ExtractsAqueousMonohydrateBlood glucose levelsAlbinoWistarStreptozotocinPancreaticDiabetes MellitusAntidiabeticInsulinOrallyAnti diabetic activityInductionLinnLipidEffectExtract was givenGlucoseIntraperitoneallyFindingsApoptosis viaPatientsVitroCell cycle arrestSerumGlibenclamideKidneyGroupsHigh Fat DietDifferencesTissueRisk factorsTreatmentActivityEffectsMale
Extracts5
- In this study, effect of different concentrations of methanolic extracts of Musa sapientum sucker on plasma lipid profile were assessed in alloxan induced diabetic rats. (scialert.net)
- The present study was aimed at investigating the anti-diabetic properties and photochemical constituents of aqueous and methanol extracts of Buchholzia coriacea seeds in albino rats. (ascidatabase.com)
- This study aims to investigate the potential effect of fresh ginger extracts Zingiber officinale roscoe (Family: Zingebiraceae) on serum lipid profile and on blood glucose in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in rats. (nih.gov)
- It revealed a decrease in the levels of total cholesterol (TC), and low density lipoprotein (LDL) in the serum of rats that were treated by ginger extracts, compared with the control groups. (nih.gov)
- 9. Derouiche S, Degachi O, Gharbi K. Phytochemistry analysis and modulatory activity of Portulacae oleracea and Aquilaria malaccensis extracts against High-fructose and high-fat diet induced immune cells alteration and heart lipid peroxidation in Rats. (ajrconline.org)
Aqueous9
- The onus of this research was to investigate the phytochemical constituents and potential of P. longifiola aqueous leaf extract against alterations in liver and kidney functions in rats injected with alloxan. (ajol.info)
- Thus P. longifiola (mast tree) aqueous leaf extract has ameliorative effects on liver and kidney functions of rats induced with diabetes and could be used in management of type 2 diabetes even at a concentration of 100 mg/kg bwt. (ajol.info)
- Alhagi graecorum aqueous alcoholic extract was given orally to alloxan induced diabetic rats once a day for 4 weeks. (derpharmachemica.com)
- This work was carried out to determine the anti-diabetic effect of aqueous extract of Gymnema sylvestre on the blood sugar level of alloxan-induced diabetic rats. (gphjournal.org)
- 250mg per kg body weight of aqueous extract of Gymnema sylvestre and 125mg per kg body weight of glibenclimide was administered to rats in groups, IE, CE and ID respectively for 28 days. (gphjournal.org)
- The findings from this work revealed that, diabetic rats treated with aqueous extract of Gymnema sylvestre had a significant drop in blood sugar level. (gphjournal.org)
- The non diabetic rats treated with aqueous extract of Gymnema sylvestre maintained normal blood sugar level, possibly because the pancreatic beta-cells were not impaired. (gphjournal.org)
- Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats. (webmd.com)
- Aqueous Leaves on Alloxan-Induced Diabetic Rats. (bvsalud.org)
Monohydrate3
- Diabetes was induced in by a single intraperitoneal injection of 120 mg/kg alloxan monohydrate. (phytojournal.com)
- of alloxan monohydrate solution. (ascidatabase.com)
- Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg, i.p).The methanol extract of Ruellia tuberosa linn leaves at a dose of 100 and 200mg/kg of body weight was administered at single dose per day to diabetes induced rats for a period of 14 days. (jocpr.com)
Blood glucose levels4
- The rats having blood glucose levels above 200mg/dl were used for the anti diabetic study. (phytojournal.com)
- The effect of extract of bitter leaf (Vernonia amygdalina) on blood glucose levels of diabetic rats. (gphjournal.org)
- Furthermore, in alloxan-induced diabetes model MEPG (200 and 400 mg/kg, p.o.) and VAD (10, 25, and 50 mg/kg, p.o.) have showed significant and dose dependent antidiabetic activity by maintaining the blood glucose levels within the normal limits. (hindawi.com)
- Daily feeding of Nelumbo nucifera leaf powder for 21 days resulted significant decrease in the blood glucose levels of alloxan-induced diabetic rats. (scirp.org)
Albino2
- Forty five adult male albino rats, placed in nine groups (A-I), of five in each group were used. (ascidatabase.com)
- Study of ethanolic extract of Trianthema portulacastrum showed a significant dose-dependent protective effect against paracetamol and thiocetamide-induced hepatotoxicity in albino rats. (stuartxchange.org)
Wistar4
- Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
- For this purpose, female Wistar rats divided into three groups (n=5), the first group of rats received mineral water serve as control, the second group of rabbits received tap water with (TDW) and the third group of rats received filtered water (FDW). (ajrconline.org)
- Electrolyte Analysis of drinking water of Djamaa (Algeria) region and study its effect on the kidneys in Wistar rats. (ajrconline.org)
- Moringaceae) on fetus and placenta of pregnant Wistar rats. (bvsalud.org)
Streptozotocin5
- Induction of Diabetes Mellitus in Rats Using Intraperitoneal Streptozotocin: A comparison between 2 strains of rats. (gphjournal.org)
- Nephroprotective effect of Combretum micranthum G. Don in nicotinamide-streptozotocin induced diabetic nephropathy in rats: In-vivo and in-silico experiments. (webmd.com)
- To induce experimental T1DM in animals, streptozotocin (STZ) has been widely used due to its cytotoxic activity against pancreatic β-cells [ 7,8 ], and chronic STZ-induced diabetic rodents mimic diabetic complications observed in diabetic humans [ 9 ]. (karger.com)
- In the studies of hypoglycemic effects, the subjected animals are being made diabetic using alloxan, streptozotocin (STZ) etc introducing inside injecting intraperitoneally (IP) or intravenously (IV). (scirp.org)
- Custom fabricated commercially pure solid cylinder titanium implants, machined and acid-etched surface were inserted in the femora of streptozotocin-induced diabetic rats (n=10) and non-diabetic rats (n=10). (bvsalud.org)
Pancreatic3
- Pancreatic histopathology slides demonstrated that stevia extract did not induce any increase in the number of β-cells. (researchgate.net)
- VAD (10, 25, and 50 mg/kg, p.o.), and glibenclamide (10 mg/kg, p.o.) treated animals showed significant protection against alloxan-induced pancreatic tissue damage. (hindawi.com)
- Therefore, the differential ability of dendritic cells and macrophages (splenic adherent cells [SACs]) to stimulate pancreatic islet allograft rejection in reversed alloxan-induced diabetic rats was examined. (diabetesjournals.org)
Diabetes Mellitus1
- Despite the fact that sexual differences increase diabetic risk and contribute to the need for gender-specific care, there remain contradictory results as to whether or not sexual dimorphism increases susceptibility to the development of type 1 diabetes mellitus. (karger.com)
Antidiabetic3
- The antidiabetic effect of hydro alcoholic extract of the leaves of S. cuspidata were investigated in alloxan induced diabetic rats and the bioactive compounds were tested for their antidiabetic potential in vitro by inhibition of α-amylase enzyme. (phytojournal.com)
- From the above results, it is concluded that methanol extract of Ruellia tuberosa linn leaves possesses significant antidiabetic, antihyperlipidaemic and hepatoprotective effects in alloxan induced diabetic rats. (jocpr.com)
- Antidiabetic activity was evaluated by Aldose reductase, α -amylase and PTP1B inhibition assays in in vitro and Alloxan-induced diabetes in rats was used as an in vivo model. (hindawi.com)
Insulin6
- Administration of insulin or Alhagi graecorum reversed the deleterious effect induced by alloxan. (derpharmachemica.com)
- The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
- Animal experiments revealed that STZ treatment rendered female rats more susceptible to induction of diabetes than their male littermates with significantly lower plasma insulin levels due to hormonal regulation. (karger.com)
- Administration of insulin to the diabetic rats showed a partial counteraction of the enzyme changes. (ias.ac.in)
- The leaf has been studied to have insulin-sensitizing and/or anti-diabetic properties. (wakeup-world.com)
- It directly stimulates the synthesis of bone matrix, and indirectly induces production of Insulin-Like Growth Factor (IGF-I) by the organism. (bvsalud.org)
Orally1
- The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days. (mdpi.com)
Anti diabetic activity2
- Different parts of Musa sapientum extract has been reported to posses anti diabetic activity. (scialert.net)
- Anti-diabetic activity of extract from Persea americana Mill. (ijp-online.com)
Induction1
- Induction of diabetes used alloxan dose of 150 mg/kg b.w intraperitoneally. (phcogj.com)
Linn1
- The aim of the present study was to evaluate the anti diabetic potential of methanolic extract of Ruellia tuberosa linn leaves in normal and alloxan induced diabetic rats. (jocpr.com)
Lipid3
- The result of the study indicates that Musa sapientum sucker extract was effective in improving plasma lipid profile associated with cardiovascular risk factors in alloxan induced diabetic rats. (scialert.net)
- In this study the effects of methanolic extract of Musa sapientum sucker on plasma lipid profile changes in alloxan induced diabetic rats was investigated with a view to finding its possible effects on cardiovascular disease induced by hyperglycemia. (scialert.net)
- Most interestingly, gender-specific proteome comparison showed that male and female rats displayed differential regulation of proteins involved in muscle contraction, carbohydrate, and lipid metabolism, as well as oxidative phosphorylation and cellular stress. (karger.com)
Effect5
- Experiment was thus designed to evaluate the possible protective effect of Alhagi graecorum extract against the alloxan diabetic rats. (derpharmachemica.com)
- This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
- Many pharmaceutical companies use the Alloxan to induce diabetes in rats when studying the effect of a new diabetic drug before seeking approval. (indiatimes.com)
- The effect of hydroethanolic extract of Matricaria chamomilla on the reproductive system of male rats exposed to formaldehyde. (sciendo.com)
- The aim of the current study is to evaluated the effect of drinking Water in Djamaa region on kidney function in rats. (ajrconline.org)
Extract was given1
- Alterations in liver function biomarkers (serum ALP, ALT, AST, GGT, TB and DB) caused by the hyperglycemic state of the test animals were reversed as the extract was given to the diabetic rats. (ajol.info)
Glucose6
- In normal rats, no significant differences were exhibited after ECE administration in body weight, fasting blood glucose level, levels of cholesterol, triglyceride, LDL and AST in serum, organ indexes, and levels of GSH and MDA in organs. (mdpi.com)
- Hyperglycemia was confirmed by the elevated glucose levels determined at 72 h after alloxan injection. (phytojournal.com)
- The results of OGTT reveal that the extract at both the dose levels (150 and 300 mg/kg) cause a significant decrease in the blood glucose level within 60 min after oral administration to normal rats. (phytojournal.com)
- Glucose levels were substantially reduced in ginger- treated diabetic groups. (nih.gov)
- There was a significant decrease of fasting blood glucose of alloxan-induced diabetic rats. (stuartxchange.org)
- Rats bearing established allografts were challenged with various dosages of donor-strain dendritic cells or SACs, and graft rejection was assessed by analysis of plasma glucose levels and/or histological criteria. (diabetesjournals.org)
Intraperitoneally1
- Diabetes was induced intraperitoneally with a single dose of 100 mg kg 1 b.wt. (ascidatabase.com)
Findings1
- Findings suggest LF1 induces apoptosis and cell cycle arrest in treated lung cancer cells. (stuartxchange.org)
Apoptosis via1
- Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)
Patients4
- About 70 to 80% of death in diabetic patients are due to vascular diseases ( Chattopadhyay and Bandyopadhyay, 2005 ). (scialert.net)
- It is estimated that, by 2025, India, China, and the United States will be the top three countries to have large number of diabetic patients [ 3 ]. (hindawi.com)
- In machined surface implants the diabetes interfere negatively in osseointegration while acid-etched surface promoted major BIC and BD index, indicating its selective use in diabetic patients. (bvsalud.org)
- This study aims to identify the infl uence of chemotherapy induced haematological toxicities on adherence to anti-cancer chemotherapy in patients treated for cancer at Yalgado Ouédraogo University Hospital (Ouagadougou, Burkina Faso). (bvsalud.org)
Vitro1
- For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
Cell cycle arrest1
- JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)
Serum2
- Diabetic mellitus and hypothyroidism lead to serum lipoproteins disorders. (nih.gov)
- Thirty-day treatment of rats with piperine significantly increased serum T levels without affecting LH concentrations. (frontiersin.org)
Glibenclamide1
- Rat were divided into eight groups (normal, negative control, glibenclamide as a positive control, and five dose extract group). (phcogj.com)
Kidney1
- The antioxidant markers, glucolytic, and gluconeogenic enzymes were significantly ameliorated and the elevated level of kidney biomarkers in the diabetic groups was restored. (hindawi.com)
Groups2
- 25 experimental animals used were divided into five groups each containing five rats. (gphjournal.org)
- In the acid-etched surface implants in both, diabetic and non-diabetic groups, the peri-implant tissue showed intense new bone formation within all threads of the implants with BIC = 74.4 ± 14.7 e BD = 35.4 ± 3.48 in non-diabetic group and BIC = 63.1 ± 12.9 e BD = 29.6 ± 4.9 in diabetic group. (bvsalud.org)
High Fat Diet1
Differences2
- A growing body of evidence indicates that sexual differences increase diabetic risk and contribute to the need for gender-specific care [ 2,3,4,5 ]. (karger.com)
- This study aimed to compare the bone formation around titanium implants with machined and acid-etched surfaces, inserted in induced diabetic rats and in non-diabetic rats, in an attempt to investigate whether there are differences in bone formation between this metabolic condition and the use of different implant surfaces. (bvsalud.org)
Tissue3
- The current proteomic study revealed that impaired protein regulation was more prominent in the muscle tissue of female diabetic rats, which were more susceptible to STZ-induced diabetes. (karger.com)
- That more dendritic cells were required to stimulate rejection in reversed diabetic recipients compared with nondiabetic recipients suggests that other factors, such as the diabetic state and the production of a tolerant status achieved by larger amounts of grafted tissue, may influence graft survival. (diabetesjournals.org)
- Peri-implant tissue in machined implant showed intense new bone formation within all threads of the implants of the non-diabetic group (BIC = 82.8 ± 9.23 e BD = 38.7 ± 4.27) while diabetic group (BIC = 35.3 ± 9.4 and BD = 20.0 ± 3.8) exhibited small and immature bone formation within threads of the implants with thickness fibrous connective tissue interposition between bone-implant interface. (bvsalud.org)
Risk factors1
- Hence, if these risk factors are not controlled in diabetic subjects, cardiovascular disease is imminent. (scialert.net)
Treatment2
- and thus could serve as a good phytomedicine for diabetic treatment. (scialert.net)
- 5 ] considered the furanocoumarin byakangelicin to be an inhibitor of aldose reductase for the treatment of diabetic cataract. (hindawi.com)
Activity2
- Changes in the activity of hexokinase and lactate dehydrogenase isoenzymes in the three brain regions and heart were studied in the 6-Aminonicotinamide-treated rats. (ias.ac.in)
- Changes in the subcellular distribution of hexokinase activity from three brain regions and heart were studied during alloxan induced diabetes. (ias.ac.in)
Effects1
- The objective of the present study was to investigate the effects of piperine on the testis development in the pubertal rat. (frontiersin.org)
Male1
- Piperine (0 or 5 or 10 mg/kg) was gavaged to 35-day-old male Sprague-Dawley rats for 30 days. (frontiersin.org)