An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors. (wikipedia.org)
The five main categories of adrenergic receptors are: α1, α2, β1, β2, and β3, although there are more subtypes, and agonists vary in specificity between these receptors, and may be classified respectively. (wikipedia.org)
Alternatively, it may refer to something which is susceptible to epinephrine, or similar substances, such as a biological receptor (specifically, the adrenergic receptors). (wikipedia.org)
The receptors are classed physiologically, though pharmacological selectivity for receptor subtypes exists and is important in the clinical application of adrenergic agonists (and, indeed, antagonists). (wikipedia.org)
Inhibitors of these enzymes act as indirect agonists of adrenergic receptors as they prolong the action of catecholamines at the receptors. (wikipedia.org)
A great number of drugs are available which can affect adrenergic receptors. (wikipedia.org)
The following headings provide some useful examples to illustrate the various ways in which drugs can enhance the effects of adrenergic receptors. (wikipedia.org)
These drugs act directly on one or more adrenergic receptors. (wikipedia.org)
these are: Adrenaline (almost all adrenergic receptors). (wikipedia.org)
What are the 4 basic categories of adrenergic receptors? (brainscape.com)
What type of receptor are adrenergic receptors? (brainscape.com)
What are the 4 main factors that can alter the degree to which an adrenergic receptors respond to a stimulus? (brainscape.com)
These results show no evidence for a generalized change in alpha adrenergic responsiveness in hypertension and support the concept that increased blood pressure responses to alpha adrenergic stimulation in hypertensives are due to structural and geometric changes in the arterial wall rather than to an increased responsiveness of postsynaptic alpha adrenergic receptors. (ox.ac.uk)
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)
The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)
Unlike other decongestants, it targets the alpha-adrenergic receptors in the blood vessels, leading to vasoconstriction. (simphiwedana.com)
The four main receptors are alpha 1 , alpha 2 , beta 1 , and beta 2 , which mediate the major responses described in Table 15.1 and illustrated in Fig. 15.1 . (basicmedicalkey.com)
The alpha-adrenergic receptors are located in the blood vessels, eyes, bladder, and prostate. (basicmedicalkey.com)
The alpha 2 receptors are located in the postganglionic sympathetic nerve endings. (basicmedicalkey.com)
Other adrenergic receptors are dopaminergic and are located in the renal, mesenteric, coronary, and cerebral arteries. (basicmedicalkey.com)
FIG. 15.1 Effects of activation of alpha 1 , alpha 2 , beta 1 , and beta 2 receptors. (basicmedicalkey.com)
Agonists Drugs such as dopamine that attach to and activate specific receptors. (nursekey.com)
Note that many TCAs , TeCAs, antipsychotics , ergolines , and some piperazines like buspirone , trazodone , nefazodone , etoperidone , and mepiprazole all antagonize α 1 -adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension . (en-academic.com)
Note that many atypical antipsychotics and azapirones like buspirone and gepirone (via metabolite 1-PP) antagonize α 2 -adrenergic receptors as well. (en-academic.com)
Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. (pharmacycode.com)
Why can this drug affect the heart rate by affecting alpha instead of beta receptors? (proprofs.com)
Because it crosses the blood-brain barrier so that the the alpha receptors it binds are ones in the CNS instead of on the effector organ. (proprofs.com)
This means that the alpha receptors it binds to are located in the central nervous system (CNS) rather than on the effector organ, which in this case is the heart. (proprofs.com)
The present data indicate that activated alpha 2-adrenergic and muscarinic receptors inhibit dihydropyridine-sensitive Ca2+ channels via pertussis toxin-sensitive G proteins without the involvement of a cAMP-dependent intermediate step. (mdc-berlin.de)
Heart failure (HF) is characterized by markedly elevated levels of catecholamines that bind to adrenergic receptors (ARs) in the heart. (unc.edu)
Epinephrine3
An adrenergic agent is a drug, or other substance, which has effects similar to, or the same as, epinephrine (adrenaline). (wikipedia.org)
Intravenous (IV) adrenergic agonists and antagonists are high-alert medications because they can cause significant harm to a patient in the event of a medication error. (basicmedicalkey.com)
Antagonists Drugs such as naloxone (Narcan) that attach to a specific receptor and do not activate it but instead prevent an agonist or body chemical such as a neurotransmitter from stimulating the receptor. (nursekey.com)
This indicates that small doses of prazosin (1-2 mg) cause significant in vivo shifts in the dose-response relationship of alpha adrenergic agonists. (ox.ac.uk)
Cooling (from 37 to 24 degrees C) augmented contractions to norepinephrine under control conditions and after alpha 1-adrenergic blockade (prazosin) but not following alpha 2-adrenergic blockade (rauwolscine). (johnshopkins.edu)
Prazosin (10(-8) M) shifted the concentration-response curves to phenylephrine and UK 14,304 to the right, but did not shift the concentration-response curves to clonidine and oxymetazoline. (aspetjournals.org)
Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. (pharmacycode.com)
In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro , and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. (pharmacycode.com)
Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. (pharmacycode.com)
Responsiveness4
A study that she conducted while completing her doctoral studies, "Job Strain, Ethnicity and Sympathetic Nervous System," examines the relationship between neighborhood socioeconomic status and alpha adrenergic responsiveness to an alpha agonist, phenylephrine. (ucsd.edu)
Responsiveness of superficial hand veins to phenylephrine in essential hypertension. (ox.ac.uk)
These experiments suggest that cooling augments alpha 2-adrenergic responsiveness without affecting alpha 1-adrenergic responsiveness. (johnshopkins.edu)
Therefore, cooling reduces alpha 1-adrenergic responsiveness in canine cutaneous veins, but in the case of full alpha 1-adrenergic agonists such as norepinephrine and phenylephrine the inhibitory effect of cooling is buffered by an alpha 1-adrenoceptor reserve. (johnshopkins.edu)
Vasoconstriction2
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. (drugbank.com)
Contractions were induced by electric field stimulation (EFS), alpha(1)-adrenergic agonists (noradrenaline, phenylephrine, methoxamine), thromboxane A(2) analog U46619, endothelin-1, or calcium chloride in an organ bath. (uni-muenchen.de)
Conclusions: GF109203X and Go6983 inhibit neurogenic, alpha(1)-adrenergic, and thromboxane A(2)-induced smooth muscle contractions in the human prostate, suggesting a role of PKC for human prostate smooth muscle contraction. (uni-muenchen.de)
Cooling augmented contractions evoked by the alpha 2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full alpha 1-adrenergic agonist phenylephrine. (johnshopkins.edu)
However, the contractions evoked by the partial alpha 1-adrenergic agonist St 587 were virtually abolished by cooling. (johnshopkins.edu)
Moreover, following partial irreversible blockade of the alpha 1-adrenoceptors with phenoxybenzamine, cooling also reduced the contractions evoked by phenylephrine. (johnshopkins.edu)
Pretreatment with chlorethylclonidine, which selectively alkylates the alpha-1B subtype, did not affect the Emax value of phenylephrine-induced contractions, but significantly shifted the curve to the right. (aspetjournals.org)
Oxymetazoline3
The maximum contractile responses (Emax) to norepinephrine, phenylephrine, oxymetazoline and UK 14,304 were of similar magnitude and were significantly greater than the contractile responses to clonidine. (aspetjournals.org)
Competitive Antagonist Occurs when the concentration of the antagonist is higher than the agonist concentration. (nursekey.com)
Pharmacology1
More selective agonists are more useful in pharmacology. (wikipedia.org)
Drugs1
Other drugs affect the uptake and storage mechanisms of adrenergic catecholamines, prolonging their action. (wikipedia.org)
Hydrochloride9
The company is recalling 10 mg/mL vials of phenylephrine hydrochloride due to potential lack of sterility assurance in several lots of the product. (outsourcing-pharma.com)
Sagent Pharmaceuticals has announced the voluntary US-wide recall of three lots of Phenylephrine Hydrochloride Injection, USP (10 mg/mL). (outsourcing-pharma.com)
Phenylephrine Hydrochloride Injection, USP is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important low blood pressure resulting primarily from the dilation of blood vessels, which decreases blood pressure in the setting of anesthesia. (outsourcing-pharma.com)
The generic name of Robitussin Severe Multi-symptom Cough Cold Flu Nighttime is acetaminophen, diphenhydramine hydrochloride, phenylephrine hydrochloride. (ndclist.com)
Labetalol hydrochloride tablets, USP are an adrenergic receptor blocking agent that has both selective alpha 1 -adrenergic and nonselective beta-adrenergic receptor blocking actions in a single substance. (nih.gov)
Labetalol hydrochloride combines both selective, competitive, alpha 1 -adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. (nih.gov)
Both the alpha- and beta-blocking actions of orally administered labetalol hydrochloride contribute to a decrease in blood pressure in hypertensive patients. (nih.gov)
Labetalol hydrochloride produces dose-related falls in blood pressure without reflex tachycardia and without significant reduction in heart rate, presumably through a mixture of its alpha blocking and beta-blocking effects. (nih.gov)
Due to the alpha 1 -receptor blocking activity of labetalol hydrochloride, blood pressure is lowered more in the standing than in the supine position, and symptoms of postural hypotension (2%), including rare instances of syncope, can occur. (nih.gov)
Responses5
Agonists of each class of receptor elicit these downstream responses. (wikipedia.org)
Cooling and alpha 1- and alpha 2-adrenergic responses in cutaneous veins: role of receptor reserve. (johnshopkins.edu)
Experiments were designed to determine the effects of cooling on alpha 1- and alpha 2-adrenergic responses in isolated canine cutaneous veins. (johnshopkins.edu)
Isometric tension responses to phenylephrine and prostaglandin F2alpha were measured at 0, 2, 6 and 12 h post-incubation. (ox.ac.uk)
Isometric tension responses to the same agonists were measured in grafts harvested 2, 6, 13 and 23 h after surgery. (ox.ac.uk)
The α1B mediates cardiac hypertrophy induced by non-selective α1-AR agonists like phenylephrine. (unc.edu)
We recently showed that an oral selective α1A agonist drug, dabuzalgron, preserves ATP content and mitochondrial function in mouse HF models. (unc.edu)
Blockade2
In man, the ratios of alpha- to beta-blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenous (IV) administration, respectively. (nih.gov)
In animals, at doses greater than those required for alpha- or beta-adrenergic blockade, a membrane-stabilizing effect has been demonstrated. (nih.gov)
Ketorolac9
FDA approved Anti-Cancer medicine OMIDRIA (phenylephrine and ketorolac injection) is available upon request. (medvitaz.com)
To get best retail price of OMIDRIA (phenylephrine and ketorolac injection) in India, For emergency product orders call 8750295029 (Mr. Neeraj Nagpal) or For enquires email [email protected] For advanced treatments in India, Medvitaz Pharma Solution can even help patient to discuss with surgeon. (medvitaz.com)
Phenylephrine/ketorolac, sold under the brand name Omidria, is a combination drug used during cataract surgery or intraocular lens replacement to prevent intraoperative miosis and to reduce postoperative pain. (medvitaz.com)
You can order phenylephrine and ketorolac injection through Medvitaz Pharma Solutions under Named Patient Program (NPP). (medvitaz.com)
Catecholamines1
Two uptake mechanisms exist for terminating the action of adrenergic catecholamines - uptake 1 and uptake 2. (wikipedia.org)
Stimulation1
Prominent among these is its reactivity to adrenergic stimulation. (wikidoc.org)
Hypertension1
Using the dorsal hand vein compliance technique we compared the changes in diameter of superficial veins in response to phenylephrine, an alpha 1 adrenergic receptor agonist, and to nitroglycerin, a venorelaxant, in patients with essential hypertension and in normotensive subjects. (ox.ac.uk)
Cardiac1
Cardiac alpha (α)1-ARs have received less attention, however data from cell and animal studies indicate that they protect against the development of HF. (unc.edu)
Endogenous1
It is unclear whether this is caused by structural changes in the arterial wall or by hyperresponsiveness of vascular smooth muscle to endogenous alpha adrenergic agonists. (ox.ac.uk)
Emax1
Maximal response (Emax) for phenylephrine was 84 +/- 13% in the hypertensive subjects and 90 +/- 6% in the control subjects. (ox.ac.uk)
Pharmacological1
5. Dittrich A, Albrecht K, Bar-Moshe O, Vandendris M. Treatment of pharmacological priapism with phenylephrine. (emboardbombs.com)
Priapism1
Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol. (en-academic.com)
Inhibit1
Phenylephrine failed to inhibit the Ca2+ channel current. (mdc-berlin.de)
Decreases1
phenylephrine decreases effects of iobenguane I 123 by receptor binding competition. (medscape.com)
Beta3
A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent. (wakehealth.edu)
Beta 2 -agonist activity has been demonstrated in animals with minimal beta 1 -agonist (ISA) activity detected. (nih.gov)
Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)
Effects4
The G-protein receptor can affect the function of adenylate cyclase or phospholipase C, an agonist of the receptor will upregulate the effects on the downstream pathway (it will not necessarily upregulate the pathway itself). (wikipedia.org)