• It is thought to be the fetal analog of serum albumin. (wikipedia.org)
  • Maternal serum alpha-fetoprotein (MSAFP) screening is performed at 16 to 18 weeks of gestation. (wikipedia.org)
  • Description: A sandwich ELISA for quantitative measurement of Human Alpha fetoprotein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (rbprotein.com)
  • Lee Biosolutions supplies and produces HUMAN SERUM ALBUMIN for medical research and in vitro diagnostic manufacturing. (leebio.com)
  • Serum albumin is the most abundant blood plasma protein and is produced in the liver and forms a large proportion of all plasma protein. (leebio.com)
  • The human version is human serum albumin, and it normally constitutes about 60% of human plasma protein. (leebio.com)
  • The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. (promab.com)
  • The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (promab.com)
  • also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the AFP gene. (wikipedia.org)
  • 1) Hepatocytes generated in this system display late fetal markers (both albumin and alpha-fetoprotein, AFP) and give rise to mature and engraftable small hepatic progenitor cells (SHPCs, which express albumin but not AFP). (warf.org)
  • AFP (alpha-fetoprotein), a major plasma protein produced by the yolk sac and the liver during fetal life. (promab.com)
  • Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. (promab.com)
  • The relevant laboratory results were as follows: WBC 13.11 × 109/L, Alanine Aminotransferase (ALT) 299 IU/L, Total Bilirubin (TBIL) 586.0 μmol/L, albumin 26 g/L, carbohydrate antigen (CA) 19-9 453.5 U/mL, CA 125 21.60 U/mL, Carcinoembryonic Antigen (CEA) 1.73 ng/mL, Alpha-Fetoprotein (AFP) 4.69 ng/mL, Hepatitis B and hepatitis C were both negative. (oncologyradiotherapy.com)
  • Application: Used to solublize lipids and albumin can be used as a blocking agent in Western blots and ELISA applications. (leebio.com)
  • It is believed to function as a carrier protein (similar to albumin) that transports materials such as fatty acids to cells. (wikipedia.org)
  • These results indicate that Gc protein appears to be regulated differently than the other members of this gene family, albumin and alpha-fetoprotein (AFP), which are negative acute phase reactants. (nih.gov)
  • Oval cells are induced between 1 and 3 days after PH inside the portal field and they express the typical onco-foetal marker alpha foeto-protein (AFP), at mRNA and protein levels. (uni-goettingen.de)
  • Kinetically down-regulated genes involved in the lipid metabolism are: hydroxyacid oxidase 3, fatty acid CoA ligase long chain 2, and steroyl CoA desaturase 1.The regulation of protein expression of the cell cycle genes CDC42 and cyclin D1 was studied by Western Blot technique, in the oval cell liver regeneration. (uni-goettingen.de)
  • Individuals with type 1 tend to have reduced amounts of a protein called albumin, which transports molecules in the blood. (medlineplus.gov)
  • A key feature of ataxia with oculomotor apraxia type 2 is high amounts of a protein called alpha-fetoprotein (AFP) in the blood. (medlineplus.gov)
  • Mutations in any of these genes reduce the amount of functional protein produced from that gene. (medlineplus.gov)
  • We developed Proteinarium , a multi-sample protein-protein interplay (PPI) instrument , to establish clusters of sufferers with shared gene networks. (rbprotein.com)
  • Then these extra genes instruct the cells to make too many HER2 receptors, which is called HER2 protein overexpression. (breastcancertalk.net)
  • The HER2/neu test can discover whether the sample is normal or whether it has too much of the HER2/neu protein or an excessive number of copies of its gene. (breastcancertalk.net)
  • 3] Nearly all patients with NBS are homozygous for the same founder mutation, ie, deletion of 5 bp (657del5) in the NBS1 gene, which encodes the protein nibrin. (medscape.com)
  • The inventors have previously shown that such SHPCs express high levels of mature hepatic genes, perform xenobiotic metabolism at rates equal to primary human hepatocytes, and support engraftment in immunodeficient mice (P180325). (warf.org)
  • Oval cells proliferate and differentiate in hepatocytes expressing albumin, and they differentiate in biliary cells expressing cytokeratin 7 (CK 7).Serial Analysis of Gene Expression (SAGE) was applied to the hepatic stem cell model of rat liver regeneration for studying gene expression pattern of liver regeneration during early stage of oval cell proliferation and differentiation. (uni-goettingen.de)
  • Currently used cell lines are derived from hepatic tumours and have altered gene expression. (ox.ac.uk)
  • The APTX , SETX , and PNKP genes provide instructions for making proteins that are involved in repairing damaged DNA. (medlineplus.gov)
  • The types are very similar but are caused by mutations in different genes. (medlineplus.gov)
  • Mutations in the APTX , SETX , or PNKP gene cause ataxia with oculomotor apraxia types 1, 2, or 4, respectively. (medlineplus.gov)
  • Mutations in another gene cause ataxia with oculomotor apraxia type 3. (medlineplus.gov)
  • Omenn syndrome is the result of mutations in the genes coding for recombinases (recombination activating genes). (medscape.com)
  • The AFP gene is located on the q arm of chromosome 4 (4q13.3). (wikipedia.org)
  • We posit the possible structure of advanced ailments is that subgroups of sufferers share variants in genes in particular networks that are enough to offer rise to a shared phenotype. (rbprotein.com)
  • They found that false duplications in GRCh37 or GRCh38 may lead to missed variants for short- and long-read technologies in relevant genes. (thepathologist.com)
  • From the data of the present study we conclude that the cell cycle genes CDC42 and cyclin D1 could be involved in the mechanism of proliferation of the oval cell in the liver regeneration process. (uni-goettingen.de)
  • Moreover, the expression of FGF18 is correlated with the expression of profibrotic genes, such as COL1A1 and ACTA2, in human liver biopsy samples. (bvsalud.org)
  • The team used simple algorithms that incorporate post-treatment liver stiffness, albumin levels, and age to accurately identify at-risk patients. (thepathologist.com)
  • Transarterially administered gene therapy for primary and secondary liver malignancies. (aetna.com)
  • Alpha-fetoprotein (AFP) is the gold standard biomarker in HCC, but its levels are affected by flares of HBV and hepatitis C virus (HCV) or deterioration of liver condition in addition to its low sensitivity in detection of early and small HCC [ 12 ]. (termedia.pl)
  • A prenatal diagnosis can be performed by measuring the alpha-fetoprotein produced by the foetal gastrointestinal tract and liver as well as foetal ultrasonography, which is considered the gold standard for diagnosis. (bvsalud.org)
  • In treatment-naïve patients, the genetic variation near the interleukin-28B (IL-28B) gene and amino acid (aa) substitution in the core 70 (core aa 70) of HCV may be the candidate predictors of the virological response to triple therapy. (hindawi.com)
  • However, in about a quarter of all breast cancer patients, the HER2 gene isnt functioning properly. (breastcancertalk.net)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • The inclusion of the albumin-to-creatinine ratio for all GFR categories recognizes the importance of defining risk and individualizing treatment. (siemens-healthineers.com)
  • All HHLs contained markers of hepatocyte and biliary phenotype (cytokeratins 7, 8, 18 and 19), Cytochrome P450 and albumin. (ox.ac.uk)
  • Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
  • Although individuals with type 2 usually have normal albumin levels, cholesterol may be elevated. (medlineplus.gov)
  • In ataxia with oculomotor apraxia type 4, albumin levels can be low, and cholesterol or AFP can be elevated. (medlineplus.gov)
  • The HHLs did not express high levels of p53 or alpha-fetoprotein. (ox.ac.uk)
  • The algorithm can also take into account alpha-fetoprotein levels and alcohol consumption. (thepathologist.com)
  • Researchers have investigated the organism's resistance to cancer and found they are able to withstand high levels of radiation damage (3), potentially due to the overexpression of genes involved in DNA repair and apoptosis. (thepathologist.com)
  • Temporal regulation of these genes in the context of the oval cell regeneration was studied by Real Time PCR. (uni-goettingen.de)
  • When PE was methylated, mutated, or replaced by the homologous element from the alpha-fetoprotein gene, activity in the context of the short promoter (PE plus the TATA box) was abolished. (pasteur.fr)
  • Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
  • By contrast, transforming growth factor (TGF)-β1 was demonstrated to markedly downregulate HGF gene expression ( 10 , 11 ). (spandidos-publications.com)
  • Furthermore, overexpression of ZIP4 resulted in increased expression of pro-metastatic genes (MMP-2, MMP-9) and decreased expression of pro-apoptotic genes (caspase-3, caspase-9, Bax). (ijbs.com)
  • Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. (promab.com)
  • We also demonstrate that HHLs contained active gap junctions, and that the cells respond to stimulation with IFN-alpha by upregulation of major histocompatibility complex (MHC)-I and -II. (ox.ac.uk)
  • It makes an excess number of copies of itself in a process known as HER2 gene amplification. (breastcancertalk.net)
  • Two buy Staurosporine copies of the gene (Dhaf_1324 and Dhaf_2460) coding for tryptophanase which converts tryptophan to indole, pyruvate, and ammonia were identified in association with two permease genes (Dhaf_1325 and Dhaf_2459). (screeninglibraries.com)
  • The gene was neither found in the Y51 genome, nor in those of other members of the Peptococcaceae family listed in IMG (Integrated Microbial Genomes), suggesting that this group of organisms may have evolved an unconventional dihydrofolate reductase for the synthesis of THF. (screeninglibraries.com)
  • Ear drops?AutoPap: Computer-assisted cytology interpretation system?AV: Aortic valve?AV: Atrioventricular?A-V: Arteriovenous?AVERT: Atorvastatin Versus Revascularization treatment?AVID: ?AVM: Arteriovenous Malformation?AVNRT: AV nodal reentry tachycardia?AVP: Arginine vasopressin?AVR: Aortic valve replacement?AVR: Augmented V lead, right arm (ECG)?AVRT: ?AVS: Arteriovenous shunt?AWS: Alcohol withdrawal syndrome?AXR: Abdominal X ray?AZF: Azoospermia factor genes?AZT: Azidothymidine (zidovudine)?B & O: Belladonna and opium?B Bx. (kuwaitpharmacy.com)
  • However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. (promab.com)
  • The tricarboxylic acid cycle (TCA) of D. hafniense DCB-2 and Y51 appears incomplete since they lack the gene coding for 2-oxoglutarate Chlormezanone dehydrogenase, and the cycle lacks the anaplerotic glyoxylate bypass (Figure 2). (screeninglibraries.com)
  • To improve genome sequencing information for diagnosing and treating disease, researchers have used the Genome in a Bottle Consortium's variant benchmark sets to characterize challenging autosomal genes (1). (thepathologist.com)
  • These gene sets were also observed in Y51 (DSY4041-4042 and DSY1331-1332). (screeninglibraries.com)