• Apart from the well-known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid reaction from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV drugs might be seen in a wide spectrum extending to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome. (springer.com)
  • Voltage-sensitive calcium channels in differentiated neuroblastoma X glioma hybrid (NG108-15) cells: characterization by quin 2 fluorescence. (nih.gov)
  • Calcium mobilization by muscarinic receptors in human astrocytoma cells: measurements with quin 2. (nih.gov)
  • Heterogeneity of muscarinic receptors coupled to phosphoinositide breakdown in guinea pig brain and peripheral tissues. (nih.gov)
  • 3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. (nih.gov)
  • Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM, KD = 2.5 nM, Bmax = 160 fmol/mg protein) and competition studies indicated that [3H]rauwolscine labeled the alpha 2-receptor. (nih.gov)
  • These results suggest that insulin, by modulating α 2 adrenergic receptor levels, is able to regulate the amount of NE present in the synaptic cleft. (springer.com)
  • 125I]PIC should prove useful in binding assays involving tissues with a low receptor density or in small tissue samples and in studies of cloned and expressed alpha 2-AR. (biomedsearch.com)
  • Both proteins showed typical alpha 2-adrenergic binding characteristics with specific binding activities of 13.85 nmol/mg and 14.17 nmol/mg protein. (cshl.edu)
  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. (genecards.org)
  • It has several general functions in common with the α1-adrenergic receptor, but also has specific effects of its own. (wikipedia.org)
  • Agonists (activators) of the α2-adrenergic receptor are frequently used in veterinary anaesthesia where they affect sedation, muscle relaxation and analgesia through effects on the central nervous system (CNS). (wikipedia.org)
  • In the event of side effects dosage is to be reduced to 1/2 caplet 3 times a day, followed by gradual increases to 1 caplet 3 times a day. (rxlist.com)
  • In the present study we have investigated this further by examining the actions of this peptide on the regulation of α 2 -adrenergic receptors in glial cells. (springer.com)
  • Heterologous up-regulation of Ni-coupled receptors in cultured neural hybrid cells by a transferable factor, whose expression is inhibited in a cyclic AMP-dependent, cell-specific manner. (nih.gov)
  • It is to be noted that in male sexual performance, erection is linked to cholinergic activity and to alpha-2 adrenergic blockade which may theoretically result in increased penile inflow, decreased penile outflow or both. (rxlist.com)
  • The present study was designed to examine the role of central noradrenergic system, especially alpha-2 adrenergic receptors in the action of various anesthetics and analgesics;nitrous oxide 75%, halothane 1.3%, pentobarbital 80mg/kg (ip), and morphine 5mg/kg (iv). (nii.ac.jp)
  • Among its related pathways are GABAergic synapse and p75 NTR receptor-mediated signalling . (genecards.org)