• Other names in common use include UDP-D-galactose:inositol galactosyltransferase, UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase, UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase, galactinol synthase, inositol 1-alpha-galactosyltransferase, and uridine diphosphogalactose-inositol galactosyltransferase. (wikipedia.org)
  • lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. (unl.edu)
  • We attempted to determine whether beta1,3-galactosyltransferase beta3Gal-T5 is involved in the biosynthesis of a specific subset of type 1 chain carbohydrates and expressed in a cancer-associated manner. (unipv.it)
  • GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. (unl.edu)
  • This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase. (unl.edu)
  • The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. (unl.edu)
  • The systematic name of this enzyme class is UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase. (wikipedia.org)
  • The animals lack the gene responsible for "alpha-1,3-galactosyltransferase" (GT)-an enzyme normally present in the pig vascular system. (science20.com)
  • Transgenic potato plants expressing a copy of the sterolalkaloid glycosyl transferase gene (Sgt2) in the backwards orientation shows inhibition of the most abundant and least desirable end product alpha-chaconine. (usda.gov)
  • The researchers suppressed the alpha 1-3 galactosyltransferase gene which produces an epitope that is easily recognized as foreign. (zmescience.com)
  • We report a strategy for efficient transgene knock-in in the endogenous collagen type I alpha 1 chain ( COL1A1 ) gene using the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system. (chinaagrisci.com)
  • Structural Snapshots of beta-1,4-Galactosyltransferase-I Along the Kinetic Pathway. (expasy.org)
  • When compared to untreated islets, Nec‐1 treatment dou‐ bled the beta‐ and alpha‐cell composition and accelerated the development of delta cells. (crenolanibinhibitor.com)
  • In this study, we genetically transformed insect cells with mammalian beta 1,4-galactosyltransferase and alpha 2,6-sialyltransferase genes. (bvsalud.org)
  • beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta 1-->3Galbeta 1-->4GlcNAcbeta 1-->R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas. (unipv.it)
  • Measured by its ability to transfer galactose from UDP-galactose to N-Acetyl-alpha -D-glucosamine. (rndsystems.com)
  • Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. (unl.edu)
  • We first vaccinated α1,3-galactosyltransferase-knockout (α1,3GalT-KO) mice, which mimic the human immune response to α-Gal glycotopes, with Galα3LN-HSA and tested its efficacy with a lethal T. cruzi challenge. (utep.edu)
  • In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. (unl.edu)
  • A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. (musc.edu)
  • In addition, by analysis of deletion mutants, we found that lgtE, which encodes a galactosyl transferase that is required for elongating the alpha-chain, is also necessary for completing the beta chain. (silverchair.com)
  • Introduction Galactosyl transferase (uridine diphosphate-D-galactose : D-glucose-l-galactosyltransferase, EC 2.4.1.22) of bovine milk catalyzes the two basic reactions below: UDPGal + GIcNAc Me(I! (docksci.com)
  • Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. (nih.gov)
  • Here we report our initial results using -1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. (medscape.com)
  • [ 6 ] To avoid this problem, 1,3-galactosyltransferase gene knockout pigs (GalT-KO) have recently been produced which do not express the Gal epitope. (medscape.com)
  • This laboratory has recently developed genetically altered alpha-1 3 galactosyltransferase knockout inbred (GalT-KO) miniature swine which lack the alpha-galactosyl epitope. (pkc-inhibitor.com)
  • The primary target of XNA is the gal epitope (galactosyl alpha-(1,3)-galactosyl beta-1,4-N-acetyl glucosaminyl), a non-reducing trisaccharide group synthesized by New World monkeys and lower mammals, but not by humans, apes, and Old World monkeys. (nih.gov)
  • The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. (unl.edu)
  • The major cell surface target for these antibodies is the alpha-galactosyl epitope which is present in all mammals except for Old World primates and humans (16). (pkc-inhibitor.com)
  • 3. Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene. (nih.gov)
  • 4. Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase. (nih.gov)
  • 5. UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. (nih.gov)
  • 10. Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. (nih.gov)
  • 13. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase. (nih.gov)
  • 17. Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor. (nih.gov)
  • To further reduce the risk of hyperacute rejection, two different strains of alpha-1,3-galactosyltransferase gene knockout pigs, which lack the expression of the gal epitope, were recently developed. (nih.gov)
  • This gene encodes alpha-lactalbumin, a principal protein of milk. (nih.gov)
  • The GMO animal was created by removing the gene for alpha-1, 3-galactosyltransferase, which "attaches alpha-galactose sugars to cell surfaces," Medpage Today reported. (elquanah.com)
  • and the B allele encodes alpha 1-3-galactosyltransferase. (omia.org)
  • A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. (nih.gov)
  • Alpha-gal syndrome is observed in 3 types of cases in the clinic: It presents as the observation of a delayed type-1 allergic reaction within 3-6 hours after the consumption of mammalian products rich in alpha gal, after drug use, and as a result of a tick bite. (jebms.org)
  • In this review, alpha Gal syndrome was examined in detail and the possible relationship between the Bourbon virus associated with the lone star tick (A. americanum) and alpha Gal syndrome is described. (jebms.org)
  • The lab-created animal, called a "GalSafe" pig, is designed to eliminate a substance found on the surface of pigs' cells called "alpha-gal sugar" that could cause people with alpha-gal (AGS) syndrome to have an allergic reaction. (elquanah.com)
  • As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. (nih.gov)
  • In recent years, it has been identified that this mammalian oligosaccharide epitope triggers a newly discovered IgE - mediated antibody response in the body and the associated disease is called Alpha-gal Syndrome. (jebms.org)
  • Description: A sandwich ELISA kit for detection of Lymphocyte Function Associated Antigen 1 Alpha from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
  • The inside of the alpha cell then becomes electrically positive due to the closure of potassium channels that were inhibited by ATP. (smpdb.ca)