ReceptorsReceptor antagonistsAntagonistDopamineBlockersSympatheticNeuromuscular blockadeSelective blockadePhentolamine or prazosinDopaminergicVentricularHyperventilation-inducedPatientsVasodilatorCardiovascularMuscarinicMyocardialTumorsEpinephrineEffectsGeneEffectivenessDrugsPropranololSignificantlyDosesEffectDiseasesAgentsAgentRoleActivityBlood pressureExpressionLeft
Receptors30
- Dopamine is a naturally occurring endogenous catecholamine that stimulates beta1- and alpha1-adrenergic and dopaminergic receptors in a dose-dependent fashion. (medscape.com)
- In midrange doses (5-15 ug/kg/min), it acts on beta-adrenergic receptors to increase heart rate and contractility. (medscape.com)
- In high doses (15-20 ug/kg/min), it acts on alpha-adrenergic receptors to increase systemic vascular resistance and raise blood pressure. (medscape.com)
- Here, we investigated the role of α-adrenergic receptors (α-AR) in the cardiovascular reactivity to a norepinephrine (NE)-stress reactivity-mimicking NE-infusion in essential hypertensive individuals (HT) as compared to normotensive individuals (NT). (nih.gov)
- The effects of propranolol are due to selective blockade of beta-adrenergic receptors, leaving alpha-adrenergic responses intact. (nih.gov)
- Beta 1 -adrenergic receptors are found primarily in the heart. (nih.gov)
- Blockade of cardiac beta 1 -adrenergic receptors leads to a decrease in the activity of both normal and ectopic pacemaker cells and a decrease in A-V nodal conduction velocity. (nih.gov)
- Blockade of cardiac beta 1 ‑adrenergic receptors also decreases the myocardial force of contraction and may provoke cardiac decompensation in patients with minimal cardiac reserve. (nih.gov)
- Beta 2 -adrenergic receptors are found predominantly in smooth muscle-vascular, bronchial, gastrointestinal and genitourinary. (nih.gov)
- Blockade of these receptors results in constriction. (nih.gov)
- Nanoparticle inhalation modulates arteriolar sympathetic constriction: role of nitric oxide, prostanoids, and alpha-adrenergic receptors. (cdc.gov)
- Nebivolol is a novel beta-blocker with both a greater degree of selectivity for beta-1 adrenergic receptors than other agents in this class and an ability to stimulate endothelial nitric oxide production, leading to vasodilation and other potential clinical effects. (escardio.org)
- Carvedilol blocks the beta-1 receptors 2-3 times more than alpha-1 receptors. (escardio.org)
- Bucindolol is a non-selective agent and blocks the alpha receptors as well. (escardio.org)
- The vasodialtor effect of these three agents is obtained via the blockade of the alpha receptors. (escardio.org)
- is a third generation lipophylic beta blocker with antioxydant properties which block both beta-1 and alpha-1 adrenergic receptors(1). (escardio.org)
- Its affinity to beta-1 receptors is 2-3 times much higher than alpha-1 receptors. (escardio.org)
- The alpha-adrenergic receptors and opiate receptors were found to be involved in the release of K+ after haemorrhage, and the release was mainly from the region drained by the hepatic vein. (gla.ac.uk)
- Other side effects occur due to effects on other receptors throughout the body (alpha adrenergic, histaminergic, cholinergic, etc. (bulletpsych.com)
- Doxazosin enhances the widening of blood vessels (vasodilation) by selective and competitive alpha blockade of α1 adrenergic receptors. (happyfamilymedstore.com)
- BOTH muscarinic receptors and alpha-adrenoceptors have been shown to exist in airway smooth muscle. (silverchair.com)
- However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei.Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. (xiaojinmitech.com)
- It blocks the central α2-adrenegic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. (xiaojinmitech.com)
- Thus, employing three complementary techniques, these observations demonstrate that blockade of α(2)-adrenoceptors triggers brain expression of the immediate early gene, Arc, and that this effect involves the recruitment of AMPA, NMDA and mGluR5 but not mGluR2/3 glutamatergic receptors. (ox.ac.uk)
- Feedback modulation of NE release occurs by activation of alpha2A and alpha2C adrenergic receptors (ARs) on sympathetic neurons. (stanford.edu)
- Modulation of sympathetic neuron signaling occurs by feedback inhibition of neurotransmitter release (autoreceptors), mediated in part via alpha2A and/or alpha2C adrenergic receptors. (stanford.edu)
- The smooth muscle tension is regulated by specific receptors termed as alpha-1-adrenergic receptors. (drbest.in)
- Therefore, alpha 1 adrenergic receptors were shown to have integral roles in the development of BPH. (drbest.in)
- The potential role of alpha 1 adrenergic receptors in the aetiology of BPH, promotes the use of selective Alpha-adrenoreceptor antagonists (alpha 1A-blockers) as the first-line treatment agents for patients with BPH. (drbest.in)
- It exhibits a higher degree of specificity for alpha-adrenergic receptors including α1A-adrenergic receptors and α1B receptors. (drbest.in)
Receptor antagonists3
- adrenergic receptor antagonists i.e. typically propranolol (Inderal) are used in management of hypertrophic obstructive cardiomyopathy. (pharmacology2000.com)
- adrenergic receptor antagonists have also shown helpful in management of acute dissecting aortic aneurysm due to -blocker-mediated reduction in myocardial contractility and reduced rate of force development . (pharmacology2000.com)
- α1-Adrenergic receptor antagonists are recommended by 80% of physicians to treat patients with BPH presenting with LUTS. (drbest.in)
Antagonist3
- Phentolamine, an alpha-adrenergic antagonist (1 microM), reduced sympathetic constriction in controls, but abolished this response in TiO2 exposed rats (max % change -22.3+/-3.1 control, -9.7+/-2.9 TiO2). (cdc.gov)
- Yohimbine hydrochloride is an α2-adrenergic receptor antagonist and increases the firing rate of the locus coeruleus with a resultant increase in sympathetic outflow (Redmond, 1987). (xiaojinmitech.com)
- Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. (xiaojinmitech.com)
Dopamine2
- The antiemetic benefits of Compazine are due to dopamine blockade in the chemoreceptor trigger zone of the brain. (medicinenet.com)
- When a patient ingests an antipsychotic medication, there is a lot more going on in the body than simply dopamine (D2) blockade in the mesolimbic system. (bulletpsych.com)
Blockers5
- Beta-adrenergic receptor blockers play an important role in the management of cardiovascular disease, including hypertension, ischemic heart disease and chronic heart failure. (escardio.org)
- In the presence of the alpha-adrenoceptor blockers, phentolamine or prazosin, the rise in plasma K+ following haemorrhage was significantly reduced. (gla.ac.uk)
- Unlike unselective α1 adrenergic receptor blockers, long use of Doxazosin does not cause addiction. (happyfamilymedstore.com)
- Patients taking beta-adrenergic blockers present a special challenge because beta blockade may limit the effectiveness of epinephrine. (ghorfeha.com)
- Alpha-blockers improve symptoms and increase the urinary flow rate by relaxing prostatic and bladder neck smooth muscles through sympathetic activity blockade. (drbest.in)
Sympathetic1
- The enhanced sensitivity to alpha-adrenergic receptor blockade following TiO2 exposure suggests an augmented responsiveness to tonic sympathetic activity. (cdc.gov)
Neuromuscular blockade1
- 3. Muscle fasciculation from Suxamethonium administration does not occur in neonates and should not be relied upon as a sign of successful neuromuscular blockade. (ghorfeha.com)
Selective blockade1
- Here we investigated the influence on regional brain Arc gene expression of selective blockade of α(2)-adrenoceptors in rats. (ox.ac.uk)
Phentolamine or prazosin1
- Alpha receptor blockade with either phentolamine or prazosin significantly reduced the number of premature ventricular complexes during coronary reperfusion (321 +/- 62-14 +/- 10 premature ventricular complexes, P less than 0.001), abolished early ventricular fibrillation (from 25% in controls to 0%), and prevented the increase in idioventricular rate seen with coronary reperfusion. (jci.org)
Dopaminergic1
- These undesirable effects include anticholinergic effects, alpha-adrenergic blockade, and dopaminergic effects, among others. (wikipedia.org)
Ventricular3
- 17. Influence of alpha-adrenergic blockade on ventricular arrhythmias, QTc interval and heart rate variability in phaeochromocytoma. (nih.gov)
- Ventricular dysrhythmias induced by coronary occlusion alone (without reperfusion) were attenuated markedly by alpha-receptor blockade under conditions in which perfusion (measured with radiolabeled microspheres) within ischemic zones was not affected. (jci.org)
- The Arg16Gly polymorphism of the beta2-adrenergic receptor and left ventricular systolic function. (cdc.gov)
Hyperventilation-induced2
- Beta-adrenoceptor and opiate receptor blockade reduced the hyperventilation-induced hyperkalaemia. (gla.ac.uk)
- The intracellular mechanisms involved in the alpha-adrenoceptor- or hyperventilation-induced bronchoconstriction remain unknown. (silverchair.com)
Patients6
- 4. Alpha blockade in preoperative preparation of patients with pheochromocytomas. (nih.gov)
- The purpose of this study was to evaluate the effects of the alpha 1-blocking agent terazosin on blood pressure (BP) and blood lipids in a large, variant population of patients with hypertension. (nih.gov)
- Both patients responded favourably to ECMO and alpha-adrenergic blockade with recovery of ejection fraction. (austinpublishinggroup.com)
- The use of β-adrenergic blockade is beneficial in patients with diverse cardiovascular diseases. (biomedcentral.com)
- Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy. (cdc.gov)
- In patients receiving a beta-adrenergic blocker who do not respond to epinephrine, glucagon, IV fluids, and other therapy, a risk/benefit assessment rarely may include the use of isoproterenol (Isuprel, a beta agonist with no alpha-agonist properties). (ghorfeha.com)
Vasodilator1
- When access to beta‑receptor sites is blocked by propranolol, chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportionately. (nih.gov)
Cardiovascular1
- Beta-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults. (cdc.gov)
Muscarinic1
- Quinidine administration results in vagal inhibition (anti-muscarinic) and alpha-adrenergic receptor blockade. (pharmacology2000.com)
Myocardial3
- Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats. (jci.org)
- Alternative sympatholytic interventions including pretreatment with 6-hydroxydopamine to deplete myocardial norepinephrine from 8.8 +/- 1.4 to 0.83 +/- 0.2 ng/mg protein and render the heart unresponsive to tyramine (120 microgram/kg) attenuated dysrhythmias induced by both coronary occlusion and reperfusion in a fashion identical to that seen with alpha-receptor blockade. (jci.org)
- Thus, enhanced alpha-adrenergic responsiveness occurs during myocardial ischemia and appears to be primary mediator of the electrophysiological derangements and resulting malignant dysrhythmias induced by catecholamines during myocardial ischemia and reperfusion. (jci.org)
Tumors1
- For the management of inoperable tumors, the usual dosage is 30 mg daily in divided doses as adjunctive therapy to alpha-adrenergic blockade. (genesight.com)
Epinephrine1
- In refractory cases not responding to epinephrine because a beta-adrenergic blocker is complicating management, glucagon, 1 mg intravenously as a bolus, may be useful. (ghorfeha.com)
Effects1
- has S and R enantiomeres and both have equal alpha blocking effects but S enantiomere shows stronger beta blockade (2). (escardio.org)
Gene3
- Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study. (ox.ac.uk)
- Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography. (cdc.gov)
- Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains. (cdc.gov)
Effectiveness1
- The effectiveness of adrenergic antagonists in this setting is likely due to reduced outflow tract pressure gradients. (pharmacology2000.com)
Drugs1
- Additional information about alpha 1 blocking drugs. (pharmacologycorner.com)
Propranolol4
- Propranolol Hydrochloride, USP is a synthetic beta-adrenergic receptor blocking agent chemically described as (+)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride. (nih.gov)
- Propranolol is a nonselective beta-adrenergic receptor blocking agent possessing no other autonomic nervous system activity. (nih.gov)
- At doses greater than required for beta blockade, propranolol also exerts a quinidine-like or anesthetic-like membrane action, which affects the cardiac action potential. (nih.gov)
- Propranolol has a distribution half-life (T½ alpha) of 5-10 minutes and a volume of distribution of about 4 to 5 L/kg. (nih.gov)
Significantly1
- Alpha adrenoceptor blockade did not significantly prevent the hyperkalaemia produced by hyperventilation per se. (gla.ac.uk)
Doses1
- The usual dosage is 60 mg Inderal daily in divided doses for three days prior to surgery as adjunctive therapy to alpha-adrenergic blockade. (genesight.com)
Effect1
- However, beta-receptor blockade was without effect. (jci.org)
Diseases1
- The goal of this activity is to educate cardiologists, urologists, internists, and primary care physicians about the use of alpha blockade in two very common diseases in the older male: hypertension and benign prostatic hypertrophy. (medscape.org)
Agents1
- It specifically competes with beta-adrenergic receptor stimulating agents for available receptor sites. (nih.gov)
Agent1
- Yohimbine hydrochloride is a pre-synaptic alpha 2-adrenergic blocking agent. (xiaojinmitech.com)
Role1
- On the other hand, some studies have reported that alpha-adrenoceptor agonists stimulate human airway smooth muscle contraction, [ 5-7 ] that alpha-adrenoceptors play a role in exercise-induced bronchoconstriction, [ 8 ] and that plasma norepinephrine (NE) increases in normal and asthmatic subjects during exercise. (silverchair.com)
Activity2
- Of these, only the primary ring oxidative product (4-hydroxypropranolol) possesses beta-adrenergic receptor blocking activity. (nih.gov)
- Indole alkaloid with α2-adrenergic blocking activity. (xiaojinmitech.com)
Blood pressure1
- Postural drop in blood pressure due to alpha-adrenergic blockade. (azspills.com)
Expression1
- In a irregular Phase II gerontology, adverse hypotheses will be improved suffering a fresh Antibody hypothesis energy characterized at Myogen, and genes that are function in heart will do classified in alpha-MHC contractions of alpha-adrenergic expression. (augenta.net)
Left1
- Alpha compared to beta adrenergic contributions to dysrhythmias induced by left anterior descending coronary occlusion and by reperfusion were assessed in chloralose-anesthetized cats (n = 96). (jci.org)