• Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. (umassmed.edu)
  • The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
  • This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (wikipedia.org)
  • The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. (encyclopedia.pub)
  • Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). (encyclopedia.pub)
  • As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together. (encyclopedia.pub)
  • The integrin proteins activate key signaling molecules, which trigger cancer cells to migrate through the body and invade other tissues. (encyclopedia.pub)
  • It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. (harvard.edu)
  • ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. (umassmed.edu)
  • Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. (umassmed.edu)
  • Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. (cusabio.com)
  • The α6β4 integrin protein is found primarily in epithelial cells, which are cells that line the surfaces and cavities of the body. (encyclopedia.pub)
  • The α6β1 integrin protein has not been as well studied as α6β4 integrin. (encyclopedia.pub)
  • GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. (umassmed.edu)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
  • It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (wikipedia.org)
  • Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. (cusabio.com)
  • Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes. (encyclopedia.pub)
  • The alpha6beta1 integrin has been implicated in breast carcinoma progression, but the mechanisms involved remain elusive. (umassmed.edu)
  • Researchers believe that both α6β1 integrin and α6β4 integrin may play critical roles in the progression of cancerous tumors called carcinomas. (encyclopedia.pub)
  • Changes in the location and activity of α6β1 integrin and α6β4 integrin within cancer cells are associated with the progression of carcinomas. (encyclopedia.pub)
  • Recent studies suggest that, in addition to their roles in the progression of existing carcinomas, α6β1 integrin and α6β4 integrin may be involved in the initial formation of these tumors. (encyclopedia.pub)
  • The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. (encyclopedia.pub)
  • The ITGA6 gene mutations responsible for EB-PA lead to a loss of functional α6β4 integrin. (encyclopedia.pub)
  • The resulting shortage of functional α6β4 integrin causes cells in the epidermis to be fragile and easily damaged. (encyclopedia.pub)
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
  • As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. (cusabio.com)
  • The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. (cusabio.com)
  • These mutations alter the normal structure and function of the α6 integrin subunit or prevent cells from producing enough of this subunit. (encyclopedia.pub)
  • Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. (cusabio.com)
  • Allegra M, Gagnoux-Palacios L, Gache Y, Roques S, Lestringant G, Ortonne JP,Meneguzzi G. Rapid decay of alpha6 integrin caused by a mis-sense mutation in thepropeller domain results in severe junctional epidermolysis bullosa with pyloric atresia. (encyclopedia.pub)
  • Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma. (cusabio.com)
  • 9. alpha6 integrin cleavage: sensitizing human prostate cancer to ionizing radiation. (nih.gov)
  • 13. Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis. (nih.gov)
  • Allegra M, Gagnoux-Palacios L, Gache Y, Roques S, Lestringant G, Ortonne JP, Meneguzzi G. Rapid decay of alpha6 integrin caused by a mis-sense mutation in the propeller domain results in severe junctional epidermolysis bullosa with pyloric atresia. (medlineplus.gov)
  • Our aim was to analyze the role of pro-inflammatory cytokines, interferons and fibrogenic cytokines TGF-beta and FGF2 in the regulation of the expression of beta1 integrins by neoplastic hepatocytes. (nih.gov)
  • An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. (nih.gov)
  • 5. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. (nih.gov)
  • Liver carcinogenesis is associated with striking changes in the integrin repertoire of hepatocytes, including the overexpression of the laminin and collagen receptors alpha1beta1 and the de novo induction of the laminin receptor alpha6beta1. (nih.gov)
  • 15. PTH-related protein modulates PC-3 prostate cancer cell adhesion and integrin subunit profile. (nih.gov)
  • The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. (medlineplus.gov)
  • The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. (medlineplus.gov)
  • These mutations alter the normal structure and function of the α6 integrin subunit or prevent cells from producing enough of this subunit. (medlineplus.gov)
  • 3. Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells. (nih.gov)
  • 7. Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin. (nih.gov)
  • 17. Laminin-1 and alpha6beta1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells. (nih.gov)
  • 16. Differential expression of integrin subunits in DU-145/AR prostate cancer cells. (nih.gov)
  • av?3 Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin. (umassmed.edu)
  • Chung J, Yoon S, Datta K, Bachelder RE, Mercurio AM. Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. (medlineplus.gov)
  • 10. Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines. (nih.gov)
  • Chung J, Mercurio AM. Contributions of the alpha6 integrins to breast carcinoma survival and progression. (medlineplus.gov)
  • 6. The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. (nih.gov)