alpha 1-Antitrypsin Deficiencyalpha 1-AntitrypsinLungPulmonary EmphysemaLung NeoplasmsEmphysemaLung DiseasesPhenotypeLiver DiseasesPulmonary Disease, Chronic ObstructiveTrypsin Inhibitorsalpha 1-AntichymotrypsinForced Expiratory VolumePancreatic ElastaseHeterozygoteHomozygoteProteostasis DeficienciesBronchiectasisLiverSmokingAllelesHepatitisLiver CirrhosisMutationSerpinsGenotypeRespiratory Function TestsSpirometry