• Glibenclamide was provided as a generous gift sample by Hoechst Pharmaceuticals, Mumbai, while alloxan (Sigma Chemical Company, USA) was a generous gift sample from Dr. Reddy's Laboratories, Hyderabad. (biomedcentral.com)
  • Most studies have shown that alloxan is not toxic to the human beta-cell, even in very high doses, probably because of differing glucose uptake mechanisms in humans and rodents. (wikipedia.org)
  • Alloxan is, however, toxic to the liver and the kidneys in high doses. (wikipedia.org)
  • Because there have been conflicting studies implicating the hypothalamus ( 28 - 31 ) or hindbrain ( 18 , 32 , 33 ) as primary mediators of the CRR to glucose deficit, we also compared the effects of toxic doses of alloxan administered into the third ventricle (3v) versus the fourth ventricle (4v) on glucoprivic CRRs. (diabetesjournals.org)
  • To understand the role of GK in glucoprivic counterregulatory responses, we injected alloxan, a GK inhibitor and toxin, into the third ventricle (3v) to target nearby GK-expressing neurons. (diabetesjournals.org)
  • Thus, neural substrates near and around the 3v affected by alloxan may be critically involved in the expression of these glucoprivic responses. (diabetesjournals.org)
  • This study evaluated the effects of alloxan on the kinetics properties of the δ-aminolevulinate dehydratase (δ-ALA-D) using mouse liver homogenates. (springer.com)
  • The alloxan (5 μM) caused a decrease in V max (65.8%) and in K m (53.1%), which is suggestive of an uncompetitive inhibition of enzyme. (springer.com)
  • In addition, rat islets were isolated, cultured, and exposed to alloxan in the presence or absence of genistein. (chiro.org)
  • Alloxan was used in the production of the purple dye murexide, discovered by Carl Wilhelm Scheele in 1776. (wikipedia.org)