It is the most used anti-integrin therapy in IBD. (wikipedia.org)
Abrilumab (anti-α4β7) is a human IgG2 monoclonal antibody that has been under investigation has another anti-integrin therapy. (wikipedia.org)
Subunit6
Integrin α4β7 (Lymphocyte Peyer's patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently linked. (wikipedia.org)
In the α4 subunit, Tyr187 was identified as a critical amino acid in integrin α4β7-mediated cell adhesion. (wikipedia.org)
Natalizumab (anti-α4) is a humanized IgG4 monoclonal antibody that targets α4 subunit therefore it targets both α4β7 and α4β1 integrins. (wikipedia.org)
Etrolizumab (anti-β7) is a monoclonal antibody that targets β7 subunit on α4β7 and αEβ7 integrins. (wikipedia.org)
An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits. (musc.edu)
Recognizes the α4 subunit of α4β1 integrin (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin. (enzolifesciences.com)
Monoclonal antibody1
Recombinant monoclonal antibody to Integrin alpha-4/beta-7. (absoluteantibody.com)
ITGa42
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Integrin Alpha 4 (ITGa4) in samples from tissue homogenates, cell lysates or other biological fluids. (ibiomagazine.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Integrin Alpha 4 (ITGa4) in Tissue homogenates, cell lysates and other biological fluids. (ibiomagazine.org)
Antibody6
This antibody selectively targets integrin α4β7 binding to MAdCAM-1 and fibronectin but not to VCAM-1. (wikipedia.org)
This antibody is specific for human α4β7 integrin and does not cross react with alpha(4)beta(1) and alpha(E)beta(7) integrins. (absoluteantibody.com)
The binding characterization of this antibody for human alpha 4 beta 7 integrin was done using flow cytometry on Hut-78 cells (US7147851B1). (absoluteantibody.com)
This antibody exclusively binds alpha4 beta7 integrin and modulates inflammation in the gastrointestinal tract without inducing the systemic immunosuppression. (absoluteantibody.com)
Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. (absoluteantibody.com)
This study reports the results of treatment with MLN02, a humanized antibody to the alpha4beta7 integrin, in patients with active ulcerative colitis. (absoluteantibody.com)
Binds1
LPAM-1 binds with less specificity to the vascular cell adhesion molecule 1 (VCAM-1) which usually interacts with integrin α4β7 (VLA-4). (wikipedia.org)
Receptors4
Human CD49d molecules are integrin a4 chains that are expressed as heterodimers with CD29 (b1 integrin) or (b7 integrin) and function as adhesion receptors. (biosave.com)
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. (abcam.co.jp)
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Ligand3
LIMBS and ADMIDAS sites regulates the cell adherence of lymphocyte by affecting the adhesion or de-adhesion of the integrin to its ligand. (wikipedia.org)
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
Drugs2
In the last two decades several integrin-targeted drugs have made their way into clinical use, many others are in clinical trials and still more are showing promise as they advance through preclinical development. (thno.org)
Herein, this review examines and evaluates the various drugs and compounds targeting integrins and the disease states in which they are implicated. (thno.org)
Alpha4
The pharmacologic properties of vedolizumab, in conjunction with the gastrointestinal tropism of alpha(4)beta(7) integrin function, make it a suitable for treatment of patients with inflammatory bowel diseases (PMID: 19509315). (absoluteantibody.com)
This product was previously labelled as Integrin alpha 4. (abcam.co.jp)
Integrin alpha-4/beta-7 is also a receptor for MADCAM1. (abcam.co.jp)
Belongs to the integrin alpha chain family. (abcam.co.jp)
Affinity1
Intracellular signaling events that converge on the cytoplasmic domain of integrin tails are also capable of activating the high affinity state. (thno.org)
Cell2
On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. (abcam.co.jp)
Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
Expression3
CD49d/CD29 is mainly expressed on thymocytes and B cells with increased expression on activated T cells. (biosave.com)
Memory gut-homing CD4+ T cells and IgA-secreting B cells have an increased expression of this integrin. (wikipedia.org)
On contrary, most of the memory T cells that circulates to non-mucosal tissues are lacking expression of β7 integrins. (wikipedia.org)
Website1
This graph shows the total number of publications written about "Integrin alpha4" by people in this website by year, and whether "Integrin alpha4" was a major or minor topic of these publications. (musc.edu)
Activation3
The binding head of the β7 chain has three metal-binding sites that contributes to the cation-dependent (Ca2+, Mg2+ and Mn2+) allosteric conformational activation of the integrin α4β7. (wikipedia.org)
The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
Intracellular signals that result in integrin activation are referred to as 'inside-out' signaling events. (thno.org)
Major1
It has been found that gp120, which is the major HIV-1 envelope glycoprotein, can bind to α4β7 integrin. (wikipedia.org)
Disease3
LPAM-1 integrin is involved in the development of graft-versus-host disease (GVHD). (wikipedia.org)
As such, integrins are central to the etiology and pathology of many disease states. (thno.org)
Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
Important1
Therefore antagonists of this integrin represent an important therapeutic strategy for IBD. (wikipedia.org)
Therapy1
In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)