• The hair loss drugs Finasteride and Dutasteride - two 5-alpha reductase inhibitors - appear to work in this way. (perfecthairhealth.com)
  • Proscar is used in the treatment of Benign Prostatic Hyperplasia and belongs to the drug class 5-alpha-reductase inhibitors . (drugs.com)
  • Cardiovascular Drugs / Antilipemic Agents / HMG-CoA Reductase Inhibitors (i.e. (tevausa.com)
  • Finasteride is an oral medication that belongs to a class of drugs known as 5-alpha-reductase inhibitors. (tangorm.com)
  • In addition, SAMS will evaluate prognostic factors, criteria for intervention and the effects of 5-alpha-reductase inhibitors, the outcome after treatment with curative intent, time to symptoms and metastases from prostate cancer, prostate cancer specific survival, and overall survival. (cancercentrum.se)
  • Cyproterone acetate, Aldactone/spironolactone, 5-alpha-reductase inhibitors, phenytoin) within the last 6 months. (who.int)
  • 5-alpha reductase deficiency is a condition that affects sexual development before birth and during puberty. (medlineplus.gov)
  • Many people with 5-alpha reductase deficiency are assigned female at birth based on their external genitalia. (medlineplus.gov)
  • People with 5-alpha reductase deficiency do not develop much facial or body hair. (medlineplus.gov)
  • Variants (also called mutations) in the SRD5A2 gene cause 5-alpha reductase deficiency. (medlineplus.gov)
  • These hormonal factors underlie the changes in sexual development seen in infants with 5-alpha reductase deficiency. (medlineplus.gov)
  • Researchers believe that people with 5-alpha reductase deficiency develop secondary male sex characteristics in response to higher levels of this hormone. (medlineplus.gov)
  • in each cell) will have the characteristic signs of 5-alpha reductase deficiency. (medlineplus.gov)
  • 5-Alpha-reductase type 2 deficiency (5-ARD) is an autosomal recessive sex-limited condition resulting in the inability to convert testosterone to the more physiologically active dihydrotestosterone (DHT). (medscape.com)
  • Because DHT is required for the normal masculinization of the external genitalia in utero, genetic males with 5-alpha-reductase type 2 deficiency are born with ambiguous genitalia (ie. (medscape.com)
  • Patients with 5-alpha-reductase type 2 deficiency classically present with striking ambiguity of the genitalia, with a clitoral-like phallus, bifid scrotum, pseudovaginal perineoscrotal hypospadias, and a rudimentary prostate. (medscape.com)
  • The cause of 5-alpha-reductase type 2 deficiency is the deficiency of the type 2 isozyme of 5-alpha-reductase. (medscape.com)
  • As with most single enzyme disorders, 5-alpha-reductase type 2 deficiency is an autosomal recessive trait and sex limited because the clinical syndrome only affects genetic males, with very subtle phenotypic findings in homozygous females. (medscape.com)
  • The root cause of this disorder is a deficiency in the 5-alpha-reductase type 2 isoenzyme, which transforms testosterone to DHT. (medscape.com)
  • Biochemical effects of 5-alpha-reductase type 2 deficiency in testosterone biosynthesis. (medscape.com)
  • Lack of expression of this gene clinically correlates with the symptoms of 5-alpha-reductase type 2 deficiency. (medscape.com)
  • Linkage analysis has demonstrated that the type 1 enzyme is unrelated to the clinical syndrome of 5-alpha-reductase type 2 deficiency. (medscape.com)
  • Interestingly, partial virilization of males with 5-alpha-reductase type 2 deficiency occurs at puberty and may be attributable to the rise in type 1 enzyme activity or expression at that time. (medscape.com)
  • Because of recent data, reconsidering the past policies of raising children with 46,XY, such as those with 5-alpha-reductase type 2 deficiency (5-ARD) with ambiguous genitalia and small phalli as females may be appropriate. (medscape.com)
  • Some males with 5-alpha-reductase type 2 deficiency respond with an increase in penile size when 2% dihydrotestosterone (DHT) cream is applied. (medscape.com)
  • Limited data suggest that testosterone therapy may increase penile shaft length and circumference, increase erectile potency and ejaculatory volume, increase facial hair and muscularity, and improve a sense of well-being in patients with 5-alpha-reductase deficiency. (medscape.com)
  • Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiency. (medscape.com)
  • Molecular genetics of steroid 5 alpha-reductase 2 deficiency. (medscape.com)
  • Maimoun L, Philibert P, Bouchard P, Ocal G, Leheup B, Fenichel P. Primary amenorrhea in four adolescents revealed 5a-reductase deficiency confirmed by molecular analysis. (medscape.com)
  • DSD due to 5a-reductase 2 deficiency - from diagnosis to long term outcome. (medscape.com)
  • Molecular diagnosis of 5a-reductase deficiency in 4 elite young female athletes through hormonal screening for hyperandrogenism. (medscape.com)
  • 5α-Reductase 2 deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2). (wikipedia.org)
  • Mutations in the SRD5A2 gene can result in a 46,XY disorder of sex development (46,XY DSD) called 5α-reductase 2 deficiency (5αR2D). (wikipedia.org)
  • Pseudovaginal perineoscrotal hypospadias presenting with female appearing genitalia and pubertal virilization is the classical syndrome attributed to 5αR2D, but modern diagnostic methods can diagnose the deficiency shortly after birth and recognize the broad spectrum of presentation. (wikipedia.org)
  • The two primary causes of male pseudohermaphroditism are androgen insensitivity syndrome and 5-alpha reductase deficiency. (chkd.org)
  • A deficiency of 5-alpha reductase is a rare genetic disorder that affects 46,XY patients. (journalmc.org)
  • In conclusion, any individual presenting with ambiguous genitalia, primary amenorrhea or virilization should be investigated for 5-alpha reductase deficiency by conducting a karyotype and full hormone profile. (journalmc.org)
  • Specifically, the steroid 5-alpha reductase 2 enzyme is responsible for a chemical reaction that converts the hormone testosterone to DHT. (medlineplus.gov)
  • Variants in the SRD5A2 gene prevent steroid 5-alpha reductase 2 from effectively converting testosterone to DHT in the developing reproductive tissues. (medlineplus.gov)
  • Only the genes coding for 5-alpha-reductase type 1 ( SRD5A1 ) and 5-alpha-reductase type 2 ( SRD5A2 ) are pertinent to the conversion of testosterone to DHT, whereas the gene coding 5-alpha-reductase type 3 is unrelated to any disorders of male sexual development, and may be implicated in a rare disorder of glycosylation. (medscape.com)
  • 5αR2 is expressed in specific tissues and catalyzes the transformation of testosterone (T) to 5α-dihydrotestosterone (DHT). (wikipedia.org)
  • The enzyme catalyzes the transformation of testosterone (T) to 5α-dihydrotestosterone (DHT) intracellularly. (wikipedia.org)
  • As a result, this gives us three major levers to reduce DHT levels: decrease 1) free testosterone, 2) 5-alpha reductase, and / or 3) androgen receptors. (perfecthairhealth.com)
  • 5-alpha reductase is the enzyme our bodies use to convert free testosterone into DHT. (perfecthairhealth.com)
  • 5-alpha reductase needs NADPH to convert free testosterone into DHT. (perfecthairhealth.com)
  • Your body uses an enzyme called 5-alpha reductase to convert testosterone into dihydrotestosterone (DHT) . (healthline.com)
  • Finasteride works by inhibiting the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). (tangorm.com)
  • Your health care provider might suggest that you take an alpha blocker and a 5-alpha reductase inhibitor at the same time if either medicine alone doesn't help enough. (mayoclinic.org)
  • An extended Fish ELS study was conducted to investigate the potential of dutasteride, as a 5-alpha-reductase inhibitor, to indirectly act as an endocrine disruptor. (janusinfo.se)
  • The SRD5A2 gene provides instructions for making an enzyme called steroid 5-alpha reductase 2. (medlineplus.gov)
  • The development of female sex characteristics does not require DHT, so a lack of steroid 5-alpha reductase 2 activity does not cause physical changes in these individuals. (medlineplus.gov)
  • Steroid 5 alpha-reductase: two genes/two enzymes. (medscape.com)
  • 1.-.-.- Oxidoreductases: steroid 5 alpha-reductase 2. (guidetopharmacology.org)
  • MAIN OUTCOME MEASURES: We measured urinary steroid metabolites including glucocorticoids and androgens and the ratios reflecting enzymatic activities involved in peripheral cortisol and androgen metabolism, 5 alpha-reductase, and 11 beta-hydroxysteroid dehydrogenase types 1 and 2. (ox.ac.uk)
  • KLK3 and steroid 5-alpha reductase type II (SRD5A2) gene polymorphisms might affect clinical reliability of serum PSA measurement. (unipd.it)
  • The V89 isoform of Steroid 5-α reductase type II (SRD5A2) by enhancing diihydrotestosterone, might also enhance PSA. (unipd.it)
  • 5alpha-reductase isozymes and androgen actions in the prostate. (medscape.com)
  • CONCLUSIONS: PCOS is associated with enhanced androgen and cortisol metabolite excretion and increased 5 alpha-reductase activity that cannot be explained by obesity alone. (ox.ac.uk)
  • Evidence suggests that zinc reduces NADPH production , thereby decreasing 5-alpha reductase activity. (perfecthairhealth.com)
  • The investigation of 5αR2D as a disease has played a key role in the biochemical characterization of the SRD5A2 gene, the 5αR2 enzyme, and DHT in male sexual differentiation. (wikipedia.org)
  • 5α-Reductase type 2 (5αR2) is an enzyme, encoded by the SRD5A2 gene, that is expressed in specific tissues in the male body from fetal development to adulthood. (wikipedia.org)
  • 5αR2 is encoded by the gene SRD5A2 which is located on the short arm of chromosome 2 and contains five exons and four introns. (wikipedia.org)
  • Cholestenone 5 alpha-Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • This graph shows the total number of publications written about "Cholestenone 5 alpha-Reductase" by people in this website by year, and whether "Cholestenone 5 alpha-Reductase" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Cholestenone 5 alpha-Reductase" by people in Profiles. (jefferson.edu)
  • There's also research showing that instead of competing with NADPH, Finasteride may instead bind to NADPH and change NADPH's structure into a different coenzyme - one that doesn't support the formation of 5-alpha reductase. (perfecthairhealth.com)
  • Of the 297 patients initially randomized to receive finasteride 5 mg, 259 completed 12 months in the double-blind period and 186 completed 48 months of open-label therapy. (angelfire.com)
  • [ 7 , 8 ] The gene for 5-alpha-reductase type 2 has been determined to be on band 2p23. (medscape.com)
  • The gene for 5-alpha-reductase type 1 is located on band 5p15. (medscape.com)
  • 5alpha-reductase type 2 mutations are present in some boys with isolated hypospadias. (medscape.com)
  • We developed a novel and convenient method of determining 5alpha-reductase activity using LC/MS. With this method, SPE was shown to inhibit 5alpha-reductase activity in rat liver with an IC(50) of 101 microg/ml. (nih.gov)
  • Similarly, all the fatty acids except palmitic acid inhibited 5alpha-reductase activity, with IC(50) values of 42.1 to 67.6 microg/ml. (nih.gov)
  • These are two mechanisms of direct 5-alpha reductase inhibition - or for the lay person - reducing 5-alpha reductase by stopping it from forming. (perfecthairhealth.com)
  • And another 5-alpha reductase inhibiting drug - Dutasteride - seems to do the same thing (using a slightly different molecule). (perfecthairhealth.com)
  • Azzouni F, Godoy A, Li Y, Mohler J. The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. (medscape.com)
  • 5αR2 consists of 254 amino acid residues with reported mutations at 67 of them with multiple different mutations at some residues. (wikipedia.org)
  • Mutations result in a spectrum of activity effects ranging from destabilizing 5αR2 to complete loss of activity. (wikipedia.org)
  • A phenotype-genotype correlation is not known to exist for many of the most common mutations, and affected males with the same 5αR2 mutations have variable phenotypes suggesting other interacting genetic factors that determine phenotype. (wikipedia.org)
  • Three genes coding for 5-alpha-reductase have been identified, each for a slightly different isoenzyme. (medscape.com)
  • The 5-alpha-reductase type 2 isoenzyme is expressed in external genital tissues early in gestation, making its action necessary for the development of normal male external genital anatomy in the fetus. (medscape.com)
  • In adulthood, the 5-alpha-reductase type 2 isoenzyme is expressed in high levels in the prostate, genital skin, epididymis, seminal vesicle, and liver. (medscape.com)
  • There are many types of 5-alpha reductase, but when it comes to hair loss, the one that gets the most attention is type II 5-alpha reductase . (perfecthairhealth.com)
  • Type II 5-alpha reductase is the enzyme expressed in our scalp skin and prostate. (perfecthairhealth.com)
  • Some men have a rare genetic mutation where their bodies can't produce any type II 5-alpha reductase. (perfecthairhealth.com)
  • The net: we need type II 5-alpha reductase to make DHT in our scalp skin. (perfecthairhealth.com)
  • And that means if we can reduce the expression of type II 5-alpha reductase, we can also reduce our DHT levels (and possibly prevent or partially reverse pattern hair thinning). (perfecthairhealth.com)
  • Data from family studies confirmed familial clustering [3-5]. (springer.com)
  • Saw palmetto extract (SPE), used widely for the treatment of benign prostatic hyperplasia (BPH) has been shown to bind alpha(1)-adrenergic, muscarinic and 1,4-dihydropyridine (1,4-DHP) calcium channel antagonist receptors. (nih.gov)
  • Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome. (ox.ac.uk)
  • Endocrinol Diabetes Nutr (Engl Ed);69(5): 384-386, 2022 05. (bvsalud.org)
  • 69(5): 384-386, 2022 05. (bvsalud.org)
  • Skin Pharmacology and Applied Skin Physiology (1997) 10 (5-6): 288-297. (karger.com)
  • Some affected people also retain a small amount of 5-alpha reductase 2 activity, which may produce DHT and contribute to the development of secondary sex characteristics during puberty. (medlineplus.gov)
  • 5αR2D is a result of impaired 5αR2 activity resulting in decreased DHT levels. (wikipedia.org)
  • 5 alpha-Reductase activity correlated with BMI, insulin levels, and homeostasis model assessment. (ox.ac.uk)
  • Thujae occidentalis inhbits 5-alpha reductase activity suggesting it may be useful for treating male pattern baldness. (greenmedinfo.com)
  • The scientific hypothesis is that this alternative schedule for follow-up will identify the aggressive cancers earlier with less health-care resources and better quality of life for the patients, without increasing the total proportion of patients receiving radical therapy within 5 years. (cancercentrum.se)
  • Alpha blockers work by relaxing the smooth muscle of the bladder neck and prostate. (mayoclinic.org)
  • There are multiple types of alpha blockers, but Flomax (tamsulosin) specifically targets the prostate. (mayoclinichealthsystem.org)
  • This belief is based on a study of 422 boys at a median age of 6 years 2 months (range, 3 mo to 16 y), of whom 186 (44.1%) received treatment involving surgery (148 circumcision, 33 preputial adhesiolysis, 5 frenuloplasty). (medscape.com)
  • Children with this condition lack an enzyme (5-alpha reductase). (chkd.org)
  • Alpha blockers include alfuzosin (Uroxatral), doxazosin (Cardura), tamsulosin (Flomax) silodosin (Rapaflo) and terazosin. (mayoclinic.org)