In a dual murine heart transplant model that has both syngeneic and allogeneic hearts engrafted in bilateral ear pinna on the recipients, OX40 immunoPET clearly depicted alloreactive T cells in the allograft and draining lymph node that were not observed in their respective isograft counterparts. (jci.org)
Cells25
In this work, we identify and characterize OX40 as a surrogate biomarker for alloreactive T cells in organ transplant rejection and monitor its expression by utilizing immunoPET. (jci.org)
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection. (ox.ac.uk)
If the collaborative requirement of Lyt 1 T helper cells is bypassed by the Lyt 1 T cell-derived mediator of T help, termed I1-2, upon antigenic stimulation, PNA + Lyt 123 thymocytes differentiate into either alloreactive or H-2-restricted PNA - Lyt 23 cytotoxic effector cells. (psu.edu)
In this report, we identified the antigenic peptide that is recognized by an alloreactive bml anti-B6 T cell clone using a novel genetic strategy that is based upon measurement of T cell receptor occupancy in single T cells. (johnshopkins.edu)
These results illustrate a novel strategy for identifying T cell-stimulating antigens in general and directly show that alloreactive T cells can respond to rather rare peptide/MHC complexes. (johnshopkins.edu)
Malarkannan, S, Afkarian, M & Shastri, N 1995, ' A rare cryptic translation product is presented by K b major histocompatibility complex class I molecule to alloreactive T cells ', Journal of Experimental Medicine , vol. 182, no. 6, pp. 1739-1750. (johnshopkins.edu)
Summary: Detection and isolation of viable alloreactive T cells at the single-cell level requires a cell surface marker induced specifically upon T cell receptor activation. (eur.nl)
In this study, a member of the tumour necrosis factor receptor (TNFR)-family, CD137 (4-1BB) was investigated for its potential to identify the total pool of circulating alloreactive T cells. (eur.nl)
Thereafter, CD137+ alloreactive T cells were phenotypically and functionally characterized by multi-parameter flow cytometry. (eur.nl)
CD137+ alloreactive T cells were detected in different T cell subsets, including naive T cells, but were found preferentially in CD28+ T cells and not in the terminally differentiated T cell subset. (eur.nl)
About 10% of the CD137+ alloreactive T cells produced any combination of interferon (IFN)-γ, interleukin (IL)-2 and TNF-α. (eur.nl)
Polyfunctional alloreactive T cells, defined by multiple cytokine expression, were observed infrequently. (eur.nl)
The latter includes patients with autoreactive clonal expanded T cell and patients with alloreactive transplacentally maternal T cells. (hindawi.com)
While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
These data imply the presence of two populations of alloreactive cytolytic T cells. (uni-muenchen.de)
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy. (harvard.edu)
Alloreactive donor T cells are important mediators of both relapse control by graft- versus -leukemia (GvL) effects, and of GvHD. (haematologica.org)
Alloreactive donor T cells recognizing patient-specific genetic polymorphisms, including mismatched HLA allotypes, play a major role in both beneficial GvL and severe GvHD after UD-HCT. (haematologica.org)
The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
2017. AhR activation increases IL-2 production by alloreactive CD4 T cells initiating the differentiation of mucosal-homing Tim3 Lag3 Tr1 cells. . (oregonstate.edu)
The trial involves intratumoral adoptive transfer of alloreactive CTL that are directed against patient HLA antigens present on brain tumor cells but not normal neuroglia. (cancer.org)
It is found that alloreactive donor-derived T cells activated through their T cell receptor (TCR) are primarily the major contributors to the immunopathobiology of GvHD. (umass.edu)
In addition to super-suppressive iTregs, we utilized induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs) to prevent GvHD via manipulating PKCtheta signaling in alloreactive T cells. (umass.edu)
Responses1
1. Transplantation immunology: allo-Ag presentation/recognition, cellular and molecular factors involved in alloreactive immune responses, antibody mediated rejection, immunotolerance induction and immunosuppression. (ncl.ac.uk)
Lymphocytes1
We suggest that a high-tolerance capacity of the alloreactive transplacentally acquired maternal lymphocytes represents a toleration advantage, yet still associated with severe immunodeficiency. (hindawi.com)
Rejection1
Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. (jci.org)
Peptide1
Noun G, Reboul M, Abastado JP, Jaulin C, Kourilsky P, Pla M. Alloreactive monoclonal antibodies select Kd molecules with different peptide profiles. (bdbiosciences.com)
Cell1
In conclusion, activation-induced CD137 expression is a fast assay allowing for detection and functional analysis of the total alloreactive T cell compartment at the single-cell level by multi-parameter flow cytometry. (eur.nl)
Multiple1
Patients undergo resection for recurrent glioma and then receive multiple infusions of alloreactive CTL through a reservoir/catheter system that is implanted at the time of surgical debulking. (cancer.org)
Eliminating alloreactive T cells1
His work has disproven the previously widely accepted paradigm that post-transplantation cyclophosphamide works by selectively eliminating alloreactive T cells. (cancer.gov)
Mouse Studies - We have found that innate natural killer T (iNKT) cells play a significant role in the generation of alloreactive responses following transplant (including humoral- and cellular-mediated rejection). (osu.edu)
Adoptive Transfer1
The trial involves intratumoral adoptive transfer of alloreactive CTL that are directed against patient HLA antigens present on brain tumor cells but not normal neuroglia. (cancer.org)
Preparation depleted6
On 5 September 2008, orphan designation (EU/3/08/561) was granted by the European Commission to Kiadis Pharma Netherlands B.V, Netherlands, for donor lymphocyte preparation depleted of functional alloreactive T-cells for the prevention of Graft-versus-Host disease. (europa.eu)
Satisfactory argumentation has been submitted by the sponsor to justify the assumption that donor lymphocyte preparation depleted of functional alloreactive T-cells might be of potential significant benefit for the prevention of GvHD, mainly because it has a new mechanism of action. (europa.eu)
The effects of donor lymphocyte preparation depleted of functional alloreactive T-cells have been evaluated in experimental models. (europa.eu)
Donor lymphocyte preparation depleted of functional alloreactive T-cells was not authorised anywhere worldwide for prevention of GvHD at the time of submission. (europa.eu)
Orphan designation of donor lymphocyte preparation depleted of functional alloreactive T-cells had been granted in the United States of America for immune reconstitution and prevention of GvHD following allogeneic haematopoietic stem cell transplantation. (europa.eu)
Donor-derived T-lymphocyte enriched leukocyte preparation depleted ex vivo of host-alloreactive T cells. (horizonscangeneesmiddelen.nl)
Clonal2
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy. (bu.edu)
Alloreactive T-lymphocytes constitute the basis of lung allograft rejection. (duke.edu)
Rejection1
8. Next generation sequencing based assessment of the alloreactive T cell receptor repertoire in kidney transplant patients during rejection: a prospective cohort study. (nih.gov)
Donor1
Generating an Alloreactive Effect: A New Factor to Consider in the Choice of a Donor? (medscape.com)
Enhancement1
Reduction of myeloid suppressor cell derived nitric oxide provides a mechanistic basis of lead enhancement of alloreactive CD4(+) T cell proliferation. (nih.gov)
Response2
If there is a mismatch between KIR and HLA class I, there is a possibility of an unopposed alloreactive response. (medscape.com)
Subsequent experiments addressed whether PRN treatment of CTLs directly inhibits their activation and revealed that 1° alloreactive CTLs exposed to PRN are unimpaired in their proliferative response and only marginally inhibited in their lytic activity. (nih.gov)
Significant1
Surprisingly, secondary stimulation of these alloreactive CTL effectors, however, even in the absence of further PRN exposure, resulted in complete abrogation of CTL lytic function and a delayed but significant long-term effect on CTL responsiveness. (nih.gov)