozens of AD susceptibility loci. (biomedcentral.com)
  • In the past 2 decades, genome-wide association studies (GWAS) have identifyed genetic susceptibility loci that confer the risk for sporadic PD [ 3 ]. (biomedcentral.com)
  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. (nature.com)
  • Our studies suggest that a new class of drugs might prevent neurodegenerative disorders by fortifying these neurons even before the onset of disease. (scienceblog.com)
  • In contrast, the etiology of the remaining 95% cases of late-onset AD, often referred to as sporadic Alzheimer's disease (sAD), requires further investigation owing to the various factors involved in the pathology, including genetic and environmental exposures [ 2 ]. (biomedcentral.com)
  • Flavonoids' combination of antioxidant and anti-inflammatory properties are thought to delay or reduce the onset of neurodegenerative diseases like Alzheimer's disease. (healthline.com)
  • Recent studies indicated that obesity is associated with cognitive decline and neurodegenerative diseases [ 5 ].The rising epidemical evidence also shows that obesity is closely related to brain dysfunction and early onset of Alzheimer's disease [ 6 ]. (hindawi.com)
  • How one man's rare Alzheimer's mutation delayed the onset of disease Genetic resilience found in a person predisposed to early-onset dementia could potentially lead to new treatments. (cdc.gov)
  • Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019). (lu.se)
  • The OECD has published a new report summarising the second Lausanne Workshop on «Global Action to Drive Innovation in Alzheimer's disease and other Dementias - Connecting Research, Regulation and Access. (neurodegenerationresearch.eu)
  • The aim of this workshop was to review the policy and stakeholder actions needed to accelerate biomedical research and health innovation for Alzheimer's disease and other dementias. (neurodegenerationresearch.eu)
  • To download the full report, entitled « Global Action to Drive Innovation in Alzheimer's Disease and Other Dementias ,» click here . (neurodegenerationresearch.eu)
  • We used a previously validated multiplexed 10-min, targeted proteomic assay to assess 54 candidate cerebrospinal fluid (CSF) biomarkers in two independent cohorts comprising individuals with neurodegenerative dementias and healthy controls. (lu.se)
  • Cd is abundant in the environment and accumulates in the striatum, the primary brain region selectively affected by Huntington's disease (HD). (biomed.news)
  • Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease. (lu.se)
  • Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients. (lu.se)
  • Identifying and studying genes that contribute to Alzheimer s disease (AD) development will help us to understand the causes of AD, providing the basis for developing new treatments. (neurodegenerationresearch.eu)
  • DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. (nature.com)
  • We have proposed a novel disease-related brain transcriptomic mapping method to identify genes whose expression profiles spatially correlated with regional diagnostic effects on a studied brain trait. (biomedcentral.com)
  • Broadly, we seek to understand what genes define the complement of cell types and cell states within healthy tissue, how cells differentiate to their final fates, and how dysregulation of genes within specific cell types contributes to human disease. (fellowshipbard.com)
  • To demonstrate the promise of our approach, we apply it to the integrative analysis of the brain transcriptome data from the Allen Human Brain Atlas (AHBA) and the amyloid imaging data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. (biomedcentral.com)
  • We trained a Bayesian machine learning neural network model to generate a neuroimaging phenotype and AD score representing the probability of AD using structural MRI data in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort (cut-off 0.5, AUC 0.92, PPV 0.90, NPV 0.93). (cdc.gov)
  • We then apply the model to a healthy population in the UK Biobank study to identify a cohort at risk for Alzheimer's disease. (cdc.gov)
  • Bonini, Auluck and colleagues showed last year that molecular chaperones can block the progression of neurodegenerative disease in Drosophila, suggesting that diseases like Parkinson's and Alzheimer's may result from reduced chaperone levels and might be averted by pharmacologically boosting chaperone activity. (scienceblog.com)
  • The mission of the lab is to gain insight into the molecular basis of these diseases in order to discover new targets for therapeutic development. (psp.org)
  • This is an interdisciplinary project with opportunities to learn new skills in biochemistry, molecular and cellular biology, transcriptomics and proteomics, stem cell culture, and mouse models of disease. (fellowshipbard.com)
  • The future of medical research relies on the ability of scientists to bridge biomedical and computational expertise to deconvolute such complex layers of molecular data and pave the way for delineating novel therapies for infectious and immune-related diseases. (lu.se)
  • This common neurodegenerative disease is clinically characterized by a progressive and gradual cognitive impairment, synapse loss, and substantial loss of neurons in later stages. (biomedcentral.com)
  • The latter diseases CBD and PSP are clinically characterized as atypical Parkinson syndromes [ 15 ]. (biomedcentral.com)
  • Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. (cdc.gov)
  • The aggregation and deposition of amyloid-β (Aβ) in the brain is thought to be an early event in the pathology of Alzheimer's disease (AD). (iospress.com)
  • Iron deposition happens in various brain areas in some diseases of the nervous system and the aging process. (springeropen.com)
  • There are different imaging methods based on MRI for examining and measuring iron deposition in the brain, like T2*-weighted imaging (T2*WI), T2-weighted imaging(T2WI), relaxation rate (R2*), field-dependent relaxation rate increase (FDRI), and susceptibility-weighted imaging (SWI) [ 2 ]. (springeropen.com)
  • There are two proteins that are known to be linked to Alzheimer's disease -- beta-amyloid, which forms what is known as a plaque in the brain, and tau, which forms tangles within brain cells. (sciencedaily.com)
  • Intense research is ongoing to better understand how toxic tau spreads in the brain, in order to develop new therapies that can stop the spread and thereby stop the disease. (sciencedaily.com)
  • Common components thought to contribute to the manifestation of these disorders and normal age-related declines in brain performance are increased susceptibility to long-term effects of oxidative stress and inflammatory insults. (sentientdevelopments.com)
  • The cross-talk between gut microbiota and brain may have crucial impact during basic neurogenerative processes, in neurodegenerative disorders and tumors of CNS. (biomedcentral.com)
  • She is also investigating how tau is regulated in the brain to determine which forms cause brain cells to die and lead to disease. (psp.org)
  • These imaging transcriptomic studies typically do not involve the disease outcome in the analysis, and thus the identified brain or transcriptomic markers may not be related or specific to the disease outcome. (biomedcentral.com)
  • The study, aptly titled 'The Potential of Blood Neurofilament Light as a Marker of Neurodegeneration in Alzheimer's disease,' recently saw its publication in the prestigious journal Brain. (thebrighterside.news)
  • PET scan of a human brain with Alzheimer's disease. (thebrighterside.news)
  • Longitudinal studies, consistent in their findings, unravel significant relationships between blood NfL levels and the atrophy of brain regions that are inherently vulnerable to Alzheimer's disease pathology. (thebrighterside.news)
  • ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. (dailymail.co.uk)
  • Amyloid deposits in the brain are a hallmark of Alzheimer disease, although many people who have them don't develop cognitive impairment. (cdc.gov)
  • These are diseases in which the cells of the brain stop working or die. (medlineplus.gov)
  • Accumulating evidence suggests that microbiota are involved in the physiology and pathology of cellular organisms, and hence has implications in both health and disease [ 3 ]. (biomedcentral.com)
  • Early white matter pathology in the fornix of the limbic system in Huntington disease. (lu.se)
  • Our findings have implications for understanding the disease, but more importantly for the development of therapies against Alzheimer's, which are directed against either beta-amyloid or tau. (sciencedaily.com)
  • In my February 2010 blog entry New views of Alzheimer's disease and new approaches to treating it , I cited evidence for the hypothesis that microglial cell senescence is probably a fundamental cause for AD, a cause upstream of beta amyloid plaque production and the setting in of tau tangles. (anti-agingfirewalls.com)
  • Alzheimer's disease (AD) is one of the most common neurodegenerative disorders characterized by progressive decline in cognitive function. (biomedcentral.com)
  • Introduction: Synaptic dysfunction and degeneration is one of the earliest events in Alzheimer's disease (AD) and the best correlate of cognitive decline. (lu.se)
  • In 2023, I started my own group at Lund University using systems immunology as a data-driven approach to decipher how biological sex impacts human immunity and disease susceptibility. (lu.se)
  • Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • There is currently no cure or (meaningful) prevention for most of these diseases. (sentientdevelopments.com)
  • Several definitions for mTBI have been proposed by various organizations including the American Congress of Rehabilitation Medicine (ACRM), Center for Disease Control and Prevention (CDC), the World Health Organization (WHO) and the Department of Defense (DOD). (checkbiotech.org)
  • Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)
  • Obesity is strongly associated with various diseases, such as diabetes, hypertension, cardiovascular and cerebrovascular diseases, and cancer [ 2 ]. (hindawi.com)
  • Dr. Iadecola's work also details how microbiota of the gut can influence a patient's susceptibility to ischemic stroke. (heart.org)
  • Both genetic and environmental factors are thought to contribute to the pathophysiology of the disease. (molvis.org)
  • This wide range of natural variation raises the possibility that susceptibility to a subset of neurodegenerative and psychiatric disorders linked to defects in the hippocampus may depend, in part, on its initial healthy volume. (biomedcentral.com)
  • To identify genetic variants underlying such differences and associated disease phenotypes, multinational consortia such as ENIGMA have used large magnetic resonance imaging (MRI) data sets in human GWAS studies. (biomedcentral.com)
  • The Amniocyte/Amniocentesis Repository and the Pre-Term Birth Registry, which includes samples of maternal blood, chorion, amnion, placenta, decidua, fetal blood, and myometrium from the uterine fundus obtained during cesarean delivery from women with four complementary phenotypes: delivering preterm with (PL) and without labor (PNL), term with (TL) and without labor (TNL) supports the Windows-of-Susceptibility theme. (upenn.edu)
  • This disease has been transmitted experimentally to Tg-mice ( 9 ) and sheep ( 10 ), but histopathologic features of atypical scrapie have suggested similarities with human spontaneous TSE (Gerstmann-Sträussler-Scheinker syndrome) ( 2 , 11 ). (cdc.gov)
  • We show that the loss of one allele of the p53 family member, p73, makes mice susceptible to neurodegeneration as a consequence of aging or Alzheimer's disease (AD). (ox.ac.uk)
  • We speculate that our findings on iron metabolism might also start to explain why very high levels of iron-rich red meat in the diet has been linked to age-related conditions such as heart disease. (genengnews.com)
  • In addition, the findings are relevant to the observations that have been made between olfaction, fat metabolism and neurodegenerative diseases. (neurosciencenews.com)
  • 1995. Copper and zinc metabolism in health and disease: Speciation and interactions. (cdc.gov)
  • Our primary focus is on diseases caused by mutations in the ion channel TRPV4, which result in Charcot-Marie-Tooth disease type 2C and related forms of spinal muscular atrophy. (fellowshipbard.com)
  • Unravelling it requires to simultaneously identify, characterize and quantify exogenous and endogenous exposures and modifiable risk factors that predispose to and predict disease throughout the human life span. (aiche.org)
  • Exposome science will help us understand the intricate web of relationships between environmental exposures, lifestyle, genetics and disease, contributing significantly to the determination of causal associations between environmental factors and human health. (aiche.org)
  • If atypical scrapie had an infectious origin, it could be influenced by risk factors associated with a pattern of infectious disease transmission as described for classical scrapie ( 12 - 14 ). (cdc.gov)
  • Understanding the genetic factors that contribute to individual differences in hippocampal volume is thus crucial in providing insight into vulnerability and severity of disease. (biomedcentral.com)
  • I think these findings have implications for therapies aiming at stopping the spread of tau and thereby halting the disease progression in Alzheimer's," says Oskar Hansson, professor of neurology at Lund University and co-lead investigator of the study. (sciencedaily.com)
  • Caspases involved with processing inflammatory signals are also implicated in disease. (wikipedia.org)
  • There is wide agreement that excessive microglial activation is a key process in nervous system disorders involving release of strong pro-inflammatory cytokines, cytokines which can trigger worsening of multiple disease states. (anti-agingfirewalls.com)
  • Research heralds a new era in the diagnosis and management of Alzheimer's disease. (thebrighterside.news)
  • This revolutionary research, led by Youjin Jung, a doctoral student in the Behavioral and Cognitive Neuroscience program, and Jessica Damoiseaux, Ph.D., an associate professor in the Institute of Gerontology and the Department of Psychology, heralds a new era in the diagnosis and management of Alzheimer's disease. (thebrighterside.news)
  • 2000. Recognition, diagnosis, and management of Wilson's disease. (cdc.gov)
  • Also, our study suggests a link between the scents each individual can perceive and his or her susceptibility to obesity. (neurosciencenews.com)
  • Cognitive dysfunction is an important complicated disease in obesity. (hindawi.com)
  • The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. (iospress.com)
  • Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)
  • In this study, expression of various stress proteins in the Alzheimer-diseased choroid plexus (CP) was assessed immunohistochemically. (iospress.com)
  • We find that MGST3 is associated with hippocampus size and is linked to a group of neurodegenerative disorders, such as Alzheimer's. (biomedcentral.com)
  • Individuals who develop and retain a large hippocampus into adulthood may be comparatively resistant to some forms of disease, particularly Alzheimer's. (biomedcentral.com)
  • p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. (ox.ac.uk)
  • Thus, p73 is essential for preventing neurodegeneration, and haploinsufficiency for p73 may be a susceptibility factor for AD and other neurodegenerative disorders. (ox.ac.uk)
  • It is a processing technique that can measure tissue susceptibility from various sequences such as Gradient echo sequences (GRE) and does not have many limitations [ 9 ]. (springeropen.com)
  • It has beneficial antioxidants that may help relieve stress, inflammation, and tissue damage that can occur alongside chronic diseases. (healthline.com)
  • Summary GSE may help reduce your risk of heart disease by inhibiting the oxidation of LDL (bad) cholesterol and reducing oxidation to heart tissue during times of stress. (healthline.com)
  • In some diseases, for example Sjögren's syndrome (SS), there is a hyposalivation related to organic disorders of salivary glandular tissue. (bvsalud.org)