AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Transplantation, HomologousHematopoietic Stem Cell TransplantationBone Marrow TransplantationStem CellsLiver TransplantationStem Cell TransplantationTransplantation ConditioningGraft vs Host DiseaseTransplantation, AutologousFetal BloodKidney TransplantationGraft SurvivalTransplantation ChimeraHematopoietic Stem CellsTissue DonorsHeart TransplantationLung TransplantationHematologic NeoplasmsTransplantation, IsogeneicGraft RejectionPeripheral Blood Stem Cell TransplantationTransplantation ImmunologyTreatment OutcomeCord Blood Stem Cell TransplantationImmunosuppressive AgentsOrgan TransplantationEmbryonic Stem CellsHistocompatibility TestingGraft vs Tumor EffectHematopoietic Stem Cell MobilizationRecurrenceAntigens, CD34Spinal CordCell TransplantationIslets of Langerhans TransplantationAdult Stem CellsHistocompatibilityPancreas TransplantationMesenchymal Stem Cell TransplantationTransplantationMyeloablative AgonistsWhole-Body IrradiationRetrospective StudiesTime FactorsCell DifferentiationBusulfanLeukemiaRemission InductionGraft vs Leukemia EffectImmunosuppressionSurvival AnalysisMultiple MyelomaPluripotent Stem CellsVidarabineSurvival RateGranulocyte Colony-Stimulating FactorBone Marrow CellsBlood Component RemovalLeukemia, Myeloid, AcuteAcute DiseaseSpinal Cord InjuriesCyclosporineAllograftsTransplantation, HeterotopicStem Cell NicheT-LymphocytesLiving DonorsNeural Stem CellsLymphocyte DepletionMesenchymal Stromal CellsPrecursor Cell Lymphoblastic Leukemia-LymphomaInduced Pluripotent Stem CellsHLA AntigensMice, Inbred C57BLCells, CulturedTransplantation ToleranceSkin TransplantationLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMelphalanCell SeparationDisease-Free SurvivalHeart-Lung TransplantationMultipotent Stem CellsTransplantation, HeterologousCombined Modality TherapyFollow-Up StudiesMyelodysplastic SyndromesLymphocyte TransfusionFetal Tissue TransplantationLeukapheresisStem Cell FactorCell LineageSalvage TherapyBlood CellsUmbilical CordTissue and Organ ProcurementSiblingsNuclear FamilyUnrelated DonorsLeukemia, Myeloid
TransplantsUmbilical cordHSCTProgenitorChemotherapyMyeloablativeTherapiesGraftHematologicMarrow transplantationPatient's own cellsCancersImmunePatients undergoingEngraftmentTissuesOmisirgeInfection2020SurvivalHaematopoietic stem cellsPeripheral blood stemPatientMesenchymalSyngeneicAdultThalassemiaRegenerative medicineGraftsDisordersHealthy stem cellsAplasticPlateletsBone marrow or stemComplicationsCellularCurativeTreatmentDonorsTransplant RecipientsMalignanciesPediatricRemissionAcute myeloid
Transplants16
  • To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
  • What are the types of stem cell transplants? (mdanderson.org)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • Other conditions treated with stem cell transplants include sickle cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich syndrome. (wikipedia.org)
  • Bone marrow transplantation, begun in 1983, and stem cell transplantation have grown to encompass allogeneic, unrelated, cord blood, autologous transplants and mini-allogeneic (reduced intensity conditioning) transplantation strategies. (nymc.edu)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
  • This center has been performing allogeneic transplants since 2012 and has been an NMDP/Be The Match transplant center since May 2015. (bethematch.org)
  • GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
  • Source material for hematopoietic (bone marrow) transplantation is in great demand as at least 20,000 allogeneic transplants are performed each year. (utoronto.ca)
  • Most of these therapies require allogeneic transplants, where the patient must use a genetically-matched cord blood donor. (bioinformant.com)
  • While successful transplants have cured blood cancer for thousands of patients, many risks are involved. (santaclara.com)
  • The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
  • The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
Umbilical cord48
HSCT20
  • Infection and graft-versus-host disease are major complications of allogeneic HSCT. (wikipedia.org)
  • Autologous HSCT requires the extraction (apheresis) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
  • For other cancers such as acute myeloid leukemia, though, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, so the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
  • The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
  • Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT). (kcl.ac.uk)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • The present study compared lower-dose melphalan (80 mg/m2, FM80) and higher-dose melphalan (140 mg/m2, FM140) when administering reduced-intensity conditioning with fludarabine in adult patients with myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). (bvsalud.org)
  • Worldwide, 50,000 hematopoietic stem cell transplant (HSCT) procedures are undertaken annually to replace a person's blood-forming cells - hematopoietic stem cells (HSCs) - to treat blood disorders and cancers, yet two-thirds of patients who need HSCT lack matched donor tissue. (utoronto.ca)
  • If more donors where available and the efficacy and safety of HSCT improved, HSCT could benefit more patients with blood diseases. (utoronto.ca)
  • In addition to limiting HSC numbers, HSCT is inefficient, as many HSC do not get to the relevant areas in the body and/or die following transplantation. (utoronto.ca)
  • For this reason, hematopoietic stem cell transplantation, better known as HSCT, can be a promising treatment approach for a wide range of conditions. (bioinformant.com)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Progenitor8
  • B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
  • As the cells reproduce, they commit to a particular task or cell line and become known as committed progenitor cells . (nationalacademies.org)
  • These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
  • CordIn is a cryopreserved stem/progenitor cell-based product of purified CD133+ cells composed of ex vivo expanded allogeneic UCB cells. (ucsf.edu)
  • The cells are processed using Gamida's proprietary nicotinamide technology, which enriches the hematopoietic progenitor cells, preserves their stemness and promotes their migration to the bone marrow. (pharmalive.com)
  • The use of human cord blood cells dates back as early as 1974, when it was first proposed that stem cell and progenitor cells were present in human cord blood . (bioinformant.com)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
Chemotherapy16
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
  • Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
  • An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
  • For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
  • INBRIEF: Stem Cells Seen Repairing Heart Attack Damage Over Time/Additional Blood Data May Improve Pediatric Leukemia Predictions/Pediatric Patients with Rare Tumor May benefit from Heated Chemotherapy/New Findings Refute Link Between UVA, Melanoma. (mdanderson.org)
  • Typically, patients receiving stem cell transplantation for hematologic cancers need to undergo an aggressive regimen of chemotherapy or radiotherapy to remove existing stem cells. (pharmalive.com)
  • Conditioning treatment - administration of chemotherapy and/or radiation to the patient in order to destroy all of the diseased cells in the body and to create space in the bone marrow for the transplanted stem cells to populate. (uchicagomedicine.org)
  • Post-transplant care - including regular examinations to monitor allogeneic transplant patients for signs of graft vs. host disease (GVHD) and to watch autologous and allogeneic patients for immune system recovery, complications related to chemotherapy or radiation and cancer recurrence (relapse). (uchicagomedicine.org)
  • In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
  • An allogeneic stem cell transplant is a procedure that is performed to repair the damage caused by high-dose chemotherapy. (radiationoncologyassociates.co)
  • High-dose chemotherapy (HDC) kills more cancer cells than lower-dose conventional chemotherapy. (radiationoncologyassociates.co)
  • A qualifying patient will still need to undergo high doses of chemotherapy or radiation as a conditioning treatment, so the infused stem cells can make their way to the bone marrow to begin the production of healthy blood cells. (santaclara.com)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Myeloablative2
  • Based on our findings, we suggest that 131 I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible. (biomedcentral.com)
  • We decided to perform cord blood stem cell transplantation (CBSCT) for hematopoietic rescue after the myeloablative therapies. (biomedcentral.com)
Therapies8
  • Cell based therapies: Academic or commercial? (ehaweb.org)
  • Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
  • The methods proposed are cutting-edge and no other team in the world has this combination of technologies, approaches and expertise to make advances in hematopoietic cell therapies. (utoronto.ca)
  • I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). (dukecancerinstitute.org)
  • There are no curative strategies for ALS, and as a result the alternative therapies are gaining ground, in particular the stem cell-based therapies which hold a promising future. (lidsen.com)
  • Gamida Cell Ltd. (NASDAQ: GMDA) is an Israeli-based developmental biotechnology company specializing in discovering and advancing cell therapies to fight blood cancer and other illnesses. (santaclara.com)
  • The company has a pipeline of NAM-enabled cell therapies. (santaclara.com)
  • Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
Graft4
  • Improving immune recovery following alternative donor stem cell transplantation using donor graft manipulation. (duke.edu)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
  • Various factors including age, sex, performance status (PS), disease status, cytogenetic risk, donor type, graft source, sex mismatch between the donor and the recipient, and year of transplantation were all shown to impact OS 2 . (apbmt.org)
Hematologic3
  • 5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
  • Blood (hematologic) disorders can impact bone marrows, blood vessels, organs and the blood itself. (santaclara.com)
  • Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
Marrow transplantation7
Patient's own cells3
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • Each dose is patient-specific, containing healthy stem cells from an allogeneic pre-screened donor, meaning it comes from a different individual rather than using the patient's own cells. (fda.gov)
  • Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Cancers16
  • A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. (wikipedia.org)
  • The US FDA has approved Gamida Cell's Omisirge (omidubicel), an allogeneic cell therapy for patients with blood cancers who are set to undergo stem cell transplantation. (bioprocessintl.com)
  • Today's approval is an important advance in cell therapy treatment in patients with blood cancers," said Peter Marks, M.D., Ph.D., director of the FDA's Center for Biologics Evaluation and Research. (fda.gov)
  • Blood cancers are a form of cancer caused by uncontrolled growth of cells in the blood, disrupting the ability of blood cells to perform their normal functions. (fda.gov)
  • Blood cancers represent about 10% of all cases of cancer each year in the U.S. Blood cancers can be fatal, with varying survival rates based on multiple factors including the specific type of blood cancer diagnosed. (fda.gov)
  • Stem cell transplantation is a common treatment for blood cancers. (fda.gov)
  • All subjects in the study had confirmed blood cancers. (fda.gov)
  • Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
  • What cancers are treated with allogeneic stem cell transplantation? (clevelandclinic.org)
  • Not all cancers or blood diseases respond to stem cell transplantation, including allogeneic stem cell transplantation. (clevelandclinic.org)
  • The FDA has approved Gamida Cell 's omidubicel-onlv, now to be marketed as Omisirge , in patients over 12 years of age with blood cancers, the company announced Monday. (pharmalive.com)
  • Disorders can range from anemia (shortage of red blood cells) to hemophilia (bleeding disorder), thrombocytopenia (low platelets), thalassemia (abnormal and insufficient hemoglobin), and blood cancers. (santaclara.com)
  • Blood cancers impact the normal production and function of healthy blood cells. (santaclara.com)
  • The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
Immune17
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Allogeneic haemopoietic stem cell transplantation offers a potentially curative treatment option for a wide range of life-threatening malignant and non-malignant disorders of the bone marrow and immune system in patients of all ages. (nih.gov)
  • Cord blood, the blood left in the placenta after a baby is born, has been proved to be as effective as bone marrow in saving children who suffer from leukemia or people whose immune system has been damaged. (china.org.cn)
  • This is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. (clevelandclinic.org)
  • These HSCs are primarily responsible for replenishing blood and regenerating the immune system. (cordlife.co.id)
  • Immune Reconstitution and Severity of COVID-19 among Hematopoietic Cell Transplant Recipients. (mdanderson.org)
  • Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
  • B-cell deficiency agammaglobulinemia is a form of total immunoglobulin deficiency, which is second most common after total variable immune deficiency. (stop-seizures-meds.com)
  • GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
  • Hematopoietic stem cells (HSCs) are defined as stem cells that have a preference for becoming cells of the blood and immune system, such as white blood cells, red blood cells, and platelets. (bioinformant.com)
  • Hematopoietic stem cells (HSCs) are the stem cells that repopulate the blood and immune system within humans, via a process known as haematopoiesis. (bioinformant.com)
  • Five years later in 1988, the first successful cord blood transplant to restore a patient's blood and immune system cells took place in France. (bioinformant.com)
  • The results range from impairing the immune system and inflammation to disrupting or shutting down blood cell production. (santaclara.com)
  • Lymphoma originates from a type of white blood cell called lymphocytes critical to the immune system. (santaclara.com)
  • Multiple myeloma originates from white blood cells called plasma cells, which are critical for the immune system as they create the antibodies the body needs to fight off infection. (santaclara.com)
  • For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Patients undergoing1
  • 1,000 new AML patients undergoing allogeneic or autologous HCT. (apbmt.org)
Engraftment4
  • CD34+ cell dose is critical for cord blood (CB) engraftment. (duke.edu)
  • Engraftment and recovery - transplanted stem cells begin to grow and reproduce healthy blood cells. (uchicagomedicine.org)
  • However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
  • There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
Tissues13
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • Human cord blood cells can also develop into blood vessels, making them promising for the repair of tissues following stroke, coronary heart disease, rheumatic heart disease, congestive heart failure, and congenital heart conditions. (bioinformant.com)
  • These abnormal cells multiply quickly throughout the bone marrow, blood and other tissues, causing anemia and a deadly risk of infections. (santaclara.com)
  • Organs and tissues are built up by specialized cells from the pool of stem cells that form shortly after fertilization. (bmrat.org)
  • Stem cells are widely defined by two main characteristics: the ability to self-renew (divide in a way that reproduces more identical stem cells) and to differentiate (to turn stem cells into specialized cells that form different organs and tissues). (bmrat.org)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
  • Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
  • In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
Omisirge7
  • Omisirge is a modified allogeneic cord blood-based cell therapy to quicken the recovery of neutrophils and reduce the risk of infection. (bioprocessintl.com)
  • Today, the U.S. Food and Drug Administration approved Omisirge (omidubicel-onlv), a substantially modified allogeneic (donor) cord blood-based cell therapy to quicken the recovery of neutrophils (a subset of white blood cells) in the body and reduce the risk of infection. (fda.gov)
  • The efficacy of Omisirge was based on the amount of time needed for recovery of the subject's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (fda.gov)
  • Omisirge also facilitates the recovery of white blood cells, leading to an overall safer transplantation procedure. (pharmalive.com)
  • In turn, Gamida's cell therapy prevented grade 2/3 bacterial or grade 3 fungal infections, which arose in 39% of Omisirge-treated patients and 60% of control counterparts. (pharmalive.com)
  • The company received its first U.S. Food and Drug Administration (FDA) approval for its Omisirge (omidubicel-only) for blood cancer treatment on April 17, 2023, causing shares to surge over 100% in two days. (santaclara.com)
  • Omisirge was FDA-approved to reduce the risk of infection for blood cancer patients following stem cell transplantation. (santaclara.com)
Infection9
20201
Survival5
  • The stem cells in our bone marrow produce blood cells essential for survival. (apollohospitals.com)
  • The 5-year probability of overall survival (OS) after allogeneic HCT was estimated to be 56% (95% confidence interval[CI], 55%- 57%) for patients receiving a transplant while in CR, and 22% (95% CI, 21%-23%) for those who were experiencing active disease. (apbmt.org)
  • 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
Haematopoietic stem cells2
Peripheral blood stem5
Patient22
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • The ability to grow blood stem cells (HSCs) in culture would greatly improve the patient outcome in transplantation, and make cord blood to be useful for adult applications. (gabriellesangels.org)
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
  • Generally, before receiving this kind of transplant, the patient will undergo a course of treatments to remove their own stem cells and prepare the body for the new stem cells. (fda.gov)
  • An important test conducted on the stem cells and the patient to identify if the stem cells match with the patient's HLA type or not.This entire process of HLA typing and matching is time-consuming and the patient is already critical waiting for treatment. (cordlifeindia.com)
  • Because it not only saves crucial time for the patient in need but also prevents wastage of precious stem cells required to identify and match the unit with various recipients till it matches. (cordlifeindia.com)
  • When it is sick and unable to produce the normal healthy blood cells, a patient is considered for a bone marrow transplant where the diseased marrow is replaced with healthy marrow. (apollohospitals.com)
  • One year after transplantation, the patient relapsed, and gilteritinib was resumed. (bvsalud.org)
  • At the University of Chicago Medicine, our transplant team works side-by-side with the patient, family and referring physician before, during and after transplantation to ensure the best possible outcome. (uchicagomedicine.org)
  • Identification of the appropriate type of transplantation - autologous (from the patient), syngeneic (from an identical twin), or allogeneic (from a related, unrelated or cord blood donor). (uchicagomedicine.org)
  • Blood is taken from a vein and circulated through a machine that removes the stem cells and returns remaining blood and plasma back to the patient. (uchicagomedicine.org)
  • Infusion of healthy stem cells into the patient - a painless process in which stem cells are transplanted into the patient through intravenous (IV) infusion. (uchicagomedicine.org)
  • Thus, alternative sources of patient-specific hematopoietic stem cells (HSCs) are required. (utoronto.ca)
  • The ultimate goal is to establish a robust platform that can be used to identify and validate novel genetic factors and protein tools to improve understanding of the process that will lead to our ability to re-constitute the entire blood ontogeny in a patient-specific manner. (utoronto.ca)
  • For these conditions, there are still unknown criteria that need to be determined before the cord blood stem cell transplant can become commonplace, such as patient criteria for optimal treatment effectiveness, optimum stem cell quantity for use in transplant, and preferred method of stem cell delivery into the patient, as shown below. (bioinformant.com)
  • The patient was viremic with CMV detected in blood and CSF by PCR. (frontiersin.org)
  • At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
  • Here we describe an ALS patient, who by choice, received allogeneic human cord-blood derived multipotent stem cells (MSC) intravenously and intrathecally. (lidsen.com)
  • Blood cancer treatments attempt to eliminate and limit the growth of cancer cells as they alleviate symptoms to improve the quality of life for the patient. (santaclara.com)
  • Since its establishment in 2010, the Adult AML Working Group within the JSHCT has been using this registry data to complete several studies focusing on various aspects of HCT in adults with AML, with particular attention paid to patient-, disease-, and transplantation-related factors. (apbmt.org)
Mesenchymal3
Syngeneic1
Adult11
Thalassemia2
Regenerative medicine4
  • In addition to a long history of use within transplant medicine, human cord blood cells are playing a growing role within regenerative medicine. (bioinformant.com)
  • Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)
  • The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
  • 8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
Grafts1
  • The Cord Blood Apgar: a novel scoring system to optimize selection of banked cord blood grafts for transplantation (CME). (duke.edu)
Disorders3
Healthy stem cells3
Aplastic1
Platelets3
Bone marrow or stem1
Complications1
  • Therefore, in order to avoid all the above complications, it is recommended to perform HLA typing on stem cells right at the time of storage. (cordlifeindia.com)
Cellular7
  • The program, which is accredited by the Foundation for the Accreditation of Cellular Therapy , has pioneered a tandem stem cell transplant for Hodgkin lymphoma, reduced intensity conditioning treatments utilizing the drug mitoxantrone, ara-C and pentostatin and refrigerated marrow storage techniques that have led to wide acclaim. (nymc.edu)
  • Extracorporeal photopheresis inactivates antigen-presenting cells and T cells, whereas TNF antagonists decrease cellular activation and local tissue damage. (oncologynurseadvisor.com)
  • Cellular therapy products for transplantation are obtained from a patient's own stem cells, a related donor, or an unrelated donor. (bethematch.org)
  • Stem cell transplantation is a treatment offered through our pioneering cellular therapy program. (uchicagomedicine.org)
  • Cellular Phone Etiquette Cell phone use in the classroom interferes with learning, productivity and is distracting to others. (fdocuments.net)
  • Transient hemophagocytosis with deficient cellular cytotoxicity, monoclonal immunoglobulin M gammopathy, increased T-cell numbers, and hypomorphic NEMO mutation. (lu.se)
  • 3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)
Curative1
Treatment17
  • Treatment focuses on blocking the expansion of donor T cells, as GVHD develops from the expansion of these cells. (oncologynurseadvisor.com)
  • Rituximab was developed in 1986 and received FDA approval for the treatment of B cell non-Hodgkin lymphomas in 1997. (oncologynurseadvisor.com)
  • Cell recovery rates are critical because a higher number of stem cells could enhance the success of the transplant or treatment. (cordlifeindia.com)
  • 5. Adipose Tissue-derived Stem Cells Treatment for Crohn's Fistula. (allstemcells.com)
  • Select patients may receive outpatient stem cell transplant care in specially designed treatment rooms within the unit. (uchicagomedicine.org)
  • For the past thirty years, cord blood has been used within transplant medicine, including for the treatment of leukemia and other blood diseases. (bioinformant.com)
  • Cord blood stem cells have been induced to develop into neural cells, suggesting that they may represent a potential treatment for neurological conditions, such as Alzheimer's, Parkinson's, spinal cord injury, dementia, and related conditions. (bioinformant.com)
  • There are more than 80 medical conditions for which transplantation of hematopoietic stem cells (including cord blood transplant) is a standard treatment option. (bioinformant.com)
  • In addition, there is a range of disease categories for which cord blood transplant could represent a viable treatment method in the future. (bioinformant.com)
  • The treatment strategy utilizing stem cell transplant is an attempt to restore the blood-producing stem cells after HDC has reduced them to dangerously low levels. (radiationoncologyassociates.co)
  • Cancer vaccines based on the knowledge of cancer stem cells have been studied and applied for cancer treatment. (bmrat.org)
  • This re- view discusses stem cell applications in transplantation, stem cell-based carriers, induced-pluripotent stem cells, can- cer stem cells, and potential of stem cells engineering to revolutionize cancer treatment. (bmrat.org)
  • Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
  • Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
  • Plasma cell neoplasms (including multiple myeloma) treatment (PDQ) - health professional version. (medlineplus.gov)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
  • These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
Donors8
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • With rapidly emerging advances in the use of alternative donors, such as mismatched unrelated, cord blood and haploidentical donors, it is now possible to find a potential donor for almost all patients in whom an allograft is indicated. (nih.gov)
  • Approximately 70% of patientswith life-threatening diseasestreatable with allogeneic bloodstem cell transplantation do not havematched related donors. (cancernetwork.com)
  • The NMDP performs thistask by maintaining a registry of morethan 4.9 million volunteer donors ofmarrow and peripheral blood stemcells (PBSC) and 12 cord blood bankscontaining more than 25,000 units ofumbilical cord blood. (cancernetwork.com)
  • Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
  • The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
Transplant Recipients2
  • [11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
Malignancies1
  • There is also a small risk of infections and malignancies from donor blood. (medscape.com)
Pediatric2
  • Comer Children's Hospital pediatric oncology experts are leaders in stem cell transplantation for children and teens. (uchicagomedicine.org)
  • Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
Remission1
Acute myeloid1