In patients with pheochromocytoma, administration of metyrosine reduces catecholamine biosynthesis by 35-80%, as measured by urinary catecholamine levels. (medscape.com)
It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors. (medscape.com)
Metyrosine inhibits tyrosine hydroxylase, the rate-limiting step in catecholamine synthesis. (medscape.com)
Inhibits1
It inhibits postsynaptic alpha-adrenergic receptors, resulting in the vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure. (medscape.com)
Agonists1
Alpha-2 agonists often have a sedating effect and are commonly used as anesthesia enhancers in surgery, as well as in treatment of drug or alcohol dependence . (wikipedia.org)
Propranolol1
After primary treatment with an alpha-receptor blocker, propranolol hydrochloride may be used as adjunctive therapy if control of tachycardia becomes necessary before or during surgery. (medscape.com)
Blockade2
Its drug action is transient and alpha-adrenergic blockade incomplete. (medscape.com)
Drug therapy for control of blood pressure includes alpha-blockade, usually combined with beta-blockade. (msdmanuals.com)
Blockers3
At low doses, alpha-adrenergic receptor blockers may be used as monotherapy in the treatment of hypertension. (medscape.com)
As a result, concurrent diuretic therapy may be required to maintain the hypotensive effects of alpha-receptor blockers. (medscape.com)
Alpha blockers , which counter a different set of noradrenaline effects, are used to treat several cardiovascular and psychiatric conditions. (wikipedia.org)
Guanfacine1
For reasons that are still unclear, some Alpha-2 drugs, such as guanfacine , have also been shown to be effective in the treatment of anxiety disorders and ADHD . (wikipedia.org)
Weeks1
Preoperatively, prepare patients with pheochromocytomas by treating them with an alpha-blocker or a tyrosine hydroxylase inhibitor, such as metyrosine, for 1-2 weeks, after which administration of a beta-blocker can be considered. (medscape.com)
Agent2
This is a nonselective alpha-adrenergic blocking agent. (medscape.com)
In March 2022, TYME Technologies, Inc. announced the availability of the poster abstract, "SM-88, D/L-alpha-metyrosine, is a novel anti-cancer agent in estrogen receptor-positive breast cancer," which was submitted by researchers from Georgetown University. (latestsharenews.com)
Drug1
α-Methyltyrosine, Metyrosine USAN, AMPT) is an antihypertensive drug. (wikipedia.org)
DEMSER3
DEMSER 1 (Metyrosine) is (-)-α-methyl- L -tyrosine or (α-MPT). (nih.gov)
When DEMSER is used preoperatively, alone or especially in combination with alpha-adrenergic blocking drugs, adequate intravascular volume must be maintained intraoperatively (especially after tumor removal) and postoperatively to avoid hypotension and decreased perfusion of vital organs resulting from vasodilatation and expanded volume capacity. (nih.gov)
While the preoperative use of DEMSER in patients with pheochromocytoma is thought to decrease intraoperative problems with blood pressure control, DEMSER does not eliminate the danger of hypertensive crises or arrhythmias during manipulation of the tumor, and the alpha-adrenergic blocking drug, phentolamine, may be needed. (nih.gov)
Paraganglioma2
6. Preoperative Metyrosine Improves Cardiovascular Outcomes for Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma. (nih.gov)
11. Perioperative hemodynamics and outcomes of patients on metyrosine undergoing resection of pheochromocytoma or paraganglioma. (nih.gov)
AMPT1
α-Methyltyrosine, Metyrosine USAN, AMPT) is an antihypertensive drug. (wikipedia.org)
Preoperative2
Preoperative preparation requires combined alpha and beta blockade to control blood pressure and to prevent an intraoperative hypertensive crisis. (medscape.com)
4. Alpha blockade in preoperative preparation of patients with pheochromocytomas. (nih.gov)
Capsule1
Each capsule contains 250 mg metyrosine. (nih.gov)
Beta blockade1
Drug therapy for control of blood pressure includes alpha-blockade, usually combined with beta-blockade. (msdmanuals.com)
Hypertensive crisis2
Alpha-adrenergic blockade, in particular, is required to control blood pressure and prevent a hypertensive crisis. (medscape.com)
Beta blockers are not administered until adequate alpha blockade has been established, however, because unopposed alpha-adrenergic receptor stimulation can precipitate a hypertensive crisis. (medscape.com)
Phentolamine2
During surgery, intravenous phentolamine, a rapid-acting alpha-adrenergic antagonist, is used to control blood pressure. (medscape.com)
Phentolamine mesylate is a nonselective alpha-adrenergic blocking agent that produces transient and incomplete alpha-adrenergic blockade. (medscape.com)
Tumor1
A novel tumor metabolism-altering oral regimen that combines a tyrosine derivative (D,L--alpha-metyrosine) with 3 repurposed agents (sirolimus, phenytoin, and methoxsalen) has demonstrated promising activity in patients with previously treated metastatic pancreatic cancer. (theoncologypharmacist.com)
Drugs1
This denatured agent [D,L-alpha-metyrosine] plus the 3 other repurposed drugs are designed to capitalize on that, such that they're going to -increase uptake of D,L-alpha--metyrosine into the cell, and hopefully that will result in cell death. (theoncologypharmacist.com)
Arrhythmias1
17. Influence of alpha-adrenergic blockade on ventricular arrhythmias, QTc interval and heart rate variability in phaeochromocytoma. (nih.gov)
Surgery1
These medications are not used to prepare patients for surgery, because of their incomplete alpha blockade. (medscape.com)
Patients4
Plasma half-life of metyrosine determined over an 8-hour period after single oral doses was 3-3.7 hours in three patients. (nih.gov)
In most patients, the duration of treatment has been two to eight weeks, but several patients have received Metyrosine for periods of 1 to 10 years. (nih.gov)
We don't have FDA-approved agents specifically for the third line, so the thought is if we can use D,L-alpha--metyrosine, which is well tolerated, there may be an opportunity to benefit patients. (theoncologypharmacist.com)
In part 1 of the trial, 38 patients were randomized to D,L-alpha-metyrosine 230 mg twice daily or 460 mg twice daily. (theoncologypharmacist.com)
Effects2
It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors. (medscape.com)
These metabolites are probably not present in sufficient amounts to contribute to the biochemical effects of metyrosine. (nih.gov)
Management1
One patient in the D,L-alpha--metyrosine 460-mg twice--daily arm had 2 adverse events (ie, rash and arthralgia) that were considered to be dose--limiting toxicities, but the patient resumed treatment after successful management of the events. (theoncologypharmacist.com)
Oral1
Metyrosine is supplied as capsules for oral administration. (nih.gov)
Control2
Metyrosine is not recommended for the control of essential hypertension. (nih.gov)
Se utiliza para el control de los síntomas de una excesiva estimulación simpática en los pacientes con FEOCROMOCITOMA. (bvsalud.org)