• Both genders report increases in somatic symptoms, but only women report decreases in emotional symptoms. (bmj.com)
  • The concept of being "asymptomatic" after exercise should be reconsidered to include expected mild increases and decreases in certain symptoms. (bmj.com)
  • Cigarette smoking increases the fractional disappearance rates of alpha-tocopherol and is associated with increased oxidative stress, but its effects on alpha-tocopherol metabolism are unknown. (oregonstate.edu)
  • Inhibition of let-7d caused increases in mesenchymal markers N-cadherin-2, vimentin, and alpha-smooth muscle actin (ACTA2) as well as HMGA2 in multiple epithelial cell lines. (nih.gov)
  • The economical benefits of adding beta-glucosidase significantly increase with decreases in beta-glucosidase cost and increases in barley cost. (usda.gov)
  • HRV can be used to estimate autonomic nervous control of the cardiovascular system and reduced HRV significantly increases cardiovascular mortality 9 . (bvsalud.org)
  • During some types of heart failure, the force-frequency relationship may become negative, so that myocardial contractility decreases as heart rate increases above a certain rate. (msdmanuals.com)
  • METHODS--Serum levels of IL-6 and TNF-alpha were measured at three hour intervals from 7:30 to 22:30 in 48 patients with different rheumatic diseases as well as ten healthy controls. (bmj.com)
  • RESULTS--IL-6 and TNF-alpha could not be detected in serum from healthy controls. (bmj.com)
  • After treatment with prednisolone, levels of serum IL-6 decreased significantly, but the circadian rhythm remained. (bmj.com)
  • Mixed model analyses (alpha = .05) did not significantly show the expected decrease in serum PON1 activity over time with either substrate. (cdc.gov)
  • Angiogenic and lymphangiogenic effect of the drugs assessed pathologically through counting of the newly formed capillaries and lymphatics that immunohistochemically expressed by vascular Endothelial Growth Factor (VEGF), CD34 and D2-40 in liver sections using Cell Image Analyzer and serologically by evaluation of serum level of Tumor Necrosis Factor-Alpha (TNF-α). (degruyter.com)
  • Our results showed significant decrease in serum TNF-α in ART-treated group compared to control infected and PZQ treated groups. (degruyter.com)
  • For instance, Deng et al ( 8 ) compared 66 pairs of hepatic carcinoma tissues and normal tissues and found that CCAT1 expression was increased in liver cancer tissues, and that the degree of upregulation was associated with tumor size, vascular invasion and serum alpha-fetoprotein level. (spandidos-publications.com)
  • Additionally, AET significantly decreased measures of investigatory behavior. (erowid.org)
  • We diagnose unstable behavior of solar wind plasma between 0.3 and 1 au via the Nyquist criterion, applying it to fits of 1.5M proton and alpha particle Velocity Distribution Functions (VDFs) observed by Helios I and II. (aps.org)
  • Instability growth rates demonstrate similar behavior, and significantly decrease with Coulomb number. (aps.org)
  • Several reports have speculated that the tryptamine-derived drug alpha-ethyltryptamine (AET) may have effects similar to those of the amphetamine-derived drug 3,4-methylenedioxymethamphetamine (MDMA). (erowid.org)
  • Similar decreases occur with MDMA or hallucinogen administration. (erowid.org)
  • In drug discrimination assays, CAB was approximately 3-fold less potent than PCA in animals trained to discriminate 3,4-methylenedioxymethamphetamine (MDMA) or its alpha-ethyl homologue, S-(+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (S-(+)-MBDB), from saline. (erowid.org)
  • After a concussion, when symptoms have decreased substantially at rest, it is recommended that athletes begin light aerobic exercise before progressing to sport specific exercise. (bmj.com)
  • Catches of both species decreased significantly and substantially with increasing elevation. (usu.edu)
  • 0.05), and smokers had lower maximal d3-alpha-CEHC (P = 0.004) and d6-alpha-CEHC (P = 0.0006) concentrations. (oregonstate.edu)
  • 0.05) the plasma total, d6-, or d3-alpha-CEHC concentrations that nonsmokers did given similar alpha-tocopherol concentrations. (oregonstate.edu)
  • Significant changes in trend (increasing or decreasing) were determined by using joinpoint modeling to identify where APCs were significantly different from zero at the alpha = 0.05 level. (cdc.gov)
  • Administration of 0.05 g/kg capsaicin showed the highest of tauro-alpha-muricholic acid sodium salt and tauro-beta-muricholic acid sodium salt and 0.1 g/kg capsaicin resulted in the highest of lithocholic acid, cholic acid and hyodeoxycholic acid. (ijpsonline.com)
  • Treatment with TKIs significantly decreases the mortality rate in patients with CML. (medscape.com)
  • Lower plasma alpha-carboxyethyl-hydroxychroman after deuterium-labeled alpha-tocopherol supplementation suggests decreased vitamin E metabolism in smokers. (oregonstate.edu)
  • After 6 d of supplementation, plasma d3- and d6-alpha-tocopherol concentrations did not differ significantly between groups. (oregonstate.edu)
  • Moreover, UPF supplementation had a positive impact on gut microbiota, decreasing the relative abundances of Blautia, Parasutterella and Fusicatenibacter which were closely related to obesity, and increasing the relative abundances of probiotics ( Allobaculum, Romboutsia, Staphylococcus , and Bacteroides ). (frontiersin.org)
  • The spearman correlation analysis revealed that UPF supplementation reduced the relative abundance of Parasutterella and possibly decreased the blood sugar levels, leading to a decrease in the relative abundances of Blautia and Fusicatenibacter and a subsequent decrease in insulin levels. (frontiersin.org)
  • Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. (nih.gov)
  • Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (nih.gov)
  • Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (nih.gov)
  • In the IRIS (International Randomized Study of Interferon and STI571) study, imatinib produced a higher rate of complete cytogenetic response (CCyR) and major cytogenetic response (MCyR) compared with interferon alpha and cytarabinenal. (medscape.com)
  • The naming convention for these keratins follows that for protein structures: alpha keratin is helical and beta keratin is sheet-like. (wikipedia.org)
  • Proteasomal inhibition caused a dose-dependent decrease in viability and induced protein aggregates formation containing alpha-synuclein and ubiquitin. (unboundmedicine.com)
  • PM 2.5 increased the mRNA and protein expression of M1 markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and inducible nitric oxide synthase (iNOS) in RAW264.7 cells. (medsci.org)
  • The protein level of TLR4 was significantly increased and the ratio of phosphorylated NF-κB p65 versus p65 subunit was also elevated in PM 2.5 group. (medsci.org)
  • PM 2.5 decreased the protein level of SIRT1 but not the mRNA expression in vitro and in vivo experiments. (medsci.org)
  • Two-dimensional immunoelectrophoresis against apo-A antiserum indicated a clear reduction of apo-A in the alpha electrophoretic region, with splitting of the protein "peak. (jci.org)
  • RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet. (heart-intl.net)
  • Taken together, our findings suggested that the anti-obesity properties of UPF could be achieved by decreasing the insulin levels, positive-regulating of the gut microbiota composition as well as altering gene expression related to glucolipid metabolism. (frontiersin.org)
  • The results showed that the addition of capsaicin further decreased the fasting blood glucose and insulin, and increased beta-muricholic acid, deoxycholic acid, chenodeoxycholic acid, and 3 beta-ursodeoxycholic acid when compared to only high fiber diet. (ijpsonline.com)
  • By increasing the stirring time, (starting from 24 to 48 hours) the particle size decreased, but agglomeration became hard for 60 hours of stirring time. (hindawi.com)
  • Proteasomal inhibition induced significantly increased alpha-synuclein aggregation in cells expressing mutant alpha-synuclein. (unboundmedicine.com)
  • This finding is consistent with other clinical studies demonstrating response of moderate to severe HS to TNF-alpha inhibition. (empr.com)
  • In early dementia, the resting alpha frequency declines. (medscape.com)
  • Most authors agree that the lower limit of normal alpha frequency is 8 Hz (cycles per second). (medscape.com)
  • In assessing the frequency of the alpha rhythm, alerting maneuvers are essential in order to ensure that the patient is in the best awake state and not drowsy. (medscape.com)
  • For women, emotional symptoms such as irritability, sadness, nervousness and feeling more emotional decreased significantly after aerobic exercise. (bmj.com)
  • Alpha-synuclein is of particular interest in PD since it is a major component of Lewy bodies and mutations in the alpha-synuclein gene were identified in familial PD. (unboundmedicine.com)
  • A 2011 study (2) amongst male mice showed that miroestrol and deoxymiroestrol could regulate genes in the testes in the same way as human estradiol, decreasing gene expression for sex hormones. (canceractive.com)
  • The present set of experiments was designed to examine the effects of extension of the alpha-methyl of p-chloroamphetamine (PCA) to an alpha-ethyl. (erowid.org)
  • A 10 mg/kg dose of PCA caused an 80% decrease in cortical and hippocampal serotonergic markers, while an equimolar dose of CAB decreased only hippocampal 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels. (erowid.org)
  • OBJECTIVES--To test the hypothesis of a diurnal variation in circulating levels of interleukin-6 (IL-6) and/or tumour necrosis factor-alpha (TNF-alpha) in rheumatoid arthritis and other inflammatory connective tissue diseases. (bmj.com)
  • Levels of TNF-alpha were low in patients with rheumatoid arthritis and high in patients with other connective tissue diseases, but without circadian rhythm. (bmj.com)
  • Body Mass Index, gender, location ( farm /rural/town), and systolic and diastolic blood pressure did not significantly influence substrate levels, though gender, BMI and location showed a marginal influence. (cdc.gov)
  • This pilot study did not conclusively confirm the assumed age-related decrease in PON1 levels or changes in these lifestyle and health parameters. (cdc.gov)
  • Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. (jci.org)
  • Significant hypertriglyceridemia with a very marked decrease of high density lipoproteins (HDL)-cholesterol levels (7-14 mg/dl) was detected in three members (father, son, and daughter) of an Italian family. (jci.org)
  • Pohl and Tylenda 2000) in Swedish breast milk samples have been decreasing, while levels of polybrominated diphenyl ethers have been increasing (Hooper and McDonald 2000). (cdc.gov)
  • Pneumococci lacking RafK showed a 50- to 80-fold reduction in expression of the raf operon genes aga (alpha-galactosidase) and rafEFG (raffinose substrate binding and permease genes), and both glucose and sucrose inhibited raffinose uptake through inducer exclusion. (lu.se)
  • However, 22 mg/kg of CAB produced a 20-40% decrease in all serotonergic markers. (erowid.org)
  • Using panel traps baited with alpha-pinene and ethanol we caught a total of 45,363 H. ligniperda and 6676 H. ater . (usu.edu)
  • In particular, ESRR alpha (ESRRa) and ESRR gamma (ESRRg) are key metabolic regulators of energy homeostasis and abnormal functions of these proteins are linked to metabolic syndromes including diabetes and fatty liver disease 5 . (nature.com)
  • a Annual percentage change from 1999-2010 is significantly different from 0 at an alpha level of .05. (cdc.gov)
  • The similar decrease in relative 5-HT neurotoxicity and the decreased ability to alter dopaminergic systems in vivo and in vitro supports the involvement of DA in the neurotoxicity of PCA. (erowid.org)
  • Breast milk monitoring studies conducted in Sweden for the past 20-30 years indicate that exposure to certain persistent chemicals may be decreasing during this period, but exposure to others may be increasing. (cdc.gov)
  • Adjunctive hyperbaric oxygen therapy was considered effective to significantly improve the efficacy of antibiotic treatment of hidradenitis suppurativa. (medscape.com)
  • Dr. Mulani concluded, "In this study, we were able to show that treatment with biologic agents significantly decreases disease activity scores. (empr.com)
  • In the DASISION (DASatinib versus Imatinib Study In treatment-Naive CML patients) trial, final 5-year analysis showed significantly higher MMR and molecular response with ≥4.5 log reduction of BCR-ABL on the International Scale (MR4.5) in patients with newly diagnosed CP-CML who received dasatinib, 100 mg once daily (n = 259), than in those who received imatinib, 400 mg once daily (n = 260). (medscape.com)
  • We further compared neutralization capacity of vaccination-induced IgG against 4 SARS-CoV-2 variants of concern (Alpha, Beta, Gamma, and Delta) by angiotensin-converting enzyme 2 receptor-binding domain competition assay. (cdc.gov)
  • Consequently, evaluating the molecular mechanism or mechanisms responsible for tocopherol metabolism under conditions of oxidative stress and the mechanisms that regulate alpha-tocopherol status is warranted. (oregonstate.edu)
  • A sensitivity study was also performed to examine the effects of alpha-glucosidase and barley costs on the final ethanol production cost. (usda.gov)
  • Thus, extension of the alpha-alkyl significantly decreases the dopaminergic effects of PCA. (erowid.org)
  • The mediatory role of experiential avoidance was confirmed in such a way that the effects of alexithymia and perceived stress decreased. (who.int)
  • Headache also decreased in the women, but no significant change was seen in the men. (bmj.com)
  • Monitoring with in vivo microdialysis, 10 mg/kg of PCA caused a large increase in extracellular DA and a significant decrease in 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. (erowid.org)
  • ART exhibited significant anti-angiogenic role on granulomas illustrated by remarkable milder intensity and significantly lower expression values of VEGF and CD34 immunostaining compared to PZQ and non-treated groups. (degruyter.com)
  • There was a dose-related decrease in pup weight that was significant in the 750 mg/kg/day group on postnatal day 4 only and in the 1500 mg/kg/day group from postnatal day 4 through postnatal day 21 but had recovered by postnatal day 90. (europa.eu)
  • First, a dose-response study revealed that all doses of AET tested (5, 10, 20 mg/kg) significantly increased locomotor activity. (erowid.org)
  • Both doses of CAB caused a decrease in extracellular DOPAC. (erowid.org)
  • Therefore, the mechanism of increased alpha-tocopherol disappearance in smokers likely operates through oxidation pathways, which is consistent with alpha-tocopherol's antioxidant function. (oregonstate.edu)
  • In fact there was a 37% decrease in the ratio of LDL to HDL after two months. (canceractive.com)
  • Smokers and nonsmokers (n = 10 per group) were supplemented with deuterium-labeled alpha-tocopheryl acetates (75 mg each d3-RRR-alpha-tocopheryl and d6-all-rac-alpha-tocopheryl acetate) from day -6 to day -1, and plasma tocopherols and CEHCs were measured (day -6 through day 17). (oregonstate.edu)
  • The survival rate was significantly lower in the highly expressed lncRNA XIST group. (spandidos-publications.com)
  • The relative alignment of the keratin fibrils significantly impacts the mechanical properties. (wikipedia.org)
  • Smoking did not increase alpha-tocopherol disappearance through P450-mediated tocopherol metabolism. (oregonstate.edu)
  • We hypothesized that smokers would have less alpha-tocopherol available and consequently lower plasma alpha-carboxyethyl-hydroxychroman (alpha-CEHC), the alpha-tocopherol metabolite produced by a cytochrome P450-mediated process. (oregonstate.edu)
  • The three affected individuals did not show any clinical signs of atherosclerosis, nor was the atherosclerotic disease significantly present in the family. (jci.org)
  • Another option, changing the chip's route to Alpha Centauri to avoid radiation, would add time without significantly decreasing the radiation problem. (panarmenian.net)
  • However, the average daily consumption of total vegetables and green salads decreased and of total fruits, fruit juices and cooked and fried potatoes increased. (who.int)
  • Inclusion body formation and cell death of differentiated neuroblastoma cells overexpressing alpha-synuclein can serve as a valuable model for elucidating the molecular components that cause neurodegeneration in PD as well as evaluating pharmacological interventions. (unboundmedicine.com)
  • Consumption increased with age and body mass index but decreased with smoking and non-exercising. (who.int)
  • Like RafK, the presence of DLDH also activated the expression of raf operon genes, as DLDH-negative pneumococci showed a significantly decreased expression of aga and rafEFG, but DLDH did not regulate rafK or the putative regulatory genes rafR and rafS. (lu.se)
  • There is strong evidence that obesity leads to increased sympathetic modulation and a decreased vagal tone leading to a lack of autonomic control (characterized by reduction of heart rate variability) that can bring about changes in the renin-angiotensin-aldosterone system in alpha agonists and central alpha 2-1 and beta-adrenergic receptors. (bvsalud.org)
  • In the USA 61% of chronic pain patients are women, starting at menarche and decreasing at menopause. (progesteronetherapy.com)
  • Fruit and vegetable consumption is an to 147 kg/year while the per capita fruit rooms of the clinics to participate in the integral component of healthy eating consumed decreased from 128 to 120 study. (who.int)
  • Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults. (medlineplus.gov)
  • In human hair the filaments of alpha keratin are highly aligned, giving a tensile strength of approximately 200MPa. (wikipedia.org)
  • The role of ESRRa in cellular metabolism is largely dependent on its transcriptional regulation of mitochondrial function and biogenesis through collaboration with the peroxisome proliferator-activated receptor γ coactivator-1 alpha (PGC1a) 6 . (nature.com)
  • Pfizer's Phase 1 average hasn't improved or decreased significantly. (seekingalpha.com)
  • The Alpha 1 Delivers an Unprecedented Combination of Resolution, Speed and Video Performance. (the-digital-picture.com)
  • let-7d was significantly reduced in IPF lungs and the number of epithelial cells expressing let-7d correlated with pulmonary functions. (nih.gov)
  • Neuroblastoma cells were stably transfected with wild type (WT) and A53T mutant alpha-synuclein. (unboundmedicine.com)
  • Beside PGC1a/b, ESRRa has been shown to potentiate a metabolic syndrome by acting downstream of mammalian target of rapamycin (mTOR) 7 and also promotes hypoxic adaptation of cancer cells by stabilizing hypoxia inducible factor 1-alpha (HIF1-a) from degradation 8 . (nature.com)
  • Alpha keratin is found in mammalian hair, skin, nails, horn and quills, while beta keratin can be found in avian and reptilian species in scales, feathers, and beaks. (wikipedia.org)
  • Finally, although not as attenuated as DLDH-negative bacteria, pneumococci lacking RafK were significantly outcompeted by wild-type bacteria in colonization experiments of murine lung and nasopharynx, indicating a role for raffinose and stachyose transport in vivo. (lu.se)
  • Coumestrol and miroestrol enhanced both ER alpha and ER beta activation, while daidzein and genestein enhanced only ER beta activation. (canceractive.com)
  • Don't confuse DHEA with 7-alpha-hydroxy-DHEA, 7-beta-hydroxy-DHEA, and 7-keto-DHEA. (medlineplus.gov)
  • Alpha-fetoprotein decreased significantly and tended to be normal. (bvsalud.org)
  • Manufacturers know that once the drug enters the marketplace, its usage can widen significantly. (crstoday.com)
  • Plasma d3- and d6-alpha-CEHCs were detectable only from day -5 to day 5. (oregonstate.edu)
  • 2008 research from Japan (1) on this phytoestrogen, miroestrol, from Pueraria showed that after two months usage it lowered LDL and increased HDL significantly. (canceractive.com)
  • To coincide with the event, Alpha 3c Tournament Edition was just released yesterday, including some important tweaks and useful little features. (moddb.com)
  • Let's dive right into the Alpha a1 features called out by Sony. (the-digital-picture.com)