Alpha 1 patients. Medical search. Frequent questions

Introduction: Alpha-1-antitrypsin (AAT) has been shown to inhibit SARS-CoV-2 cell entry and suggested as a therapeutic agent for COVID-19. (lu.se)
Furthermore, epidemiological association of high prevalence of Alpha-1-antitrypsin deficiency (AATD) and regional severity of COVID-19-impact has been hypothesized. (lu.se)
The NEJM article was published online ahead of print and is titled, "Fazirsiran for Liver Disease Associated with Alpha-1 Antitrypsin Deficiency. (daum.net)
The EASL presentation was titled, "Reduction of Intra-hepatic Z-AAT Synthesis by Fazirsiran Decreases Globule Burden and Improves Histological Measures of Liver Disease in Adults with Alpha-1 Antitrypsin Deficiency. (daum.net)
Fazirsiran is a potential first-in-class investigational RNA interference (RNAi) therapy designed to reduce the production of mutant alpha-1 antitrypsin protein (Z-AAT) as a potential treatment for the rare genetic liver disease associated with AATD. (daum.net)
What is alpha-1 antitrypsin deficiency (AAT deficiency)? (medlineplus.gov)
Alpha-1 antitrypsin deficiency (AAT deficiency, or AATD) is an inherited condition that raises your risk for lung and liver disease. (medlineplus.gov)
If you have this condition, your body doesn't make enough alpha-1 antitrypsin (AAT). (medlineplus.gov)
What are the symptoms of alpha-1 antitrypsin deficiency (AAT deficiency)? (medlineplus.gov)
Participate in the on-demand webcast series designed for healthcare professions to improve knowledge and competence in diagnostics and treatment of Alpha-1 Antitrypsin Deficiency (AATD). (clevelandclinicmeded.com)
The educational online series is designed for primary care practitioners, internal medicine physicians, pediatricians, pulmonologists, and other physicians, respiratory therapists, geneticists, and allied health care professionals treating patients with Alpha-1 Antitrypsin Deficiency. (clevelandclinicmeded.com)
Background Although bronchiectasis has been recognised as a feature of some patients with Alpha1-Antitrypsin deficiency the prevalence and characteristics are not widely known. (gencat.cat)
Conclusions The data indicates the bronchiectasis alone is a feature of 9.1% of patients with the PiZZ genotype of Alpha1-antitrypsin deficiency but although emphysema is the dominant lung pathology bronchiectasis is also present in 27% of emphysema cases and may require a different treatment strategy. (gencat.cat)
Alpha-1 antitrypsin is a vital protein produced by the liver to protect the lungs. (alpha1.ie)
Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic condition which, after cystic fibrosis, is the commonest genetic disorder in Ireland. (alpha1.ie)
Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/434551/all/Intravenous_alpha‐1_antitrypsin_augmentation_therapy_for_treating_patients_with_alpha‐1_antitrypsin_deficiency_and_lung_disease. (unboundmedicine.com)
Opinions and Attitudes of Pulmonologists About Augmentation Therapy in Patients with Alpha-1 Antitrypsin Deficiency. (dovepress.com)
Augmentation therapy (AT) is the only specific treatment licensed for patients with alpha-1 antitrypsin deficiency (AATD) associated lung disease. (dovepress.com)
Stoller J.K. Stoller, James K. Alpha-1 Antitrypsin Deficiency. (mhmedical.com)
Alpha-1 antitrypsin (AAT) deficiency is an autosomal codominant condition characterized by a decrease in the circulating level of AAT, a member of the serine protease inhibitor (serpin) family of proteins. (mhmedical.com)
Objectives: To identify predictors of portal hypertension, liver transplantation, and death in North American youth with alpha-1-antitrypsin (AAT) deficiency, and compare with patients with AAT deficiency elsewhere. (northwestern.edu)
Alpha-1 Antitrypsin deficiency (AATD) , a genetic disorder mainly affecting lungs and liver, occurs in 1/1,600 people globally. (sebia.com)
Four months earlier, Wilson , a School of Medicine assistant professor of medicine, had submitted a proposal for a highly competitive R01 grant from the National Institutes of Health (NIH) to study the genetic disease alpha-1 antitrypsin deficiency. (bu.edu)
In alpha-1 antitrypsin deficiency, liver transplant can effectively cure the liver damage. (mayo.edu)
Alpha-1 Antitrypsin Deficiency Severe and No Severe. (archbronconeumol.org)
titled "Labelling Alpha-1 antitrypsin deficiency in the medical record - A call to action", 1 and we would like to make some considerations in this regard. (archbronconeumol.org)
The first is that the authors classify subjects diagnosed with alpha-1 antitrypsin deficiency (AATD) into severe and non-severe according to 2 criteria: having a Pi*ZZ genotype or serum levels of alpha-1 antitrypsin (AAT) ≤ 57 mg/dL (≤11 μmol/L). From our point of view, this classification brings more risks than benefits. (archbronconeumol.org)
Your asthma or COPD could be a serious hereditary disease called Alpha-1 Antitrypsin Deficiency. (alpha1canada.ca)
Alpha-1 Antitrypsin Deficiency, also called Alpha-1, A1AD or AATD is a common serious hereditary disorder and can result in life-threatening lung, liver or skin disease. (alpha1canada.ca)
Everyone's liver produces Alpha-1 Antitrypsin (AAT). (alpha1canada.ca)
Testing for Alpha-1 Antitrypsin Deficiency is simple and quick. (alpha1canada.ca)
People at risk for Alpha-1 Antitrypsin Deficiency should be tested. (alpha1canada.ca)
TA positive diagnosis of Alpha-1 Antitrypsin Deficiency represents an opportunity to take concrete steps to avoid risk factors, limit symptoms, or slow the progression of symptoms you may already be experiencing. (alpha1canada.ca)
Augmentation therapy increases the amount of Alpha-1 Antitrypsin in a patient's blood stream thereby providing protection for the lungs. (alpha1canada.ca)
Alpha-1 antitrypsin deficiency is congenital lack of a primary lung antiprotease, alpha-1 antitrypsin, which leads to increased protease-mediated tissue destruction and emphysema in adults. (msdmanuals.com)
Hepatic accumulation of abnormal alpha-1 antitrypsin can cause liver disease in both children and adults. (msdmanuals.com)
Alpha-1 antitrypsin is a neutrophil elastase inhibitor (an antiprotease), the major function of which is to protect the lungs from protease-mediated tissue destruction. (msdmanuals.com)
Inheritance of some variant alleles causes a change in conformation of the alpha-1 antitrypsin molecule, leading to polymerization and retention within hepatocytes. (msdmanuals.com)
In the lungs, alpha-1 antitrypsin deficiency increases neutrophil elastase activity, which facilitates tissue destruction leading to emphysema (especially in smokers, because cigarette smoke also increases protease activity). (msdmanuals.com)
Alpha-1 antitrypsin deficiency and various occupational. (msdmanuals.com)
A rare genetic condition called alpha-1 antitrypsin deficiency can also cause the disease-but it is rare. (medlineplus.gov)

Guidelines recommend testing for AAT deficiency in all symptomatic adults with fixed airflow obstruction on postbronchodilator spirometry, as well as individuals with panniculitis, patients with otherwise unexplained cirrhosis, unexplained bronchiectasis, and siblings of AAT-deficient individuals. (mhmedical.com)
It considers severe to healthy patients, or on the contrary it considers not serious deficiency to patients with AATD-related disease and finally one must take into account the psychological considerations of the patients. (archbronconeumol.org)

Our primary aim was to examine the prevalence rate of AATD among hospitalized COVID-19-patients. (lu.se)
Patients were screened for AATD with PI-typing and if results were inconclusive, PCR for the S-and Z-genes were performed. (lu.se)
Two patients out of 61 (3%) had mild AATD (PI*MZ) and none had moderate-to-severe AATD. (lu.se)
Both patients with mild AATD developed severe COVID-19. (lu.se)
Conclusion: Mild AATD (PI*MS or PI*MZ) was rare in a small cohort of hospitalized patients with COVID-19 in a study setting with a high background prevalence of AATD. (lu.se)
Z-AAT accumulation is believed to be the cause of progressive liver disease in patients with AATD. (daum.net)
The exciting data on fazirsiran treatment from the open label AROAAT-2002 Phase 2 study in patients with AATD liver disease suggest a treatment effect and the potential to improve multiple downstream markers of liver health. (daum.net)
These early results demonstrate the potential for an RNAi therapy like fazirsiran to reverse liver disease in patients with AATD liver disease and we are hopeful fazirsiran will one day help patients avoid the need to undergo liver transplantation," said Chinwe Ukomadu, M.D., Ph.D., Head, Gastroenterology Therapeutic Area Unit at Takeda. (daum.net)
AROAAT-2002 (NCT03946449) is a pilot open-label, multi-dose, Phase 2 study to assess the response to fazirsiran in 16 patients with AATD associated liver disease and baseline liver fibrosis. (daum.net)
This activity is intended for pulmonologists, allergists/clinical immunologists, and other clinicians who treat patients with AATD. (medscape.org)
The goal of this activity is for learners to be better able to incorporate specific strategies to improve testing for AATD into clinical practice, and counsel patients on testing and early diagnosis. (medscape.org)
Since patients with severe AATD may have a very different prognosis and AT requires intravenous infusions for life, the decision to initiate AT may be challenging. (dovepress.com)
In 2020, it has been estimated that 90% of patients with AATD in the United States went undiagnosed because of several obstacles, and were not receiving appropriate treatment. (sebia.com)

The first cohort of patients recruited to the EARCO (European Alpha1 Research Collaboration) International Registry data base by the end of 2021 was analysed for radiological evidence of both emphysema and bronchiectasis as well as baseline demographic features. (gencat.cat)
Between October 12 and November 1 of 2021, four children under the age of six years presented to the emergency department of a large pediatric hospital in Alabama. (cdc.gov)

Saturday, Track 3: "Transplants for Alpha-1 Children" presented by Dr. Nitika Arora Gupta at the 2023 Alpha-1 National Conference. (alpha1.org)
Saturday, Track 1: "Pre and Post Transplant" moderated by Dr. Lorrinda Gray-Davis at the 2023 Alpha-1 National Conference. (alpha1.org)
Bronchiectasis Management & Lung Transplant presented by Dr. Kevin Tsui at the 2023 Chicago Alpha-1 Education Day. (alpha1.org)
Finally, CDC announced the four sites selected as TB Centers of Excellence for Training, Education, and Medical Consultation (TB COE) for the new project period beginning January 1, 2023. (cdc.gov)

1998).Linkage and molecular scaning analysis of MODY 3/hepatocyte nuclear factor 1-alpha gene in typical familial type 2 diabetes: Evidence for novel mutation in exon 8 and 10. (scirp.org)

Llame al 866.731.COPD (2673) y presione 9 para hablar en español con un paciente o cuidador. (copdfoundation.org)
Effect of roflumilast on exacerbation rate in patients with COPD treated with fixed combinations of LABA and ICS. (astrazenecaclinicaltrials.com)
The objective of the REACT trial is to investigate the effect of roflumilast 500 μg tablets once daily versus placebo on exacerbation rate and pulmonary function in COPD patients who are concomitantly treated with a fixed combination of long-acting β2-agonists (LABA) and inhaled glucocorticosteroids (ICS). (astrazenecaclinicaltrials.com)
Patients to be included are required to have severe COPD associated with chronic bronchitis and a history of frequent exacerbations and must be concomitantly treated with a fixed combination of LABA and ICS. (astrazenecaclinicaltrials.com)
This study investigated the effect of roflumilast 500 μg tablets once daily versus placebo on exacerbation rate, pulmonary function, and major adverse cardiovascular events (MACE) in COPD patients who were concomitantly treated with a fixed combination of long-acting beta-agonists (LABA) and inhaled glucocorticosteroids. (astrazenecaclinicaltrials.com)
Some COPD patients wait to seek help as symptoms such as increased shortness of breath may seem like a natural part of aging. (medlineplus.gov)

The remaining 303 (72.5%) ZZ patients all had emphysema on the scan and 113 (27%) had additional evidence of bronchiectasis. (gencat.cat)
The disease, called alpha-1 for short, causes emphysema in the lungs and cirrhosis in the liver, and has been the focus of Wilson and his mentor, Darrell Kotton , for more than a decade. (bu.edu)

Patients were categorized as severe or moderate COVID-19 and 30-day-mortality data were collected. (lu.se)
Peritoneal lavage with aprotinin in patients with severe acute pancreatitis. (nih.gov)
Although high-dose aprotinin given intraperitoneally to patients with severe acute pancreatitis seems to inhibit activated trypsin in the peritoneal cavity, the treatment has little effect on the balance between proteases and antiproteases. (nih.gov)
Plasma levels of leukocyte proteases were high in all the patients, indicating leukocyte activation to be an important feature of the pathophysiology of severe acute pancreatitis. (nih.gov)
Although most studies have shown protease inhibitor therapy to have little or no effect on acute pancreatitis, in an earlier study we found that very high doses of the protease inhibitor aprotinin given intraperitoneally to patients with severe acute pancreatitis seemed to reduce the need of surgical treatment for pancreatic necrosis. (nih.gov)
In a prospective double-blind randomized multicenter trial, 48 patients with severe acute pancreatitis were treated with intraperitoneal lavage. (nih.gov)
Clinicians who treat patients in occupations with frequent exposure to ticks, or with mild to severe gastrointestinal reactions when they eat red meat, should access sensitization to galactose-a-galactose. (cdc.gov)
[ 1 , 2 ] MG is sometimes identified as having an ocular and generalized form, although one is not exclusive of the other and the ocular form is considered an initial, milder form of illness that progresses to the more severe generalized form in most but not all patients. (medscape.com)

Drugs that act as selective antagonists at specific alpha-1 adrenergic receptor subtypes have also been developed. (wikipedia.org)
In patients with neurogenic hypertension who fail in achieving blood pressure control with angiotensin converting enzyme inhibitors (ACEi), Angiotensin receptor blockers (ARB) and calcium channel blockers (CCB), alpha- and beta- adrenergic receptor blockers constitute the main treatment options. (wikipedia.org)
Prazosin has been established as an effective and safe centrally active alpha-1 adrenergic receptor antagonist. (wikipedia.org)
This level of risk was subsequently confirmed and was thereafter described with all currently used alpha-1 adrenergic receptor antagonists [3,4,5,6]. (urotoday.com)
The FDA considers the risk for IFIS to be a class effect for alpha-1 adrenergic receptor antagonists [8,9]. (urotoday.com)

An association between tick bites and this allergy has been described in studies that detected serum IgE (sIgE) in antibodies to alpha-gal in persons reporting a history of tick bites. (cdc.gov)

Fazirsiran has shown a high level of activity across all patients studied and is representative of how the RNA interference pathway can be leveraged to reliably and consistently silence gene expression and potentially have a positive impact on patients with various genetic diseases. (daum.net)
Since just an estimated 1 to 2 percent of those with diabetes have a genetic mutation leading to MODY, there isn't much discussion about it within the patient community, and most medical professionals don't bring it up unless they are questioned. (healthline.com)

Results Of the first 505 patients with the PiZZ genotype entered into the data base 418 (82.8%) had a reported CT scan. (gencat.cat)
Most cases were recommended AT according to guidelines, but a significant number of patients with genotype Pi*SZ and almost 10% Pi*MZ were recommended to initiate AT despite the lack of evidence of efficacy in these genotypes. (dovepress.com)
Our aim was to evaluate the prevalence of insulin resistance in Egyptian patients with chronic HCV genotype 4 infection, to assess factors associated with insulin resistance and to test the impact of insulin resistance on outcomes of treatment with pegylated interferon/ribavirin. (who.int)

This study shows that persons in occupations such as timber harvesting and forestry and wildlife practitioners who encounter frequent exposure to ticks may have a high prevalence of sensitization to the sugar molecule galactose-a-1,3 galactose. (cdc.gov)

The protease-antiprotease balance was studied by measuring immunoreactive anionic trypsin (irAT), cationic trypsin (irCT), complexes between cationic trypsin and alpha 1-protease inhibitor (irCT-alpha 1 PI), leukocyte elastase and neutrophil proteinase 4 (NP4), as well as the endogenous protease inhibitors, pancreatic secretory trypsin inhibitor (PSTI), alpha 2-macroglobulin (alpha 2M), alpha 1-protease inhibitor (alpha 1 PI), antichymotrypsin (ACHY), and secretory leukocyte protease inhibitor (SLPI). (nih.gov)
Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)
Darunavir is an inhibitor of the human immunodeficiency virus ( HIV -1) protease . (rxlist.com)

After 2 months of follow-up, during which patients and clinicians were blinded to treatment group, ambulatory systolic BP had fallen a mean of 8 mmHg in those who had undergone renal denervation with triple-drug therapy. (medscape.com)

Next January 27, respiratory patients and healthcare professionals will present their Breathe Vision for 2030, a document outlining the critical priorities Europe should work against to better prevent and care better for lung health, which include and urgent need for more data and research on respiratory health to inform decisions, educate the public, and better prepare to reduce the toll from lung disease. (efanet.org)

We wished to determine the prevalence of bronchiectasis and patient characteristics. (gencat.cat)
The prevalence of unrecognized pregnancy is up to 6% in ED patients. (medscape.com)
Prevalence of alpha-gal sensitization among Kentucky timber harvesters and forestry and wildlife practitioners. (cdc.gov)

Patients with significant pre-existing cardiac or pulmonary disease. (knowcancer.com)

Clinical Genomics: Practical Applications in Adult Patient Care, 1e Murray MF, Babyatsky MW, Giovanni MA, Alkuraya FS, Stewart DR. Murray M.F., & Babyatsky M.W., & Giovanni M.A., & Alkuraya F.S., & Stewart D.R.(Eds. (mhmedical.com)
The use of IFN-alpha in clinical oncology has generally been based on the rationale of exploiting its antiproliferative and antiangiogenic activities. (uniroma1.it)
Although further clinical studies are needed to show the adjuvant activity of IFN-alpha, the present data represent an important starting point for considering a new clinical use of IFN-alpha and new immunologic end points, potentially predictive of clinical response. (uniroma1.it)
A history of cardiac events is the most typical clinical presentation in patients with LQTS. (medscape.com)
Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
Clinical data from all patients who underwent cataract surgery between 2000 and 2005 at University Hospital (UH) and Audie L. Murphy Memorial Veterans Hospital (ALMMVH), San Antonio, Texas, were reviewed. (urotoday.com)

This toolkit is intended to help hospitals work as partners with patients and caregivers through empowerment and improved communication on continuity of care and discharge planning. (copdfoundation.org)

Today, patient and physician organizations joined together in commending the Centers for Medicare and Medicaid Services (CMS) for its recognition of numerous problems associated with access to oxygen in general and liquid oxygen systems, specifically. (pulmonaryfibrosis.org)
RADIANCE-HTN TRIO entered adult patients up to age 75 years at 53 centers on both sides of the Atlantic who had BP 140/90 mmHg despite multiple antihypertensive meds. (medscape.com)

The results from the AROAAT-2002 study provide multiple lines of evidence that preexisting liver damage in these patients may be meaningfully improved following treatment with fazirsiran," said Pavel Strnad, M.D., Professor at University Hospital RWTH Aachen and principal investigator of the AROAAT-2002 study who presented the data at EASL. (daum.net)
Everyone deserves the opportunity to live a full and healthy life and, together, we ask CMS to use its existing authority to exclude liquid oxygen from competitive bidding and take meaningfulaction to ensure that all patients who require supplemental oxygen receive the treatment they need. (pulmonaryfibrosis.org)
Alpha-1 blockers are first line treatment for the symptoms of BPH in men. (wikipedia.org)
Alpha-1 blockers are used as second line treatment for high blood pressure. (wikipedia.org)
Prazosin is commonly used as an anti-hypertensive, but because alpha-1 adrenergic activity has been connected to fear and startle responses, it sees use as a PTSD treatment. (wikipedia.org)
It is therefore important when starting treatment with an alpha-1 blocker to monitor the blood pressure to minimize the risk for adverse effects connected to low blood pressure. (wikipedia.org)
In the present study we have further analyzed plasma and peritoneal samples from the same patients to ascertain whether the aprotinin treatment affects the balance between proteases and endogenous antiproteases. (nih.gov)
In all patients, treatment augmented significantly the percentage of CD14(+) monocytes and particularly of the CD14(+)CD16(+) cell fraction. (uniroma1.it)
I agree with the audience that oral and topical/periocular therapy is optimal treatment for most patients. (aao.org)
[ 45 ] The American College of Cardiology Foundation/American Heart Association (ACCF/AHA) 2014 recommendations for treatment of patients with cocaine toxicity are based on class C evidence (ie, consensus opinion of experts, case studies, or standard of care). (medscape.com)
Epinephrine has been the drug of choice for the treatment of cardiac arrest, primarily for its alpha-adrenergic effects. (medscape.com)
The 136 patients with an ambulatory BP of 135/85 mmHg or more after a month of treatment with the triple pill, signifying drug-resistant hypertension, underwent angiography and were assigned to renal denervation therapy (69 patients) or to a sham control procedure (67 patients). (medscape.com)
Previous treatment with thymosin alpha 1. (knowcancer.com)
Knowing that you have Alpha-1 opens up many lifestyle and treatment decisions as well as the knowledge to avoid risk factors, all of which can improve your quality of life. (alpha1canada.ca)
A treatment called augmentation therapy is an option for many patients. (alpha1canada.ca)
There is no specific treatment for Alpha-1 associated liver disease. (alpha1canada.ca)
Follow-up of patients with complete early virological response until the end of treatment showed a statistically significant decrease in HOMA-IR score. (who.int)

We present a rare case of giant mature sacrococcygeal teratoma in an adult female patient. (ispub.com)
When the current focus on sacrococcygeal teratoma is on prenatal assessment, fetal intervention [1] and outcome after surgery in the pediatric age group [2], sporadic cases of sacrococcygeal teratoma in the adult age group come as a surprising rarity. (ispub.com)
11] Most adult teratomas described are small, found in female patients and rarely present externally. (ispub.com)

Alpha-1 blockers (also called alpha-adrenergic blocking agents or alpha-1 antagonists) constitute a variety of drugs that block the effect of catecholamines on alpha-1-adrenergic receptors. (wikipedia.org)
Over the last 40 years, a variety of drugs have been developed from non-selective alpha-1 antagonists to selective alpha-1 antagonists and alpha-1 inverse agonists. (wikipedia.org)
Currently, several relatively selective alpha-1 antagonists are available. (wikipedia.org)

As alpha-blocker medications are the first line of therapy for men with LUTS, these reports of IFIS led the Food and Drug Administration, American Urological Association, American Academy of Ophthalmology, and American Society of Cataract and Refractive Surgery to issue statements alerting physicians and patients to potential difficulties during cataract surgery in patients using alpha-1 blocker therapy [7,8,9]. (urotoday.com)
3 Therefore, subjects with very deficient genotypes but who are healthy would be classified as serious when in reality they are not, confusing the responsible physicians and the patients themselves. (archbronconeumol.org)

Findings on physical examination usually do not indicate a diagnosis of LQTS, although some patients may present with excessive bradycardia for their age, and some patients may have hearing loss (congenital deafness), indicating the possibility of Jervell and Lange-Nielsen syndrome. (medscape.com)

The long-term effect of the new liver on the lungs is unknown since abnormal alpha-1 protein can still be made by some lung cells and cause lung damage. (mayo.edu)
Synphilin-1 (Sph1) is a novel alpha-Syn-interacting protein also present in the LBs. However, the roles of alpha-Syn-Sph1 interaction in LB formation and in the related pathogenesis are still unclear. (rcsb.org)
the remaining patients are probably able to degrade the abnormal protein, although the exact protective mechanism is unclear. (msdmanuals.com)
However at the end of the first growing season needles of saplings exposed to 10 or 100 Î¼g l-1 foliage-applied TCA showed significantly more visible damage, higher activities of some detoxifying enzymes, lower protein contents and poorer water control than needles of saplings dosed with the same TCA concentrations to the soil. (who.int)

These observations demonstrate that the alpha-Syn-Sph1 interaction significantly promotes the formation of cytoplasmic alpha-Syn inclusions, which may have implications for LB formation in neural cells. (rcsb.org)

High-resolution quantitative determination of whole-body burden of gamma emitting radionuclides for photon energies between 100 keV and above, within 10% (k=1) accuracy for adults in the range of 50 to 110 kg. (lu.se)
Low-resolution quantitative determination of whole-body burden of 137Cs, 134Cs, 60Co and 40K 10% (k=1) accuracy for children and adults in the range of 20 to 150 kg. (lu.se)

Patients with cocaine toxicity should receive initial evaluation and stabilization, including attention to ABCs, oxygen, intravenous access, and cardiac and pulse oximetry monitoring. (medscape.com)
Alcohol or intravenous drug abuse within the previous 1 year. (knowcancer.com)

alpha-Synuclein (alpha-Syn) is the major component of Lewy bodies (LBs) deposited in the brains of patients with Parkinson's disease. (rcsb.org)

Medical treatments can dramatically improve the blood pressure and thus allow safe liver transplant in some patients. (mayo.edu)

First generation alpha-1 blockers, like prazosin are not recommended to treat lower urinary tract symptoms because of their blood-pressure-lowering effect. (wikipedia.org)
As Alpha-1-a blockers affect the symptoms of BPH more specifically than the Alpha-1 blockers, the adverse effects seem to be more linked to the reproductive system while minimizing the effect on the blood-pressure system. (wikipedia.org)
Alpha-blocker medications are the first line of therapy for men with these urinary symptoms. (urotoday.com)
While it is important to know that not everyone who has Alpha-1 will develop symptoms, even people who are 'only carriers' can develop symptoms. (alpha1canada.ca)

The first drug that was used was a non-selective alpha blocker, named phenoxybenzamine and was used to treat BPH. (wikipedia.org)
This is supported by studies that show surprisingly though consistently that neither alpha- nor beta-blocker mono- therapy reduces sympathetically mediated blood pressure reactivity to acute experimental stressors. (wikipedia.org)
Studies of combined oral alpha- and beta-blockade using an alpha-blocker (e.g., doxazosin or terazosin) in combination with a nonlipophilic beta-blocker with more reliable bioavailability (e.g., betaxolol, bisoprolol, atenolol and others) have shown a larger antihypertensive effect. (wikipedia.org)
Hypotension and its complications (such as weakness and dizziness) are a constant risk, however, even though a selective alpha-1a blocker is being used. (wikipedia.org)
To assess the frequency of cataract surgery complications arising from alpha-blocker therapy in a large patient population. (urotoday.com)
If possible, alpha blocker medications should be discontinued prior to eye surgery in older patients. (urotoday.com)
The purpose of this study was to assess the impact of alpha-blocker therapy on complications during cataract surgery in a large patient population. (urotoday.com)

A 20-30% risk of secondary infection and a 1-12.5% risk of malignant degeneration has been calculated. (ispub.com)
[ 1 ] In 2016, the Society for Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (EISCM) published new definitions for sepsis and septic shock, according to which sepsis was defined as a "dysregulated host immune response to infection" and septic shock as "a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities are profound enough to substantially increase mortality. (medscape.com)
Nous avions pour objectif d'évaluer la prévalence de la résistance à l'insuline chez des patients égyptiens atteints d'une infection par le virus de l'hépatite C de génotype-4, d'étudier les facteurs associés à la résistance à l'insuline et de tester l'impact de la résistance à l'insuline sur les résultats du traitement par interféron pégylé/ribavirine. (who.int)

From posterior polar cataract and temporal negative dysphotopsia to phaco in uveitis and glaucoma patients, the 2016 Cataract Spotlight session covered much ground. (aao.org)

Clinically, patients with neurogenic shock may present with temperature dysregulation, bradycardia, and hypotension that is not responsive to volume resuscitation. (medscape.com)

1999) High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes. (scirp.org)
This study aimed to explore whether there is an alternative gut microbiota profile in patients with early-onset colorectal cancer. (frontiersin.org)
Early-onset colorectal cancer patients have a different gastrointestinal microbiota derangement compared to late-onset colorectal cancer patients. (frontiersin.org)

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. (nih.gov)
Methods: In our study enzyme amplification (PCR) of the 10 target exons of the said gene with simultaneous mutation detection in them by PCR-SSCP (Polymerase chain reaction-single strand conformational polymorphism) reaction analysis method was attempted by screening of exon 1 - 10 with respect to normal healthy controls without Diabetes Mellitus. (scirp.org)
Result: It was observed that maximum number of variations exist in exon 5 of HNF1-alpha gene which may be referred to as "Mutational Hotspot" in our Eastern Indian population. (scirp.org)

Patients must be pre-treated with LABA and ICS for at least 12 months before baseline Visit V0. (astrazenecaclinicaltrials.com)
In the last 3 months before baseline Visit V0 patients must be pre-treated with fixed combinations of LABA and ICS at a constant dose (maximum approved dosage strength of the combination). (astrazenecaclinicaltrials.com)
Single-blind baseline period (4 weeks) during which all patients received placebo. (astrazenecaclinicaltrials.com)

The Annual Alpha-1 Patient Conference will take place this year on Friday the 30th of October in the Marino Institute of Education in North Dublin. (alpha1.ie)

The HIQA Report on the investigation into the quality, safety and governance of the care provided by Tallaght Hospital for patients requiring acute admission has recommended that an Emergency Department-specific system of physiological monitoring and triggered responses comparable to the National Early Warning Score (NEWS) should be. (hrb.ie)

Early intervention targeting prevention of work disability has potential to enhance patient outcomes and the effectiveness of care, with positive spill over effects for. (hrb.ie)
The outcomes obtained depict the good deposition effect of lipiodol chemotherapy emulsion (LCTE) in the contrast group with rich blood type accounted for 53.14% and the patients with the poor blood type accounted for 25.73% showed poor deposition effect. (hindawi.com)

whereas tamsulosin is a selective antagonist for all alpha-1 subtypes. (wikipedia.org)
The incidence of IFIS was 2.0% in the general population but was noted in 63% of patients using tamsulosin. (urotoday.com)

1 In the past, we attempted to suppress inflammation in patients with uveitis, but now the goal is to eliminate inflammation in order to optimize surgical results. (aao.org)
Approximately 2.8 million cataract surgical procedures are performed each year in the United States [1]. (urotoday.com)

Notably, postvaccination monocytes from two of the three patients showing stable disease or long disease-free survival showed an enhanced antigen-presenting cell function and capability to secrete IP10/CXCL10 when tested in mixed leukocyte reaction assays, associated to a boost of antigen and melanoma-specific CD8+ T cells. (uniroma1.it)
The specific interaction between alpha-Syn and Sph1 provides mechanistic insights into the inclusion-body formation in cells and pathological implication in Parkinson's disease. (rcsb.org)
Patients who are poor medical risk or who have any non-malignant systemic disease that, in the opinion of the investigator, would make it unlikely that the patient could complete the protocol. (knowcancer.com)
But treatments and lifestyle changes can help patients feel better, stay active, and slow the progression of the disease. (medlineplus.gov)

It has been discovered that people develop an allergy to an oligosaccharide galactose-a-1,3-galactose, also called alpha-gal, after experiencing tick bites. (cdc.gov)

New England Journal Medicine & Surgery 1:1-11. (jameslindlibrary.org)
The "intra-operative floppy iris syndrome" cataract surgery complication has been reported in men using alpha-blockers. (urotoday.com)
The risk of complicated cataract surgery was 14.9% in patients using alpha-blockers, approximately 50% higher than those not receiving this medication (9.5%) (p=0.003). (urotoday.com)
The increased rate of complicated surgeries was restricted primarily to patients over 65 years of age, as 15.6% of surgeries performed on these patients resulted in complicated surgery (p=0.03). (urotoday.com)

In support of improving patient care, Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. (clevelandclinicmeded.com)
These trainee doctors learn while they work, providing care to patients. (hrb.ie)
Alpha Centauri - Specialized Care for the Future As a tactical response to the regional deficit of primary care providers and a marked stressing of local emergency departments along with urgent care facility resource overburden, Alpha Centauri has been developed from the ground-up as a premier walk-in healthcare entity in Elk County, Pennsylvania. (bartleby.com)
These specialties are often the most sought out after residential patients are referred from local urgent care and emergency departments, and our primary goal is to deliver these vital services to our patients without delay, and prioritize the care needed without the potential of degenerating conditions caused by the inability of local health systems to deliver this care in a timely manner. (bartleby.com)
Our priorities in developing a comprehensive continuum of care for our patients are as follows: 1. (bartleby.com)
IT is as important as health care professionals as the facility runs through its own insurance and keeps records through their system that are up to date and make it efficient for patients being seen in this facility. (bartleby.com)
The website is helpful for a patient seeking care, but not for someone looking for a career. (bartleby.com)
Holzer is a nonprofit organization whose mission is friendly visits, excellent care, every patient, every time. (bartleby.com)
This guide was developed by the Agency for Healthcare Research and Quality (AHRQ) to promote increased engagement by patients and families in their health care. (copdfoundation.org)
Caution is appropriate because the patient may attempt to harm care providers. (medscape.com)
Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. (mskcc.org)

Related statistics have proved that 360 million people in the world suffer from abnormal liver dysfunction, and about 1.1 million new hepatocellular carcinoma (HCC) patients are added each year, of which about 25% are from China and about 20% are from India [ 2 ]. (hindawi.com)

New evidence suggests that it can augment the blood pressure (BP) reductions achieved with aggressively stepped-up antihypertensive therapy in patients who hadn't responded well to first-line agents. (medscape.com)
In the next stage of the trial, called RADIANCE-HTN TRIO , patients in both the renal denervation and control groups at 6 months showed further BP reductions after stepwise intensification of antihypertensive therapy, starting with an aldosterone antagonist. (medscape.com)

The tabular representation of these applications is incited in Table 1 . (hindawi.com)

Anatomy22

Organisms12

Diseases3

Chemicals and Drugs141

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes51

Disciplines and Occupations1

Information Science4

Antitrypsin41

Deficiency2

AATD13

20212

20234

Hepatocyte nuclear factor 1 alpha1

COPD6

Emphysema2

Severe8

Adrenergic receptor5

Serum1

Genetic2

Genotype3

Molecule1

Protease3

Clinicians1

Lung Disease1

Prevalence3

Pulmonary disease1

Clinical6

Caregivers1

Centers2

Treatment17

Adult3

Antagonists3

Physicians2

Congenital1

Protein4

Significantly1

Adults2

Intravenous2

Lewy1

Liver Transplant1

Symptoms4

Blocker7

Infection3

20161

Neurogenic1

Early-onset3

Gene3

Baseline3

30th1

Acute1

Outcomes2

Tamsulosin2

Surgical2

Disease4

Allergy1

Surgery4

Care11

Abnormal1

Antihypertensive2

Tabular1