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Receptors, Nicotinicalpha7 Nicotinic Acetylcholine ReceptorNicotinic AntagonistsNicotinic AgonistsAcetylcholineTorpedoBungarotoxinsNicotineReceptors, CholinergicConotoxinsAconitineAzocinesMecamylamineQuinolizinesDihydro-beta-ErythroidineBicyclo Compounds, HeterocyclicElectric OrganCobra Neurotoxin ProteinsCholinergic AgentsTubocurarineXenopus laevisProtein SubunitsAzetidinesPyridinesMyasthenia GravisDimethylphenylpiperazinium IodideCarbacholReceptors, MuscarinicOocytesAmphibian VenomsNeuronsNeuromuscular JunctionAnabasineMusclesDose-Response Relationship, DrugBenzylidene CompoundsPatch-Clamp TechniquesGanglionic StimulantsCholinergic AgonistsMolecular Sequence DataGalantamineAmino Acid SequenceBinding SitesAlkaloidsAzirinesAgrinIon ChannelsXenopusHexamethoniumCholinergic AntagonistsVesicular Acetylcholine Transport ProteinsCholineMollusk VenomsRadioligand AssayElectrophysiologyDrug Partial AgonismRats, Sprague-DawleyBinding, CompetitiveLigandsMembrane PotentialsGanglia, ParasympatheticConus SnailTobacco Use DisorderPhotoaffinity LabelsCholinesterase InhibitorsKineticsProtein BindingMuscarinic AgonistsIon Channel GatingQuinoxalinesMotor EndplateProadifenSynaptic TransmissionReceptor, Muscarinic M1Nitro CompoundsBenzazepinesReceptor AggregationReceptors, Serotonin, 5-HT3Macromolecular SubstancesMuscarinic AntagonistsModels, MolecularCells, CulturedAllosteric RegulationBicyclo CompoundsMyasthenic Syndromes, CongenitalBrainCell LineReceptor, Muscarinic M3Receptor, Muscarinic M2IsoxazolesSynaptic MembranesCell MembraneStructure-Activity RelationshipElectrophorusErabutoxinsNeurotoxinsCalciumDecamethonium CompoundsLobelineAzabicyclo Compounds
SubunitAgonistNAChRsAgonistsModulateSubunitsAllostericCholinergicAlpha4beta2Vagus nerveLigandsPharmacologySubtypesStimulationCharacterizationLIGAND-GATEDNeurotransmitterNicotineInhibitionChrna7AntagonistsPrefrontalMiceProteinGenesModulationInteractionGene ExpressionPharmacological2020MediateWangHomoProteinsCognitiveSchizophreniaActivationStructuralIncreasesRole
Subunit9
  • Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. (bioseek.eu)
  • Here we report that the nicotinic acetylcholine receptor alpha7 subunit is required for acetylcholine inhibition of macrophage TNF release. (bioseek.eu)
  • Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway. (bioseek.eu)
  • SLURP-1 specifically interacts with the alpha7 (α7) subunit, which is a piece of some nAChRs. (medlineplus.gov)
  • RT-PCR was used to show that the beta3 and alpha2 subunit RNAs were present in zebrafish embryos only 2-5hours post-fertilization (hpf) while alpha7 subunit RNA was not detected until 8hpf, supporting the differential regulation of nAChRs during development. (zfin.org)
  • Broide RS, Winzer-Serhan UH, Chen Y and Leslie FM: Distribution of alpha7 nicotinic acetylcholine receptor subunit mRNA in the developing mouse. (spandidos-publications.com)
  • Association between a genetic variant of the alpha-7 nicotinic acetylcholine receptor subunit and four types of dementia. (cdc.gov)
  • Changes in nicotinic acetylcholine receptor (nAChR) subunit composition may alter electrophysiologic, pharmacologic, and metabolic characteristics of the receptor inducing hyperkalemia on exposure to succinylcholine. (druglib.com)
  • however, the proportion of alpha7 and gamma subunit increases was significantly higher in burn patients than in control surgical intensive care unit patients. (druglib.com)
Agonist5
  • Although nicotine is an agonist of ionotropic acetylcholine receptors, we found that nicotine-induced polyspermy was neither mimicked by acetylcholine and carbachol nor inhibited by specific antagonists of nicotinic acetylcholine receptors. (mdpi.com)
  • Levin ED, Bettegowda C, Blosser J and Gordon J: AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. (spandidos-publications.com)
  • 3-Bromocytisine is a potent agonist of α 4 β 4, α 4 β 2 and α 7 nACh receptors (IC 50 values are 0.28, 0.30 and 31.6 nM respectively). (tocris.com)
  • April 21, 2016: Nainika Roy is presenting a poster titled "Effects of a Novel alpha7 Nicotinic Acetylcholine Receptor Agonist on Neuronal Activity Evaluated by Multi-electrode Electrophysiology" at the Undergraduate Research Week Symposium at UIUC. (illinois.edu)
  • The agonist ligand nicotine shows an up to 30-fold higher affinity to nACHRs than acetylcholine (ACh). (biomedcentral.com)
NAChRs9
  • Laboratory studies show that SLURP-1 can bind to nicotinic acetylcholine receptors (nAChRs). (medlineplus.gov)
  • Part of the work will be devoted to studying the interaction of these compounds with nicotinic acetylcholine receptors (nAChRs). (sfbi.fr)
  • Information on the three-dimensional structure of the binding site is available, notably for the alpha7 isotype of the human nAChR ( 1 ) ( Figure 1 ), and in the case of a model of the extracellular binding domain of nAChRs, AChBP (Acetylcholine Binding Protein) cocrystallized with several neonicotinoids. (sfbi.fr)
  • In addition to the bee nAChRs, the alpha4beta2 rat receptors will be modeled in order to rationalize the electrophysiology measurements performed at the University of Orleans. (sfbi.fr)
  • This information will allow us to estimate the binding energies of each neonicotinoid to the targeted nAChRs and to establish a relative ranking of these insecticides for these receptors. (sfbi.fr)
  • Recent discoveries from this lab have demonstrated that activation of alpha7 nicotinic acetylcholine receptors (α7 nAChRs) on retinal ganglion cells (RGCs) in the retina is linked to neuroprotection of RGCs that are typically lost in glaucoma-like conditions. (wmich.edu)
  • Several investigators could demonstrate that the SARS-CoV-2 related spike glycoprotein (SGP) attaches not only to ACE-2 receptors but also shows DNA sections highly affine to nicotinic acetylcholine receptors (nAChRs). (biomedcentral.com)
  • Aβ perturbs a number of synaptic components including nicotinic acetylcholine receptors containing α7 subunits (α7-nAChRs), which are abundantly expressed in the hippocampus and found on GABAergic interneurons. (biomedcentral.com)
  • 3H]-Methyllycaconitine ([3H]-MLA) is a new radioligand with selectivity for alpha7-type neuronal nicotinic acetylcholine receptors (nAChRs). (ox.ac.uk)
Agonists3
  • Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. (uu.se)
  • Unlike non-specific nicotinic agonists, GTS inhibited serum protein TNF levels in both normal and splenectomized, haemorrhagic animals. (utmb.edu)
  • Our studies suggest that GTS provides significant advantages as compared with non-specific nicotinic agonists, and it could be a promising anti-inflammatory supplement to improve survival during resuscitation. (utmb.edu)
Modulate1
Subunits3
  • As a first step toward using zebrafish as a model, we cloned three zebrafish cDNAs with a high degree of sequence similarity to nAChR beta3, alpha2 and alpha7 subunits expressed in other species. (zfin.org)
  • Gene expression of the nAChR subunits alpha1, alpha7, gamma, and epsilon were performed using real-time reverse transcriptase polymerase chain reaction. (druglib.com)
  • Because gene expression is the basis of protein production, the upregulation of alpha7 and gamma genes might translate into more alpha7 and gamma protein subunits. (druglib.com)
Allosteric2
  • PNU-120596 is a drug that acts as a potent and selective positive allosteric modulator for the α7 subtype of neural nicotinic acetylcholine receptors. (wikipedia.org)
  • Bionomics' lead drug candidate BNC210 (currently in Phase 2 for the treatment of agitation) is a novel, proprietary negative allosteric modulator of the alpha-7 (α7) nicotinic acetylcholine receptor. (businessnews.com.au)
Cholinergic1
  • however, the identity of the essential macrophage acetylcholine-mediated (cholinergic) receptor that responds to vagus nerve signals was previously unknown. (bioseek.eu)
Alpha4beta21
  • Alijevic O, McHugh D, Rufener L, Mazurov A, Hoeng J, Peitsch M ( 2020 ) An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human alpha4beta2 and alpha7 nicotinic acetylcholine receptors. (multichannelsystems.com)
Vagus nerve1
  • Electrical stimulation of the vagus nerve inhibits TNF synthesis in wild-type mice, but fails to inhibit TNF synthesis in alpha7-deficient mice. (bioseek.eu)
Ligands2
Pharmacology1
  • its pharmacology and distribution in crudely dissected brain regions closely paralleled that of the well-established alpha7-ligand [125I]-alpha-bungarotoxin. (ox.ac.uk)
Subtypes2
  • Gotti C, Zoli M and Clementi F: Brain nicotinic acetylcholine receptors: Native subtypes and their relevance. (spandidos-publications.com)
  • The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory. (uu.se)
Stimulation2
  • The Yale team discovered this stimulation requires the neurotransmitter acetylcholine to activate a specific protein in the nicotinic family of receptors -- the alpha7 nicotinic receptor. (sciencedaily.com)
  • A great majority of schizophrenics smoke, which makes sense because stimulation of the nicotinic alpha7 receptors would strengthen mental representations and lessen thought disorder. (sciencedaily.com)
Characterization2
  • The understanding of the toxicity of these insecticides requires the characterization of their lipophilicity, an essential parameter to understand their effect on the cellular membrane system, and the precise description of their interactions with their target receptors. (sfbi.fr)
  • This study demonstrates the utility of [3H]-MLA for characterization of alpha7-type nicotinic receptors in mammalian brain, and suggests that it labels a population identical to that defined by [125I]-alpha-bungarotoxin. (ox.ac.uk)
LIGAND-GATED1
Neurotransmitter1
  • Genes encoding proteins that affect neurotransmitter release, receptor function and inactivation have been implicated in autism. (sfari.org)
Nicotine6
  • Unlike acetylcholine and carbachol, nicotine uniquely induced drastic rearrangement of egg cortical microfilaments in a dose-dependent way. (mdpi.com)
  • Nicotine may also activate thyroid receptor signaling pathways to improve memory impairment caused by hypothyroidism. (spandidos-publications.com)
  • Finally, nicotine administration has been demonstrated to rescue long‑term potentiation in individuals with sleep deprivation, AD, chronic stress and hypothyroidism, primarily by desensitizing α7 nicotinic acetylcholine receptors. (spandidos-publications.com)
  • Dani JA: Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine. (spandidos-publications.com)
  • As their name suggests, nicotinic alpha-7 receptors are also activated by nicotine, which may may help to explain why smoking can focus attention and calm behavior, functions of the prefrontal cortex. (sciencedaily.com)
  • Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration? (biomedcentral.com)
Inhibition1
  • Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition of high-mobility group box 1 release mechanism. (biomedcentral.com)
Chrna71
Antagonists1
  • Stevenson's research has focused on the 5,8-disubstituted indolizidines, which are selective antagonists of the alpha-4, beta-2 and alpha-7 nicotinic acetylcholine receptors, and the pumiliotoxins, which cause contraction of striated muscle, in the case of allopumiliotoxin with very high potency. (soci.org)
Prefrontal3
  • Carl Björkholm, Monica M. Marcus, Åsa Konradsson-Geuken, Kent Jardemark and Torgny H. Svensson The novel antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism. (uu.se)
  • These receptors allow prefrontal circuits to come "online" when we awaken, allowing us to perform complex mental tasks. (sciencedaily.com)
  • Mor M, Nardone S, Sams D, Elliott E (2015) Hypomethylation of miR-142 promoter and upregulation of microRNAs that target the oxytocin receptor gene in the autism prefrontal cortex. (biu.ac.il)
Mice1
  • In addition, mice in which the receptor gene for TNFα has been knocked out are resistant to alcohol-induced liver injury[ 5 ]. (wjgnet.com)
Protein2
  • 0.05) decreased mRNA and protein expression of retinoic acid signaling pathway elements, including retinoic acid receptor alpha and retinoic acid receptor beta, with the greatest number of changes observed between postnatal days 3-5. (biomedcentral.com)
  • 2018 ). NLRP3 inflammasome is composed of NLRP3 (nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing 3), ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) and procaspase-1, subsequently amplifying the production and secretion of proinflammatory cytokines, apoptotic and pyroptotic cell deaths(Zhong et al. (biomedcentral.com)
Genes1
  • RESULTS: alpha7 and gamma nAChR genes were significantly upregulated in burn patients, whereas alpha1 and epsilon nAChR genes were minimally affected, showing no significant changes over time. (druglib.com)
Modulation1
  • Nicotinic receptor modulation. (inra.fr)
Interaction2
  • Through its interaction with these receptors, SLURP-1 may be involved in skin growth and development. (medlineplus.gov)
  • Here we describe the discovery of a low-molecular weight hIL-1ß antagonist that blocks the interaction with the IL-1R1 receptor. (bvsalud.org)
Gene Expression1
Pharmacological1
  • Reduction in glutamate-receptor activity by genetic or pharmacological means reverses cellular and behavioral deficits in fragile X mouse models. (sfari.org)
20201
  • da Costa Couto A, Price KL, Mesoy S, Capes E, Lummis SCR ( 2020 ) The M4 Helix Is Involved in α7 nACh Receptor Function. (multichannelsystems.com)
Mediate1
  • Below we discuss the role of early neurotransmitters and their receptors prior to the formation of circuits that mediate vision. (org.es)
Wang1
  • 2009 ) and regulate the Reperfusion Injury Salvage Kinase (RISK) signaling pathway (ERKε, PKC, GSK-3β, STAT3) via cannabinoid receptor 1 (CB1R)(Wang et al. (biomedcentral.com)
Homo1
  • In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (ptglab.com)
Proteins1
  • Like other Ly6/uPAR-related proteins, SLURP-1 folds into a particular shape and is thought to attach (bind) to other proteins called receptors to carry out signaling within cells. (medlineplus.gov)
Cognitive1
  • Arnsten said that new medications that stimulate alpha-7 nicotinic receptors may hold promise for treating cognitive disorders. (sciencedaily.com)
Schizophrenia1
  • The results also intrigued researchers because alpha7 nicotinic receptors are genetically altered in schizophrenia, a disease marked by disorganized thinking. (sciencedaily.com)
Activation1
  • 0.05) decreased retinoic acid-induced binding and activation of the retinoic acid receptor response element in A549 cells. (biomedcentral.com)
Structural1
Increases1
Role4
  • Nicotinic acetylcholine receptors are best known for their role in chemical signaling between nerve cells, but they are also found in other tissues. (medlineplus.gov)
  • Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. (medlineplus.gov)
  • We propose to use the zebrafish (Danio rerio) as a vertebrate model to study the role of neuronal nicotinic acetylcholine receptors (nAChR) in development. (zfin.org)
  • Acetylcholine (ACh) signaling plays a key role in the development of the retina. (org.es)