InhibitorsInhibitorEnzymeAcarboseInhibitoryEnzymesGlucoseDeficiencyInhibition assay showedPompeVitro inhibitionIC50ActivityBiochemicalCompoundsCatalyticHumanResiduesTypeRecognitionReleaseProductionEffectGlycogenInhibition of alpha glucosidaseNeutral alpha-glucosidaseAcid maltaseLysosomal acidIntestinalGlucanGlucoamylasePompe DiseaseGene coding foStarchAspergillusEnzyme responsibleProteinMutationsResultsRoleClassEffects
Inhibitors4
- α-glucosidase inhibitors are used as adjuncts to help regulate glucose levels in patients with type 2 diabetes mellitus. (guidetopharmacology.org)
- Alpha-glucosidase inhibitors, such as miglitol (Glyset) and acarbose (Precose), impair the digestion of carbohydrates and can help prevent spikes in blood sugar throughout the day, according to StatPearls . (everydayhealth.com)
- One of the first-line therapy of diabetes mellitus is alpha-glucosidase inhibitors. (thesciencein.org)
- Alpha-glucosidase inhibitors are a less popular class of medicines for type 2 diabetes. (healthworldnet.com)
Inhibitor2
- Alpha-glucosidase inhibitor which acts within the gastrointestinal tract without being absorbed, reducing intestinal absorption of glucose. (e-lactancia.org)
- SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. (frontiersin.org)
Enzyme10
- Lysosomal alpha-glucosidase may refer to: Glucan 1,4-a-glucosidase, an enzyme Acid alpha-glucosidase, an enzyme This set index page lists enzyme articles associated with the same name. (wikipedia.org)
- Acid alpha-glucosidase, also called α-1,4-glucosidase and acid maltase, is an enzyme (EC 3.2.1.20) that helps to break down glycogen in the lysosome. (wikipedia.org)
- α-glucosidase is an essential enzyme for the production of isomaltooligosaccharides (IMOs). (mdpi.com)
- Recombinant alpha glucosidase agents are used as enzyme replacement therapies to treat Pompe disease. (guidetopharmacology.org)
- Pompe disease (PD) is caused by the deficiency of the lysosomal enzyme acid α-glucosidase (GAA), resulting in systemic pathological glycogen accumulation. (nih.gov)
- Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene. (wikipedia.org)
- This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. (wikipedia.org)
- The food enzyme with glucan 1,4-α-glucosidase (EC 3.2.1.3) and α-amylase (EC 3.2.1.1) activities is produced with the genetically modified strain of Aspergillus niger NZYM-BX by Novozymes A/S. The genetic modifications do not give rise to safety concerns. (ilvo.be)
- A study published in the April 2008 edition of 'Journal of Food Biochemistry' discovered that tea inhibits the activities of the enzyme known as alpha-glucosidase. (livestrong.com)
- Alpha glucosidase is a potential target enzyme in the management of diabetes mellitus. (researchgate.net)
Acarbose1
- After oral application of acarbose, human intestinal α-glucosidases are inhibited, which leads to a retarded release of monosaccharides. (frontiersin.org)
Inhibitory6
- Due to side effects caused by synthetic drugs and limited sources, various studies have been conducted on herbal plants and macroalgae consisting of bioactive compounds with alpha-glucosidase inhibitory activity. (thesciencein.org)
- This study examines the alpha-glucosidase inhibitory activity and phytochemical compounds in ethyl acetate and ethanol extract of Bornetella oligospora , an abundant green alga in eastern Indonesia. (thesciencein.org)
- The aim of this work was to evaluate the inhibitory activities of methanolic extracts of tomato powder incorporated rice based cold extrudates on α- amylase and α-glucosidase enzymes. (journalcra.com)
- The total phenolic content (TPC), antioxidant activity, and in vitro inhibitory activity of yeast alpha-glucosidase were examined for the extracts in the present study. (cranberryinstitute.org)
- GT had higher TPC and antioxidant activity, but CR demonstrated a greater alpha-glucosidase inhibitory activity, on phenolic basis. (cranberryinstitute.org)
- TPC, antioxidant activity, and yeast alpha-glucosidase inhibitory activity were determined for the fractions. (cranberryinstitute.org)
Enzymes7
- GAA is one member of the α-glucosidase family of enzymes which break down starch and disaccharides to glucose. (guidetopharmacology.org)
- Successful treatment of patients with glycolipid processing defects using iminosugars highlights the clinical exploitation of iminosugar inhibition of enzymes other than ER α-glucosidases. (ox.ac.uk)
- It provides a structural model for enzymes representing the major specificity in glycoside hydrolase family 31 (GH31), including a-glucosidases from higher organisms, involved in glycogen degradation and glycoprotein processing. (ku.dk)
- Among the various anti-diabetic therapeutic approaches one major strategy is reducing gastrointestinal absorption of glucose by inhibition of carbohydrate metabolizing enzymes α -amylase and α - glucosidase. (journalcra.com)
- Alpha-glucosidase is one of the enzymes involved in the starch degradation pathway that produces sugars for the growing embryo in barley (Hordeum vulgare L.) seeds. (usda.gov)
- Unfortunately, alpha-glucosidase is one of the most thermolabile of the starch hydrolyzing enzymes in barley seeds so its contribution to the production of fermentable sugars at these temperatures is limited. (usda.gov)
- The company produced the industrial enzymes alpha-amylase, amyl glucosidase, and protease. (cdc.gov)
Glucose8
- This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. (wikipedia.org)
- Catalysis of the hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose. (yeastrc.org)
- It is caused by deficiency of functional lysosomal acid alpha-glucosidase (GAA) which leads to accummulation of glucose in muscle cells, that causes irreversible cell damage. (guidetopharmacology.org)
- By comparison to bicyclic glucose-mimicking iminosugars which inhibit glycoprotein processing but do not inhibit glycolipid processing and galactose-mimicking iminosugars which do not inhibit glycoprotein processing but do inhibit glycolipid processing, we demonstrate that inhibition of endoplasmic reticulum-resident α-glucosidases, not glycolipid processing, is responsible for iminosugar antiviral activity against DENV. (ox.ac.uk)
- Green tea (GT), cranberry (CR), and tart cherry extracts were evaluated for their ability to inhibit yeast alpha-glucosidase, relevant to glucose uptake. (cranberryinstitute.org)
- Our findings suggest that CR has the greatest potential to possibly manage post-prandial blood glucose levels via the inhibition of alpha-glucosidase, and that the effect is through synergistic activity of the extract's phenolic compounds. (cranberryinstitute.org)
- Alpha-glucosidase regulates the absorption of glucose by the small intestine. (livestrong.com)
- 2013) compared conventional standard therapy with lifestyle modification to a single type of Bariatric operation (Roux-en-Y gastric procedure [RYGB]) and measured the effect on glucose control in patients with T2DM. (bartleby.com)
Deficiency2
- Alpha-glucosidase deficiency. (hopkinsmedicine.org)
- Alpha 1-antitrypsin deficiency. (hopkinsmedicine.org)
Inhibition assay showed1
- The alpha-glucosidase inhibition assay showed IC50 values of the ethanol extract was 11.702 ug/mL and ethyl acetate extract was 95.384 ug/mL. (thesciencein.org)
Pompe1
- Pompe en cuidados intensivos. (bvsalud.org)
Vitro inhibition2
- 2000) In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives. (guidetopharmacology.org)
- Evaluation of Phenolic Phytochemical Enriched Commercial Plant Extracts on the In Vitro Inhibition of alpha-Glucosidase. (cranberryinstitute.org)
IC501
- The α- glucosidase IC50 for the extrudate extracts of control extrudates and TP extrudates was found to be 52.50 mg/ml and 45.14 mg/ml respectively. (journalcra.com)
Activity5
- It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a diverse spectrum of viruses, including dengue virus (DENV). (ox.ac.uk)
- Evidence correlating antiviral activity with successful inhibition of ER glucosidases together with the exclusion of alternative mechanisms of action of iminosugars in the context of DENV infection is limited. (ox.ac.uk)
- View of In-vitro Alpha-amylase and Alpha-glucosidase activity of Costus pictus D. Don and Costus speciosus (J. Koenig) Sm. (tojqi.net)
- Parameters evaluated in this research were phytochemical screening, total phenolics, flavonoid content, DPPH free-radical scavenging activity, and alpha glucosidase inhibiting (AGI) activity. (ipb.ac.id)
- CAE had a greater TPC and antioxidant activity than CME, but the two fractions had a synergistic effect when inhibiting yeast alpha-glucosidase. (cranberryinstitute.org)
Biochemical1
- Biochemical properties such as production of alpha-amylase, beta-glucosidase, tannase, antimicrobials (presumptive bacteriocin and H(2)O(2)-production), acidification and fermentation of the indigestible sugars raffinose and stachyose, were evaluated in vitro for selection of potential starter strains. (who.int)
Compounds1
- Compounds that inhibit ALPHA-GLUCOSIDASE. (bvsalud.org)
Catalytic1
- Allowing α-glucosidase to operate at higher temperatures (above 60 °C) has many advantages, including reducing the viscosity of the reaction solution, enhancing the catalytic reaction rate, and achieving continuous production of IMOs. (mdpi.com)
Human1
- Human lysosomal alpha-glucosidase. (wikipedia.org)
Residues1
- It reveals Arg400, Asp87, Trp284, Met321 and Phe327 as invariant residues forming the +1 subsite in the GH31 a-glucosidases. (ku.dk)
Type1
- En 2010, l'ACMTS a produit un rapport d'utilisation optimale au sujet des pharmacothérapies de deuxième et troisième intention dans le traitement du diabète de type 2 (DT2), puis une mise à jour en 2013. (cadth.ca)
Recognition1
- One mutation that inserted a N-glycosylation recognition sequence towards the C-terminus of barley alpha-glucosidase resulted in a 7C increase in the enzyme's thermostability. (usda.gov)
Release1
- Our data suggest that inhibition of ER α-glucosidases prevents release of virus and is the primary antiviral mechanism of action of iminosugars against DENV. (ox.ac.uk)
Production1
- Isoeugenol (2-methoxy-4-(prop-1-en-1-yl)phenol), a component of from clove (Eugenia caryophylata) oil, is a starting material for both the biotechnological and synthetic production of vanillin and vanillic acid. (researchgate.net)
Effect1
- 2012) specifically examined the long term effect of Roux-en-Y gastric bypass surgery on patients with T2DM with Class I obesity (BMI between 30-35 kg/m2). (bartleby.com)
Glycogen7
- Acid alpha-glucosidase, also called α-1,4-glucosidase and acid maltase, is an enzyme (EC 3.2.1.20) that helps to break down glycogen in the lysosome. (wikipedia.org)
- This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. (wikipedia.org)
- Without enough of this enzyme, called acid alpha-glucosidase (GAA), glycogen can accumulate destructively in the liver, heart, and skeletal muscles, making it increasingly difficult to walk, eat, and even breathe. (nih.gov)
- Lysosomal Alpha Glucosidase (GAA, otherwise called Alpha Acid-Glucosidase) is a catalyst that corrupts glycogen into glucose. (phrconference.org)
- This biochemical analysis of Alpha-glucosidase enzyme activity can be used as a 1st tier test for patients with a clinical suspicion of Glycogen Storage Disease Type II, Pompe disease. (ggc.org)
- Acid alpha-glucosidase normally breaks down a complex sugar called glycogen into a simpler sugar called glucose. (nih.gov)
- Mutations in this gene significantly reduce the activity of acid alpha-glucosidase, preventing the enzyme from breaking down glycogen effectively. (nih.gov)
Inhibition of alpha glucosidase3
- Intestinal absorption studies using noneverted intestinal sacs, as well as in vivo studies in streptozotocin-induced diabetic rats using oral glucose tolerance with maltose and sucrose load, revealed better inhibition of alpha glucosidase as compared to acarbose. (hindawi.com)
- In the present study Cymbopogon martinii (CM) belonging to the poaceae (Gramineae) family has been evaluated for its antidiabetic action through inhibition of alpha glucosidase in streptozotocin-induced diabetic rats and by evaluation of intestinal transport of sucrose and maltose. (hindawi.com)
- 3. Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. (nih.gov)
Neutral alpha-glucosidase2
- Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene. (wikipedia.org)
- Martiniuk F, Hirschhorn R , Human neutral alpha-glucosidase C: genetic polymorphism including a "null" allele. (coriell.org)
Acid maltase1
- The GAA gene provides instructions for producing an enzyme called acid alpha-glucosidase (also known as acid maltase). (nih.gov)
Lysosomal acid1
- Lysosomal acid alpha-glucosidase consists of four different peptides processed from a single chain precursor. (nih.gov)
Intestinal4
- In the in vitro study, d-psicose potently inhibited the intestinal sucrase and maltase, however, slightly inhibited the intestinal and salivary alpha-amylase activities. (nih.gov)
- Effective Control of Postprandial Glucose Level through Inhibition of Intestinal Alpha Glucosidase by Cymbopogon martinii (Roxb. (hindawi.com)
- Inhibition of intestinal alpha glucosidase plays a major role in preventing rise in postprandial glucose level in diabetics. (hindawi.com)
- Alpha glucosidase is an intestinal brush border enzyme responsible for the hydrolysis of disaccharides which is necessary for the absorption of starch, dextrins and disaccharides. (nih.gov)
Glucan1
- Lysosomal alpha-glucosidase may refer to: Glucan 1,4-a-glucosidase, an enzyme Acid alpha-glucosidase, an enzyme This set index page lists enzyme articles associated with the same name. (wikipedia.org)
Glucoamylase1
- The alpha glucosidases are exoglycosidases found on the luminal surface of enterocytes containing maltase/glucoamylase and sucrase/isomaltase activity [ 2 ]. (hindawi.com)
Pompe Disease2
- The emerging data from the first clinical acid alpha-glucosidase for enzyme replacement therapy trials with rhGAA suggested that the most critical factor have been major milestones in Pompe disease research. (medpdfarticles.com)
- Pompe disease is caused by mutations in a gene that makes acid alpha-glucosidase. (medscape.com)
Gene coding fo1
- The gene coding for human lysosomal alpha-glucosidase was cloned and its structure was determined. (nih.gov)
Starch1
- Cell-associated oligo-1,6-alpha-glucosidase (EC 3.2.1.10) was isolated from Thermoanaerobium Tok6-B1 grown on starch-containing medium. (waikato.ac.nz)
Aspergillus1
- Streptozotocin, α -amylase from Aspergillus oryzae , alpha glucosidase from Saccharomyces cerevisiae , and p -Nitrophenyl α -D-glucopyranoside (PNPG) were purchased from Sigma Chemicals, USA. (hindawi.com)
Enzyme responsible1
- defining the outcome of therapy is the underlying skeletal Acid alpha-glucosidase is the enzyme responsible muscle pathology at the start of therapy. (medpdfarticles.com)
Protein3
- Many of these mutations change one of the protein building blocks (amino acids) used to make acid alpha-glucosidase. (nih.gov)
- In addition, abnormal clumps called Lewy bodies, which contain the protein alpha-synuclein, are found in many brain cells of individuals with Parkinson's disease. (medicinenet.com)
- SNCA (synuclein, alpha non-A4 component of amyloid precursor): SNCA makes the protein alpha-synuclein. (medicinenet.com)
Mutations1
- It is caused by mutations in a gene that makes an enzyme called acid alpha-glucosidase (GAA). (biospace.com)
Results1
- Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I. (nih.gov)
Role2
- Tyrosinase folding and copper loading in vivo: a crucial role for calnexin and alpha-glucosidase II. (ox.ac.uk)
- Thus, tyrosinase folds off calnexin, giving alpha-glucosidase II a critical role, but the association with calnexin is essential to promote the correct folding which enables it to acquire copper. (ox.ac.uk)
Class1
- As peptides loaded onto newly synthesized MHC class I complexes are predominantly derived from proteasomes, the possibility that glucosidase inhibition could increase presentation by MHC class I was determined. (nih.gov)
Effects1
- In this study, we investigated the effects of d-psicose on the activities of alpha-amylases and alpha-glucosidases in vitro, and evaluated the effects of d-psicose on the in vivo postprandial glycemic response using rats. (nih.gov)