Compared to alpha-blockers that focus on providing the rapid relief of symptoms, 5α-reductase inhibitors aim to target the underlying disease by blocking the effects of the primary androgen involved in benign prostate hyperplasia and androgenic alopecia, thus reducing the risk for secondary complications while providing symptom control. (drugbank.com)
DHT plays a primary role in the formation of the male genitalia during embryogenesis and it acts as the primary androgen in the prostate and hair follicles in adulthood. (chromservis.eu)
Receptor4
DHT is thought to be approximately 30 times more potent than testosterone because of increased affinity to the androgen receptor. (foodb.ca)
CSGV was identified in the androgen receptor genes in all breast tumors examined. (oaepublish.com)
For example, in breast cancer, specific external environmental factors have included estrogen receptor alpha (ER) activation by estradiol [ 4 ] and conversion of estrogen into genotoxic metabolites that can cause DNA double-strand breaks [ 5 ] . (oaepublish.com)
Steroid5
The systematic name of this enzyme class is steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating). (wikipedia.org)
These are 3-hydroxylated C19 steroid hormones. (foodb.ca)
Finasteride is a synthetic 4-azasteroid compound 13 and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). (drugbank.com)
Oxandrolone is a well tolerated 17 alpha alkylated anabolic steroid with very low hepatic toxicity. (redespaulista.com)
Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane, catalyzes this reaction. (reactome.org)
Hair follicles1
Dihydrotestosterone (DHT) (INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5-alpha-reductase by means of reducing the alpha 4,5 double-bond. (foodb.ca)
Androgenic2
Dihydrotestosterone belongs to the class of compounds called androgens, also commonly called androgenic hormones or testoids. (foodb.ca)
Both benign prostatic hyperplasia and androgenic alopecia are androgen-dependent disorders that are characterized by in situ high levels of DHT. (drugbank.com)
Glucocorticoid1
These findings seem to suggest a novel mechanism for ST whereby membrane associated glucocorticoid binding activity is targeted by the 16beta hydroxylated metabolite of ST. Healthcare settings must also be certified with the REMS Program and must have the resources to provide emergency medical treatment in cases of serious POME and anaphylaxis. (redespaulista.com)
Testosterone1
Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. (foodb.ca)
Compounds2
Belongs to the class of organic compounds known as androgens and derivatives. (foodb.ca)
These are polycyclic compounds containing a hydroxylated isoflavan skeleton. (drugbank.com)
Prostate1
2 In the treatment of benign prostate hyperplasia, alpha-blockers such as tamsulosin and terazosin are also used. (drugbank.com)
Effects2
It works in a similar fashion as dutasteride , which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects. (drugbank.com)
It's been the key ingredient in Alpha-T2 for its fat loss and thermogenic effects, and we deliver it here with an even more complete blend of ingredients and synergy. (helpyougetgains.com)
Loss1
Finasteride is an antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. (drugbank.com)
Biologically active alpha-hydroxylated2
Following a single 250 mg oral dose to normal adult volunteers, the biologically active alpha-hydroxylated metabolite reaches maximum plasma concentrations in about 2 hours, indicating that it is rapidly formed from flutamide. (nih.gov)
The major plasma metabolite is a biologically active alpha-hydroxylated derivative which accounts for 23% of the plasma tritium 1 hour after drug administration. (sdrugs.com)
Hydrogen-donor:oxygen oxidoreductase1
The systematic name of this enzyme class is steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating). (wikipedia.org)
Metabolites4
UGT1A3 was also inactive towards androgens and their metabolites. (nih.gov)
The enzyme preferentially glucuronidated the N-hydroxy metabolite of 2-acetylaminofluorence and was more active towards the 6- and 12-hydroxylated metabolites of benzo[alpha]pyrene. (nih.gov)
Morfin R, Courchay G. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice . (scholaris.sk)
30. Different action of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolites on ERα and ERβ gene and protein expression. (nih.gov)
Metabolite1
The plasma half-life for the alpha-hydroxylated metabolite of flutamide is approximately 6 hours. (nih.gov)
Estrone2
Estrone is hydroxylated through Phase 1 detox to form 4-OH-E1. (healthmatters.io)
It was observed that metabolism of both E2 and EE2 proceeded with the formation of estrone, which was then hydroxylated to 4-hydroxy estrone, followed by ring opening at the C4-C5 position, and was further metabolized by the 4,5 seco pathway leading to the formation of 3-(7a-methyl-1,5-dioxooctahydro-1H-inden-4-yl) propanoic acid (HIP). (bvsalud.org)
Cytochrome1
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE . (nih.gov)
Target tissues1
It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. (nih.gov)
Flutamide1
23. The effect of flutamide on expression of androgen and estrogen receptors in the gubernaculum and surrounding structures during testicular descent. (nih.gov)
Synthesis1
For skin, silicon is important for optimal collagen synthesis and activation and hydroxylating enzymes, improving skin strength and elasticity. (vitagene.co.za)
Secondary1
The weight gain and improvement in sexual behavior parameters observed in rats could be secondary to the androgen increasing property of TT (PTN) that was observed in our earlier study on primates. (ironmaglabs.com)
Subsequent2
25. Androgen receptors are acquired by healthy postmenopausal endometrial epithelium and their subsequent loss in endometrial cancer is associated with poor survival. (nih.gov)
The increase in ICP which confirms the proerectile aphrodisiac property of TT could possibly be the result of an increase in androgen and subsequent release of nitric oxide from the nerve endings innervating the corpus cavernosum. (ironmaglabs.com)
Activity2
In particular, unbalanced androgen/estrogen levels and/or activity are believed to represent the key events for TGCT development and progression. (nih.gov)
It is concluded that TT extract appears to possess aphrodisiac activity probably due to androgen increasing property of TT (observed in our earlier study on primates). (ironmaglabs.com)
[ 8 ] When local oxygen tension is low, HIF1α cannot be hydroxylated and binds to an enhancer sequence region on the erythropoietin gene, leading to an increase in the erythropoietin production. (medscape.com)