Alpha mrna during liver. Medical search. Frequent questions

The results showed that the hepatic steatosis in liver tissues of HFD mice injected with MitoTEMPO was significantly ameliorated. (hindawi.com)
We previously determined that tTG activity increased in an animal model of hepatic fibrogenesis and in human liver disease. (nih.gov)
Because TNF-alpha expression is upregulated in hepatic inflammation, the data suggest TNF-alpha-mediated increases in tTG expression may play an important role in the process of hepatic fibrogenesis. (nih.gov)
The aim of this study was to determine such a dose and time-point after exposure which lead to a mild liver lesion and to increased hepatic levels of TNF-α and IL-1 mRNA in rats. (helsinki.fi)
Non-alcoholic fatty liver disease is associated with obesity, non-insulin dependent diabetes, and hypertriglyceridemia and represents the hepatic manifestation of the metabolic syndrome[ 4 ]. (wjgnet.com)
Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult male rats. (oregonstate.edu)
Adult rats fed the peroxisome proliferator-activated receptor alpha (PPARalpha) agonist WY14,643 have increased hepatic elongase activity, Elovl-1, Elovl-5, Elovl-6, Delta5, Delta6, and Delta9 desaturase mRNA abundance, and mead acid (20:3,n-9) content. (oregonstate.edu)
Developmental changes in hepatic elongase activity paralleled the postnatal induction of Elovl-5 mRNA and mRNAs encoding the PPARalpha-regulated transcripts, Delta5 and Delta6 desaturase, and cytochrome P450 4A. (oregonstate.edu)
In contrast, Elovl-6, Delta9 desaturase, and FAS mRNA abundance paralleled changes in hepatic sterol regulatory element binding protein 1c (SREBP-1c) nuclear content. (oregonstate.edu)
Oval cells proliferate and differentiate in hepatocytes expressing albumin, and they differentiate in biliary cells expressing cytokeratin 7 (CK 7).Serial Analysis of Gene Expression (SAGE) was applied to the hepatic stem cell model of rat liver regeneration for studying gene expression pattern of liver regeneration during early stage of oval cell proliferation and differentiation. (uni-goettingen.de)
Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. (harvard.edu)
However, it appears more plausible that lupin proteins and/or lupin protein-associated compounds, respectively, exert their physiological effects in the intestine which in turn indirectly alter the hepatic protein and mRNA concentrations of LDL receptor and CYP7A1. (biomedcentral.com)
SNE reduced the hepatic hydroxyproline and alpha-smooth muscle actin protein levels of TAA-treated mice. (bestayurveda.ca)
Fulminant hepatic failure (FHF) is a devastating syndrome, which sometimes results in death or liver transplantation, in which inflammation would aggravate the development of fetuin-A which would act as an anti-inflammatory factor and may be an available approach to attenuate FHF. (hofstra.edu)
Meanwhile, fetuin-A was negatively correlated with the hepatic pathological score and TNF-alpha protein staining in FHF mouse. (hofstra.edu)

This mRNA contains the instructions, derived from DNA, to create proteins, the building blocks of cells. (livescience.com)
These cells then contained much more heart mRNA than skin or brain mRNA, causing the cell to build heart-cell proteins. (livescience.com)
Treatment of human Hep G2 cells with 1 ng/ml TNF-alpha increased [14C]putrescine cross-linking to cellular proteins. (nih.gov)
In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
In liver, the precursor protein is cleaved in the Golgi network by a furin-like enzyme to release constituent proteins, which undergo glycosylation before their export from the cell. (betalifesci.com)
The alpha(1)-microglobulin and bikunin proteins are accordingly present in developing hepatocytes, pancreas, kidney, and gut. (betalifesci.com)
Herein we investigated whether lupin proteins compared to casein modulate sterol excretion and mRNA expression of intestinal sterol transporters by use of pigs as an animal model with similar lipid metabolism as humans, and cellular cholesterol-uptake by Caco-2 cells. (biomedcentral.com)
Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection. (uchicago.edu)

Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses. (cdc.gov)

This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in vivo stimulation. (ox.ac.uk)
Although previously believed to be constitutively expressed exclusively in liver, the present study demonstrates the induction of this gene by oxalate in porcine proximal tubular LLC-PK1 cells and rat kidney. (betalifesci.com)

In the liver of obesity, the resident immune cells such as macrophages (Kupffer cells) and dendritic cells produce proinflammatory chemokines and cytokines, including monocyte chemoattractant protein-1 (MCP-1), interleukin-1 β (IL-1 β ), and tumor necrosis factor- α (TNF- α ) in response to hepatocellular damage [ 10 - 12 ]. (hindawi.com)
To further study the role of tTG in liver disease, we initiated investigations into the effect of a proinflammatory mediator, tumor necrosis factor (TNF)-alpha, on tTG activity in cultured liver cells. (nih.gov)
Endotoxin tolerance is associated with a reduction of tumor necrosis factor alpha and interleukin-1 production in response to LPS. (helsinki.fi)
Gene expression of tumor necrotic factor alpha (TNF-α) was done by real-time PCR. (civilica.com)
This contrasts with tumor necrosis factor alpha (TNF alpha) mRNA, which is produced by fewer cells in the granuloma, and which can be massively induced by lipopolysaccharide administration. (ox.ac.uk)
Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. (qxmd.com)
Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology. (qxmd.com)

Then the HUCMSCs with distinct immunomodulatory effects were tested for treating liver fibrosis in mice and then therapeutic effects were observed. (researchsquare.com)
Inhibitory effect of Solanum nigrum on thioacetamide-induced liver fibrosis in mice. (bestayurveda.ca)
The purpose of this study was to investigate the effects of Solanum nigrum extract (SNE) on thioacetamide (TAA)-induced liver fibrosis in mice. (bestayurveda.ca)

However, the role of MitoTEMPO on nonalcoholic fatty liver disease (NAFLD) and its possible mechanisms are largely unknown. (hindawi.com)
Nonalcoholic fatty liver disease (NAFLD) is a common pandemic disease [ 1 ], which is affecting about 1/3 of the adult population in developed countries [ 2 , 3 ]. (hindawi.com)
Moreover, NAFLD induced by obesity closely associates with immune dysfunction in the liver [ 7 ] and reflects a generalized chronic proinflammatory state [ 8 , 9 ]. (hindawi.com)
Here, we explored immune cell MDSCs and inflammatory activities in obesity-associated NAFLD and further investigated the protective effect of MitoTEMPO on alleviating the severity of NAFLD via regulating immune response in the liver tissues. (hindawi.com)
Non-alcoholic fatty liver disease (NAFLD) parallels the global obesity epidemic with unmet therapeutic needs. (springer.com)
The prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing, currently affecting a quarter of people worldwide [ 1 ]. (springer.com)
Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
In this review, we summarize how impaired autophagy affects liver function and contributes to NAFLD, AFLD, and HCC progression. (hindawi.com)
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular carcinoma. (wjgnet.com)
An estimated 30% of adults and 10% of children and adolescents in the United States have nonalcoholic fatty liver disease (NAFLD), defined as liver fat content exceeding 5% (Figure 1 )[ 1 - 3 ]. (wjgnet.com)
Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. (biomedcentral.com)
Thus, this study's intentions are to establish a NAFLD model of zebrafish larvae and to examine the role of caffeine on fatty liver with the model. (biomedcentral.com)
NAFLD is becoming one of the most common causes of chronic liver diseases. (biomedcentral.com)
Because of the advantage of transparent body in juvenile period suitable for identifying lipid accumulation in liver by whole-mount oil red O staining, in present study we attempted to determine whether juvenile zebrafish can be used as a model for diet-induced NAFLD. (biomedcentral.com)

The resting resident tissue M phi of most tissues do not contain enough lysozyme mRNA to be detected by in situ hybridization using 35S-labeled RNA probes. (ox.ac.uk)
The alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. (betalifesci.com)

This gene is primarily expressed in the liver, brain, placental, and small intestine tissues. (wikipedia.org)
The protein is localized to the cell membrane and cytoplasm in liver, brain, and placental tissues. (wikipedia.org)
Moreover, real-time quantitative PCR, western blot, and immunohistochemistry were conducted to detect the mRNA and protein expressions in the liver tissues. (hindawi.com)
The intake of fructose in majority of the Hif-p4h-2 gt/gt tissues, including the liver, was 15-35% less than in the WT. (springer.com)
Fetuin-A mRNA and protein expression in liver tissues was assessed by RT-PCR, Western blotting and immunohistochemical staining. (hofstra.edu)

In a study of embryonic liver samples lacking hepatocyte nuclear factor 4 alpha (HNF4α), the expression of C2orf72 was downregulated. (wikipedia.org)

C2orf72 mRNA and protein products are found preferentially in the liver, kidney, and placenta. (wikipedia.org)
A complete primary series, preferentially with an mRNA COVID-19 vaccine, should be offered to individuals 12 years of age and older without contraindications to the vaccine. (canada.ca)

In vitro translation of human liver mRNA hybridizing with this cDNA gives a protein mol. (rti.org)

An increase in tTG mRNA content was observed 1 h after addition of TNF-alpha, and levels of tTG mRNA remained elevated after 24 h. (nih.gov)
On both diets, the Hif-p4h-2 gt/gt mice gained less weight and had less white adipose tissue (WAT) and its inflammation, lower serum cholesterol levels, and lighter livers with less steatosis and lower serum ALT levels than the wild type (WT). (springer.com)
Endotoxin treatment resulted in significantly increased levels of TNF- α:n and IL-1 mRNA in all endotoxin-treated rats. (helsinki.fi)
Diabetes is related with the higher blood levels of liver enzymes and inflammatory factors. (civilica.com)
Blood concentration of liver enzymes, urea, glucose, white blood cells count and TNF-α mRNA levels in visceral adipose tissue significantly declined in diabetic rats receiving Ag-NPs.Conclusion: The synthesized Ag-NPs using Galega officinalis extract may improve complication of diabetes via preventing liver hepatocyte damage and reducing inflammatory factors. (civilica.com)
Lysozyme mRNA levels in liver granulomas remain relatively constant during the infection, and lysozyme is produced by most granuloma cells. (ox.ac.uk)
Glycogen breakdown is highly regulated in the body, especially in the liver , by various hormones including insulin and glucagon , to maintain a homeostatic balance of blood-glucose levels. (wikidoc.org)
Oval cells are induced between 1 and 3 days after PH inside the portal field and they express the typical onco-foetal marker alpha foeto-protein (AFP), at mRNA and protein levels. (uni-goettingen.de)
SNE inhibited TAA-induced collagene (alpha1)(I) and transforming growth factor-beta1 (TGF-beta1) mRNA levels in the liver. (bestayurveda.ca)
At different time points after d-GalN/LPS intervention, serum TNF-alpha and IL-6 levels were measured by ELISA. (hofstra.edu)
AFP is highly expressed in the fetal liver, silenced at birth, and remains at very low levels in the adult liver. (uky.edu)
Transgenes regulated by the wild-type AFP promoter are expressed at low levels in the adult liver. (uky.edu)
Mouse strain-specific differences in adult liver Elovl3 mRNA levels and transgenic mouse data indicate that Zhx2 activates Elovl3 expression in the female adult liver. (uky.edu)

A pre-intervention of exogenous fetuin-A significantly improved the liver function, decreased TNF-alpha and IL-6 expression in peripheral blood, and liver tissue inhibited hepatocyte apoptosis responded to d-GalN/LPS induction so as to decrease the mortality rates of FHF mouse. (hofstra.edu)
At 100 microM deltamethrin 2-3 fold induction of CYP1A1 and CYP2B6 mRNA was observed, while at the same time an approximately 25-fold induction of CYP3A4 was noted. (cdc.gov)

Together with phosphorylases , debranching enzymes mobilize glucose reserves from glycogen deposits in the muscles and liver. (wikidoc.org)
Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver. (harvard.edu)
A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. (cassiopaea.org)
The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)

A complete primary series with an mRNA COVID-19 vaccine may be offered to children 6 months to less than 5 years of age and should be offered to children 5 to 11 years of age without contraindications to the authorized vaccine, with a dosing interval of at least 8 weeks between the first and second dose. (canada.ca)
A first booster dose of mRNA COVID-19 vaccine should be offered to adults 18 years of age and older and select children and adolescents 5 to 17 years of age. (canada.ca)
A first booster of mRNA COVID-19 vaccine may also be offered to all other children and adolescents 5 to 17 years of age. (canada.ca)
It is recommended that mRNA COVID-19 vaccines should be offered to individuals 6 months of age and older with previous SARS-CoV-2 infection without contraindications to the vaccine. (canada.ca)
It is recommended that an authorized protein subunit COVID-19 vaccine (Novavax Nuvaxovid) should be offered to individuals in the authorized age groups without contraindications to the vaccine who are not able or willing to receive an mRNA COVID-19 vaccine. (canada.ca)
Characterisation of vaccine breakthrough syndrome coronavirus 2 Omicron variant, we determined infections of SARS-CoV-2 Delta and Alpha variants and serial intervals and secondary attack rates among house- within-host viral load dynamics in the community, France, June to July 2021. (cdc.gov)

HIF-P4H-2 inhibition enhances intestinal fructose metabolism protecting the liver. (springer.com)
The mRNA abundances of intestinal lipid transporters were analysed by real-time RT-PCR. (biomedcentral.com)

Elovl activity is low in fetal liver but increases significantly after birth. (oregonstate.edu)
SREBP-1c is present in fetal liver nuclei, absent from nuclei immediately after birth, and reappears in nuclei at weaning, 21 days postpartum. (oregonstate.edu)

Diet-induced changes in elongase activity correlate with Elovl-5 and Elovl-6 mRNA abundance. (oregonstate.edu)

NASH can progress from steatohepatitis to liver cirrhosis, and may eventually develop hepatocellular carcinoma after decade years. (biomedcentral.com)

C2orf72's mRNA transcript is reported to be about 3,629 base pairs long. (wikipedia.org)
It appears to have two polyadenylation sites near the 5′ end of the mRNA transcript, each preceded by their respective regulatory sequences, such as ATTAAA or AATAAA. (wikipedia.org)
splicing of the SMN2 transcript usually results in an mRNA lacking exon 7. (dovepress.com)

It may be argued whether the observed alterations in liver lipid metabolism can be attributed to intact lupin polypeptides that enter the organism. (biomedcentral.com)

A pharmacological pan-HIF-P4H inhibitor protected WT mice on both diets against obesity, metabolic dysfunction, and liver damage. (springer.com)
In addition, three HUCMSC lines applied to mice liver fibrosis model had different therapeutic outcomes, in line with individual immune regulation capability. (researchsquare.com)
The purpose of this study was to investigate the effects of fetuin-A on d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver failure in mice. (hofstra.edu)

MCP-1 further mediates the infiltration of chronic inflammatory cells such as macrophages and monocytes to the liver, resulting in amplification of inflammation in the liver microenvironment [ 11 ]. (hindawi.com)
These results are consistent with tissue damage and inflammation in the liver. (helsinki.fi)

Endotoxins can provoke Kuppfer cells to release pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF-α) and interleukin-1 (IL-1), which can lead to systemic inflammatory response and damage liver. (helsinki.fi)
The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. (thermofisher.com)
Fetuin-A might be a protective agent of liver damage partly through inhibiting liver inflammatory response and hepatocyte apoptosis. (hofstra.edu)

Additionally, MitoTEMPO reduced the frequency of CD11b + Gr-1 + MDSCs in peripheral circulation and decreased Gr-1 + cell accumulation in the livers. (hindawi.com)
It is estimated that approximately 20-30 % of adults and 3-10 % of children in western countries suffer from excessive fat accumulation in the liver [ 1 ]. (biomedcentral.com)

Kinetically down-regulated genes involved in the lipid metabolism are: hydroxyacid oxidase 3, fatty acid CoA ligase long chain 2, and steroyl CoA desaturase 1.The regulation of protein expression of the cell cycle genes CDC42 and cyclin D1 was studied by Western Blot technique, in the oval cell liver regeneration. (uni-goettingen.de)
Moreover, caffeine treatment was associated with upregulation of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1). (biomedcentral.com)

Besides, an observation of liver tissue injury, the apoptosis of hepatocytes, was analyzed by TUNEL assay. (hofstra.edu)
Expression of fetuin-A mRNA and protein in liver tissue were significantly and gradually decreased after d-GalN/LPS administration. (hofstra.edu)

Primary hepatocytes isolated from a transgenic mouse line containing the mouse tTG promoter driving the beta-galactosidase reporter, show similar time-dependent increases in promoter activity when treated with TNF-alpha. (nih.gov)
Hence, it was proposed that oval cells could represent a second compartment involved in the liver regeneration when the insult of the organ is too massive and proliferation of hepatocytes is suppressed.We performed the model of rat liver regeneration via oval cells using the protocol of 70% partial hepatectomy (PH) plus 2-Acetoamidofluorene (2-AAF) treatment. (uni-goettingen.de)

A GA substitution located at -119 of the human AFP promoter is associated with hereditary persistence of AFP (HPAFP) expression in the adult liver (Hum Molec Genet, 1993, 2:379). (uky.edu)
Transgenes with a GGAA mutation (similar to the G-A human mutation) are more active in the adult liver. (uky.edu)

In 1946, it was proposed that circulating colloids, including serum albumin, may affect the synthesis and/or secretion of albumin in the liver. (jci.org)
Glucose is the major substrate for ATP synthesis through glycolysis and oxidative phosphorylation (OXPHOS), whereas intermediary metabolism through the tricarboxylic acid (TCA) cycle utilizes non-glucose-derived monocarboxylates, amino acids, and alpha ketoacids to support mitochondrial ATP and GTP synthesis. (molvis.org)

Among 564 contacts from 206 households, Alpha variant was significantly associated with household transmission (odds ratio 1.52, 95% CI 1.06-2.18) compared with B.1.1.214. (cdc.gov)

In earlier studies, LDs were found only in fatty liver and in the foam cells of atherogenic plaques. (asbmb.org)
Growth and the incidence of fatty liver of zebrafish larvae increased with the increased amount of feeding in a dose-dependent manner. (biomedcentral.com)

Figure 1 Liver histology ranging from normal liver to steatohepatitis with fibrosis. (wjgnet.com)

MitoTEMPO, a mitochondrial antioxidant, has protective effects on liver-related diseases. (hindawi.com)
In the present article, we aimed to critically review experimental evidence regarding the active components and the molecular bases underlying the beneficial role of coffee against chronic liver diseases. (mdpi.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)

Gel shift experiments using nuclear extracts from TNF-alpha-treated cells and oligonucleotides containing the tTG nuclear factor (NF)-kappa B motif revealed increased binding, concordant with mRNA data. (nih.gov)
My first project was to investigate the role of Hepatocyte Nuclear Factor 1 (HNF1) and Nuclear Factor I (NFI) on alpha-fetoprotein (AFP) promoter activity during liver development. (uky.edu)

It had been suggested that alpha and beta polypeptides could be synthesized via a common precursor polypeptide. (rti.org)
One of the clones, pULB1148, carries a full length copy coding for both alpha 2 and beta polypeptides. (rti.org)

Nonalcoholic steatohepatitis affects approximately 3% of the lean population and 19% of obese persons, making it the most prevalent cause of chronic liver disease in the country[ 6 ]. (wjgnet.com)

We found upregulation of the key fructose transporter and metabolizing enzyme mRNAs, Slc2a2 , Khka , and Khkc , and higher ketohexokinase activity in the Hif-p4h-2 gt/gt small intestine relative to the WT, suggesting enhanced metabolism of fructose in the former. (springer.com)
p53 deletion and mutation as well as upregulation of alpha-fetoprotein (AFP) are hallmarks of hepatocarcinogenesis. (jgld.ro)

Following Bacille Calmette Guerin or Plasmodium yoelli infection, however, M phi recruited to liver and spleen hybridize strongly to the lysozyme probe. (ox.ac.uk)
AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. (betalifesci.com)

From the data of the present study we conclude that the cell cycle genes CDC42 and cyclin D1 could be involved in the mechanism of proliferation of the oval cell in the liver regeneration process. (uni-goettingen.de)
mRNA expression data of energy-related genes were extracted from our whole retinal Affymetrix microarray data. (molvis.org)

Further studies demonstrated that MitoTEMPO administration suppressed the mRNA and protein expressions of MDSC-associated proinflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), S100 calcium-binding protein A8 (S100A8), and S100 calcium-binding protein A9 (S100A9). (hindawi.com)

The Alpha VOC was estimated to have a reproduction number 43%-90% higher than previous variants and has spread worldwide, including throughout Japan ( 8 ). (cdc.gov)
The 50% plaque reduction neutralization test (PRNT50) and PRNT90 titers against wild-type (ancestral) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Alpha, Beta and Delta variants were higher in the delayed-interval group. (cdc.gov)
The dominant variants in the United States and much of the world are Alpha, Beta, Delta, and Omicron. (msdmanuals.com)

Spinal muscular atrophy (SMA) is an autosomal recessive, inherited genetic disease characterized by degeneration of alpha motor neurons in the spinal cord. (dovepress.com)
Moreover, NASH represents a progressive form of liver disease. (wjgnet.com)

Almost all studies highlighted the beneficial effects of this beverage against liver fibrosis with the most solid results indicating a pivot role for both caffeine and chlorogenic acids. (mdpi.com)

These include messenger ribonucleic acid (mRNA) vaccines, protein subunit and virus-like particle (VLP) vaccines, and non-replicating viral vector vaccines. (canada.ca)
The prevalent viral lineage shifted from B.1.1.214 in the third wave to the Alpha variant in the fourth wave. (cdc.gov)

This glucose-induced increase in microsomal DAG was attended by increases in immunoreactive PKC alpha, beta, and epsilon. (jci.org)
Amylo-α-1,6-glucosidase ( EC 3.2.1.33 ), or glucosidase , cleaves the remaining alpha-1,6 linkage, producing glucose and a linear chain of glycogen. (wikidoc.org)
In E. coli , Glucose transfer is performed by 4-alpha-glucanotransferase, a 78.5 kDa protein coded for by the gene malQ. (wikidoc.org)

Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1. (uchicago.edu)

Hep G2 cells, transiently transfected with a luciferase reporter containing 1.67 kb of the human tTG promoter, showed an increase in reporter activity after addition of TNF-alpha. (nih.gov)
Furthermore, Hep G2 cells are incapable of upmodulating tTG promoter reporter activity in the presence of TNF-alpha when those cells overexpress a transdominant, negative mutant NF-kappa B subunit. (nih.gov)
To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
Within 24 h of infection, cells found in the marginal zone of the spleen begin to produce lysozyme mRNA. (ox.ac.uk)
Later in the infection, other cells in the red and white pulp of the spleen, and cells in granulomas in the liver, become lysozyme-positive. (ox.ac.uk)

This down-regulation appears to control the steady-state level of albumin mRNA in the liver. (jci.org)
Accordingly, full-length isoforms of p53, p63 and p73 efficiently downregulated AFP both on mRNA and protein level. (jgld.ro)
I also demonstrate that Elovl3 is repressed in the regenerating liver and that the level of Elovl3 repression is controlled by alpha-fetoprotein regulator 2 (Afr2). (uky.edu)

Predicted to enable importin-alpha family protein binding activity. (nih.gov)
In conclusion, changes in Elovl-5 expression may account for much of the nutritional and developmental control of fatty acid elongation activity in the rat liver. (oregonstate.edu)

Human haptoglobin (Hp) is a plasma glycoprotein composed of alpha and beta polypeptide chains that are covalently associated by disulfide bonds. (rti.org)
We report the molecular cloning of DNA complementary to human Hp mRNA. (rti.org)
DEHP is not classifiable as to its carcinogenicity to humans (Group 3) because peroxisome proliferation has not been documented in human hepatocyte cultures exposed to DEHP nor in the liver of exposed non-human primates. (who.int)

Anatomy26

Organisms13

Diseases19

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes54

Disciplines and Occupations1

Information Science3

Hepatic15

Proteins8

BNT162b21

Study demonstrates the induction2

Tumor7

Fibrosis in mice3

NAFLD14

Situ hybridization2

Tissues5

Hepatocyte nucle1

Preferentially2

Vitro1

Levels13

Induction2

Enzymes4

Vaccine6

Intestinal2

Fetal liver2

Correlate1

Hepatocellular1

Transcript3

Alterations1

Mice3

Inflammation in the liver2

Inflammatory response3

Accumulation2

Lipid2

Tissue2

Hepatocytes2

Adult2

Synthesis2

Significantly1

Fatty liver2

Ranging from normal liver1

Diseases3

Nuclear2

Polypeptides2

Steatohepatitis1

Upregulation2

Strongly2

Genes2

Mediators1

Variants3

Disease2

Results1

Viral2

Glucose3

Regulatory1

Cells5

Level3

Activity2

Human3