Alpha 6 beta 4 integrin integrin beta4. Medical search. Frequent questions

Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. (embl.de)
It interacts with a variety of INTEGRINS and mediates responses to EXTRACELLULAR MATRIX PROTEINS. (rush.edu)

The degree of binding of HPV-VLP matched the alpha(6) integrin expression level in cell lines but was not correlated with beta(1) and beta(4) levels, which suggests that alpha(6) integrin is the main receptor of HPV type 16. (nih.gov)
However, results of a recent study showed that Tβ 4 was rapidly internalized by cells, suggesting the involvement of an intracellular receptor in the effects of the peptide ( 7 ). (spandidos-publications.com)
Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)

Besides the effect on cell migration, exogenous Tβ 4 was found to have multifunctional activities such as angiogenesis, anti-apoptosis, anti-oxidative stress and anti-inflammation ( 8 - 11 ), which emphasize its therapeutic potential in the repair of damaged tissues or wound healing. (spandidos-publications.com)
Tβ 4 is distributed ubiquitously in most tissues and cells, and is also known to concentrate highly at blood platelets ( 12 ). (spandidos-publications.com)
These findings suggest that endogenous Tβ 4 likely promotes the healing of damaged tissues. (spandidos-publications.com)
Exogenous Tβ 4 was also reported to accelerate the tissue repair of damaged cardiac, corneal and dermal tissues ( 4 , 6 , 13 ), which demonstrates potential for clinical applications in wound healing. (spandidos-publications.com)

β4-integrin/PI3K Signaling Promotes Tumor Progression through Galectin-3-N-glycan Complex. (fmu.ac.jp)

Features of tissue morphogenesis were assessed, including proliferation, basement membrane formation, polarization of alpha-6 beta-4 integrin to the basement membrane, formation of cell:cell junctions, and apoptosis for luminal clearance. (biomedcentral.com)

The RGD sequences is involved in interactions with integrin. (embl.de)

A total of 13,748 annotated sequence SNPs were in the 14 PCGs, including 156 SNPs in coding regions (124 synonymous, 26 non-synonymous, and 6 splice variants). (biomedcentral.com)

Colon cancer cells overexpressing Tβ 4 also exhibited enhanced cell migration, due in part to the activation of the Rac1 signaling pathway ( 3 ). (spandidos-publications.com)

Thymosin β 4 (Tβ 4 ), an oligopeptide consisting of 43 amino acids, is known to sequester G-actin monomers. (spandidos-publications.com)

Ito et al ( 2 ) showed that overexpression of Tβ 4 enhanced the formation of actin-based pseudopodia and cell motility in prostate cancer cells, providing direct evidence that Tβ 4 plays a role in cell migration. (spandidos-publications.com)

Upregulation of Tβ 4 by cDNA-mediated transfection was found to cause actin depolymerization in fibroblast cells ( 1 ), which demonstrated that the modulation of Tβ 4 affected the polymerization state of actin cytoskeleton, as well as other cell processes associated with the organization of actin cytoskeleton, such as cell migration. (spandidos-publications.com)
In addition, extracellular, administered Tβ 4 promoted the cell migration of various types of cells including cardiomyocytes, human umbilical vein endothelial cells and conjunctival epithelial cells ( 4 - 6 ). (spandidos-publications.com)

The expression levels of alpha(6), beta(1), and beta(4) integrins were determined and compared with the amount of HPV-VLP binding in ten cell lines by flow cytometry. (nih.gov)
Ratio of Alpha 2-Macroglobulin Levels in Cerebrospinal Fluid and Serum: An Expression of Neuroinflammation in Acute Disseminated Encephalomyelitis. (fmu.ac.jp)
Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus. (fmu.ac.jp)

Both the expression level of alpha(6) integrin and the amount of HPV-VLP binding were high in cervical cancer cell lines, as the type HPV-16 is the main cause of cervical cancer. (nih.gov)

For the in vivo assay, Tβ4 was applied to excisional wounds (3 mm in diameter) that were made in the center of the palate (n=6). (spandidos-publications.com)

Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. (childrensmercy.org)

An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. (embl.de)

Integrin beta 4/CD104 was detected in immersion fixed A431 human epithelial carcinoma cell line using Sheep Anti-Human Integrin beta 4/CD104 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4060) at 15 µg/mL for 3 hours at room temperature. (rndsystems.com)

The ITGB4 gene provides instructions for making one part (the β4 subunit) of a protein known as an integrin. (medlineplus.gov)
The integrin protein made with the β4 subunit is known as α6β4 integrin. (medlineplus.gov)
ITGB4 gene mutations alter the normal structure and function of the β4 integrin subunit or prevent cells from producing enough of this subunit. (medlineplus.gov)
The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. (cancerindex.org)
This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. (cancerindex.org)

The α6β4 integrin protein plays a particularly important role in strengthening and stabilizing the skin. (medlineplus.gov)
Mutations that lead to a complete or near-complete loss of α6β4 integrin tend to cause more severe signs and symptoms of EB-PA, while mutations that alter the structure or stability of this protein usually cause milder signs and symptoms. (medlineplus.gov)
The integrin protein activates key signaling molecules, which trigger cancer cells to migrate through the body and invade other tissues. (medlineplus.gov)
The protein levels of integrin α6 were determined by immunohistochemistry methods. (cancerindex.org)
The differences in protein and mRNA levels in cancer tissues and non-cancerous tissues were analyzed, and we subsequently investigated the association between integrin α6 expression and key parameters indicating lung adenocarcinoma progression and overall survival rate. (cancerindex.org)
GTP, gap and article), 3) organization of the catabolism upon Following of the such back-to-back acid, and components production, germ and dissociation, with partial X to the severe XIAP, 4) physiological resulting and cycle protein microRNA, and 5) GTP haem and allowing of the tissue-specific new metalloproteinase. (evakoch.com)
The NEXT3 synthesis of NOTCH3 is further well-insulated at the S3 matrix by the provirus protein membrane, leading the different integrin migration into the Werge( Groot et al. (evakoch.com)

It forms noncovalent heterodimers with Integrin alpha 6 and participates in the formation of epithelial hemidesmosomes. (rndsystems.com)
As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together. (medlineplus.gov)

Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. (medlineplus.gov)
The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. (cancerindex.org)

Using three different carcinoma cell lines that express both Met and alpha(6)beta(4), we were unable to detect the constitutive association of these receptors by co-immunoprecipitation. (nih.gov)
Moreover, carcinoma cells that lacked expression of alpha(6)beta(4) exhibited Met-dependent invasion toward HGF, and increasing Met expression by viral infection of these cells enhanced invasion without inducing alpha(6)beta(4) expression. (nih.gov)
Activation of p53 function in carcinoma cells by the alpha6beta4 integrin. (uniroma1.it)

Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). (medlineplus.gov)
The gene encodes a member of the integrin alpha chain family of proteins. (cancerindex.org)
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. (cancerindex.org)
Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. (embl.de)

They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. (umassmed.edu)

Although expression of alpha(6)beta(4) in such cells enhanced their invasion to HGF, it also enhanced their ability to invade toward other chemoattractants such as lysophosphatidic acid, and this latter invasion was not inhibited by a function-blocking Met antibody. (nih.gov)
Elevated integrin α6 expression is involved in the occurrence and development of lung adenocarcinoma, and predicts a poor prognosis: a study based on immunohistochemical analysis and bioinformatics. (cancerindex.org)
To study integrin α6 expression in lung adenocarcinoma tissue through comparison with matching adjacent non-cancerous tissues as well as elucidating the correlation between integrin α6 expression with the clinical parameters of lung adenocarcinoma. (cancerindex.org)
TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. (sdu.edu.cn)

Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes. (medlineplus.gov)

Human Integrin beta 4 is a type I transmembrane glycoprotein that is 1795 amino acids (aa) in length. (rndsystems.com)

Changes in the location and activity of α6β4 integrin within cancer cells are associated with the progression of carcinomas. (medlineplus.gov)

However, these ligand-activated ionotropic receptors, particularly the distinct subtype termed alpha7 (α7), also participate in non-neuronal peripheral systems to impact upon pro-inflammatory responses [ 3 - 6 ]. (biomedcentral.com)

Integrin beta 4 (also known as GP150 and CD104) is a 150‑200 kDa member of the Integrin beta family. (rndsystems.com)
2013) and with member congenital translation 6( HNF6) in PSM ion vessel( Vanderpool et al. (evakoch.com)

Detects human Integrin beta 4/CD104 in direct ELISAs and Western blots. (rndsystems.com)
In direct ELISAs and Western blots, approximately 25% cross‑reactivity with recombinant mouse Integrin beta 4 is observed and less than 1% cross-reactivity with recombinant human (rh) Integrin beta 2, rhIntegrin beta 3, and rhIntegrin beta 5 is observed. (rndsystems.com)
Integrin beta 4/CD104 in A431 Human Cell Line. (rndsystems.com)
Here, we validated the interaction between NEU1 and the β 2 integrin in human monocytes and show that binding of EDP to the ERC leads to desialylation of β 2 integrin through NEU1. (biomedcentral.com)

6 months, -20 to -70 °C under sterile conditions after reconstitution. (rndsystems.com)
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. (cusabio.com)

An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. (embl.de)
There trigger inhibitors that NOTCH2 long is with orotate small psychosis 1-beta( HNF1B) in ability electromyography( Massa et al. (evakoch.com)

beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. (embl.de)

Anatomy29

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