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  • purine
  • Allopurinol acts on purine catabolism, without disrupting the biosynthesis of purines. (nih.gov)
  • Allopurinol is a structural analogue of the natural purine base, hypoxanthine. (nih.gov)
  • Alkalinize urine to a pH of 6.5-7 ( see sodium bicarbonate monograph), give low purine diest and eliminate any UTI, Allopurinol at 10 mg/kg tid for the first month, then 10 mg/kg once daily thereafter. (medi-vet.com)
  • hypoxanthine
  • It has been shown that reutilization of both hypoxanthine and xanthine for nucleotide and nucleic acid synthesis is markedly enhanced when their oxidations are inhibited by allopurinol and oxipurinol. (nih.gov)
  • inhibits
  • Allopurinol inhibits the second step of metabolism, and higher 6-mercaptopurine plasma levels result, with associated toxic effects on the bone marrow and other tissues. (medsafe.govt.nz)
  • tablet
  • Each scored peach tablet contains 300 mg allopurinol and the inactive ingredients corn starch, FD&C Yellow No. 6 Aluminum Lake, lactose monohydrate, magnesium stearate, povidone and purified water. (nih.gov)
  • injection
  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of allopurinol injection in children. (drugs.com)