ExperimentsTissuesRatsSilicoTissueOrgan-on-a-chip technologyResearchersMethodsExperimentationTreatmentsClinicalResearchComplexitiesOrganoidsDiseasesSpeciesBiologyMetabolismPredictVeterinaryChemicalsMiceStudiesVivo2023EmbryonicPotencyPredictionAdvancesTherapiesStudyBeingsScientistsWelfareExposureInflammatoryAnatomicalHealthComputerPractice2020ViableAssessment2021Laboratory animalTumourTrialsDescribeMethodologiesDiseaseLaboratoriesPathologicalDevelopmentMorphologyPopulationsComputationalData
Experiments27
- Experiments on animals for medical purposes are not only cruel they are unreliable. (alv.org.au)
- Experiments on Animals - Why Are They Still Done? (alv.org.au)
- Unlike crude, archaic animal tests, non-animal methods usually take less time to complete, cost only a fraction of what the animal experiments that they replace cost, and are not plagued with species differences that make extrapolation difficult or impossible. (alv.org.au)
- Our goal is to replace animal experiments with animal-free alternative methods based on isolated human cells, tissues or computer models. (basf.com)
- The 3R concept is the basis for bringing this demand into practice: Replace animal experiments with alternatives where. (awionline.org)
- The Philpott model has allowed scientists to carry out many experiments previously impossible to investigate the effects of growth regulatory factors on human hair growth. (qmul.ac.uk)
- Whereas the research establishment and its stakeholders would have us believe that the rights of individual human subjects are well protected by Institutional Review Boards (IRB), this Court has rightfully recognized that IRBs are "primarily, in-house organs" which are neither designed to be objective nor are they "sufficiently concerned with the ethicality of the experiments they review as they are with the success of the experiments. (ahrp.org)
- Animals are used by scientists to develop research for new medications and experiments daily. (bartleby.com)
- Is it morally right or wrong to use animals during experiments? (bartleby.com)
- Due to experiments on animals we have treatments for diabetics, tuberculosis, breast cancer, malaria and brain injuries. (bartleby.com)
- Animal testing is not only beneficial to human but also animals, at least to those who are not used in the experiments, such as pets and endangered species. (bartleby.com)
- All of this goes a long way towards fooling the public, particularly those who want to believe that animals are "treated cruelly in unnecessary experiments" and are really looking for confirmation of what they want to be true. (huffingtonpost.co.uk)
- In preliminary experiments with a standard nanoLC-MS set-up (i.e. trap column for extraction + separation column), injecting protein precipitated pooled human plasma clogged the column(s) (see Fig. 1A ). (nature.com)
- What are animal experiments? (aerzte-gegen-tierversuche.de)
- It rather serves as a basis for requirements that need to be met in order to use animals in experiments. (aerzte-gegen-tierversuche.de)
- The experiments do not serve the well-being of the animal, but aim to answer a wide variety of the researcher's scientific questions. (aerzte-gegen-tierversuche.de)
- For what purpose are animal experiments conducted? (aerzte-gegen-tierversuche.de)
- Basic research has accounted for more than half of all animal experiments in Germany for years. (aerzte-gegen-tierversuche.de)
- This is due to the fact that, as proven by many scientific studies, the transferability of findings from animal experiments to humans is by no means assured. (aerzte-gegen-tierversuche.de)
- Given the significant differences in organ function and metabolism between animals and humans, the results of such experiments do not accurately predict the toxicity for humans. (aerzte-gegen-tierversuche.de)
- Genetically modified animals now constitute approximately 45% of all animals used in experiments. (aerzte-gegen-tierversuche.de)
- Also, this kind of animal experiments is unnecessary. (aerzte-gegen-tierversuche.de)
- However, like alchemists, materials scientists are plagued by time-consuming and labor-intensive experiments to build high-accuracy ML models. (bvsalud.org)
- Experiments on 60 datasets show that compared with the traditional modeling method from scratch, Auto-MatRegressor automatically selects appropriate algorithms at lower computational cost, which accelerates constructing ML models with good prediction accuracy. (bvsalud.org)
- entitled "One health: perspectives on ethical issues and evidence from animal experiments" [1], touches on a number of important points, but fails to go far enough in exploring the innovative nature of a One Health approach to a number of scientific and ethical issues related to the overlap of human and animal health. (who.int)
- Our article focuses on One Health in relation to ethics and a pathway to generating robust evidence from animal experiments and certainly not, as seems to be understood by Dr Lederman, that One Health provides an alternative to the conventional animal experiments. (who.int)
- Evidence: Many systematic reviews published in the Cochrane library are inconclusive and unable to provide clinical recommendations after randomized controlled trials have been undertaken based on the results of animal experiments. (who.int)
Tissues5
- Human reconstructed airway (RHuA) tissues present a platform that more closely resembles airways in vivo. (iivs.org)
- Grown at the air-liquid interface (ALI), RHuA tissues offer apical and basal compartments that allow flexibility in modeling physiologically relevant exposures and provide sampling location-specific results. (iivs.org)
- e.g., computer modeling, organ-on-a-chip technology, and cell and tissue tests using human tissues. (cosmeticsandtoiletries.com)
- Dr Mohamed Abdallah has wide experience in applying mass spectrometric techniques for analysis of trace levels of environmental pollutants in biotic and abiotic matrices including different human tissues. (birmingham.ac.uk)
- We need to see if the virus `hides out' in body fluids and tissues of animals it can infect, and if the virus can be passed between animals through copulation. (cdc.gov)
Rats8
- In the present study, we showed that LPS could be used to establish a retinal inflammatory model on SD rats as well. (nature.com)
- 2021. Sustained release buprenorphine effectively attenuates postoperative hypersensitivity in an incisional pain model in neonatal rats (Rattus norvegicus). (awionline.org)
- 2021. Buprenorphine, but not lidocaine, effectively attenuates post-operative thermal hypersensitivity in an incisional model in neonatal rats (Rattus norvegicus). (awionline.org)
- 2021. Comparison of nociceptive effects of buprenorphine, firocoxib, and meloxicam in a plantar incision model in Sprague-Dawley rats. (awionline.org)
- Roughly ninety-five percent of all lab animals are special-bred mice and rats. (bartleby.com)
- Typical tests involve daily administration of a substance by gavage directly into the stomach of mice, rats, or other animals. (aerzte-gegen-tierversuche.de)
- Studies using rats and rabbits or other small animals have usually yielded penetration values that are much higher than those seen in humans. (cdc.gov)
- Newer animal models using weanling pigs, micro-pigs or mini-pigs, and human skin grafted rats appear to be viable alternatives to the use of rhesus-monkeys. (cdc.gov)
Silico3
- for developmental toxicity by combining in vitro toxicity data and calculated an even higher number of laboratory animals in silico kinetic modeling. (cdc.gov)
- In vitro toxicity data of these metabolites derived in the development of validated and accepted in vitro and in silico embryonic stem cell test were used as input in the PBK model to extrapolate in vitro concentration-response curves to predicted approaches is urgently needed. (cdc.gov)
- response curves for rat were found to be in concordance with the 2004), in vitro and in silico alternatives for developmental embryotoxic dose levels measured in reported in vivo rat studies. (cdc.gov)
Tissue9
- Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that have started to revolutionize medical science in terms of understanding disease, testing pharmacologically active compounds, and offering novel ways to treat disease. (mdpi.com)
- August 23, 2019 - Clarifying Competing Application Instructions and Notice of Publication of Frequently Asked Questions (FAQs) Regarding Proposed Human Fetal Tissue Research. (nih.gov)
- July 26, 2019 - Changes to NIH Requirements Regarding Proposed Human Fetal Tissue Research. (nih.gov)
- The FAL then produces 'scaffolding' from donated human liver tissue that has had the original cells removed. (frame.org.uk)
- In addition to such traditional research methods as clinical trials, epidemiological investigations, biopsy and autopsy, some technologically advanced methods, such as CAT and PET scans, cell and tissue cultures, computer models, and computerized post-market surveillance of drugs, permit safe, direct study of human disease. (uft.org)
- Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
- Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)
- He uses fruit fly models to study how a cell becomes one kind of tissue (like an eye) and not another (like a wing or an antenna). (medlineplus.gov)
- In humans, our immune response causes scar tissue to form, which can stop parts of the retina from responding to light. (medlineplus.gov)
Organ-on-a-chip technology1
- Despite its current reliance on animals, South Korea is actively involved in the pursuit of innovative approaches including organ-on-a-chip technology, organoids and computer-based modelling. (hsi.org)
Researchers9
- To address these problems, innovative swine and poultry producers and researchers who take a holistic view of animal production, and who enjoy the challenge of working with nature rather than trying to control it, are developing production systems that give animals access to the outdoors and the opportunity to gain some nutrition from forage. (ucsusa.org)
- To better understand Plasmodium biology, researchers can whether proceed to in vitro studies or use in vivo models. (wjgnet.com)
- Here, we explain the FAL's research into the liver and how its researchers use human cells to model liver disease. (frame.org.uk)
- With a mandate to evaluate the dynamics of pulmonary exposure to inhaled materials such as tobacco-based products, researchers are employing complex, human, three-dimensional pulmonary models. (iivs.org)
- Researchers still do not know why our human ancestors shifted from gathering and hunting to agricultural systems. (theconversation.com)
- Animal researchers and their academic colleagues determine medical school curricula and edit scientific journals. (uft.org)
- If researchers want, they can also buy cells from Emulate, which we call a "Biokit," across the five organ models we are building. (hsi.org)
- Small animals teach researchers big lessons about how vision works, how it can go wrong (and why), and new ways to treat eye diseases. (medlineplus.gov)
- Let's explore how other NIH-funded vision researchers are using different animal models in their work. (medlineplus.gov)
Methods16
- The government organizations enforce laws and regulations, raise funds to support non-animal testing methods such as tests on human volunteers, and advanced computer-modeling techniques, and also fund studies with human volunteers. (thebusinessresearchcompany.com)
- In order to support non-animal testing, People for the Ethical Treatment of Animals (PETA) India, in 2022, announced a grant of 7 lakh rupees in order to advance animal-free methods for toxicology testing. (thebusinessresearchcompany.com)
- June 19, 2018 - Notice of Addition of Letter of Intent Due Dates on BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed). (nih.gov)
- March 19, 2018 - Notice of Change to Expiration Date on BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed). (nih.gov)
- Together with seven other partners from science and industry, we have therefore made an appeal to politicians and campaigned for the targeted promotion of alternative methods. (basf.com)
- Lastly, animal testing not only leads away from the direction of resources from more effective testing methods but also prolongs the duration of time humans may need to wait for an effective cure. (bartleby.com)
- The billions of dollars currently spent on animal experimentation should be redirected to more productive research methods, preventative health programs, and treatment facilities. (uft.org)
- The success of these methods counters claims that animal experimentation is necessary. (uft.org)
- This bill, the Act on the Promotion of Development, Dissemination and Use of Alternative to Animal Testing Methods, was introduced in 2020 at Korea's National Assembly by Assemblymember Ms. In-soon Nam. (hsi.org)
- We asked Dr. Ewart to explain how these technologies can shift the paradigm of health research toward more human-predictive methods. (hsi.org)
- Animals are used in medicine, veterinary science, and biology studies to teach students basic biological knowledge although a broad spectrum of pedagogically superior, animal-free teaching methods exist. (aerzte-gegen-tierversuche.de)
- Computational techniques, including predictive algorithms and mathematical models that describe a selected process (e.g., skin permeation) by means of analytical or numerical methods. (cdc.gov)
- At present, regulatory assessment of systemic toxicity is almost to 3.9 million if the use of alternative methods is not accepted solely carried out using animal models. (cdc.gov)
- Three alternative methods for in vivo developmental toxicity risk assessment. (cdc.gov)
- Approaching zoonotic and environmental risks from a One Health perspective involves considering what research and disease control and prevention methods are mutually beneficial to humans, animals and the environment. (who.int)
- Jonas Svensson is going to study two alternative measurement methods, both of which involve measuring the amount of aggrecan, an important protein in cartilage. (lu.se)
Experimentation10
- Additionally, it has been debated that the results of animal experimentation are unreliable across a wide range of areas. (bartleby.com)
- Therefore, the potential benefits of animal experimentation are greatly outweighed by the risks and collective harm of humans and animals which is why resources should be directed towards more human-based testing procedures. (bartleby.com)
- Document epidemiological, case study, or experimental research that advances human health without dependence on animal experimentation. (uft.org)
- First, animal experimentation has had little, if anything, to do with most medical advances. (uft.org)
- While animal experimentation has uncovered some useful information, this is hardly surprising, given the billions of dollars invested in it annually. (uft.org)
- Given the enormous time, effort, and money poured into animal experimentation and the meager benefits this research has yielded to date, it is reasonable to conclude that animal research is neither an efficient nor valuable research method. (uft.org)
- The ethical justification and scientific utility of laboratory animal experimentation are rightly criticized, necessitating efforts to enhance humane aspects of animal research as well as to address biases and difficulties in extrapolating data from animal research to humans. (who.int)
- The authors also provide four proposals to improve the ability to apply data from laboratory animal experimentation to humans. (who.int)
- While agreeing with their premise, I would disagree with the conclusion and would argue that the authors fail to adequately describe how the One Health approach provides alternatives to traditional use of animal experimentation. (who.int)
- The One Health paradigm, whether applied to zoonotic disease or other health issues affecting both animals and humans, can provide important alternatives to animal experimentation. (who.int)
Treatments4
- Animal testing provides a useful model for treatments of diseases and possible cures. (bartleby.com)
- Animal testing is essential for developing lifesaving treatments. (bartleby.com)
- Animal research remains a small but vital part of the quest for new medicines, vaccines and treatments for humans and animals. (understandinganimalresearch.org.uk)
- These models are crucial for the understanding of inflammatory bowel diseases, development of alternative treatments and more effective therapeutic agents thus contributing to the control of the disease. (intechopen.com)
Clinical10
- Animals are not good models for predicting human clinical outcomes because of differences in physiology, metabolism and other differences between human and non-human animals. (alv.org.au)
- However, efforts to improve both animal and human experimental model selection, on the basis of increased understanding of the underlying pathophysiological pain mechanisms, have been disappointing, with poor translation of results to clinical analgesia. (nih.gov)
- We have developed an alternative approach to the selection of suitable pain models that can correctly predict drug efficacy in particular clinical settings. (nih.gov)
- This is based on the analysis of successful or unsuccessful empirical prediction of clinical analgesia using experimental pain models. (nih.gov)
- Thus, based on empirical evidence of agreement between drugs for their efficacy in experimental and clinical pain settings, it is possible to identify pain models that reliably predict clinical analgesic drug efficacy in cost-effective experimental settings. (nih.gov)
- Several medical historians have found that most major advances in areas such as heart disease and cancer have developed from human clinical investigation. (uft.org)
- As the home of the number one NIH funded genetics department , the largest clinical genetics program in the nation and the BCM Human Genome Sequencing Center -- one of only four such centers in the nation and one of the three leaders of the Human Genome Sequencing Project -- Baylor College of Medicine is an international leader in genetics and genomics. (bcm.edu)
- These are comparatively underexplored issues insofar as the literature on vets tends to be descriptive and statistical, focusing primarily on clinical matters and associated human-animal interactions. (open.ac.uk)
- One Health is a comparative clinical approach which promotes better collaboration between human and animal health professionals in order to reduce the spread of zoonotic diseases. (who.int)
- A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
Research56
- Tests performed on animals for medical research and teaching are so common in Australia that in 2017, over 20 million animals were experimented on. (alv.org.au)
- This non-animal alternatives testing market research report provides a comprehensive view of everything you require, including an in-depth analysis of the industry's current and future scenario. (thebusinessresearchcompany.com)
- The IIDP facilitates the distribution of human cadaveric islets for biomedical research. (nih.gov)
- Human islets are an essential resource for diabetes research, both to advance our understanding of human islet cell biology and to develop therapies for the treatment of diabetes. (nih.gov)
- The IIDP coordinating center provides critical services to the research community by enhancing access to human islets and by fostering improved standardization and quality of this important research resource. (nih.gov)
- By fostering the use of human islets in fundamental research, IIDP resources support advances in human islet biology and promote the development of new therapies for the prevention and treatment of diabetes. (nih.gov)
- The National Institutes of Health support many multi-faceted programs to advance human islet research, with the goal of developing new approaches to prevent and treat diabetes. (nih.gov)
- NIH support for the procurement, processing, and distribution of human islets was initiated through an Islet Cell Resource Center (ICR) program established in 2001 by the National Center for Research Resources (NCRR), together with the NIDDK and the Juvenile Diabetes Foundation International (JDRFI). (nih.gov)
- The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. (wjgnet.com)
- Funded by an annual grant made by FRAME to support its work, the FAL is based at the University of Nottingham Medical School and aims to produce human-based research systems for medical research that are better and more relevant to humans than current animal models. (frame.org.uk)
- This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research. (awionline.org)
- Sociocultural changes in the human-animal relationship have led to increasing demands for animal welfare in biomedical research. (awionline.org)
- His research has a strong emphasis in the 3R's and in particular animal replacement. (qmul.ac.uk)
- He currently directs the Animal Free Research UK (AFRUK) centre of excellence within the Blizard Institute. (qmul.ac.uk)
- According to the US-based foundation of Biomedical Research, animal testing has made a major advance within the last century- for veterinary health and humans. (bartleby.com)
- Does federal law ensure that animals used in research are treated humanely? (bartleby.com)
- The essential need for animal research and observation is supported by health agencies and medical associations around the world. (bartleby.com)
- As of 2015, 200 to 225 million animals are said to used in laboratory research for the biomedical industry annually worldwide. (bartleby.com)
- First off, the laboratory conditions that are instigated upon millions of animal models for the sake of medical research has been said to be unethical and cruel. (bartleby.com)
- Hundreds of lives and millions of dollars have been wasted on research regarding human prisoners. (bartleby.com)
- Today, 30 June 2022, Understanding Animal Research (UAR) has published a list of the ten organisations that carry out the highest number of animal procedures - those used in medical, veterinary, and scientific research - in Great Britain. (understandinganimalresearch.org.uk)
- These statistics are freely available on the organisations' websites as part of their ongoing commitment to transparency and openness around the use of animals in research. (understandinganimalresearch.org.uk)
- For more information on the 2021 animal research statistics for Great Britain, you can read our analysis . (understandinganimalresearch.org.uk)
- Each organisation's name links to its animal research webpage, which includes more detailed statistics. (understandinganimalresearch.org.uk)
- UAR has also produced a list (see appendix) of 63 organisations in the UK that have publicly shared their 2021 animal research statistics. (understandinganimalresearch.org.uk)
- This includes organisations that carry out and/or fund animal research. (understandinganimalresearch.org.uk)
- However, as institutions expand and conduct more research, the total number of animals used can rise even if fewer animals are used per study. (understandinganimalresearch.org.uk)
- All organisations listed are signatories to the Concordat on Openness on Animal Research in the UK , a commitment to be more open about the use of animals in scientific, medical and veterinary research in the UK. (understandinganimalresearch.org.uk)
- We know that the majority of the British public accepts that animals are needed for this research, but it is important that organisations that use animals in research maintain the public's trust in them. (understandinganimalresearch.org.uk)
- By providing this level of information about the numbers of animals used, and the experience of those animals, as well as details of the medical breakthroughs that derive from this research, these Concordat signatories are helping the public to make up their own minds about how they feel about the use of animals in scientific research in Great Britain. (understandinganimalresearch.org.uk)
- Animal research continues to be an important part of biomedical science, but as research institutions it is vital that we do not take public support for granted, and instead explain clearly why and how we work with animals and the steps we take to ensure good animal welfare. (understandinganimalresearch.org.uk)
- Since first signing the Concordat in 2014, Cambridge University has strived to be as open about our animal research as possible, sharing a wealth of information and case studies, and continuing to engage the public. (understandinganimalresearch.org.uk)
- This unit will aquatint students with some of the Medical Research Modernization Committee's concerns about the scientific value of animal research. (uft.org)
- It will also suggest a variety of non-animal methodologies that could be used as alternatives to animal research. (uft.org)
- By these means, they have been able to promote the historically inaccurate view that animal research has been vital to medical progress. (uft.org)
- Virtually every time Medical Research Modernization Committee (MRMC) scientists and clinicians have been asked to review animal research projects, they have found significant scientific shortcomings that make the value of the research highly questionable. (uft.org)
- An article in the New England Journal of Medicine justified animal use in cancer research on the ground that "cancer kills humans and animals alike. (uft.org)
- The animal research debate is of major importance to public health. (uft.org)
- However, the politically powerful animal research establishment continues to receive the largest share of available research funds. (uft.org)
- I took my job at Understanding Animal Research for a couple of reasons. (huffingtonpost.co.uk)
- The topic of animal research has all of them. (huffingtonpost.co.uk)
- The finest example of this isn't anything to do with animal research, but pertains to the opening of the Large Hadron Collider. (huffingtonpost.co.uk)
- I often feel that this is the case with animal research. (huffingtonpost.co.uk)
- So we have a generally poor public understanding of the realities of animal research and people willing to misrepresent it, which means that talking about animal research doesn't occur in a vacuum. (huffingtonpost.co.uk)
- Top of the pile has to be that there are "modern alternatives" for all animal research, so we must make it clear right off the bat that this simply isn't the case. (huffingtonpost.co.uk)
- In 2021, the number of animals used for research testing in South Korea reached a record high of 4.8 million. (hsi.org)
- We sell the Human Emulate System, which includes the chips, the microfluidic instrument, software and accessories needed for scientists to use OOC in their research. (hsi.org)
- Crucial aspects of causes for disease in humans, such as nutrition, stress, or lack of exercise, are not taken into account in this kind of research. (aerzte-gegen-tierversuche.de)
- Aim: To evaluate the morphology of enamel from species Bubalus bubalis as a replacement for human enamel in laboratory research studies, considering its wider availability in the Amazon region. (bvsalud.org)
- Currently, laboratory dental research studies are limited by the small number of healthy extracted human teeth available, as well as by the ethical aspects in obtaining them. (bvsalud.org)
- This has led to an increase in the illegal use of human teeth in research, through postmortem extraction and illegal trade in dental organs, which goes against Law 9434, from February 4th, 19972. (bvsalud.org)
- Given the difficulty in using human teeth in scientific research studies, due both to access factors and ethical issues, an animal substitute as similar as possible to human teeth becomes extremely important 15 . (bvsalud.org)
- This investigation began by submitting the project to the Ethics Committee for Animal Experiment Research of the Federal University Pará (CEPAE- UFPA) and granting its approval under the protocol #BIO013/09. (bvsalud.org)
- Zoonoses are important threats to human and animal health, and animal research has played a role in assessing risk across species. (who.int)
- Watch this video to learn more about fruit flies as animal models in vision research. (medlineplus.gov)
- Discover more about the newt eye lens as a research model in this video . (medlineplus.gov)
Complexities1
- Presumably inspired by the whizzy computers in NCIS, heartburn relief adverts, or maybe the movie " Innerspace ", this meme imagines that we have the computing power and indeed knowledge of how biological processes work, to build a computer model of the human body, or a culture of cells in a petri dish is close enough to modelling the complexities of a living creature. (huffingtonpost.co.uk)
Organoids1
Diseases7
- Bioterrorism, foreign animal diseases, and other security-related topics were the dominant themes of the evening. (avma.org)
- The importance of educating veterinarians and veterinary students to increase their vigilance with respect to foreign animal diseases was the overarching message delivered by the participants. (avma.org)
- An increased emphasis on foreign animal diseases and public health in the professional curriculum was also promoted. (avma.org)
- Non-human animals do not appear to suffer from mental diseases as schizophrenia. (uft.org)
- The objective of this chapter is to present current concept on animal models of inflammatory bowel diseases. (intechopen.com)
- Mice are genetically altered to replicate conditions like cancer, Alzheimer's, diabetes, and other human diseases. (aerzte-gegen-tierversuche.de)
- For centuries, scientists have used small animal models to study everything from how genes work to how diseases develop. (medlineplus.gov)
Species5
- Animals of different species don't necessarily react the same as other animals or humans, and therefore a substance tested on an animal can have a completely different effect on a human. (alv.org.au)
- In this paper, we review the different protocols available to study human Plasmodium species either by using stem cell or alternative animal models. (wjgnet.com)
- As an alternative to these limitations, studies have been proposed using different animals, including several mammal species, to be adopted as experimental models 3-5 . (bvsalud.org)
- Therefore, the objective of this study was to evaluate the morphology of tooth enamel from buffalo species Bubalus bubalis as a replacement for human enamel in laboratory studies, using scanning electron microscopy (SEM). (bvsalud.org)
- As such, groups concerned with animal ethics would do well to further explore the applications of a One Health approach: what are the ethical guideposts as we move toward a future of health care that considers the health of multiple species as well as the environment? (who.int)
Biology4
- They have shown that changes in biodiversity through the Phanerozoic correlate much better with hyperbolic model (widely used in demography and macrosociology) than with exponential and logistic models (traditionally used in population biology and extensively applied to fossil biodiversity as well). (wikipedia.org)
- In parallel, the development of animal models opened new opportunities to study parasite biology in vivo . (wjgnet.com)
- As a part of ongoing efforts to raise stakeholder awareness around the PAAM Act and the need for wider adoption of NAMs, HSI/Korea's director of government affairs, Borami Seo, spoke to Dr. Lorna Ewart, chief scientific officer at Emulate, Inc. Emulate produces human cell-based technologies that recreate human biology, Organ-Chips, also known as microphysiological systems. (hsi.org)
- Use the insights you gain to illuminate evolution, elucidate new biology, and potentially guide the development of new treatment options to improve human health. (bcm.edu)
Metabolism2
- In 2013, Abdallah was awarded a prestigious 2-year Marie-Curie Fellowship during which he pioneered the application of 3D-Human Skin Equivalent models (3D-HSE) to study the human dermal bioavailability and metabolism of chemical pollutants in dust, fabrics, and cosmetics. (birmingham.ac.uk)
- Human dermal uptake and metabolism of PFAS from fabrics. (birmingham.ac.uk)
Predict2
- During these studies, Dr Abdallah gained theoretical and practical experience in advanced chromatographic and spectroscopic techniques, in addition to applying pharmacokinetic models to predict in vivo levels of drugs. (birmingham.ac.uk)
- Using animal models to predict human absorption was discussed. (cdc.gov)
Veterinary5
- Those attending the Sept. 15 roundtable dinner were Drs. Bonnie Buntain, chief veterinary public health officer with the Department of Agriculture, Peter J. Fernandez, associate administrator of the USDA Animal and Plant Health Inspection Service, Tom McGinn, medical adviser for the Federal Emergency Management Agency, and T.J. Myers, director of certification and control team with APHIS. (avma.org)
- One way to accomplish this is through modifying national veterinary accreditation to encompass foreign animal disease instruction. (avma.org)
- For their assistance in recovery operations and contributions in restoring animal and human well-being in Florida, AVMA Veterinary Medical Assistance Teams are deserving of national accolades, according to the attendees. (avma.org)
- Dr. Stephen Sundlof, director of the Food and Drug Administration's Center for Veterinary Medicine, touched on the recent request made by the FDA for Fort Dodge Animal Health to withdraw its ProHeart 6 heartworm preventive (see JAVMA , Oct. 15, 2004 ). (avma.org)
- The American Veterinary Medical Association has defined One Health as "…the collaborative efforts of multiple disciplines working locally, nationally and globally, to attain optimal health for people, animals, and our environment" [2]. (who.int)
Chemicals8
- These technologies replace animal testing in end-use industries including pharmaceuticals, medical devices, chemicals and pesticides, food, and others. (thebusinessresearchcompany.com)
- Animal testing is mandatory for the registration of chemicals and the authorization of plant protection products. (basf.com)
- The negative environmental impacts of the chemicals used to eliminate pests and the detrimental health impacts of contaminated food have led to resurgences in models of organic and sustainable food production. (theconversation.com)
- The Canadian government has committed to end animal testing for the toxicity of chemicals, according to reports by CTVnews and animal rights organizations. (cosmeticsandtoiletries.com)
- This follows a recent move in the UK to ban the issuance of licenses for the animal testing of chemicals used as cosmetic ingredients. (cosmeticsandtoiletries.com)
- This problem could be solved by individual action to stop using ozone-depleting chemicals, if alternatives are available to consumers. (eubios.info)
- In this context, chemicals, pesticides, or drugs are tested on animals for market approval. (aerzte-gegen-tierversuche.de)
- In addition, they indicated that with sion's REACH legislation stimulates the use of animal-free the expected acceptance scenario for alternative approaches, approaches to obtain information on the toxicity of chemicals. (cdc.gov)
Mice1
- In this study, the antinociceptive activity of (-)-linalool was examined in two different pain models in mice: the acetic acid-induced writhing response, a model of inflammatory pain, and the hot plate test, a model of supraspinal analgesia. (researchgate.net)
Studies5
- born 17 February 1961) is a Russian anthropologist, economic historian, comparative political scientist, demographer and sociologist, with major contributions to world-systems theory, cross-cultural studies, Near Eastern history, Big History, and mathematical modelling of social and economic macrodynamics. (wikipedia.org)
- During his PhD studies, Dr. Abdallah published 19 papers in high-impact peer-reviewed journals investigating environmental behaviour, fate, human exposure and risk assessment of persistent organic pollutants (POPs). (birmingham.ac.uk)
- If this work turns up something promising, we can try to perform epidemiologic studies of Zika virus transmission to humans living in endemic areas. (cdc.gov)
- Due to the need for an adequate substitute for human teeth in laboratory studies, buffalo teeth can be regarded as an interesting alternative animal model. (bvsalud.org)
- Nevertheless, striking new data from cer agents from Volume 100A of these studies show increased risks the IARC Monographs are used to Therapeutic applications and of almost all site-specific cancers make qualitative comparisons be- trends in use that emerge during the fol ow-up tween cancers induced in humans period. (who.int)
Vivo3
- Work published in Environmental Pollution describes an invertebrate alternative in vivo skin corrosion test that reportedly is more sensitive to acids and alkalis than traditional skin models. (cosmeticsandtoiletries.com)
- Rhesus-monkeys appear to be the most suitable in-vivo model for predicting human percutaneous absorption. (cdc.gov)
- Because it is expected that more in vivo dose-response curves for developmental toxicity of than 20% of the laboratory animals needed for REACH will be the parent glycol ethers in rat and man. (cdc.gov)
20234
- The global non-animal alternatives testing market size grew from $1.78 billion in 2022 to $1.94 billion in 2023 at a compound annual growth rate (CAGR) of 9.2% . (thebusinessresearchcompany.com)
- Bill S-5, the "Strengthening Environmental Protection for a Healthier Canada Act," which includes banning testing for chemical toxicity in animals, received royal assent on June 13, 2023, making it official. (cosmeticsandtoiletries.com)
- While the Modernization of Cosmetics Regulations Act of 2022 (MoCRA) passed as part of the 2023 Consolidated Appropriations Act, which expands the U.S. Food and Drug Administration's regulatory authority over the cosmetics industry, specific animal testing restrictions were not included, thus missing an opportunity to address one of the most important issues amongst the public and cosmetics users," the source stated. (cosmeticsandtoiletries.com)
- The legislation will go into effect as of Jan. 1, 2023, and will end the sale of cosmetics tested on animals in New York State, WBNG reports. (cosmeticsandtoiletries.com)
Embryonic2
Potency1
- indicate tative comparisons of carcinogens been narrowed and their therapeutic that no agents classified as carci- with respect to potency in humans use has declined, with the possible nogenic to humans (Group 1) are and in experimental animals are exception of cyclophosphamide. (who.int)
Prediction3
- IIVS has a long-standing history of working with various industries to help establish or utilize in vitro models for the prediction of risk and the assessment of products under development. (iivs.org)
- Here, we propose an automatic modeling method based on meta-learning for materials property prediction named Auto-MatRegressor, which automates algorithm selection and hyperparameter optimization by learning from previous modeling experience, i.e., meta-data on historical datasets. (bvsalud.org)
- PBK model allows the prediction of dose-response curves for implantation rat whole-embryo culture test, the rat limb bud human developmental toxicity. (cdc.gov)
Advances1
- In addition to the new in vitro systems, in recent years there were also significant advances in the development of new animal models that allows studying the entire cell cycle of human malaria. (wjgnet.com)
Therapies3
- On the other hand, it is possible that many promising therapies were abandoned because inaccurate animal models yielded discouraging results. (uft.org)
- This procedure entails significant suffering for the animals, yet it does not yield therapies that accurately address the underlying processes in humans. (aerzte-gegen-tierversuche.de)
- This agent was approved by the FDA in December 2012 for treatment of inhalational anthrax or for prevention when alternative therapies are not available or appropriate. (medscape.com)
Study3
- Human experimental pain models are widely used to study drug effects under controlled conditions. (nih.gov)
- Our study used a speaker-audience model to examine the efficacy of two popular types of DIY air filtration units, the Corsi-Rosenthal cube and a modified Ford air filtration unit, in reducing exposure to simulated respiratory aerosols within a mock classroom. (cdc.gov)
- Instead, they have to study either animal models or cartilage from amputated human body parts. (lu.se)
Beings4
- Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model. (uanl.mx)
- The use of vertebrate animals, except human beings, in the R&D and quality control of personal hygiene products, cosmetics and perfumes that use ingredients or compounds with safety and efficacy already scientifically proven is prohibited. (cosmeticsandtoiletries.com)
- Antimicrobial resistance is a drain on the global economy with economic losses due to reduced productivity caused by sickness (of both human beings and animals) and higher costs of treatment. (who.int)
- Drug-resistant bacteria can circulate in populations of human beings and animals, through food, water and the environment, and transmission is influenced by trade, travel and both human and animal migration. (who.int)
Scientists5
- They choose animals that have a life span of two to three years because that allows the scientists to observe what happens during the "fast forward" stage. (bartleby.com)
- MRMC scientists have been particularly critical of animal models of mental illness and addiction. (uft.org)
- Those scientists are either using models that we have developed or we train them to build their own models. (hsi.org)
- Almost a century later, scientists discovered that humans have their own version of the eyeless gene, called PAX6 . (medlineplus.gov)
- Researching this ability could someday help scientists treat blindness in humans. (medlineplus.gov)
Welfare8
- Dr. Chester Gipson, deputy administrator for APHIS Animal Care, commenced the presentations by thanking Dr. Beaver for her statements relating to animal welfare in her presidential address at the July AVMA convention. (avma.org)
- He emphasized the need for veterinarians to gain greater recognition as advocates for animal welfare. (avma.org)
- Agriculture, in particular, needs a strategy for animal welfare, perhaps in the form of a central policy point. (avma.org)
- In addition, Dr. Gipson recognized the need for industry to play a role in policy making related to laboratory animal welfare. (avma.org)
- A Judeo-Christian interpretation from the Bible stated that "dominion over animals meant that any degree of exploitation was acceptable has changed for most people to mean that each person has responsibility for animal welfare (Aquinas T., 2006). (bartleby.com)
- minimising the number of animals used per experiment and optimising the experience of the animals to improve animal welfare. (understandinganimalresearch.org.uk)
- But the Animal Welfare Act is by no means intended to protect animals from this pain, suffering, and harm. (aerzte-gegen-tierversuche.de)
- In other words, animals can be harmed in almost any way under the guise of the Animal Welfare Act, without there being any medical benefit. (aerzte-gegen-tierversuche.de)
Exposure4
- He has particular interest in assessing the risk from human exposure to emerging contaminants using various exposure and pharmacokinetic models. (birmingham.ac.uk)
- Human exposure to microplastics in the indoor environment. (birmingham.ac.uk)
- Comparative evaluation of human exposure to PFAS from drinking water in UK and China. (birmingham.ac.uk)
- Human dietary exposure to organophosphate esters. (birmingham.ac.uk)
Inflammatory1
- 2016), and hyperalgesic and allodynic responses in inflammatory and neuropathic models (Peana et al. (researchgate.net)
Anatomical2
- The basic problem is that animal models show fundamental anatomical, physiological, and pathological differences from the human disease they are said to mimic. (uft.org)
- In analysing vets' experiences, we pay attention to the anatomical models of science, where linear causal analysis is expected to provide orderly and predictable outcomes or 'right' answers to problems, as well as notions of expertise that turn out to be illusory. (open.ac.uk)
Health11
- This poses many problems for the environment, farmers, farm workers, and animal and public health. (ucsusa.org)
- After this, human populations grew exponentially, but to the detriment of human health and of social relations based on equality . (theconversation.com)
- Typically defended by arguments of reliability and human health benefits, recently the question of ethics and values placed on animal testing have caused it to become a relevant and pressing topic that has been more widely discussed and debated. (bartleby.com)
- Further, the bill mandates the Ministers of Environment and Health to publish a plan in the next two years promoting such alternatives, and provide annual updates on its progress. (cosmeticsandtoiletries.com)
- Health Canada confirmed plans are in the works to implement an animal testing ban for cosmetics, according to The Globe and Mail. (cosmeticsandtoiletries.com)
- These decisions affect the environment, human health, society and international policy. (eubios.info)
- This resistance to antimicrobial medicines is happening in all parts of the world for a broad range of microorganisms with an increasing prevalence that threatens human and animal health. (who.int)
- The development of this draft global action plan on antimicrobial resistance, requested by the Health Assembly in resolution WHA67.25 in May 2014, reflects a global consensus that antimicrobial resistance poses a profound threat to human health. (who.int)
- If your goal is to contribute to our understanding of fundamental genetic principles and use the insights you gain to guide the development of new treatment options to improve human health, then we invite you to join us. (bcm.edu)
- This is very different from traditional attitudes of maximizing human health alone. (who.int)
- Rabinowitz P, Scotch M, Conti L. Human and animal sentinels for shared health risks. (who.int)
Computer1
- At BASF, we understand artificial intelligence (AI) as the development of computer-based systems that can perform tasks that typically require human intelligence. (basf.com)
Practice3
- The practice of using animals for testing has been debated for many decades. (bartleby.com)
- Polling by MORI revealed that 31% of people think animals are used to test cosmetics or their ingredients, a practice that has been illegal since 1998. (huffingtonpost.co.uk)
- Such data chal enge the "ca- and in experimental animals, with The four anticancer agents dis- nonical" site-specificity of carcino- reference to the possible underlying cussed here were first used in clin- ical practice in the 1960s, but since genesis. (who.int)
20201
- In Australia, a ban on cosmetic testing on animals has been in effect since July 2020. (alv.org.au)
Viable1
- This suggests that a natural cocktail containing cocoa, coffee and honey may be a tasty and viable alternative for those trying to overcome PPC. (healthyfellow.com)
Assessment1
- 2004). Taking into account the offspring produced during curves are regularly used for human risk assessment. (cdc.gov)
20211
- This list coincides with the publication of the Home Office's report on the statistics of scientific procedures on living animals in Great Britain in 2021. (understandinganimalresearch.org.uk)
Laboratory animal2
- Scandinavian Journal of Laboratory Animal Science 47(1), 1-11. (awionline.org)
- Laboratory Animal Science Professional 8(2) (March/April), 62-65. (awionline.org)
Tumour2
- An additional source of quantita- erations for compounds that cause of tumour-free animals by 50% (Gold tive data on cancer risks is the group cancer in experimental animals. (who.int)
- No evidence of tumour formation was observed in the transplanted animals, a major concern when utilising a pluripotent cell source. (lu.se)
Trials2
- Yet, a staggering 95% of drugs tested 'successfully' on animals fail in human trials because they don't work or are dangerous. (alv.org.au)
- [ 4 ] The efficacy of raxibacumab as a prophylactic agent and after disease onset was assessed in 4 randomized controlled animal model trials to provide surrogate endpoints applicable to human use. (medscape.com)
Describe3
- In collaboration with Alexander V. Markov he has demonstrated that a similar mathematical model can be developed to describe the macrotrends of biological evolution. (wikipedia.org)
- We describe a robust nano liquid chromatography-mass spectrometry (nanoLC-MS) platform for measuring the total amount of OT in human plasma/serum. (nature.com)
- In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)
Methodologies1
- This trend of increased animal testing in South Korea cuts against the global trend of development and adoption of innovative, non-animal approaches-the New Approach Methodologies. (hsi.org)
Disease4
- To model this process, the FAL uses all the primary human cells involved in the liver, including hepatocyte cells, Kupffer cells, stellate cells and cells with liver disease (fibrosis), all derived from liver samples which are ethically sourced from hospitals in the East Midlands region. (frame.org.uk)
- This encompasses animal testing for drug development, where animals serve as "disease models. (aerzte-gegen-tierversuche.de)
- One key type of direct disease control and prevention is the use of animal collars and vaccinations [5]. (who.int)
- Of course we refer models were trained using 63 SRBCT ment or disease progression. (lu.se)
Laboratories1
- The Humane Society is working to decrease the use of animals in laboratories by promoting the advancement of affective alternative approaches. (bartleby.com)
Pathological1
- Chiropractors are taught that "The basic principle of chiropractic is that disturbances of the nervous system, resulting from subluxation of the bones of the spine and other parts of the body, are a primary or contributory factor in the pathological process of many common human and animal ailments. (quackometer.net)
Development4
- Development of a Novel Micronucleus Assay in the Human 3-D Skin Model, EpiDermTM. (iivs.org)
- MBBS : Fundamentals of Medicine, Locomotor and Human development PBL facilitator. (qmul.ac.uk)
- The development of the human blood-CSF-brain barrier. (cdc.gov)
- In paper №1, I detail the neurodegenerative and behavioural outcomes in a mouse lesion model of PD, which can be used as a platform for the development of novel therapeutic strategies. (lu.se)
Morphology2
- Results: The SEM micrographs revealed an aprismatic surface enamel as well as prismatic enamel, the latter being similar to human enamel, in both arrangement and morphology. (bvsalud.org)
- Conclusions: Buffalo enamel showed prismatic morphology, requiring further tests to corroborate its use as a substitute for human teeth. (bvsalud.org)
Populations1
- Human organoid model was originally developed by Neves Lab to generate mucosal immune cell populations. (kcl.ac.uk)
Computational1
Data4
- Cell quality is a challenge for the industry at large, but it is important because good cells make good models, and this equals good data. (hsi.org)
- 3) Review existing and unexamined/previously unpublished (potentially classified) animal data related to dose response. (cdc.gov)
- In this chapter, data on antican- limited or lacking in animals. (who.int)
- Homemade or Do-It-Yourself (DIY) air filtration units are a popular alternative to commercially produced devices, but performance data is limited. (cdc.gov)