Allogeneic umbilical cord blood clinical allogeneic cord blood. Medical search. Frequent questions

While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
Among these, umbilical cord-derived mesenchymal stem cells (UC-MSCs), commonly referred to as Wharton's Jelly, have garnered attention for their promising applications in regenerative medicine. (innatehealthcare.org)
Rogulska O, Tykhvynska O, Revenko O, Grischuk V, Mazur S, Volkova N, Vasyliev N, Petrenko A, Petrenko Y. Novel cryopreservation approach providing off-the-shelf availability of human multipotent mesenchymal stromal cells for clinical applications. (in.ua)
SMUP-IA-01 , SMUP allogeneic umbilical cord blood-derived mesenchymal stem cells, is currently under development for the treatment and prevention of Osteoarthritis. (medi-post.co.kr)
The ambitious Xcellerate proposal plans to raise USD 20 million over five years to cover cerebral palsy research using three types of cells: umbilical cord blood stem cells, mesenchymal stem cells, and induced neural progenitor stem cells. (parentsguidecordblood.org)

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Therefore, for any specific patient, the transplant physician may be faced with a myriad of potential choices, including decisions concerning which donor to prioritize where there is more than one, the optimal selection of specific umbilical cord blood units and which conditioning and graft-versus-host disease prophylactic schedule to use. (nih.gov)
CB units not fulfilling the criteria for banking for transplant purposes were processed within 48 h of collection to obtain CBPG according to the "Italian Cord Blood Platelet Gel project" protocol (9) (for complete details see Appendix S1 ). (medicaljournals.se)
Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
The company highlighted positive data, productive regulatory interactions and progress on commercial readiness activities supporting its lead product candidate, omidubicel, an advanced cell therapy candidate for allogeneic stem cell transplant, as it advances toward its May 1, 2023 target Prescription Drug User Fee Act (PDUFA) action date. (advfn.com)
Recently presented data continue to support the clinical benefits and safety of omidubicel, which, if approved, may be a valuable new donor source for patients in need of allogeneic stem cell transplant. (advfn.com)
Omidubicel has received positive feedback from leading transplant centers, including ones that did not participate in the company's clinical trials. (advfn.com)
The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)
Additionally, the study met key secondary endpoints related to the speed of platelet engraftment, decrease in infections and reduction in hospitalizations, all significant clinical measures in bone marrow transplant. (biospace.com)
In February 2021, the company presented details of the results of the omidubicel Phase 3 study at the Transplantation & Cellular Therapy Meetings of the American Society of Transplantation and Cellular Therapy and Center for International Blood & Marrow Transplant Research. (biospace.com)
The data showed sustained clinical benefits in the first-year post-transplant with omidubicel, as demonstrated by significant reduction in infectious complications. (gamida-cell.com)
Omidubicel is an advanced cell therapy under development as a potential life-saving allogeneic hematopoietic stem cell transplant for patients with hematologic malignancies (blood cancers), for which it has been granted Breakthrough Status and orphan drug designation by the FDA. (gamida-cell.com)
These data add to the substantial body of knowledge that supports omidubicel's potential, if approved, as a new advanced cell therapy donor source for patients in need of an allogeneic stem cell transplant. (oilnow.gy)
Transplant of haematopoietic progenitors (autologous, allogeneic relatives and unrelated donors). (vallhebron.com)
Measurable Residual IDH1 before Allogeneic Transplant for Acute Myeloid Leukemia. (mcw.edu)
Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients. (mcw.edu)
Real-World Data Showing Trends and Outcomes by Race and Ethnicity in Allogeneic Hematopoietic Cell Transplantation: A Report from the Center for International Blood and Marrow Transplant Research. (mcw.edu)
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research. (mcw.edu)
Ex Vivo expanded unrelated donor umbilical cord blood transplant protocol for patients with severe sickle cell or transfusion dependent thalassemia. (ucsf.edu)
who are medically suitable for transplant who do not have an identified matched sibling or fully matched unrelated donor with an identified suitably matched unrelated donor cord blood unit. (ucsf.edu)
[11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases. (duke.edu)
For pediatric patients with acute lymphoblastic leukemia (ALL), relapse is an important cause of treatment failure after unrelated cord blood transplant (UCBT). (duke.edu)
Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
The overall and sustained clinical benefit of omidubicel makes it an important addition to the options for allogeneic HSCT. (gamida-cell.com)
Since then, allogeneic hematopoietic stem cell transplantation (HSCT) has evolved to become a frequently used and effective therapy for many hematologic malignancies. (longdom.org)
In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (longdom.org)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. (bvsalud.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)

Autologous and allogeneic platelet (PLT) preparations, in particular a blood component termed "platelet gel", traditionally obtained from adult blood platelets, are rich in regenerative growth factors, which are valu-able for the treatment of chronic wounds (5). (medicaljournals.se)
Duke University has conducted multiple clinical trials investigating the use of both autologous and allogeneic umbilical cord blood (UCB) in the treatment of cerebral palsy ( NCT01147653 , NCT02599207 ) and autism spectrum disorder ( NCT02847182 ). (upstatecordbloodbank.com)
By type, the global cell therapy market has been segmented into autologous and allogeneic. (medgadget.com)

After UMSC transplantation (UMSCT), the frequencies of Tregs and CD4 + memory T cells were significantly increased, and the frequencies of T helper (Th) 17 and CD4 + naive T cells were significantly decreased in peripheral blood (PB) of psoriasis patients. (nature.com)
The three sources of stem cells include bone marrow, umbilical cord blood, and peripheral blood. (oncologynurseadvisor.com)
NK cells were obtained from peripheral blood (PB) of healthy volunteers. (springer.com)
peripheral blood, or placental/umbilical cord blood). (cdc.gov)

This article discusses the current status of clinical trials of rituximab to treat GVHD in the pediatric population. (oncologynurseadvisor.com)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
Several of those are now considered applicable for patient treatments beyond the need for regulated clinical trials. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
The public clinical trials database http://clinicaltrials.gov shows 123 clinical trials using MSCs for a very wide range of therapeutic applications (Figure 1 ), the majority of which are in Phase I (safety studies), Phase II (proof of concept for efficacy in human patients), or a mixture of PhaseI/II studies (Figure 2 ). (biomedcentral.com)
My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. (dukecancerinstitute.org)
The safety of any medical treatment is best assessed through rigorous clinical trials and scientific research. (innatehealthcare.org)
Since 2009, numerous clinical trials have explored the safety of umbilical cord-derived stem cell therapy, providing valuable insights into its potential risks and benefits. (innatehealthcare.org)
In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
In this comprehensive article, we embark on a journey to explore the current landscape, ongoing clinical trials, the promise of cell and gene therapy, and the tantalizing possibility of a future where diabetes is not just managed but cured. (rootsanalysis.com)
Although details on the launch plans are not available yet, the approval has sparked interest in other cell therapies in clinical trials. (rootsanalysis.com)
Researchers worldwide are diligently conducting clinical trials to assess both the safety and efficacy of innovative approaches. (rootsanalysis.com)
Cord blood is now being used in clinical trials to potentially regenerate or facilitate repair by stimulating the body's self-healing's abilities. (cordforlife.com)
According to Save the Cord Foundation, landmark trials are currently underway in regenerative medicine that are investigating treatments for brain injuries, juvenile diabetes, heart disease, and corneal regeneration 3 . (cordforlife.com)
Cord for Life ® is committed to advancing research into the potential for cord blood in regenerative medicine, beginning with clinical trials in the treatment of lower back pain arising from the Sacroiliac Joint (SIJ) using a biological therapeutic derived from umbilical cord blood. (cordforlife.com)
Today, over 80 diseases have been treated with cord blood stem cells because of ongoing cord blood research and clinical trials! (upstatecordbloodbank.com)
The FDA regularly reviews the results of clinical trials for new treatments. (upstatecordbloodbank.com)
The Breakthrough Therapy designation for expedited access is based on the results of phase 2 clinical trials. (upstatecordbloodbank.com)
As stated in the new open access clinical trial, "The use of (UCB) in this fashion is based on safety and efficacy data from prior and ongoing clinical trials at Duke University Medical Center in over 700 patients with these diagnoses infused with autologous or sibling UCB over the past decade. (upstatecordbloodbank.com)
We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
As of today, the TransLab has enabled 11 clinical trials. (childrenshospital.org)
Its GDA-201 for non-Hodgkin Lymphoma is in phase 1 clinical trials. (santaclara.com)
To date, five clinical trials have been published 1-5 that demonstrated the effectiveness of stem cell treatment for cerebral palsy. (parentsguidecordblood.org)
In order to enable children with cerebral palsy to receive multiple stem cell therapies, cord blood clinical trials are exploring therapy with sibling units and eventually unrelated allogeneic cord blood. (parentsguidecordblood.org)

[ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
FDA OKs Stem Cell Therapy to Reduce Infection Risk The agency called the approval of omidubicel 'an important advance' for patients with blood cancer who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
While successful transplants have cured blood cancer for thousands of patients, many risks are involved. (santaclara.com)

We hypothesized that intravenous (IV) infusion of banked unrelated allogeneic umbilical cord blood (UCB) would improve functional outcomes in patients with ischemic stroke. (duke.edu)

Cord Blood In Regenerative Medicine: Do We Need Immune Suppression? (jointsrestoration.com)
Prior to the advent of regenerative medicine and cellular expansion, cord blood treatments typically required the entire unit to help rebuild the blood and immune system. (cordforlife.com)
In support of this emerging potential for utilization of stem cells in regenerative medicine, Cord for Life ® now offers the option of storing cord blood in a 5-compartment cryo-bag. (cordforlife.com)
Although we offer the option to store cord blood in a two-chamber cryo-bag, we recommend the five-chamber bag to anyone who wants to keep their options open for using cord blood in regenerative medicine applications as they become available. (cordforlife.com)
Cord for Life ® 's 5-chamber cryo-bag offers maximum flexibility for storing cord blood stem cells - whether you need the entire unit for one of the 80+ FDA treatments or a portion of the unit for regenerative medicine. (cordforlife.com)
Research has shown that umbilical cord blood is a trustworthy source of multipotent stem cells for regenerative medicine 2 . (cordforlife.com)
The human umbilical cord is being increasingly recognized by the medical community for its potential in regenerative medicine and cellular therapies. (cordforlife.com)

With rapidly emerging advances in the use of alternative donors, such as mismatched unrelated, cord blood and haploidentical donors, it is now possible to find a potential donor for almost all patients in whom an allograft is indicated. (nih.gov)
Especially since our engineered NK cell therapy candidates, which are derived from healthy donors, have demonstrated encouraging pre-clinical data that differentiate them from other NK cell therapy approaches. (advfn.com)
Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
Allogeneic bone marrow transplantation, as we understood it, allows saving lives, but cannot take place without donors. (longdom.org)
Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)

Cell source comparisons between autologous sources (from bone marrow and adipose tissue), and allogeneic sources such as birth tissue (umbilical cord blood, cord tissue, amniotic membrane, amniotic fluid, etc. (aaict.org)
By cell source, the global cell therapy market has been segmented into bone marrow, adipose tissue, and umbilical cord blood-derived cells. (medgadget.com)

Omidubicel is also being evaluated in a Phase 1/2 clinical study in patients with severe aplastic anemia (NCT03173937). (gamida-cell.com)
The translational data from our Phase 3 study of omidubicel, our lead product candidate, show faster, multi-faceted immune response - as quickly as seven days-in omidubicel-treated patients compared to standard cord blood. (oilnow.gy)
The company received its first U.S. Food and Drug Administration (FDA) approval for its Omisirge (omidubicel-only) for blood cancer treatment on April 17, 2023, causing shares to surge over 100% in two days. (santaclara.com)
The US FDA has approved Gamida Cell's Omisirge (omidubicel), an allogeneic cell therapy for patients with blood cancers who are set to undergo stem cell transplantation. (bioprocessintl.com)

Therefore, we performed a phase 1/2a, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs (UMSCs) in the treatment of psoriasis and to preliminarily explore the possible mechanisms. (nature.com)
Fortunately, clinical research on UC-MSCs has generated promising results in terms of safety. (innatehealthcare.org)
Though larger long-term studies are warranted, this supports our understanding of a good safety profile for the clinical use of UC-MSCs. (innatehealthcare.org)
Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
MSCs have also been derived from embryonic tissues, such as Wharton's jelly and umbilical cord blood [ 13 , 14 ]. (hindawi.com)
MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)

Increasing the number of hematopoietic stem and progenitor cells within an umbilical cord blood (UCB) graft shortens the time to hematopoietic recovery after UCB transplantation. (duke.edu)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)

These abnormal cells multiply quickly throughout the bone marrow, blood and other tissues, causing anemia and a deadly risk of infections. (santaclara.com)

A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
BOSTON--( BUSINESS WIRE )-- Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, today reported financial results for the quarter ended March 31, 2021. (biospace.com)
Gamida Cell is pioneering a proprietary NAM-enabled immunotherapy pipeline of diverse potentially curative cell therapies for patients with solid tumor and blood cancers and other serious blood diseases. (gamida-cell.com)
Disorders can range from anemia (shortage of red blood cells) to hemophilia (bleeding disorder), thrombocytopenia (low platelets), thalassemia (abnormal and insufficient hemoglobin), and blood cancers. (santaclara.com)
Blood cancers impact the normal production and function of healthy blood cells. (santaclara.com)
It is intended for use in patients with blood cancers planned for umbilical cord blood transplantation following a myeloablative conditioning regimen, such as radiation or chemotherapy. (bioprocessintl.com)
For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)

Together, these data suggest that a single i.v. dose of allogeneic non-HLA matched human UCB cells is safe in adults with ischemic stroke, and support the conduct of a randomized, placebo-controlled phase 2 study. (duke.edu)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
Higher doses of infused nucleated cells (NCs) are associated with improved clinical outcomes in bone marrow transplantation (BMT) recipients. (bvsalud.org)
First, T or NK cells are isolated from patient's or donor's blood. (nature.com)
We also continue to expand our clinical pipeline with plans to submit an IND for our GDA-201 natural killer cell therapy, initiate a multi-center Phase 1/2 clinical study in NHL and continue to advance our R&D activities to pursue the development of genetically modified NAM-enabled NK cells in solid tumors. (biospace.com)
In contrast, type 2 diabetes primarily stems from insulin resistance, where the body's cells become less responsive to insulin signalling, resulting in elevated blood sugar. (rootsanalysis.com)
With stem cell therapy, the application of stem cells helps our body identify the neovascular problem that won't allow blood flow through the penis and get a firm erection to have sexual intercourse. (giostarmexico.com)
With GIOSTAR Mexico unique specialized stem cell therapy, stem cells will boost blood vessel development allowing blood to flow normally. (giostarmexico.com)
Storing the cord blood unit in five smaller volumes makes it possible to use a portion of the stem cells and save the rest for future use. (cordforlife.com)
Cord for Life ® collects umbilical cord blood, from which we extract and cryogenically store stem cells for potential future use. (cordforlife.com)
Researchers continue to explore new applications for the use of cord blood stem cells around the world. (upstatecordbloodbank.com)
Pross and Jondal were studying cell-mediated cytotoxicity in normal human blood and the effect of the removal of various receptor-bearing cells on this cytotoxicity. (wikipedia.org)
INBRIEF: Stem Cells Seen Repairing Heart Attack Damage Over Time/Additional Blood Data May Improve Pediatric Leukemia Predictions/Pediatric Patients with Rare Tumor May benefit from Heated Chemotherapy/New Findings Refute Link Between UVA, Melanoma. (mdanderson.org)
The objective of this retrospective cohort study was to analyze the muscle, nerve, urinary, and gastrointestinal function in subjects with SCI, treated with either human umbilical cord blood-derived mononuclear cells (hUCMNCs) or conventional therapy. (cellr4.org)
Researchers at Duke University have been studying whether intravenous infusions of cord blood stem cells can help young children with autism spectrum disorder (ASD). (parentsguidecordblood.org)
An initial study (Duke ABC study) from this group published in 2017 treated 25 children ages 2-6 years with stem cells from their own cord blood. (parentsguidecordblood.org)
The Autologous arm held 56 children that received an infusion of stem cells from their own cord blood on their first visit to Duke. (parentsguidecordblood.org)
Then, on their second visit 6 months later, these children received cord blood stem cells. (parentsguidecordblood.org)
Notice that all of the children in this study received cord blood stem cells at some point, either at their initial visit or 6 months later. (parentsguidecordblood.org)
The National Health System has designated the Vall d'Hebron University Hospital as a reference centre ( CSUR ) in Neuroblastoma, Childhood sarcomas , and Paediatric allogeneic stem cells . (vallhebron.com)
Stem cells develop into platelets, red blood cells and white blood cells. (santaclara.com)
Sometimes, the development of blood cells can get mutated, resulting in abnormal blood cells that become cancerous to crowd out healthy blood cells. (santaclara.com)
Multiple myeloma originates from white blood cells called plasma cells, which are critical for the immune system as they create the antibodies the body needs to fight off infection. (santaclara.com)
Blood cancer treatments attempt to eliminate and limit the growth of cancer cells as they alleviate symptoms to improve the quality of life for the patient. (santaclara.com)
Stem cell transplantation replaces the damaged and abnormal blood-producing stem cells with healthy stem cells from a donor. (santaclara.com)
A qualifying patient will still need to undergo high doses of chemotherapy or radiation as a conditioning treatment, so the infused stem cells can make their way to the bone marrow to begin the production of healthy blood cells. (santaclara.com)
It's a single intravenous (IV) dose of human allogeneic stem cells from umbilical cord blood. (santaclara.com)
CordIn is a cryopreserved stem/progenitor cell-based product of purified CD133+ cells composed of ex vivo expanded allogeneic UCB cells. (ucsf.edu)
Bone marrow is the place for the production of the hematopoietic cells which differentiate in to three groups: red blood cells, white blood cells and platelets. (longdom.org)
Autologous Cord Blood Stem Cells for Autism Researchers from Sutter Health have released results. (medadvisor.co)
Recent Studies in Neurological Disorders Adipose Stem Cells for Traumatic Spinal Cord. (medadvisor.co)
A meta-analysis 6 led by CP Alliance Research Foundation compared these five previous studies and concluded that stem cell interventions for people with cerebral palsy had a small but statistically significant impact on gross motor skills, over the follow-up period of six months, with the most efficacy seen from umbilical cord blood stem cells. (parentsguidecordblood.org)
In theory, children with cerebral palsy would benefit the most from neural stem cells to repair neurologic damage in the brain, but these cells do not migrate like cord blood cells and therefore must be implanted directly into the brain, which raises additional safety concerns for their administration. (parentsguidecordblood.org)
White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
The bone marrow produces blood cells. (medlineplus.gov)
Stem cells in the bone marrow give rise to all of your different blood cells. (medlineplus.gov)
After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
Stem cells are removed from a newborn baby's umbilical cord right after birth. (medlineplus.gov)
Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
Due to the smaller number of stem cells, blood counts take much longer to recover. (medlineplus.gov)
The stem cells travel through the blood into the bone marrow. (medlineplus.gov)
Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
The red blood cells are returned to the donor. (medlineplus.gov)

Clinical studies involving Wharton's Jelly stem cell therapies have shown a notable absence of severe adverse reactions. (innatehealthcare.org)
Gamida Cell Ltd. (NASDAQ: GMDA) is an Israeli-based developmental biotechnology company specializing in discovering and advancing cell therapies to fight blood cancer and other illnesses. (santaclara.com)

Parent's Guide to Cord Blood Foundation reported in their March 2016 newsletter that CP Alliance is partnering with Cell Care , the largest family cord blood bank in Australia, on a clinical trial that offers sibling cord blood therapy at the Murdoch Childrens Research Institute to cerebral palsy patients in Australia. (parentsguidecordblood.org)

ClinicaTrials.gov identifier NCT01597778) was a multicenter phase III randomized trial comparing the clinical outcomes and quality of life (QoL) of patients with hematologic malignancies undergoing double umbilical cord blood transplantation (dUCBT) or HLA-haploidentical bone marrow transplantation (haplo-BMT) after reduced-intensity conditioning. (bvsalud.org)

5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
Blood (hematologic) disorders can impact bone marrows, blood vessels, organs and the blood itself. (santaclara.com)

The Allogeneic bone-marrow transplantation represents the only curative treatment and requires a compatible donor HLA. (longdom.org)

Half of the children on the Placebo arm received Autologous cord blood on the second visit and half received Allogeneic. (parentsguidecordblood.org)

Pulmonary Complications in Pediatric and Adolescent Patients Following Allogeneic Hematopoietic Cell Transplantation. (duke.edu)

Previous studies have reported that human umbilical cord blood-derived stem cell therapy is safe and effective for subjects with Spinal Cord Injury (SCI). (cellr4.org)

However, amidst this pressing challenge, the approval of first allogeneic cell therapy for Type 1 diabetes in June 2023 has kindled the hope for the fields of cell and gene therapy to provide a cure for diabetes. (rootsanalysis.com)
The first breakthrough for cell therapy in diabetes treatment came in July 2023, when FDA approved CellTrans Inc.'s allogeneic cell therapy , Lantidra for the treatment of adults with type 1 diabetes who are unable to approach target glycated hemoglobin because of current repeated episodes of severe hypoglycemia. (rootsanalysis.com)
The stock revisited $15.00 at the beginning of February on positive clinical trial data, only to drift lower over the next two years, selling down to a low of $0.56 at the end of March 2023. (santaclara.com)

We performed a randomized trial comparing Tac/MTX (full-MTX) with Tac/mini-MTX/MMF (mini-MTX/MMF) for GVHD prevention after allogeneic hematopoietic cell transplantation (HCT). (bvsalud.org)
My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)

Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission. (duke.edu)

Veliparib (ABT-888) is a potent PARP 1/2 inhibitor with clinical evidence of potentiation of antitumor activity in combination with cisplatin in breast cancer gene (BRCA) mutation carriers and patients with sporadic triple-negative breast cancer. (survivornet.com)
There are three types of blood cancer: leukemia, Lymphoma, and multiple myeloma. (santaclara.com)
Omisirge was FDA-approved to reduce the risk of infection for blood cancer patients following stem cell transplantation. (santaclara.com)

To investigate this, we conducted a phase I open-label trial to assess the safety and feasibility of a single IV infusion of non-human leukocyte antigen (HLA) matched, ABO matched, unrelated allogeneic UCB into adult stroke patients. (duke.edu)

ALTAMONTE SPRINGS, FL (October 2 9 , 2021 ) Cord for Life ® , a full-service cord blood bank with over 25 years of experience, today announced plans to conduct a clinical trial to treat lower back pain arising from the Sacroiliac Joint (SIJ) using a biological therapeutic derived from umbilical cord blood. (cordforlife.com)
Blood Adv 2021. (harvard.edu)

Gulevsky OK, Moiseyeva NN, Gorina OL, Nikolchenko AYu, Schenyavsky I. Comparative evaluation of biological activity of fraction below 5 kDa from cattle cord blood after low-temperature storage (at -80°C) or lyophilization to treat burn wounds in rats. (in.ua)
Thrombopathies are hemorrhagic pathologies involving diverse anomalies and of which the clinical and biological expression are variables. (longdom.org)

In conclusion, allogeneic UMSCT is safe and partially effective in psoriasis patients, and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT. (nature.com)

Phenotypic variation between siblings with MLD suggests that a number of biochemical and epigenetic factors contribute to the clinical phenotype. (medscape.com)
Genotype-phenotype correlations are being delineated to provide a molecular explanation for the clinical variability seen in patients with Krabbe disease. (medscape.com)

Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades. (mcw.edu)
Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)

Scholars@Duke publication: Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study. (duke.edu)
The placebo was an inert infusion designed to look, feel, and even smell like a cord blood infusion. (parentsguidecordblood.org)

Effects last for 3 months or more, according to clinical trial results. (medscape.com)
To reduce expenses, the company will discontinue development of its preclinical NK cell therapy candidates while continuing to enroll patients in the GDA-201 Phase 1 clinical trial. (advfn.com)
Spinal Cord Stimulation: Thoracic and Lumbar Trial -- 16. (nshealth.ca)
Spinal Cord Stimulation Hybrid Lead Array: Epidural and Peripheral Nerve Field Stimulation Trial -- 17. (nshealth.ca)
Duke University Medical Center has received permission from the FDA to offer cord blood therapy for conditions like autism spectrum disorder and cerebral palsy under an expanded access clinical trial. (upstatecordbloodbank.com)
This protocol establishes an umbrella clinical trial NCT03327467 registered on 31 Oct. 2017 which enables children who have these neurological disorders to receive therapy with their own cord blood or cord blood from a sibling, regardless of whether they qualify for a targeted clinical trial. (upstatecordbloodbank.com)
The registration of this clinical trial is a watershed moment, opening the door for many children who are afflicted with an acquired neurological disorder to travel to Duke University for cord blood therapy, provided they have a suffienctly matching cord blood unit in a family bank. (upstatecordbloodbank.com)
However, in order to be eligible to participate in the new clinical trial, patients must have their own or a sibling's cord blood preserved in a family bank. (upstatecordbloodbank.com)
Breaking News: The Cord Blood Association (CBA) announces 13 Nov. 2017 they are seeking funds to convert this protocol into a multi-center clinical trial administered by CBA and Duke. (upstatecordbloodbank.com)
Our goal is to support your specific clinical research needs whatever they may be and we have significant experience in developing new assays and/or transferring assays from a research laboratory context into a validated format for clinical trial support. (childrenshospital.org)

Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018 8 25 (1): 100-106. (cdc.gov)
69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 6 25 (10): 1975-1983. (cdc.gov)

Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide. (duke.edu)

Despite improvements, mortality after allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases remains a significant problem. (duke.edu)

In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)

Treatment of thrombopathy requires, first of all symptomatic measures: haemostatic glues, desmopressin and the blood transfusion which must be only reserved for the difficult gestures or for the high hemorrhagic risk. (longdom.org)
The process is similar to getting a blood transfusion. (medlineplus.gov)

Omisirge is a modified allogeneic cord blood-based cell therapy to quicken the recovery of neutrophils and reduce the risk of infection. (bioprocessintl.com)
In April 2019, Vineti Inc., a leading cloud-based platform has announced its partnership with Marker Therapeutics, Inc., a clinical-stage immuno-oncology company, for supporting a diverse cell therapy portfolio. (medgadget.com)

Allogeneic haemopoietic stem cell transplantation offers a potentially curative treatment option for a wide range of life-threatening malignant and non-malignant disorders of the bone marrow and immune system in patients of all ages. (nih.gov)

The results range from impairing the immune system and inflammation to disrupting or shutting down blood cell production. (santaclara.com)
Lymphoma originates from a type of white blood cell called lymphocytes critical to the immune system. (santaclara.com)
In another embodiment, umbilical cord blood plasma is administered with immune stimulatory agents in order to concurrently inhibit propagation of viral load in the lung while suppressing pulmonary deficiencies. (justia.com)
HSCs are characterized by their unique ability to self-renew and give rise to the entirety of the blood and immune system throughout the lifetime of an individual. (longdom.org)

A statistically significant difference was observed for reported pain and clinical size of lesions from the first day of treatment provided ( Table I ). Statistical analysis was performed only until T4. (medicaljournals.se)
300 clinical research articles/documents for trainees to take home, including detailed IV protocol, consent form, pre- and post-treatment recommendations, etc. (aaict.org)
Disclosed are means, methods and compositions of matter useful for treatment of lung inflammation associated with viral and bacterial infections, as well as with systemic inflammation, through administration of umbilical cord blood derived plasma-based compositions. (justia.com)
The present invention pertains to the treatment of pulmonary inflammation, such as from COVID-19, through the use of umbilical cord plasma based compositions. (justia.com)

Anatomy24

Organisms3

Diseases13

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology1

Phenomena and Processes16

Anthropology, Education, Sociology and Social Phenomena1

Named Groups6

Health Care5

Mesenchymal5

Transplant30

HSCT11

Autologous and allogeneic3

Peripheral blood4

Trials26

Transplants3

Banked unrelated1

Regenerative Medicine7

Donors6

Adipose tissue2

Omidubicel4

MSCs6

Progenitor Cells2

Tissues1

Cancers7

Cells46

Therapies2

Parent's Guide to Cord Blood Foundation1

Malignancies1

Hematologic2

Bone marrow transpla1

Received Autologous cord blood1

Pediatric1

Stem Cell Th1

20233

GVHD3

Unrelated cord blood transplantation1

Cancer3

Human1

20212

Biological2

Efficacy1

Phenotype2

Transplantation in Children2

Infusion2

Trial10

Marrow Transplantation4

Phase1

Mortality1

Graft3

Transfusion2

Cell therapy2

Curative treatment1

Immune4

Treatment4