AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed Groups
ThrombocytopeniaAntigens, Human PlateletPlatelet CountThrombocytopenia, Neonatal AlloimmuneIsoantibodiesIsoantigensGraft RejectionTransplantation, HomologousHLA-DRB3 ChainsHeart TransplantationTransplantation ToleranceSkin TransplantationTransplantation ImmunologyBlood Transfusion, IntrauterineErythroblastosis, FetalGraft SurvivalPlatelet TransfusionTransplantation, HeterotopicHistocompatibility, Maternal-FetalLymphocyte Culture Test, MixedMaternal-Fetal ExchangeRats, Inbred WFPurpura, ThrombocytopenicMice, Inbred BALB CImmunoglobulins, IntravenousImmunoconjugatesOrgan TransplantationIslets of Langerhans TransplantationMice, Inbred C57BLInfant, Newborn, DiseasesAntibodies, BlockingInfant, NewbornT-Lymphocytes
NAITPlateletsGestational thrombocytopeniaAntibodyFNAITPurpuraAntibodiesSevereTransfusionMaternalBenignMild thrombocytopeniaPregnancyPregnanciesDiagnosisIntracranial hemorrhageDrug-inducedImmune-mediated50,000IncidenceAntenatalNewbornsClinicallyDiagnoseSymptomsFetusPregnant womenMedicationBloodManagementDeliveryPotentialStudyCases
NAIT7
  • Neonatal alloimmune thrombocytopenia (NAITP, NAIT, NATP or NAT) is a disease that affects babies in which the platelet count is decreased because the mother's immune system attacks her fetus' or newborn's platelets. (wikipedia.org)
  • Neonatal alloimmune thrombocytopenia (NAITP, NAIT, NATP or NAT) is a disease that affects babies in which the platelet count is decreased. (checkorphan.org)
  • During the first pregnancy, NAIT is often not detected until birth when the newborn presents with classic symptoms of thrombocytopenia including petechiae, bruising or intracranial hemorrhage. (checkorphan.org)
  • In utero intracranial hemorrhage occurs in about 10% to 30% of affected cases (and NAIT is thought to be the underlying cause in the majority of cases of intracranial hemorrhage due to thrommbocytopenia- greater than all other causes of thrombocytopenia combined). (checkorphan.org)
  • To assess the value of antenatal screening to detect neonatal alloimmune thrombocytopenia (NAIT) due to anti-HPA-1a, a prospective study was carried out to quantify the potential clinical benefits and determine whether screening would be cost-effective. (napier.ac.uk)
  • Neonatal alloimmune thrombocytopenia (NAIT) is a uncommon however doubtlessly extreme situation that impacts newborns. (dietbab.com)
  • When my daughter was born, she was diagnosed with a rare genetic blood disorder, neonatal alloimmune thrombocytopenia (NAIT)-the effect of which was the catalyst for me to become a midwife Although. (britishjournalofmidwifery.com)
Platelets4
  • Immune thrombocytopenic purpura (ITP), sometimes called idiopathic thrombocytopenic purpura is a condition in which autoantibodies are directed against a patient's own platelets, causing platelet destruction and thrombocytopenia. (wikipedia.org)
  • Autoimmune thrombocytopenia, extra generally often called immune thrombocytopenia (ITP), happens when the immune system wrongly targets and destroys its personal platelets. (dietbab.com)
  • Disorders of platelets can be divided into acquired or congenital thrombocytopenias and acquired or congenital functional disorders (thrombocytopathias), with acquired thrombocytopenia being the most common. (msdvetmanual.com)
  • Fetal and neonatal alloimmune thrombocytopenia is a rare disorder that occurs when maternal antibodies are produced against a paternal antigen on fetal platelets. (msdvetmanual.com)
Gestational thrombocytopenia8
Antibody1
  • Killie MK, Husebekk A, Kjeldsen-Kragh J, Skogen B. A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn. (ijrcog.org)
FNAIT4
  • Doctors additionally name it fetal and neonatal alloimmune thrombocytopenia (FNAIT), as it could possibly additionally have an effect on fetuses. (dietbab.com)
  • Current research have demonstrated that maternal anti-CD36 antibodies signify a frequent explanation for fetal/neonatal alloimmune thrombocytopenia (FNAIT) in Asian and African populations. (aabioetica.org)
  • Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare immune disorder. (javararesearch.com)
  • Most cases of fetal and neonatal thrombocytopenia (FNAIT) are caused by maternal anti-human platelet antigen-1a antibodies (anti-HPA-1a). (bvsalud.org)
Purpura2
  • One such disease in children is immune thrombocytopenia (also called immune thrombocytopenic purpura or ITP), which is the most common acquired bleeding illness in children [3]. (who.int)
  • The incidence of the disease in high-income mune thrombocytopenia (also called im- countries is about 3-10 per 100 000 chil- mune thrombocytopenic purpura or ITP), dren per year below 16 years of age [ 8,9 ]. (who.int)
Antibodies6
  • 1. Chen S, Cooper N, Müller M, Bein G, Sachs UJ (2020) Piperacillin-dependent anti-platelet antibodies are a relevant, easy to confirm differential diagnosis in patients with rapid-onset thrombocytopenia. (uni-giessen.de)
  • 12. Sachs UJ, Wienzek-Lischka S, Duong Y, Qiu D, Hinrichs W, Cooper N, Santoso S, Bayat B, Bein G (2020) Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia. (uni-giessen.de)
  • 17. Wu Y, Chen D, Xu X, Mai M, Ye X, Li C, Santoso S, Xia W, Fu Y (2020) Hydrops fetalis associated with anti-CD36 antibodies in fetal and neonatal alloimmune thrombocytopenia: Possible underlying mechanism. (uni-giessen.de)
  • Anti-platelet antigens and HLA antibodies were monitored monthly throughout the pregnancy to assess the risk of neonatal alloimmune thrombocytopenia. (bmj.com)
  • We found weak evidence that a small proportion of pregnant women presenting with anti-HPA-5b antibodies will give birth to a newborn with mild thrombocytopenia. (bvsalud.org)
  • The current experimental and epidemiological evidence does not support the hypothesis that anti-HPA-5b antibodies cause severe thrombocytopenia or bleeding complications in the fetus or newborn. (bvsalud.org)
Severe9
  • In case of severe thrombocytopenia, the neonates may exhibit bleeding complications at or a few hours after delivery. (wikipedia.org)
  • Mild to severe thrombocytopenia can be seen, and excessive bleeding is a potential complication. (msdvetmanual.com)
  • This diagnosis should be considered for foals with severe thrombocytopenia when other causes can be excluded. (msdvetmanual.com)
  • A group of lambs artificially reared and fed bovine colostrum developed severe thrombocytopenia with prolonged bleeding from puncture wounds from ear tag placement, subcutaneous bruising, weakness, and pale mucous membranes. (msdvetmanual.com)
  • A retrospective study by Shin et al indicated that in pregnant women with aplastic anemia, obstetric and disease complications are more prevalent in those with severe thrombocytopenia than in those with nonsevere thrombocytopenia. (medscape.com)
  • The study, which included 61 patients with aplastic anemia, found that in women with severe thrombocytopenia, the incidence of transfusion during pregnancy or the postpartum period (72.7% and 45%, respectively) was greater than in those with nonsevere thrombocytopenia (15.4% and 2.7%, respectively). (medscape.com)
  • It was also found that 25% of women with severe thrombocytopenia underwent bone marrow transplant after delivery, compared with 0% of those in the nonsevere thrombocytopenia group. (medscape.com)
  • Moreover, the odds ratios for composite disease complications and composite obstetric complications were higher in the women with severe thrombocytopenia than in the nonsevere thrombocytopenia patients. (medscape.com)
  • In addition, among patients in the severe thrombocytopenia group, gestational age at the platelet count's nadir and at delivery was lower than in the women with nonsevere thrombocytopenia. (medscape.com)
Transfusion2
Maternal3
  • Fetal and neonatal alloimmune thrombocytopenia is a rare disorder in which maternal alloantibodies cross the placenta and cause fetal thrombocytopenia. (ijrcog.org)
  • Some causes of thrombocytopenia are serious medical disorders that have the potential for maternal and fetal morbidity. (nih.gov)
  • Because of the increased recognition of maternal and fetal thrombocytopenia, there are numerous controversies about obstetric management of this condition. (nih.gov)
Benign1
Mild thrombocytopenia2
Pregnancy8
  • Fetal and neonatal alloimmune thrombocytopenia: Parental evaluation and pregnancy management. (ijrcog.org)
  • But there could be other causes of thrombocytopenia during pregnancy that may require treatment. (healthline.com)
  • What else can cause thrombocytopenia in pregnancy? (healthline.com)
  • To diagnose GT, your doctor will rule out other potential causes of thrombocytopenia during pregnancy by asking about your symptoms, medical history, and family history. (healthline.com)
  • Thrombocytopenia can result from a variety of physiologic or pathologic conditions, several of which are unique to pregnancy. (nih.gov)
  • This Practice Bulletin is a targeted revision to reflect limited changes to information about new estimates for thrombocytopenia in pregnancy and the risk of recurrence of fetal-neonatal alloimmune thrombocytopenia in subsequent pregnancies, and to provide new information on the level of thrombocytopenia that permits regional anesthesia. (nih.gov)
  • Thrombocytopenia can result from a wide range of conditions with several of them being pregnancy related. (medscape.com)
  • Classification of thrombocytopenia in pregnancy is arbitrary and not necessarily clinically relevant. (medscape.com)
Pregnancies2
  • In this article we present two clinical cases of fetal and neonatal alloimmune thrombocytopenia in first-born children, after uneventful pregnancies, with different outcomes and discuss the obstetric management and follow-up in future pregnancies. (ijrcog.org)
  • Thrombocytopenia, or a low blood platelet count, is encountered in 7-8% of all pregnancies. (medscape.com)
Diagnosis1
  • Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. (ijrcog.org)
Intracranial hemorrhage2
  • Delbos F, Bertrand G, Croisille L, Ansart-Pirenne H, Bierling P, Kaplan C. Fetal and neonatal alloimmune thrombocytopenia: predictive factors of intracranial hemorrhage. (ijrcog.org)
  • Intracranial hemorrhage in alloimmune thrombocytopenia: stratified management to prevent recurrence in the subsequent affected fetus. (ijrcog.org)
Drug-induced1
  • The American Society of Hematology defines it as an isolated thrombocytopenia with clinically no apparent associated conditions or no other cause of thrombocytopenia, such as HIV infection, systemic lupus erythematosus, lymphoproliferative disorders, myelodysplasia, agammaglobulinaemia or hypogammaglobulinaemia, drug-induced thrombocytopenia, alloimmune thrombocytopenia or congenital/hereditary non-immune thrombocytopenia [7]. (who.int)
Immune-mediated1
50,0001
Incidence2
  • The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: a UK national study using three data sources. (ijrcog.org)
  • Kamphuis M, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D. Incidence and consequences of neonatal alloimmune thrombocytopenia: a systematic review. (ijrcog.org)
Antenatal2
  • Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a. (napier.ac.uk)
  • Available from: http://www.researchgate.net/publication/7400069_Prospective_epidemiologic_study_of_the_outcome_and_cost-effectiveness_of_antenatal_screening_to_detect_neonatal_alloimmune_thrombocytopenia_due_to_anti-HPA-1a [accessed Nov 13, 2015]. (napier.ac.uk)
Newborns1
Clinically1
  • Swiss children found significant differences bocytopenia with clinically no apparent in history of infection preceding the onset associated conditions or no other cause of of ITP between the Asian and European thrombocytopenia, such as HIV infection, cohorts [ 16 ]. (who.int)
Diagnose1
Symptoms1
  • Below is a list of common medications used to treat or reduce the symptoms of neonatal+alloimmune+thrombocytopenia. (webmd.com)
Fetus1
Pregnant women1
  • 16. Wienzek-Lischka S, Sawazki A, Ehrhardt H, Sachs UJ, Axt-Fliedner R, Bein G (2020) Non-invasive risk-assessment and bleeding prophylaxis with IVIG in pregnant women with a history of fetal and neonatal alloimmune thrombocytopenia: management to minimize adverse events. (uni-giessen.de)
Medication1
  • Considering taking medication to treat neonatal+alloimmune+thrombocytopenia? (webmd.com)
Blood1
  • While a complete blood count (CBC) can identify platelet levels that fall below the threshold for thrombocytopenia, it does not explain the cause. (healthline.com)
Management1
  • Pacheco LD, Berkowitz RL, Moise KJ Jr, Bussel JB, McFarland JG, Saade GR. Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. (ijrcog.org)
Delivery2
  • Babies of HPA-1a-negative women were tested at delivery for thrombocytopenia and examined for signs of bleeding. (napier.ac.uk)
  • Thrombocytopenia usually goes away on its own within 6 weeks of delivery. (healthline.com)
Potential1
Study1
  • Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. (ijrcog.org)
Cases1