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  • GABA
  • Tiagabine is a gamma-aminobutyric acid (GABA) reuptake inhibitor, with its metabolism enhanced by cytochrome P-450 inducers. (medscape.com)
  • In addition, we studied the effects of infusion of GABA (gamma-amino-butyric acid) after blockade of the alpha2-delta subunit of voltage-gated calcium channels (VGCC) with pregabalin, to assess the responsiveness of the glutamatergic synapses to exogeneous GABA when the presynaptic release of glutamate was blocked. (biomedcentral.com)
  • subunit
  • After their initial expression, the MAP1A and MAP1B polypeptides are cleaved into light and heavy chains, which are then assembled into mature complexes together with the separately encoded light chain 3 subunit (LC3). (biomedcentral.com)
  • derivatives
  • Subgroup 3 includes piracetam derivatives with unknown clinical efficacies, and of these nefiracetam failed to improve cognition in post-stroke patients and rolipram is currently in clinical trials as an antidepressant. (springer.com)
  • seizures
  • Of note, Eisai presented three post-hoc analyses evaluating the potential of FYCOMPA to help patients experience long-term, sustained convulsive seizure freedom, as well as data that supported the recent U.S. Food and Drug Administration (FDA) approval of FYCOMPA for monotherapy and adjunctive use in pediatric patients 4 years and older for the treatment of partial-onset seizures (POS) with or without secondarily generalized seizures. (biospace.com)
  • These long-term seizure freedom data showed about 53% of patients with secondarily generalized seizures experienced convulsive seizure freedom at 2 years and close to 35% at 3 years," said Trevor Resnick , MD, Pediatric Neurologist at Nicklaus Children's Hospital. (biospace.com)
  • In September 2018 , FYCOMPA was approved for monotherapy and adjunctive use in pediatric patients 4 years and older for the treatment of POS with or without secondarily generalized seizures. (biospace.com)
  • FYCOMPA
  • WOODCLIFF LAKE, N.J. , Dec. 4, 2018 /PRNewswire/ -- Eisai Inc. presented new data on FYCOMPA ® (perampanel) CIII at the American Epilepsy Society Annual Meeting in New Orleans which included analyses of convulsive seizure freedom rates in adult and pediatric epilepsy patients. (biospace.com)
  • domain
  • The extracellularly located amino-terminal domain (ATD) mediates dimerization in a subfamily-specific manner ( Mayer, 2011 ). (jneurosci.org)
  • Research
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