Alpha 2 receptors adrenergic alpha 2. Medical search. Frequent questions

Agonists (activators) of the α2-adrenergic receptor are frequently used in anaesthesia where they affect sedation, muscle relaxation and analgesia through effects on the central nervous system (CNS). (wikipedia.org)
Agonists 4-NEMD 7-Me-marsanidine (also I1 agonist) Agmatine (also I agonist, NMDA, 5-HT3, nicotinic antagonist and NOS inhibitor) Apraclonidine Brimonidine Cannabigerol (also acts as a moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist). (wikipedia.org)
Adrenergic alpha-2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Adrenergic alpha-2 Receptor Agonists" by people in this website by year, and whether "Adrenergic alpha-2 Receptor Agonists" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Adrenergic alpha-2 Receptor Agonists" by people in Profiles. (rush.edu)
These agents compete with beta-adrenergic agonists for available beta-receptor sites. (medscape.com)
Cooling augmented contractions evoked by the alpha 2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full alpha 1-adrenergic agonist phenylephrine. (johnshopkins.edu)
Therefore, cooling reduces alpha 1-adrenergic responsiveness in canine cutaneous veins, but in the case of full alpha 1-adrenergic agonists such as norepinephrine and phenylephrine the inhibitory effect of cooling is buffered by an alpha 1-adrenoceptor reserve. (johnshopkins.edu)
2-adrenergic agonists (e.g. clonidine) or with somatostatin. (druglibrary.org)
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. (rndsystems.com)
If you combine any of these alpha 2 antagonists with caffeine or beta-agonists (aka synergists), the necessary dose decreases quite a bit. (anabolicminds.com)
This means caffeine, exercise, forskolin, and beta-agonists all work exceptionally well with alpha-2 antagonists. (anabolicminds.com)
beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. (duke.edu)
The regional and subtype selectivity are compatible with primary deficits in the development of noradrenergic projections to the cerebellum identified in previous studies and provide further evidence that therapeutic use of beta-adrenergic agonists may produce neurobehavioral teratology. (duke.edu)
Guanfacine is in a class of medications called centrally acting alpha 2A -adrenergic receptor agonists. (medlineplus.gov)

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. (aspetjournals.org)
Doxazosin mesylate is a quinazoline compound that is a selective alpha1-adrenergic antagonist. (medscape.com)
We restored DNIC in spinal nerve ligated animals by blocking 5-HT3 descending facilitations with the antagonist ondansetron or by enhancing norepinephrine modulation through the use of reboxetine (a norepinephrine reuptake inhibitor, NRI) or tapentadol (μ-opioid receptor agonist and NRI). (nih.gov)
This augmentation was blocked by the CB1 receptor antagonist SR141716A or the D2 antagonist sulpride. (jneurosci.org)
These data indicate that low doses of the alpha-2 receptor antagonist piperoxane and rauwolscine act centrally to increase SND. (erowid.org)
Management of opioid withdrawal includes the use of other opioids, benzodiazepines and alpha-2 adrenergic receptor antagonist, clonidine. (nih.gov)
These 3 categories of alpha-2-antagonist each possess a unique goal-specific attribute, but before we delve into specifics, let's look at how effective these compounds are for fat loss. (anabolicminds.com)
If there's one supplement to consume orally for stubborn fat loss, it's an alpha 2 antagonist. (anabolicminds.com)
All effects were antagonized by the alpha 1-adrenoceptor antagonist prazosin (0.1 microM), indicating receptor-mediated effects. (aspetjournals.org)
Alpha-receptor antagonist medications potentially interfere with iris muscle dilation, resulting in difficult lens removal and possibly increasing complications. (urotoday.com)

The α2A-adrenergic agonist, guanfacine, is now used to treat prefrontal cortical cognitive disorders such as Attention Deficit Hyperactivity Disorder. (wikipedia.org)
However, the contractions evoked by the partial alpha 1-adrenergic agonist St 587 were virtually abolished by cooling. (johnshopkins.edu)
Dexmedetomidine, an alpha 2 agonist, has been used to manage symptoms of delirium in pediatric patients and is gaining popularity in treatment for pediatric patients with severe anticholinergic toxidrome [ 5 , 6 ]. (hindawi.com)
In striatal neurons in primary culture, both the CB1 receptor agonist [3-(1,1-dimethylheptyl)-11-hydroxy-Δ 8 tetrahydrocannabinol] (HU210) and the D2 receptor agonist quinpirole inhibited forskolin-stimulated cAMP accumulation when applied separately. (jneurosci.org)
Brimonidine tartrate ophthalmic solution, 0.15% is an alpha-2 adrenergic receptor agonist indicated for the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension ( 1 ). (nih.gov)
Synthesis and in vitro characterisation of N -[5-(4,5-dihydro-1 H -imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α 1A receptor agonist. (rndsystems.com)
A-61603, a potent α 1 -adrenergic receptor agonist, selective for the α 1A receptor subtype. (rndsystems.com)
An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. (rndsystems.com)
Agmatine acts as an agonist at imidazoline and alpha-2-adrenergic receptors, also modulating NMDA receptor activity. (psicothema.com)
It is classified as a centrally acting alpha 2 adrenergic agonist and imidazoline receptor agonist and has been in clinical use since 1966. (uspharmacist.com)

The other clone (M alpha 2-10H) closely resembles the human alpha 2-C10 subtype in sequence but binds with significantly lower affinity to yohimbine and rauwolscine, members of a distinct class of bulky alpha 2-selective antagonists commonly used to evaluate alpha 2-AR function in vivo. (aspetjournals.org)
Mccall RB, Schuette MR, Humphrey SJ, Lahti RA, Barsuhn C. "Evidence for a Central Sympathoexcitatory Action of Alpha-2 Adrenergic Antagonists" The Journal Of Pharmacolocy And Experimental Therapeutics . (erowid.org)
The effect of alpha-2 adrenergic receptor antagonists on sympathetic nerve discharge (SND) recorded from the external carotid and splanchnic nerves were studied in baroreceptor-denervated cats.Low i.v. doses of piperoxane end rauwolscine dramatically increased SND and produced a concomitant rise in mean arterial pressure and heart rate. (erowid.org)
It belongs to the class of alpha-2 adrenergic receptor antagonists , influencing the sympathetic nervous system's activity by blocking specific receptors. (enhancedlabs.com)
As many of you may already know, alpha-2-antagonists are simply compounds that antagonize the alpha-2-adrenoreceptor. (anabolicminds.com)
And then we have the various yohimbe alkaloids like 11-OH yohimbine, that are alpha-2-antagonists (not to be confused with a broad-spectrum extract of alkaloids). (anabolicminds.com)
What works best with alpha-2-antagonists? (anabolicminds.com)
For those seeking to lose stubborn fat, alpha-2-antagonists are a great option. (anabolicminds.com)
Alpha-2 antagonists synergize with anything that potentiates catecholamine release. (anabolicminds.com)
We previously demonstrated that alpha-1 adrenergic receptor (α1-AR) antagonists can prevent cytokine storm syndrome in mice. (stanford.edu)
Competitive neuromuscular blocking drugs act as antagonists at acetylcholine receptors, reducing the effectiveness of acetylcholine in generating an end-plate potential . (britannica.com)
This level of risk was subsequently confirmed and was thereafter described with all currently used alpha-1 adrenergic receptor antagonists [3,4,5,6]. (urotoday.com)
The FDA considers the risk for IFIS to be a class effect for alpha-1 adrenergic receptor antagonists [8,9]. (urotoday.com)

For example, the alpha-2A adrenergic receptor subtype is post-synaptic in the prefrontal cortex and these receptors strengthen cognitive and executive functions by inhibiting cAMP opening of potassium channels, thus enhancing prefrontal connections and neuronal firing. (wikipedia.org)
These studies have not, however, identified distinct subtype-specific functions for these receptors in vivo. (aspetjournals.org)
It should be possible to extend the analysis of alpha 2-AR subtype function to the animal level through the use of experimental mammalian embryology in mice. (aspetjournals.org)
Sequence homology and ligand binding data allow the assignment of one clone (M alpha 2-4H) as the mouse homolog of the human alpha 2-C4 subtype. (aspetjournals.org)
This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)
Pretreatment with chlorethylclonidine, which selectively alkylates the alpha-1B subtype, did not affect the Emax value of phenylephrine-induced contractions, but significantly shifted the curve to the right. (aspetjournals.org)
Receptor subtype involved in α 1A -adrenergic receptor-mediated Ca 2+ signaling in cardiomyocytes. (rndsystems.com)
The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries. (rndsystems.com)
Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. (rndsystems.com)

Selective alpha 2-receptor that reduces aqueous humor formation and increases uveoscleral outflow. (medscape.com)
Furthermore, it's partially adrenolytic, as it is less selective than yohimbine on the adrenergic system, partially antagonizing alpha-1- adrenoreceptors. (anabolicminds.com)
Scholars@Duke publication: Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding. (duke.edu)
Despite the absence of body or brain growth impairment, selective increases were seen postnatally in cerebellar alpha 1- and alpha 2-receptor subtypes, whereas the same receptor populations were decreased by small amounts in cerebral cortex and midbrain + brainstem. (duke.edu)
SSRIs are selective to the 5-HT system but not specific for the different 5-HT receptors. (msdmanuals.com)

Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α2-adrenergic receptor in the central and peripheral nervous systems. (wikipedia.org)
The α2-adrenergic receptor binds both norepinephrine released by sympathetic postganglionic fibers and epinephrine (adrenaline) released by the adrenal medulla, binding norepinephrine with slightly higher affinity. (wikipedia.org)
Adrenergic receptors bind the norepinephrine, epinephrine and catecholamines. (kidneyurology.org)
Due to the property of blocking the alpha 2 adrenergic receptors, the levels of blood epinephrine and norepinephrine is increased. (kidneyurology.org)
It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors. (medscape.com)
Cooling (from 37 to 24 degrees C) augmented contractions to norepinephrine under control conditions and after alpha 1-adrenergic blockade (prazosin) but not following alpha 2-adrenergic blockade (rauwolscine). (johnshopkins.edu)
With norepinephrine, this permits the potentiating effect of cooling on the alpha 2-adrenergic component of the response to predominate. (johnshopkins.edu)
These receptors play a role in regulating the release of neurotransmitters like norepinephrine. (enhancedlabs.com)
By antagonizing these receptors, alpha yohimbine potentially increases norepinephrine release, leading to heightened alertness, improved mood, and enhanced fat mobilization. (enhancedlabs.com)

Analysis of these receptors identified a conservative Cys201 to Ser201 change in the fifth transmembrane domain of M alpha 2-10H as being responsible for the low affinity of the mouse receptor for yohimbine. (aspetjournals.org)
It has been found through scientific studies that Yohimbine Hydrochloride is an alpha 2 adrenergic receptor inhibitor. (kidneyurology.org)
Since Yohimbine Hydrochloride is a blocker of adrenergic receptors, it would help in curing erectile dysfunctions. (kidneyurology.org)
The Truth About Alpha Yohimbine! (enhancedlabs.com)
Alpha Yohimbine, also known as rauwolscine, is a compound derived from the bark of the Pausinystalia yohimbe tree. (enhancedlabs.com)
With its potential effects on weight loss and sexual health, alpha yohimbine has captured the interest of researchers and supplement enthusiasts alike. (enhancedlabs.com)
As an expert in the field, this article delves into the intricate details of alpha yohimbine supplements, including their mechanism of action, historical background, potential benefits, side effects, usage guidelines, and intriguing facts. (enhancedlabs.com)
Alpha yohimbine, scientifically termed yohimbine, is an alkaloid compound found in the bark of the Pausinystalia yohimbe tree, native to Central and West Africa. (enhancedlabs.com)
This makes alpha yohimbine a potentially more tolerable choice for those with pre-existing medical conditions or a predisposition to experiencing adverse reactions to stimulants. (enhancedlabs.com)
However, individual responses can vary, and consulting a healthcare professional is crucial when considering either alpha yohimbine or yohimbine HCl supplementation. (enhancedlabs.com)
After 21 days of yohimbine supplementation, placebo remained unchanged but the yohimbine group lost about 2% bodyfat, taking them all the way to 7% BF. (anabolicminds.com)
3 weeks of Yohimbine supplementation caused a 2% reduction in bodyfat from an already shredded baseline of 9% BF, all the while preserving muscle mass and strength/endurance. (anabolicminds.com)
Yohimbine possess extreme affinity for the alpha-2-adrenoreceptor, but due to receptor homology with various 5-HT receptors, yohimbine HCl is highly anxiogenic and is clinically used to model panic disorder. (anabolicminds.com)
2. The recommended dose for yohimbine is 0.2mg/kg BW in isolation. (anabolicminds.com)

Molecular cloning and ligand binding studies have shown the alpha 2 class of adrenergic receptor (alpha 2-AR) to be a family of at least three related subtypes in humans. (aspetjournals.org)
To begin this process, we have isolated two mouse genomic clones encoding alpha 2-AR subtypes and expressed these genes in COS-7 cells for binding studies. (aspetjournals.org)
Two subtypes of cannabinoid receptors have been identified. (jneurosci.org)
There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. (nih.gov)

The present data indicate that activated alpha 2-adrenergic and muscarinic receptors inhibit dihydropyridine-sensitive Ca2+ channels via pertussis toxin-sensitive G proteins without the involvement of a cAMP-dependent intermediate step. (mdc-berlin.de)

It inhibits postsynaptic alpha-adrenergic receptors, resulting in the vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure. (medscape.com)
The alpha-2 receptor is an autoreceptor, meaning it is located NOT on the postsynaptic neuron chiefly, but on the pre-synaptic neuron. (anabolicminds.com)
By preventing reuptake of 5-HT presynaptically, SSRIs result in more 5-HT to stimulate postsynaptic 5-HT receptors. (msdmanuals.com)

Tramadol is an orally administered, centrally acting analgesic drug that interacts with opioid, adrenergic and serotonin receptors. (vin.com)

In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)

Many presume that such adrenergic receptors may inhibit erection. (kidneyurology.org)
Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)
whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)
Previously, CB1 receptors have been shown to inhibit D1 receptor-mediated cAMP accumulation ( Bidaut-Russell and Howlett, 1991 ). (jneurosci.org)

Nanoparticle inhalation modulates arteriolar sympathetic constriction: role of nitric oxide, prostanoids, and alpha-adrenergic receptors. (cdc.gov)

This is a nonselective alpha-adrenergic blocking agent. (medscape.com)
This is a nonselective beta-adrenergic receptor blocker. (medscape.com)

In vitro binding experiments indicated that piperoxane and rauwolscine bound selectively to the alpha-2 adrenergic receptor and had little affinity for alpha-1 receptor sites. (erowid.org)
Rauwolscine lacks significant activity at the 5HT receptors, but it has its own issues. (anabolicminds.com)

At low doses, alpha-adrenergic receptor blockers may be used as monotherapy in the treatment of hypertension. (medscape.com)
As a result, concurrent diuretic therapy may be required to maintain the hypotensive effects of alpha-receptor blockers. (medscape.com)
The "intra-operative floppy iris syndrome" cataract surgery complication has been reported in men using alpha-blockers. (urotoday.com)
The risk of complicated cataract surgery was 14.9% in patients using alpha-blockers, approximately 50% higher than those not receiving this medication (9.5%) (p=0.003). (urotoday.com)
Except in special conditions, vasodilators and alpha- and beta-blockers are 3rd-line drugs, which if needed should be used after consultation with a specialist. (msdmanuals.com)

Heart failure (HF) is characterized by markedly elevated levels of catecholamines that bind to adrenergic receptors (ARs) in the heart. (unc.edu)

Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)

Pretreatment of cells with pertussis toxin or intracellular infusion of the GDP analogue guanosine-5'-O-(2-thiodiphosphate) was without effects on the control Ca2+ channel current but abolished its hormonal inhibition. (mdc-berlin.de)
Pertussis toxin treatment of striatal neurons prevented the inhibition of cAMP accumulation by D2 receptors but unmasked a cannabinoid receptor-mediated stimulatory effect on cAMP accumulation. (jneurosci.org)
Similar augmentation of cAMP accumulation after pertussis toxin treatment was observed in Chinese hamster ovary (CHO) cells transfected with, and stably expressing, the CB1 receptor. (jneurosci.org)
Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a G s -type G-protein. (jneurosci.org)
Stimulation of cAMP accumulation was not observed after pertussis toxin treatment of CHO cells expressing the human CB2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid CB1 receptor. (jneurosci.org)

The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together with a gain of 5-HT3 receptor-mediated facilitations after neuropathy. (nih.gov)

Alpha adrenergic receptors are blocked by TCAs in the periphery, causing vasodilation. (emra.org)

Moreover, following partial irreversible blockade of the alpha 1-adrenoceptors with phenoxybenzamine, cooling also reduced the contractions evoked by phenylephrine. (johnshopkins.edu)

To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)
Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)

After primary treatment with an alpha-receptor blocker, propranolol hydrochloride may be used as adjunctive therapy if control of tachycardia becomes necessary before or during surgery. (medscape.com)

The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. (wikipedia.org)
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. (nih.gov)

It may be used to treat excessive beta-receptor stimulation in patients with inoperable metastatic pheochromocytoma. (medscape.com)
Existence and alpha 1-adrenergic stimulation of inositol polyphosphates in mammalian heart. (aspetjournals.org)
1,4,5-IP3 (significant at 10 microM) and both IP4 isomers (significant at 1 microM) increased after alpha-adrenoceptor stimulation, whereas 1,3,4,5,6-IP5 and IP6 remained unaffected. (aspetjournals.org)
Increased inositol polyphosphate turnover may be involved in the mechanism(s) whereby alpha 1-adrenoceptor stimulation produces an increase in myocardial force of contraction. (aspetjournals.org)

[ 6 ] These effects have been postulated to be mediated through micro-opioid receptors. (medscape.com)

These experiments suggest that cooling augments alpha 2-adrenergic responsiveness without affecting alpha 1-adrenergic responsiveness. (johnshopkins.edu)

Its drug action is transient and alpha-adrenergic blockade incomplete. (medscape.com)

In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase. (jneurosci.org)
Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
Furthermore, because alpha-2 antagonism can increase insulin release, these compounds are best taken fasted. (anabolicminds.com)

The American journal of physiology , 249 (5 Pt 2), H950-955. (johnshopkins.edu)

The afferent input from these fibers inhibits propagation of nociception carried in the small, unmyelinated C fibers by blocking transmission along these fibers to the target or T cells located in the substantia gelatinosa (laminae 2 and 3) of the dorsal horn. (medscape.com)

Preoperatively, prepare patients with pheochromocytomas by treating them with an alpha-blocker or a tyrosine hydroxylase inhibitor, such as metyrosine, for 1-2 weeks, after which administration of a beta-blocker can be considered. (medscape.com)

Experiments were designed to determine the effects of cooling on alpha 1- and alpha 2-adrenergic responses in isolated canine cutaneous veins. (johnshopkins.edu)

The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)

Clonidine hydrochloride (HCl) (Catapres, Duraclon, C 9 H 9 Cl 2 N 3 .HCl, MW 266.55) occurs as a white to off-white, crystalline powder that is odorless and has a bitter taste. (uspharmacist.com)

In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regions of the offspring. (duke.edu)

It has several general functions in common with the α1-adrenergic receptor, but also has specific effects of its own. (wikipedia.org)
Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)
receptors may cause respiratory depression and other undesired effects (e.g. nausea, vomiting, pruritus). (druglibrary.org)
While alpha yohimbine's influence on the alpha-2 adrenergic receptors can lead to various desirable effects, it can also trigger unwanted side effects. (enhancedlabs.com)
Drugs that are commonly used in other species, such as opioids, non-steroidal anti-inflammatory agents, alpha-2 agents, the dissociative, ketamine, and local anesthetics often produce side effects in cats. (vin.com)
They stimulate 5-HT 1 receptors, with antidepressant and anxiolytic effects, but they also stimulate 5-HT 2 receptors, commonly causing anxiety, insomnia, and sexual dysfunction, and 5-HT 3 receptors, commonly causing nausea and headache. (msdmanuals.com)

This is a long-acting adrenergic alpha-receptor blocker that can produce and maintain a chemical sympathectomy. (medscape.com)
Alpha-blocker medications are the first line of therapy for men with these urinary symptoms. (urotoday.com)
To assess the frequency of cataract surgery complications arising from alpha-blocker therapy in a large patient population. (urotoday.com)
If possible, alpha blocker medications should be discontinued prior to eye surgery in older patients. (urotoday.com)
As alpha-blocker medications are the first line of therapy for men with LUTS, these reports of IFIS led the Food and Drug Administration, American Urological Association, American Academy of Ophthalmology, and American Society of Cataract and Refractive Surgery to issue statements alerting physicians and patients to potential difficulties during cataract surgery in patients using alpha-1 blocker therapy [7,8,9]. (urotoday.com)
The purpose of this study was to assess the impact of alpha-blocker therapy on complications during cataract surgery in a large patient population. (urotoday.com)

It may take 2 weeks before you feel the full benefit of guanfacine extended-release tablets. (medlineplus.gov)

Within the striatum, CB1 receptors have been shown to be localized on the same neurons as G i -coupled dopamine D2 receptors. (jneurosci.org)
The two populations also contain different populations of dopamine receptors. (jneurosci.org)

It is also located on the vascular smooth muscle cells of certain blood vessels, such as those found in skin arterioles or on veins, where it sits alongside the more plentiful α1-adrenergic receptor. (wikipedia.org)
Cooling and alpha 1- and alpha 2-adrenergic responses in cutaneous veins: role of receptor reserve. (johnshopkins.edu)

Alpha yohimbine's primary mechanism of action centers on its interaction with alpha-2 adrenergic receptors. (enhancedlabs.com)

receptors located on axon terminals, near to the release sites of the excitatory amino acids and peptides. (druglibrary.org)

A 2% aqueous solution has a pH of 6.5 to 8.0. (uspharmacist.com)

Cardiac alpha (α)1-ARs have received less attention, however data from cell and animal studies indicate that they protect against the development of HF. (unc.edu)
Dr. Beak discovered that the orphan nuclear receptor, RORα, is expressed in the mouse and human heart and mediates cardiac hypertrophy in response to angiotensin II. (unc.edu)

The contractile mechanism of skeletal muscles entails the binding of acetylcholine to nicotinic receptors on the membranes of muscle fibres. (britannica.com)

CB1 receptors have been identified on both subpopulations of medium spiny neurons ( Mailleux and Vanderhaeghen, 1992 ). (jneurosci.org)

Diseases2

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes3

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Health Care1

Agonists15

Antagonist10

Agonist10

Antagonists13

Subtype9

Selective5

Norepinephrine9

Yohimbine14

Subtypes4

Muscarinic Receptors1

Postsynaptic3

Serotonin1

Alpha1-adrenergic1

Inhibit4

Sympathetic1

Nonselective2

Rauwolscine2

Blockers5

Catecholamines1

Characterization1

Pertussis Toxin5

Noradrenaline1

Vasodilation1

Phenylephrine1

Antibodies3

Propranolol1

Protein-coupled receptor2

Stimulation4

Opioid1

Augments1

Blockade1

Adenylate cyclase2

Compounds2

Physiology1

Inhibits1

Inhibitor1

Canine1

Pharmacological1

Clonidine1

Rats1

Effects6

Blocker6

Guanfacine1

Dopamine2

Veins2

Mechanism of Act1

Peptides1

Aqueous1

Cardiac2

Membranes1

Neurons1