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Nucleoplasminsalpha KaryopherinsIntegrin alpha5beta1Integrin alpha5Integrin alpha2beta1Integrin alpha3beta1Integrin alpha2Integrinssrc-Family KinasesIntegrin alpha1beta1Integrin alpha6Integrin alpha6beta4Integrin alpha3Integrin alpha ChainsIntegrin alpha6beta1Integrin alpha1Integrin alphaVbeta3Integrin alpha4Integrin beta3Cell AdhesionIntegrin alpha4beta1Integrin beta ChainsPhosphatidylinositol 3-KinasesSignal TransductionIntegrin beta4PhosphorylationAntigens, CD29Protein-Tyrosine KinasesIntegrin alphaVProtein-Serine-Threonine KinasesMAP Kinase Signaling SystemProtein BindingReceptors, VitronectinFibronectinsMolecular Sequence DataProto-Oncogene Proteins c-fynProtein KinasesReceptors, CollagenCell MovementProtein Kinase InhibitorsAmino Acid SequenceTransfectionReceptors, FibronectinProto-Oncogene Proteins c-hckCell Linealpha 1-AntitrypsinCells, CulturedPlatelet Glycoprotein GPIIb-IIIa ComplexBinding SitesEnzyme ActivationProto-Oncogene Proteins c-yesBase SequenceRecombinant ProteinsFocal Adhesion Protein-Tyrosine KinasesTyrosineCalcium-Calmodulin-Dependent Protein KinasesFocal Adhesion Kinase 1Protein Kinase CCell Line, TumorProtein Structure, TertiaryAntigens, CDTumor Cells, Culturedp38 Mitogen-Activated Protein KinasesMutationKineticsReceptors, Adrenergic, alphaBlotting, WesternMice, KnockoutRecombinant Fusion ProteinsLigandsHypoxia-Inducible Factor 1, alpha SubunitProto-Oncogene ProteinsOligopeptidesLamininCollagenMitogen-Activated Protein Kinase 1Blood PlateletsGene Expression RegulationMice, Inbred C57BLCHO CellsCell Adhesion MoleculesCyclic AMP-Dependent Protein KinasesInterleukin-1betaCricetinaeRNA, MessengerExtracellular Signal-Regulated MAP KinasesDose-Response Relationship, DrugVitronectinPhosphoproteinsAntibodies, MonoclonalMitogen-Activated Protein Kinase KinasesProto-Oncogene Proteins pp60(c-src)Mitogen-Activated Protein KinasesPyrimidinesIntracellular Signaling Peptides and ProteinsMitogen-Activated Protein Kinase 3JNK Mitogen-Activated Protein KinasesSequence Homology, Amino AcidIsoenzymesEnzyme Inhibitors
ProteinBindExpressionDifferentiating cellsHumanMember
Protein1
  • The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
Bind1
  • Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
Expression3
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
Differentiating cells1
  • These results demonstrate that TrkA kinase initiates differentiation, and p75 enhances differentiation by rescuing differentiating cells from apoptosis via the PI3K pathway. (umassmed.edu)
Human2
  • 12. Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. (nih.gov)
  • 17. Cyr61, a member of the CCN family, is required for MCF-7 cell proliferation: regulation by 17beta-estradiol and overexpression in human breast cancer. (nih.gov)
Member1
  • CD151 is the first characterized member of the tetraspanin family. (oncotarget.com)