SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. (frontiersin.org)
Acarbose1
After oral application of acarbose, human intestinal α-glucosidases are inhibited, which leads to a retarded release of monosaccharides. (frontiersin.org)
Enzyme4
α-glucosidase is an essential enzyme for the production of isomaltooligosaccharides (IMOs). (mdpi.com)
Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene. (wikipedia.org)
This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. (wikipedia.org)
Pompe disease (PD) is caused by the deficiency of the lysosomal enzyme acid α-glucosidase (GAA), resulting in systemic pathological glycogen accumulation. (nih.gov)
Glycogen1
It provides a structural model for enzymes representing the major specificity in glycoside hydrolase family 31 (GH31), including a-glucosidases from higher organisms, involved in glycogen degradation and glycoprotein processing. (ku.dk)
Residues1
It reveals Arg400, Asp87, Trp284, Met321 and Phe327 as invariant residues forming the +1 subsite in the GH31 a-glucosidases. (ku.dk)
Higher1
Allowing α-glucosidase to operate at higher temperatures (above 60 °C) has many advantages, including reducing the viscosity of the reaction solution, enhancing the catalytic reaction rate, and achieving continuous production of IMOs. (mdpi.com)
Intestinal alpha-Glucosidase2
Effective Control of Postprandial Glucose Level through Inhibition of Intestinal Alpha Glucosidase by Cymbopogon martinii (Roxb. (hindawi.com)
Inhibition of intestinal alpha glucosidase plays a major role in preventing rise in postprandial glucose level in diabetics. (hindawi.com)
Inhibitors6
Alpha glucosidase inhibitors are useful as they reduce the cardiovascular risk [ 1 ]. (hindawi.com)
Using either a model epitope, or a natural MHBs epitope, it was demonstrated that glucosidase inhibitors enhanced presentation by MHC class I and promoted activation of antigen-specific CTLs, suggesting a pharmacologic approach to immune modulation. (nih.gov)
Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. (nih.gov)
Whereas tea extracts and catechin 3-gallates were less effective inhibitors of α-amylase, they were potent inhibitors of α-glucosidase. (nih.gov)
The data show that plant extracts containing catechin 3-gallates, in particular epigallocatechin gallate, are potent inhibitors of α-glucosidase activity and suggest that procyanidins in grape seed extract strongly inhibit α-amylase activity. (nih.gov)
Inhibition4
Intestinal absorption studies using noneverted intestinal sacs, as well as in vivo studies in streptozotocin-induced diabetic rats using oral glucose tolerance with maltose and sucrose load, revealed better inhibition of alpha glucosidase as compared to acarbose. (hindawi.com)
In the present study Cymbopogon martinii (CM) belonging to the poaceae (Gramineae) family has been evaluated for its antidiabetic action through inhibition of alpha glucosidase in streptozotocin-induced diabetic rats and by evaluation of intestinal transport of sucrose and maltose. (hindawi.com)
Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I. (nih.gov)
As peptides loaded onto newly synthesized MHC class I complexes are predominantly derived from proteasomes, the possibility that glucosidase inhibition could increase presentation by MHC class I was determined. (nih.gov)
Gene coding fo1
The gene coding for human lysosomal alpha-glucosidase was cloned and its structure was determined. (nih.gov)
Acarbose1
Results showed that grape seed extract strongly inhibited both α-amylase and α-glucosidase activity, with equal and much higher potency, respectively, than acarbose. (nih.gov)
Maltase2
In the in vitro study, d-psicose potently inhibited the intestinal sucrase and maltase, however, slightly inhibited the intestinal and salivary alpha-amylase activities. (nih.gov)
The alpha glucosidases are exoglycosidases found on the luminal surface of enterocytes containing maltase/glucoamylase and sucrase/isomaltase activity [ 2 ]. (hindawi.com)
Activity3
The alpha glucosidase inhibitory activity was detected in the chloroform fraction. (hindawi.com)
Genomic organization and promoter activity of glucosidase I gene. (nih.gov)
This study evaluated the inhibitory effects of plant-based extracts (grape seed, green tea, and white tea) and their constituent flavan-3-ol monomers (catechins) on α-amylase and α-glucosidase activity, two key glucosidases required for starch digestion in humans. (nih.gov)
Role2
Tyrosinase folding and copper loading in vivo: a crucial role for calnexin and alpha-glucosidase II. (ox.ac.uk)
Thus, tyrosinase folds off calnexin, giving alpha-glucosidase II a critical role, but the association with calnexin is essential to promote the correct folding which enables it to acquire copper. (ox.ac.uk)