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  • cerebral cortex
  • The disease is characterized by the destruction of nerve cells and neural connections in the cerebral cortex of the brain and by a significant loss of brain mass. (britannica.com)
  • mild
  • A condition called mild cognitive impairment, in which a person experiences an inability to form memories for events that occurred a few minutes ago, typically is the first sign of the disease. (infoplease.com)
  • These drugs have been shown to benefit patients with mild-to-moderate disease and some studies suggest a benefit for those with advanced disease. (news-medical.net)
  • deficits
  • Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis," Cell Death & Disease , vol. 4, article e789, 2013. (hindawi.com)