Alternatives and animal. Medical search. Frequent questions

Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. (wikipedia.org)
Replacement refers to the preferred use of non-animal methods over animal methods whenever it is possible to achieve the same scientific aim. (wikipedia.org)
Reduction refers to methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain more information from the same number of animals. (wikipedia.org)
Refinement refers to methods that alleviate or minimize potential pain, suffering, or distress, and enhance animal welfare for the animals used. (wikipedia.org)
However, even though cell or tissue culture methods may reduce the number of experiments performed on intact animals, the maintenance of cells in culture normally requires the use of animal-derived serum. (wikipedia.org)
ARS scientists continue to seek solutions by developing new methods to control and prevent animal diseases and reduce bacterial pathogens in our food supply. (usda.gov)
and the optimisation and validation of novel or existing methods for use as non-animal alternatives. (sagepub.com)
However, ethical and economic concerns and the recent European legislative framework triggered intensive research efforts in the development and validation of alternative methods. (cosmeticsdesign.com)
The European Commission has presented its yearly report to the European Parliament and Council highlighting the development of alternative methods to animal testing in cosmetics, but is yet to confirm the full marketing ban will be implemented by 2013. (cosmeticsdesign-europe.com)
Despite this commitment and progress in research finding alternative methods for testing, the Commission says these remaining 'complex endpoints' will not be possible by the 2013 deadline. (cosmeticsdesign-europe.com)
Validated alternative methods have been made available for the identification of corrosive substances, skin irritants and severe eye irritants, skin phototoxicity and skin penetration as well as to assess genotoxicity. (cosmeticsdesign-europe.com)
For many of the tests needed to ensure the safety of cosmetic products, the EC claims alternative methods are developed and validated by now. (cosmeticsdesign-europe.com)
The European Union must invest more in next-generation, non-animal chemical safety assessments to achieve its European Green Deal goals, and there are opportunities in in silico methods, says Cruelty Free Europe. (cosmeticsdesign-europe.com)
A drive to better understand all the chemicals we are exposed to must be underpinned by investment in scientifically sound non-animal hazard testing methods, exposure monitoring methods and risk assessment strategies. (cosmeticsdesign-europe.com)
"If REACH and ECHA would like to reduce animal testing in industry, they should reduce the bureaucracy in approving new alternative methods for evaluating the chemical safety," she said. (cosmeticsdesign-europe.com)
To eliminate unnecessary government-mandated animal testing and facilitate greater use of modern alternative methods, we request that the FDA develop and release Guidance for Industry on how alternatives to animal testing can be used to meet regulatory requirements. (house.gov)
Furthermore, we ask the FDA to detail a transparent process by which sponsors can engage with the Agency on this issue and gain approval for non-animal testing methods. (house.gov)
Studies show that modern non-animal drug testing methods like organs-on-chips are more effective, economical, and humane. (house.gov)
The government organizations enforce laws and regulations, raise funds to support non-animal testing methods such as tests on human volunteers, and advanced computer-modeling techniques, and also fund studies with human volunteers. (thebusinessresearchcompany.com)
In order to support non-animal testing, People for the Ethical Treatment of Animals (PETA) India, in 2022, announced a grant of 7 lakh rupees in order to advance animal-free methods for toxicology testing. (thebusinessresearchcompany.com)
The webinar focuses on the standard information requirements for REACH registration, including the following endpoints: Skin corrosion and irritation Serious eye damage and eye irritation Skin sensitisation Acute toxicity The webinar explains recent developments in alternative methods and approaches to address these endpoints, including their recent REACH Annex revisions. (norecopa.no)
While the skin sensitization hazard of substances can readily be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. (iivs.org)
Gaithersburg, MD - May 8, 2019 - The Institute for In Vitro Sciences, Inc. (IIVS) has received a grant from the European Partnership for Alternative Approaches to Animal Testing (EPAA) to support its annual training of Chinese scientists in non-animal testing methods. (iivs.org)
Gaithersburg, MD - April 3, 2019 - The Institute for In Vitro Sciences (IIVS) applauds China's National Medical Products Administration (NMPA) for their acceptance of certain non-animal (alternative) test methods for the regulation of cosmetics. (iivs.org)
Additionally, the bill includes funding for the development of alternative test methods. (iivs.org)
Following the methodology described in OECD Test Guideline 497, KeratinoSens is an alternative to animal testing methods necessary for the purpose of hazard identification. (iivs.org)
Other alternative methods to enhance physical capabilities include: homeopathy, herbs, nutritional diets and supplements. (dvm360.com)
Prediction of Skin Sensitizers using Alternative Methods to Animal Experimentation. (lu.se)
A recent ban on the use of animal tests within the cosmetics industry has led to an urgent need for alternative animal-free test methods that can be used for assessment of chemical sensitizers. (lu.se)
Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments. (bvsalud.org)
Current animal protection laws require replacement of animal experiments with alternative methods , whenever such methods are suitable to reach the intended scientific objective. (bvsalud.org)
However, searching for alternative methods in the scientific literature is a time -consuming task that requires careful screening of an enormously large number of experimental biomedical publications . (bvsalud.org)
Our SMAFIRA - "Smart feature-based interactive" - search tool ( https//smafira.bf3r.de ) will employ this classifier for supporting the retrieval of alternative methods to animal experiments . (bvsalud.org)

November 2023 Animal Law Updates: Will Animals be Recognized as Family Members in South America? (onegreenplanet.org)
BILTHOVEN, Netherlands, Sept. 19, 2023 (GLOBE NEWSWIRE) -- Intravacc, a Leading Contract Development and manufacturing Organisation for translational research and development of preventive and therapeutic vaccines together with MAT services at Sanquin Diagnostic Services, today announced the publication of a scientific article of an in vitro alternative assay to the replace rabbit pyrogen test for vaccines. (kfor.com)
The global non-animal alternatives testing market size grew from $1.78 billion in 2022 to $1.94 billion in 2023 at a compound annual growth rate (CAGR) of 9.2% . (thebusinessresearchcompany.com)

This paper shows that the MAT is a valuable assay to assess reactogenicity levels of OMV based vaccines at multiple stages of vaccine development and the data presented could help to substantiate the switch from small animal testing to cellular assays at several stages of vaccine development. (kfor.com)
The resulting report examines the debate around horseshoe crabs and identifies ways to move forward with implementing the 3Rs, with the principal aim of replacing the LAL assay with a completely humane, animal-free alternative. (eurogroupforanimals.org)
To be clear, reducing animal usage is not as simple as swapping out an animal assay for an in vitro alternative. (understandinganimalresearch.org.uk)
To date, no such alternative assay has yet completed formal validation. (lu.se)

However, it is still currently assessing the impacts of the implementation of the full marketing ban by 2013 (environmental, animal welfare, economic and social) and on the basis of that assessment the EC will decide whether or not to make a proposal in relation to the marketing ban. (cosmeticsdesign-europe.com)
The Atlantic horseshoe crab (Limulus polyphemus) is increasingly impacted upon by the growing global demand for medicines and medical devices, prompting serious questions around animal welfare and sustainability. (eurogroupforanimals.org)
As the report explains, regulatory approval is only the first step - large scale cultural change is also required within the sector, including recognition of the need to respect the welfare needs of, and conserve, these remarkable animals. (eurogroupforanimals.org)
Increasing concerns about health, animal welfare, and the environment are causing more consumers to turn to plant-forward diets. (freedoniagroup.com)
Eating plant-based dairy or egg alternatives instead of conventional animal products is more environmentally friendly and better for animal welfare. (freedoniagroup.com)
The different alternative approaches can either target parasite populations in the host or on pasture, with the final aim to reduce parasite intensity to levels able to minimize endo and ectoparasite impact on host health, welfare and performance. (mdpi.com)
Congresswoman Titus has a long history of fighting for animal welfare in Congress and will continue to prioritize their safety. (house.gov)
The Animal Welfare Information Center (AWIC) is mandated by the Animal Welfare Act (AWA) to provide information for improved animal care and use in research, testing, teaching, and exhibition. (uiowa.edu)

Ongoing ICH revisions and their adoption tend to be driven by research into and validation of in vitro alternatives conducted by and published in collaboration between pharmaceutical companies, CROs and academia, so in other words as alternatives are confirmed as validated they become the new norm. (understandinganimalresearch.org.uk)

Alternatives to Laboratory Animals (ATLA) is an established peer-reviewed journal dedicated to the Three Rs - the reduction, refinement and replacement of animals in research and testing. (sagepub.com)
ATLA is a peer-reviewed journal, intended to cover all aspects of the development, validation, implementation and use of alternatives to laboratory animals in biomedical research and toxicity testing. (sagepub.com)

There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved. (wikipedia.org)
By "alternatives" to the use of animals in research, Norecopa endorses the internationally accepted tenet of The Three R's (Replacement, Reduction, Refinement), developed by Russell and Burch in the UK in the 1950s. (norecopa.no)
When talking about the '3Rs' of reduction, replacement and refinement which govern and guide animal research in the UK, it can be hard to quantify successes - how can you count an experiment which didn't take place? (understandinganimalresearch.org.uk)

The report published by the EC stresses the continued commitment in Europe and worldwide to find alternative approaches. (cosmeticsdesign-europe.com)
Please join us at booth #34 to meet our representatives who are looking forward to discussing trends and New Methodologies in Alternative Approaches (NAMs) to toxicological research, as well providing updates on services offered by our organization! (iivs.org)
As part of the agreement, two scientists from BASF SE, a member of EPAA, will join IIVS to provide hands-on training in China for four non-animal approaches for skin sensitization. (iivs.org)

In an advance in efforts Bruno Miguel Neves and colleagues at the University of Aveiro, are describing a new, highly accurate non-animal test for skin-sensitizers. (cosmeticsdesign.com)
Neves explains that concerns about the ethics and costs of animal-based tests for skin sensitizers, plus regulations in the European Union, are fostering a search for alternative tests. (cosmeticsdesign.com)

As the consumption of meat and animal products increases with population growth, there is a need for feed management strategies that are more sustainable for animals and the environment. (nutrevent.com)
By piecing together building blocks of meat from plant-foods, and processing them together with new technology, they are able to create meat alternatives that smell, taste, feel, and cook just like meat. (planetforward.org)
By offering "meat made from plants" to appease the carnivore palate, companies like Beyond Meat and Impossible Foods are a wiser way to channel animal subsidy dollars, and offer an appealing, yet sustainable meat choice for meat-lovers in many parts of the world. (planetforward.org)
For those looking for another alternative that comes from animals rather than plants, several start up companies are working to bring lab-grown meat to market. (planetforward.org)
Mosa Meat products, for example, are made from small samples of muscle stem cells taken from real animals. (planetforward.org)
Strands of cells are then layered together to create real meat - the only difference being that theirs is grown outside - rather than inside - the animal. (planetforward.org)
Avoid adding fatty scraps, meat and bones to the compost heap, however, because you can attract unwanted animals to your yard. (ehow.com)
If you happen to live on a farm, pigs, cows, horses, goats, sheep and chickens will happily dine on your food waste, although you should not feed meat to farm animals. (ehow.com)
Bush meat of infected animals can also transmit the infection. (who.int)

The Cosmetics Directive prohibits animal testing in the EU of finished cosmetic products since 2004, and animal testing of ingredients of cosmetic products is prohibited since 2009. (cosmeticsdesign-europe.com)
A marketing ban is also in place in the EU which prohibits selling cosmetic products containing ingredients which have been tested on animals irrespective of the place of the testing after March 2009. (cosmeticsdesign-europe.com)
While animals, largely mice, remain extensively used for medical research and testing, the European Union implemented a ban on all animal testing for cosmetic products and cosmetics ingredients under its Cosmetics Regulation 1223/2009 in 2013. (cosmeticsdesign-europe.com)
Although, once these ingredients were integrated into cosmetic formulations, further animal testing was prohibited. (cosmeticsdesign-europe.com)
What new ingredients offer alternatives? (nutrevent.com)
The non-animal alternatives testing is testing products and services that do not involve testing on animals to determine the safety and efficacy of products and ingredients used in any industry sector. (thebusinessresearchcompany.com)

However, some claim they are not true alternatives because simulations use data from prior animal experiments and cell cultures often require animal derived products, such as serum or cells. (wikipedia.org)
In addition to replacement, the journal also features research that aims to reduce or refine in vivo experiments that are still carried out, as well as advocating for changes to global animal use policies. (sagepub.com)
In addition to the replacement of animals, it also covers work that aims to reduce the number of animals used and refine the in vivo experiments that are still carried out. (sagepub.com)
The PREPARE guidelines and their associated webpages give comprehensive guidance on how to plan animal experiments in the spirit of these principles. (norecopa.no)

Dyadic's proprietary Dapibus™ filamentous fungal based microbial protein production platform will be used to design, develop, and commercialize innovative animal-free dairy enzymes and related proteins and biomaterials. (fox2now.com)
Joe Hazelton continued, "We are very pleased with the progress our Dapibus™ platform continues to make in the non-animal alternative protein market in a short period of time, while our C1-cell protein production platform for animal and human biopharmaceuticals is also advancing at a rapid pace. (fox2now.com)
This agreement furthers our market penetration into this rapidly growing dairy protein segment along with our recent announcement of success in producing animal-free casein proteins for the potential use in various dairy foodstuffs, such as vegan cheese, yogurt, and milk products. (fox2now.com)
Dyadic International, Inc. is a global biotechnology company focused on building innovative microbial platforms to address the growing demand for global protein bioproduction and unmet clinical needs for effective, affordable, and accessible biopharmaceutical products and alternative proteins for human and animal health. (fox2now.com)
Our lead technology, C1-cell protein production platform, is based on an industrially proven microorganism (named C1), which is currently used to speed development, lower production costs, and improve performance of biologic vaccines and drugs at flexible commercial scales for the human and animal health markets. (fox2now.com)
Several protein-alternative startups are building brands on this principle. (planetforward.org)
Leaves have a high nutritive value (high palatability, digestibility, intake and crude-protein content), resulting in 70-100% increase in animal live weight gain compared with feeding on pure grass pasture. (unitedcaribbean.com)

Holistic veterinarians use both conventional and alternative therapies in their patients. (vcahospitals.com)
Holistic veterinary medicine looks at all aspects of the entire animal with emphasis on both conventional and alternative therapies as options for treatment. (vcahospitals.com)

Today's announcement further demonstrates the growing interest and commercial potential of our Dapibus™ platform for use in developing and manufacturing alternative proteins for non-pharmaceutical applications. (fox2now.com)
Alternative proteins are alternatives to animal proteins, which are obtained from a variety of sources and used to replace conventional animal-based proteins. (fox2now.com)
This includes a shift towards more sustainable proteins for animal feed. (nutrevent.com)

A team of scientists in Portugal are working on a new non-animal method of testing for skin sensitivity and help eliminate the need for animals in cosmetics testing once and for all. (cosmeticsdesign.com)
Speaking to CosmeticsDesign-Europe, Dr Mojgan Moddaresi, regulatory expert and director of cosmetics compliance firm Personal Care Regulatory, said when it came to chemical safety assessment within cosmetics, it would be important industry looked to animal alternatives wherever possible. (cosmeticsdesign-europe.com)
Rob Taalman, science and research director of Cosmetics Europe, recently said next-generation in vitro safety assessments for cosmetics would see good uptake in the coming years , though, becoming accepted by regulators and public alike as "robust and powerful" alternatives to animal studies. (cosmeticsdesign-europe.com)

In search of a safe, healthy alternative to rawhide? (onlynaturalpet.com)
Search for Alternative Bands in Hamilton, New Jersey above. (gigsalad.com)

The investigation in Nicaragua is examining the possibility that infection in humans resulted from exposure to water and soil contaminated by animal urine following recent heavy rainfall and flooding in that region. (cdc.gov)
Rather than rely on animal models in laboratories, NIOSH stepped in and developed a system to assess potential health effects following exposure to molds at levels found in water-damaged buildings. (cdc.gov)
Exposure data to alternative PFAS in the U.S. general population do not exit. (cdc.gov)
To fill these exposure data gaps, we measured seventeen PFAS, including three fluorinated alternatives used as PFOA or PFOS replacements, in one-third subsample of participants 6+ years of age using surplus urine collected for the measurement of select personal care product chemicals as part of NHANES 2013-2014. (cdc.gov)

Research and development expenditure by the pharmaceutical industry has increased by £1 billion since 2002, yet the Home Office figures for animal use by commercial organisations have stayed largely unchanged with around 1.5 million procedures a year. (understandinganimalresearch.org.uk)

Public health officials, animal health officials, veterinarians, and wildlife health specialists should collaborate using a One Health approach when deciding to test an animal or conduct epidemiologic investigations for animals with confirmed SARS-CoV-2 infection. (cdc.gov)

The post 'Report: Horseshoe crabs and the pharmaceutical industry - Challenges and alternatives' is modified from an article published by The Royal Society for the Prevention of Cruelty to Animals in their original language. (eurogroupforanimals.org)
The consultations highlighted, however, the facts that allogeneic (human-to-human) transplantation poses major challenges and that xenotransplantation, which offers a potential alternative to allogeneic transplantation in certain conditions, requires better oversight and management in view of its specific potential risks and related problems. (who.int)

Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. (wikipedia.org)
This is especially important because certain bacterial strains have become resistant to some of the current antibiotics used to treat infections in humans and animals, escalating the need worldwide to find and develop alternatives to antibiotics. (usda.gov)
A One Health approach embraces the idea that a disease problem impacting the health of humans, animals, and the environment can only be solved through improved communication, cooperation, and collaboration across disciplines and institutions. (usda.gov)
With its partners, USDA's objective through this multidisciplinary approach is to preserve, maintain or reduce health risks to animals, humans, the environment and society. (usda.gov)
The monkeypox virus is an orthopoxvirus which can spread from infected animals to humans and also from person to person through skin-to-skin contact with skin lesions or body fluids from patients with monkeypox. (cdc.gov)

VEGEA is a grape-based vegan alternative to animal leather, sourced from the agricultural waste of wineries in Northern Italy. (stellamccartney.com)
Some consumers are abstaining from animal products by going vegan or vegetarian, but many more are simply reducing consumption of animal products with a flexitarian or semi-vegetarian diet. (freedoniagroup.com)

Guidance was expanded from only companion animals to include other animal groups, including animals in zoos, rehabilitation facilities, sanctuaries and aquariums, and free-ranging wildlife. (cdc.gov)

Further progress will come from the same place as today's successes - collaboration between industry, academia and bodies such as the National Centre for the 3Rs, creating, validating and normalising the use of alternatives to animal models. (understandinganimalresearch.org.uk)
German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Germany. (bvsalud.org)

The USDA's Agricultural Research Service (ARS) is developing new technologies to address antibiotic resistance and reduce the use of antibiotics through agricultural management, which includes food, animals, crops and the environment-water, soil and climate. (usda.gov)
It is of relevance to research scientists, academics, and those involved in regulatory affairs or in the field of animal ethics. (sagepub.com)
This research and development has not only reduced the number of animals used in testing, it is at the same time yielding important results in terms of better science to the benefit of consumer safety. (cosmeticsdesign-europe.com)
The bottom line is that they still very much need to use animals in this area of research since 'alternative' assays simply can't model complex biological systems yet, but they clearly are pressing ahead to make whatever gains they can using available technology. (understandinganimalresearch.org.uk)
Get the latest articles and news from Understanding Animal Research in your email inbox every month. (understandinganimalresearch.org.uk)
However, she acknowledged that current procedures to validate and approve such alternatives remained "so time consuming" it often hindered research efforts in this area. (cosmeticsdesign-europe.com)
This non-animal alternatives testing market research report provides a comprehensive view of everything you require, including an in-depth analysis of the industry's current and future scenario. (thebusinessresearchcompany.com)

The control of parasite infections of farm animals is still based mainly on the use of synthetic short- and large-spectrum drugs. (mdpi.com)
This toolkit is for health officials managing cases of zoonotic SARS-CoV-2 infections within their jurisdiction, including state public health veterinarians, state animal health officials, zoonotic disease epidemiologists, and wildlife health specialists. (cdc.gov)
STLT officials managing SARS-CoV-2 infections in animals should be informed of all animals that are being tested for SARS-CoV-2 within their jurisdiction. (cdc.gov)

There are debates around the horseshoe crab's sentience and capacity to suffer , with serious concerns about how the animals are caught, transported, cleaned and restrained, which involves long periods out of the water. (eurogroupforanimals.org)

The EC also pointed out that significant advances have been made in reducing the number of animals used in tests, for example in relation to acute toxicity. (cosmeticsdesign-europe.com)
The greatest advantage of natural products with anti-parasite action is that they generally show low toxicity for mammals, fast elimination from the animal and the environment, and low selection pressure for parasite-resistance. (mdpi.com)
However, under the European Chemicals Agency ECHA's REACH regulation 1907/2006 , certain aspects require or enable animal testing - notably testing for environmental endpoints like aquatic toxicity, the pre-registration of some new chemical substances and registering of chemicals used in non-cosmetic products. (cosmeticsdesign-europe.com)
Every year countless animals, including thousands of dogs and puppies, are used in painful and deadly toxicity tests performed to earn FDA approval for new drugs and medical devices. (house.gov)

The sensitizing potential of chemicals is currently assessed using animal models. (cosmeticsdesign.com)
These technologies replace animal testing in end-use industries including pharmaceuticals, medical devices, chemicals and pesticides, food, and others. (thebusinessresearchcompany.com)

Instead the Commission is currently assessing the impact of the entry into force of the ban in 2013 without alternatives and will decide on next steps on the basis of the full impact assessment. (cosmeticsdesign-europe.com)
In this MiniReview, we aim to summarize and give our view on the recent progress of method development for alternative assessment of chemical sensitizers. (lu.se)

USDA has gained in-depth knowledge about antimicrobial resistance through its work on the agricultural environment, animal health and food safety. (usda.gov)
VEGEA is a biomaterials company that have developed a namesake plant-based alternative to animal leather sourced from and repurposing the agricultural waste of Italian wineries. (stellamccartney.com)

Leptospirosis is a zoonotic disease of worldwide distribution, involving many wild and domestic animals (3). (cdc.gov)

The material is crafted with repurposed grape waste - the pulp, seeds, skin and stems - from wineries, creating a luxurious cruelty-free alternative to animal leather without engaging in the impactful practices of traditional animal leather production. (stellamccartney.com)
Congresswoman Titus also introduced the Planning for Animal Wellness (PAW) Act which directs the Federal Emergency Management Agency (FEMA) to establish an advisory group of outside experts who will align FEMA guidance to match current best practices in animal care for disaster preparedness, response, and recovery. (house.gov)
STLT public health veterinarians, animal health officials, attending veterinarians, and other relevant partners should discuss management of a test-positive animal, including best practices for animals requiring in-patient care and daily monitoring of isolated animals. (cdc.gov)

Biological, made of human or animal tissue. (medlineplus.gov)

Establish relations with local partners that may detect SARS-CoV-2 infection in animals, including veterinarians, researchers, diagnosticians, and animal caretakers. (cdc.gov)
Confirmatory testing through NVSL is required for all animals except domestic cats and dogs from STLT jurisdictions that have previously confirmed SARS-CoV-2 infection in cats and dogs. (cdc.gov)
Additional studies are under way to confirm the role of leptospiral infection in the outbreak of acute febrile illness, establish animal reservoirs of infection, and identify potentially modifiable risk factors for disease. (cdc.gov)

The testing of cosmetic products directly onto an animal can be minimized or eliminated by the use of in vitro cell growth and development. (wikipedia.org)
Much of the time this method of cosmetic testing is less time-consuming and less expensive than alternative choices. (wikipedia.org)

They recognize that modern veterinary techniques are necessary in caring for an animal but also believe that alternative medicine modalities such as herbal medicine, acupuncture, and chiropractic care have a role as well. (vcahospitals.com)
In addition, some of these, acupuncture in particular, have been used to enhance production and reproduction in food and fiber animals. (dvm360.com)
Chiropractic and acupuncture, either separately or in combination, have become so popular as an effective way to ease pain and to enhance musculo-skeletal functionality, many athletes - human as well as animal - are treated routinely, perhaps once a week or a few days previous to every competition. (dvm360.com)

What they found is that development and uptake of alternative technologies has been steadily gaining pace, culminating in an exponential rise since the millennium. (understandinganimalresearch.org.uk)

And workers and livestock -- primarily swine, cattle and poultry -- have been forced to coexist under inhumane conditions that, as Dove noted in his presentation, often lead to animal cruelty. (bloomingtonalternative.com)
On this latter goal, Dr Katy Taylor, director of science at animal protection network Cruelty Free Europe, said it would be critical the Commission relied on sound science without animal testing to achieve this. (cosmeticsdesign-europe.com)

In addition to this, there are inherent disincentives to using animals such as ethical costs, bureaucracy or the financial burden of maintaining animal houses, with vets and animal techs. (understandinganimalresearch.org.uk)

Another alternative is so-called microdosing, in which the basic behaviour of drugs is assessed using human volunteers receiving doses well below those expected to produce whole-body effects. (wikipedia.org)
Human skin equivalent tests can be used to replace animal-based corrosive and irritative studies. (wikipedia.org)
While you may be a human among critters in Animal Crossing, Garden Paws gives you the chance to be one of the animals yourself. (wepc.com)
The NIH reports that 90 percent of drugs that pass these animal tests fail in human trials because they are toxic or ineffective. (house.gov)
As the European leading partnering event, NutrEvent is dedicated to innovation in Food, Human and Animal Nutrition. (nutrevent.com)
Fortunately, especially when we are dealing with dogs and horses, we have several centuries of developing the traits that make these animals assume their human-helping duties as a normal course of their day-to-day activities. (dvm360.com)
Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. (medscape.com)
Animal studies show risk and human studies not available or neither animal nor human studies done. (medscape.com)
The lack of documentation makes it difficult to 1 Animal-to-human, or xenogeneic, transplantation. (who.int)
This section focuses on topics related to human or animal health, and medicine. (curlie.org)

Guiding principles for more ethical use of animals in testing are the Three Rs (3Rs) first described by Russell and Burch in 1959. (wikipedia.org)
And he's not a member of People for the Ethical Treatment of Animals. (bloomingtonalternative.com)

Fungi like Cunninghamella elegans can be used as a microbial model of mammalian drug metabolism thereby reducing the need for laboratory animals. (wikipedia.org)
The scientists describe development of a cell-based alternative test that enlists genes and signaling pathways in mouse skin cells growing in the laboratory. (cosmeticsdesign.com)

Establish bi-directional information flows between STLT public health and animal health officials, local partners, and federal One Health partners including CDC and the U.S. Department of Agriculture (USDA). (cdc.gov)
Report test-positive animals to federal partners, including CDC and USDA. (cdc.gov)

Alternatives can't always tell us, for instance, if a compound will cause DNA damage leading to cancer, but they can some of the time, so we may be able to avoid using animals in the case of compounds with well understood adverse pathways. (understandinganimalresearch.org.uk)
this is due in part to the rapid upregulation of compensatory alternative pathways as. (lu.se)

Finding alternatives to antibiotics has become a global issue as the demand for animal food products increases to meet the nutritional needs of a growing population. (usda.gov)

One of the easiest alternatives to a garbage disposal is to eliminate the need for one in your kitchen. (ehow.com)

The use of this test may contribute to a significant reduction in the use of animals, currently the standard for vaccine safety profiles. (kfor.com)
Animal test alternatives. (cdc.gov)
Use a One Health approach that includes STLT and federal public health and animal health officials, as well as jurisdictional wildlife health specialists where free-living wildlife are concerned, when deciding to test an animal for SARS-CoV-2. (cdc.gov)
Use clinical judgement and consider other common causes of morbidity and mortality when deciding to test an animal for SARS-CoV-2. (cdc.gov)

In a similar vein models to influence the content of a moral judgment by monitoring capturing the dynamics of the controlled and automatic participants' eye-movements as they deliberate between processes competing and mutually influencing one another alternatives and prompting their choice at a point in time in the generation of a moral judgement have recently been determined by their gaze behaviour. (lu.se)

Two major alternatives to in vivo animal testing are in vitro cell culture techniques and in silico computer simulation. (wikipedia.org)
Prokaryotes are often used as an alternative to animal testing. (wikipedia.org)
Fungi is also used as an alternative for animal testing. (wikipedia.org)
Peptides, for example, because used elsewhere may have been subject to animal testing. (cosmeticsdesign-europe.com)
Today Congresswoman Dina Titus (NV-01), a member of the Congressional Animal Protection Caucus, was joined by Rep. Brian Mast (R-FL) in sending a letter to Food and Drug Administration (FDA) Commissioner Robert Califf, M.D. requesting that the FDA develop and release Guidance for Industry on alternatives to animal testing. (house.gov)
The market size of global non-animal alternatives testing is expected to grow from $2.9 billion in 2027 at a CAGR of 10.5% . (thebusinessresearchcompany.com)
The support from the government and non-governmental organizations boosts the growth of the non-animal testing market. (thebusinessresearchcompany.com)
The constant support from the government drives the growth of the non-animal testing market. (thebusinessresearchcompany.com)
Stringent regulations related to safety, efficacy, and quality are projected to act as a major challenge for players operating in the non-animal alternative testing market. (thebusinessresearchcompany.com)
From 24th to 27th of August, the Congress on Alternatives to Animal Testing takes place again in Linz (Austria). (invitrojobs.com)
It will be organized by the European Society for Alternatives to Animal Testing (EUSAAT). (invitrojobs.com)
The Evaluation for SARS-CoV-2 Testing in Animals guidance document was added into this document. (cdc.gov)
If an animal tests positive for SARS-CoV-2, seek confirmatory testing. (cdc.gov)

The blood removal process would also be painful and distressing for a sentient animal, and significant quantities of blood can be removed. (eurogroupforanimals.org)
There is no evidence that animals play a significant role in spreading SARS-CoV-2 to people. (cdc.gov)

Allowing the pharmaceutical industry and government agencies to utilize high-tech alternatives to wasteful and inhumane animal tests will save time, money, and animals' lives. (house.gov)

We here describe an alternative methodology for marking orb-web spiders intended for behavioral field studies. (bvsalud.org)

Anatomy15

Organisms17

Diseases6

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Psychiatry and Psychology4

Phenomena and Processes80

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Information Science13

Health Care26

Geographicals1

Methods33

20233

Assay4

Welfare8

Vitro alternatives1

ATLA2

Refinement3

Approaches3

Skin sensitizers2

Meat9

Ingredients6

Experiments4

Protein7

Conventional and alternative2

Proteins3

Cosmetics3

Search2

Exposure4

20021

Epidemiologic1

Challenges2

Humans5

Vegan2

Sanctuaries1

Centre2

Research7

Infections3

Concerns1

Toxicity4

Chemicals2

Assessment2

Agricultural2

Zoonotic1

Practices3

Biological1

Infection3

Cosmetic2

Acupuncture3

Uptake1

Cruelty2

Bureaucracy1

Human10

Ethical2

Laboratory2

USDA2

Pathways2

Products increases1

Eliminate the need1

Test4

Models1

Testing13

Significant2

Pharmaceutical1

Behavioral1