• citation needed] Two faint bands may be seen representing alpha-1 antichymotrypsin and vitamin D binding protein. (wikipedia.org)
  • In previous studies, NBR rats were shown not to develop renal disease when exposed to decalin, a compound known to induce α2u-globulin nephropathy in other rat strains. (uni-konstanz.de)
  • Interferon alpha has been used for control of serious viral infections, such as widespread warts or herpes simplex virus. (wikipedia.org)
  • Initial research focused on their role in human disease: alpha 1-antitrypsin deficiency is one of the most common genetic disorders, causing emphysema, and antithrombin deficiency results in thrombosis. (wikipedia.org)
  • When the blood contains inadequate amounts of A1AT or functionally defective A1AT (such as in alpha-1 antitrypsin deficiency), neutrophil elastase is excessively free to break down elastin, degrading the elasticity of the lungs, which results in respiratory complications, such as chronic obstructive pulmonary disease, in adults. (wikipedia.org)
  • Disorders of this protein include alpha-1 antitrypsin deficiency, an autosomal codominant hereditary disorder in which a deficiency of alpha-1 antitrypsin leads to a chronic uninhibited tissue breakdown. (wikipedia.org)
  • Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. (wikipedia.org)
  • Alpha-1 antitrypsin deficiency was first described in the 1960s. (wikipedia.org)
  • Play media Symptoms of alpha-1 antitrypsin deficiency include shortness of breath, wheezing, rhonchi, and rales. (wikipedia.org)
  • In newborns, alpha-1 antitrypsin deficiency has indicators that include early onset jaundice followed by prolonged jaundice. (wikipedia.org)
  • It is decreased in the nephrotic syndrome and absence could indicate possible alpha 1-antitrypsin deficiency. (wikipedia.org)
  • On the other hand, low globulin levels could ring a different set of alarm bells, being a possible indicator of things like celiac disease, irritable bowel syndrome, anaemia, and some kidney diseases. (high-globulin.com)
  • These bands fuse and intensify in early inflammation due to an increase in alpha-1 antichymotrypsin, an acute phase protein. (wikipedia.org)
  • If a test finds abnormally high globulin levels, this could be an indicator of the following diseases: rheumatoid arthritis, leukaemia, various chronic inflammatory diseases (e.g. syphilis and tuberculosis), liver diseases such as cirrhosis and jaundice, ulcerative colitis, various autoimmune disorders, plus chronic viral and bacterial infections (e.g. hepatitis and HIV). (high-globulin.com)
  • Alpha-1 antitrypsin (A1AT) is produced in the liver, and one of its functions is to protect the lungs from neutrophil elastase, an enzyme that can disrupt connective tissue. (wikipedia.org)
  • When testing for the possibility of quite a large number of different diseases and disorders, establishing globulin levels is an important part of a doctor's diagnosis. (high-globulin.com)