Among the human lipoxygenases, ALOXE3 is most closely (54% identity) related in amino acid sequence to ALOX12B. (wikipedia.org)
ALOXE3, ALOX12B, and ALOX15B are often classified as epidermal lipoxygenases, in distinction to the other three human lipoxygenases (ALOX5, ALOX12, and ALOX15), because they were initially defined as being highly or even exclusively expressed and functioning in skin. (wikipedia.org)
The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases with mouse Aloxe3 (also termed e-Lox-3) being the ortholog to human ALOXE3, mouse Alox12b being the ortholog to human ALOX12B (MIM 603741), and mouse Alox8 being the ortholog to human ALOX15B (MIM 603697)[supplied by OMIM]. (wikipedia.org)
ALOX12B and ALOXE3 in humans, Alox12b and Aloxe3 in mice, and comparable orthologs in other in other species are proposed to act sequentially in a multistep metabolic pathway that forms products that are structurally critical for creating and maintaining the skin's water barrier function. (wikipedia.org)
Aloxe3 and Alox12b mRNA was detected in the tongue, forestomach, trachea, brain, testis, and adipose tissue of mice and in the spinal cord of rats. (wikipedia.org)
ALOX12B metabolizes the LA in EOS to its 9R-hydroperoxy derivative which ALOXE3 then converts to three ceramide-esterified products: a) 9R,10R-trans-epoxide,13R-hydroxy-10E-octadecenoic acid, b) 9-keto-10E,12Z-octadecadienoic acid, and c) 9R,10R-trans-epoxy-13-keto-11E-octadecenoic acid. (wikipedia.org)
Polyclonal1
Acquiring suitable inhibitors to stop PDGF-mediated transactivation of AXL might provide brand-new therapeutic choices for mesangioproliferative kidney illnesses such as for Rabbit polyclonal to ALOXE3 example IgAN. (nipponkaigi-tokyo.com)
Amino1
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ALOXE3 (NP_067641.2). (prosci-inc.com)
Barrier1
All three insulators can block enhancers in the genome, but only ALOXE3 can act as a heterochromatin barrier. (biorxiv.org)
Human1
AloxE3 appears responsible for forming hepoxilins A and/or B from 12R-HpETE in the spinal fluids of rats and ALOXE3 is proposed to be responsible for the formation of these hepoxilins in various human tissues although the presence and activity of ALOXE3 in many of these hepoxilin-forming tissues has not yet been demonstrated. (wikipedia.org)
Autosomal recessive congenital ichthyosis1
Variants in NIPAL4 and ALOXE3 cause autosomal recessive congenital ichthyosis in Pakistani families. (nih.gov)
Genes1
the function of Aloxe3 in this differentiation appears to be to its metabolism 12R-HpETE into hepoxilins A3 or B3 which directly activate(s) Peroxisome proliferator-activated receptor gamma which in turn initiates the expression of adipocyte-differentiation genes. (wikipedia.org)
ELOX32
The ALOXE3 gene provides instructions for making an enzyme called eLOX3. (medlineplus.gov)
Many ALOXE3 gene mutations lead to the production of a nonfunctional eLOX3 enzyme, which disrupts the processing of the molecules involved in the formation of the lipid layers within the epidermis. (medlineplus.gov)
Congenital2
At least 20 mutations in the ALOXE3 gene have been found to cause nonbullous congenital ichthyosiform erythroderma (NBCIE). (medlineplus.gov)
Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi's Granuloma: The Consequences of Skin Barrier Dysfunction. (nih.gov)
Chromosome 171
The ALOXE3 gene is found on chromosome 17 . (medlineplus.gov)
Gene2
in humans, it is encoded by the ALOXE3 gene. (wikipedia.org)
As ALOXE3 is mainly expressed in skin tissue, the observed association might reflect the fact that both DNA methylation at the ALOXE3 gene and urinary 8-isoprostane concentrations depend on the level of OS in tissues. (biomedcentral.com)
Lamellar1
Lamellar ichthyosis caused by a previously unreported homozygous ALOXE3 mutation in East Asia. (nih.gov)
Levels1
Inverse associations of DNA methylation at cg25365794 ( ALOXE3 ) and cg08862778 ( MTOR ) with 8-isoprostane levels were observed in a derivation set ( n = 1000) and validated in two independent subsets of the cohort ( n = 548 and n = 741). (biomedcentral.com)