Allogeneic transplantation for hematologic malignancies blood and bone marrow bone marrow transplantation. Medical search. Frequent questions

Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
The year 2020 marked the 30th anniversary of the Nobel Prize in Medicine awarded to E. Donnall Thomas for the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat hematologic malignancies and other blood disorders. (broadinstitute.org)
The purpose of this study is to evaluate the effectiveness of vedolizumab when added to background aGvHD prophylaxis regimen compared to placebo and background aGvHD prophylaxis regimen on intestinal aGvHD-free survival by Day +180 in participants who receive allo-HSCT as treatment for a hematologic malignancy or myeloproliferative disorder. (mayo.edu)
The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
Since then, allogeneic hematopoietic stem cell transplantation (HSCT) has evolved to become a frequently used and effective therapy for many hematologic malignancies. (longdom.org)
In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (longdom.org)
Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
In the section on aspergillosis, the revised recommendations include the use of a room with high-efficiency particulate air filters rather than laminar airflow as the protective environment for allogeneic HSCT recipients and the use of high-efficiency respiratory-protection devices (e.g. (cdc.gov)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

Biol Blood Marrow Transplant. (stembook.org)

Younger Matched Unrelated Donors Confer Decreased Relapse Compared to Older Sibling Donors in Older B-cell ALL Patients Undergoing Allogeneic Hematopoietic Cell Transplantation. (stembook.org)

Since approximately 30% of leukemia patients relapse after allogeneic BMT using total body irradiation (TBI)-based preparative regimens, treatment intensity may be suboptimal. (nature.com)
Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. (sagepub.com)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)

Antithymocyte gobulin, derived from rabbits or horses against human thymocytes, has predominantly been used for the treatment of severe aplastic anemia but also within conditioning for allogeneic HCT in selected protocols, mainly for non-malignant indications. (haematologica.org)
To assess the safety of donor natural killer (NK) cell infusion after HLA-mismatched/haploidentical allogeneic hematopoietic stem cell transplantation from a familial donor in patients with advanced malignant disorders. (bioseek.eu)
When someone has mycosis fungoides, malignant cells in the blood travel to the skin, causing lesions that appear as an itchy rash. (stanford.edu)
Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. (bvsalud.org)

To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
The myeloproliferative neoplasms (MPNs) are a heterogeneous group of chronic hematological malignancies that are generally divided into the Philadelphia chromosome-positive (Ph-positive) MPNs, which refers to chronic myelogenous leukemia (CML) and the Philadelphia chromosome-negative (Ph-negative) MPNs. (cancernetwork.com)

The collaboration supports NiCord ® , Gamida Cell's investigational cell therapy, which has the potential to serve as a universal bone marrow donor source for patients with hematologic malignancies, or blood cancers, and bone marrow failure disorders requiring bone marrow transplantation. (bethematchbiotherapies.com)
While allogeneic transplantation can be life saving for patients with hematologic malignancies, or inherited disorders such as several forms of immuno-deficiency, the transplant-related side effects and complications remain the biggest hurdles. (stanford.edu)
The myelodysplastic syndromes (MDS) are a group of clonal neoplastic hematologic disorders characterized by varying degrees of bone marrow failure, abnormal hematopoiesis, and proliferation of myeloid blast cells. (acgtfoundation.org)
Children and teens with rare childhood non-Hodgkin lymphoma are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through the Childhood Lymphoma Program in our Childhood Hematologic Malignancy Center . (dana-farber.org)

In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
Currently, he is the Head of the Graft-versus-host disease (GVHD) and Autoimmunity Unit and Senior Clinician at the Experimental Transplantation and Immunology Branch of the National Cancer Institute's (NCI) Center for Cancer Research at the U.S. National Institutes of Health (NIH). (wikipedia.org)
He is presently also an Adjunct Professor of Medicine and Oncology at Lombardi Cancer Center, Georgetown University, Washington, D.C. Pavletic's main area of research is in the field of hematopoietic stem cell transplantation for hematologic malignancies, chronic Graft-versus-host disease (GVHD) and transplantation for autoimmune disease, with a particular interest in addressing late effects in cancer therapy survivors. (wikipedia.org)
He is best known for his research on chronic GVHD, the most common late effect in cancer survivors who underwent allogeneic stem cell transplantations as a form of treatment. (wikipedia.org)
The United States Embassy in Zagreb, Croatia, granted Pavletic a United States Government stipend to spend six weeks at the University Hospital Centre Zagreb, Croatia, in 2013, to assist in the establishment of a multidisciplinary center for the treatment of chronic GVHD resulting from allogeneic stem cell transplantations. (wikipedia.org)
Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
Purpose: Diarrhea associated with acute gastrointestinal (GI) graft- versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) can result in severe morbidity and mortality. (elsevierpure.com)
A pilot study was conducted to evaluate the efficacy and toxicity of octreotide in the management of diarrhea in patients with GVHD after allogeneic BMT. (elsevierpure.com)
The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
Discovery and availability of biomarkers suitable for screening high risk patients using early, non-invasive, blood tests specific for GvHD-therapy resistance would significantly aid in the management of patients with this disease and would allow for rational drug development and drug approval by regulatory authorities. (cryostem.org)
Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
The median time for onset of stage 3-4 gut GVHD was 35 (4-135) days after allogeneic HCT. (nature.com)

Although it is proving to be a heterogeneous disease process, the only treatment with proven survival benefit for poor risk AML remains allogeneic hematopoietic cell transplant. (sagepub.com)
Predictors of lost to follow-up among pediatric and adult hematopoietic cell transplant survivors: A report from the Center for International Blood and Marrow Transplant Research. (stembook.org)

Bone marrow aspiration is carried out by a puncture on the level of the sternum or the posterior iliac peaks under local anesthesia by the doctor. (longdom.org)
In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
Bone marrow biopsy is performed in addition to aspiration to assess cellularity qualitatively and quantitatively. (medscape.com)
Because the chromosomal t(14;18) translocation is found in the majority of patients with follicular lymphoma, bone marrow aspiration and chromosome analysis can also help establish the diagnosis. (medscape.com)

The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)

Sixteen evaluable patients with advanced hematologic malignancies were treated with twice daily TBI using a high-energy source (18-24 MV). The first patient cohort ( n = 11) received a total dose of 14.4 Gy in nine fractions, and the second cohort ( n = 5) received doses escalated to 15.3 Gy. (nature.com)
All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
[ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
Analyze the course of lower respiratory tract infection with pandemic (H1N1) 2009 among patients with hematologic malignancy. (cdc.gov)
Develop appropriate management strategies for pandemic (H1N1) 2009 infection for patients with hematologic malignancy. (cdc.gov)
To assess outcomes of patients with hematologic ma- rhea. (cdc.gov)
Pandemic (H1N1) 2009 may cause serious illness in patients with hematologic malignancy, primarily those with LRTI. (cdc.gov)
Infl uenza is a major cause of illness and death in patients zanamivir, use of concomitant antimicrobial therapy, and with hematologic malignancy and in hematopoietic cell intravenous immunoglobulin was determined by the treat- transplant (HCT) recipients. (cdc.gov)
Patients received either peripheral- blood stem cells (n = 13) or bone marrow (n = 8). (elsevierpure.com)
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens. (sagepub.com)
Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. (sagepub.com)
More specifically, the development of minimal intensity or so called "nonmyeloablative" conditioning regimens paved the way towards the application of allogeneic HCT in older patients and all of those who probably would not tolerate classical intensity conditioning. (haematologica.org)
He created the Sports Legends Golf Classic in Delray Beach, Florida, to benefit the Bone Marrow & Cancer Foundation, raising over 2.5 million dollars for patients. (bonemarrow.org)
Since beginning the BMCF in 1992, Christina has dedicated her life to improving the quality of life for cancer patients and bone marrow/Hematopoietic Cell Transplantation (HCT) transplant patients and their families. (bonemarrow.org)
After undergoing an allogeneic haematopoietic stem cell transplantation (alloHCT), patients need intensive physiological and psychological rehabilitation. (mdpi.com)
Under the terms of the collaboration agreement, Gamida Cell and Be The Match BioTherapies will explore opportunities to work together across Gamida Cell's ongoing clinical development program for NiCord, including the Phase 3 clinical study in patients with high-risk blood cancers. (bethematchbiotherapies.com)
Gamida Cell's work to bring a new therapeutic option to patients in need of a bone marrow transplant aligns with our core mission to help organizations deliver cellular therapies that save more lives and improve the quality of life for patients," said Amy Ronneberg, President of Be The Match BioTherapies. (bethematchbiotherapies.com)
Despite the curative potential of bone marrow transplants, it is estimated that more than 40 percent of eligible patients in the U.S. do not receive one for various reasons, including difficulty in finding a matched donor. (bethematchbiotherapies.com)
NiCord, Gamida Cell's lead clinical program, is under development as a universal bone marrow transplant solution for patients with high-risk hematologic malignancies. (bethematchbiotherapies.com)
Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
In the first quarter of this year, we made significant progress on key initiatives across all functions of our business, starting with omidubicel, a potentially transformative treatment option for patients with hematological malignancies," said Julian Adams, Ph.D., chief executive officer of Gamida Cell. (biospace.com)
In this episode, the doctors delve into what Minimal/Measurable Disease (MRD) is, which blood cancers testing is currently used on, and how we can utilize it to more accurately monitor patients and customize treatment. (stanford.edu)
The BMT-CT program at Stanford performs autologous and allogeneic transplantations for over 450 patients each year. (stanford.edu)
While the graft-versus-tumor effect provided by the donor graft can be very powerful in controlling the disease, disease relapse is still the primary reason that patients do not do well after an allogeneic transplantation. (stanford.edu)
Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients. (nature.com)
Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
This is a single arm, open-label, multi-center, Phase 1 study to determine the safety and tolerability of an experimental therapy called NKX019 (allogeneic CAR NK cells targeting CD19) in patients with relapsed/refractory non-Hodgkin lymphoma (NHL), chronic lymphocytic. (uchicagomedicine.org)
This global trial evaluated omidubicel versus standard cord blood in patients with hematologic malignancies, who needed a bone marrow transplant, but did not have a suitable match donor. (seekingalpha.com)
To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
Evidence exists that immune activation against hematopoietic elements frequently occurs in MDS patients, based on the identification of lymphocytic infiltrates in the marrow, oligoclonal expansion of T cells, and excessive production of tumor necrosis factor alpha. (acgtfoundation.org)
Nevertheless, MDS are thought to be immunologically responsive diseases, as immunomodulatory drugs can induce remissions, and allogeneic bone marrow transplantation can be curative in the small fraction of patients for whom this is an option. (acgtfoundation.org)
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial. (wustl.edu)
Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy. (wustl.edu)
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia. (wustl.edu)
Such immune dysfunction may be due to a disorder in thymic output function (in particular in young patients), which results in a lower level of naive T-cells in the peripheral blood available for an immune response to the proliferation and abnormal expression of the T cell receptor (TCR) repertoire. (biomedcentral.com)
Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
Patients with CLL have a higher-than-normal white blood cell count, which is determined by complete blood count (CBC). (medscape.com)
The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)
Most patients with follicular lymphoma present at an advanced stage, and most patients have bone marrow involvement at diagnosis. (medscape.com)
Rarely, patients have no M-protein in blood and urine, although the currently used serum free light chain assay now demonstrates monoclonal light chains in many of these formerly so-called nonsecretory patients. (msdmanuals.com)
Patients with fully excised BCC/SCC/CIN or other minor malignancy are not excluded. (who.int)

Autologous stem cell transplants , which are stem cells that come from your own bone marrow or blood. (bidmc.org)
Autologous Hematopoietic Stem Cell Transplantation for Liver Transplant Recipients With Recurrent Primary Sclerosing Cholangitis: A Pilot Study. (stembook.org)
Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (msdmanuals.com)

The aim of this review is to summarize the PD-1 and PD-L1 biological functions and their alterative expression in hematological malignancies. (biomedcentral.com)
The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. (biomedcentral.com)
Leukemia, particularly aggressive refractory hematological malignancies unresponsive to upfront therapy, remains a difficult condition to treat. (biomedcentral.com)

biopsy - either a bone marrow biopsy to examine blood cells, or a surgical or CT-guided biopsy to obtain lymph node tissue samples. (bidmc.org)
Our radiologists report on your imaging studies and our hematopathologists (pathologists who specialize in blood diseases) review the results of your biopsy. (bidmc.org)
Other tests that may be helpful for diagnosis include bone marrow biopsy and ultrasonography of the liver and spleen. (medscape.com)

Gamida Cell is a clinical stage biopharmaceutical company leveraging its proprietary technology to develop cell therapies that are designed to cure cancer and rare, serious hematologic diseases. (bethematchbiotherapies.com)
BOSTON--( BUSINESS WIRE )-- Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, today reported financial results for the quarter ended March 31, 2021. (biospace.com)
Some of these diseases develop mainly after bone marrow transplantation. (bvsalud.org)

2002 until 2007), two were included in TK007 (2005-2009) and six serves as a control group for outcome after haploidentical transplantation without HSV-TK-transduced DLI. (frontiersin.org)

Intravenous Busulfan-Based Myeloablative Conditioning Regimens Prior to Hematopoietic Cell Transplantation for Hematologic Malignancies. (stembook.org)
An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)

The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
He then completed a clinical fellowship in bone marrow transplantation in 1992 at the Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine in Seattle, Washington. (wikipedia.org)
Additionally, the study met key secondary endpoints related to the speed of platelet engraftment, decrease in infections and reduction in hospitalizations, all significant clinical measures in bone marrow transplant. (biospace.com)
We are a nationally recognized center of excellence, fully accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a proud member of the Blood and Marrow Transplant Clinical Trials Network of the National Cancer Institute. (stanford.edu)
While the role for the individual cell population of the donor graft is not fully understood after allogeneic transplant, recent works in the field have yielded some interesting observations which may lead to advances in clinical care. (stanford.edu)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
Clinical and translational research in hematologic malignancies and stem-cell transplantation. (wustl.edu)
The clinical course of individuals with MF is heterogeneous and characterized by constitutional symptoms, bone marrow myeloproliferation and fibrosis, progressive cytopenias, and symptomatic splenomegaly. (cancernetwork.com)
The clinical course of individuals with MF is characterized by constitutional symptoms (fevers, night sweats, and weight loss), bone marrow myeloproliferation and reticulin/collagen fibrosis, worsening cytopenias, thrombosis, and progressive symptomatic splenomegaly. (cancernetwork.com)

Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. (sagepub.com)

Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)

Doctors extract stem cells from your blood or bone marrow, place them in frozen storage, and re-infuse them back into your body following high-dose chemotherapy to eliminate blood cancers. (bidmc.org)

Dr. Thomas, "father of bone marrow transplantation," first developed and reported this technique in 1957, and in the ensuing decades, this seminal study has impacted fundamental work in hematology and cancer research, including advances in hematopoiesis, stem cell biology, tumor immunology, and T-cell biology. (broadinstitute.org)

Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)

Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)

Impact of Donor Age on Allogeneic Hematopoietic Cell Transplantation Outcomes in Older Adults with Acute Myeloid Leukemia. (stembook.org)
Inferior Outcomes with Cyclosporine and Mycophenolate mofetil after Myeloablative Allogeneic Hematopoietic Cell Transplantation. (stembook.org)

Severe or very severe aplastic anemia is a hematologic emergency, and care should be instituted promptly. (medscape.com)

2020 was an important year for Gamida Cell as we made significant progress across our entire pipeline, including omidubicel, which is poised to become the first FDA approved cell therapy for bone marrow transplantation. (seekingalpha.com)

Pavletic's research also includes pioneering work on the use of peripheral blood cells in allogeneic stem cell transplantation as a form of cancer treatment, as opposed to the use of stem cells from the bone marrow. (wikipedia.org)
G-CSF mobilizesCD34+ hematopoietic stem cells from bone marrow into the blood. (fliphtml5.com)
G-CSF was found to mobilize both CD34+ stem cells (p=0.02)and even more dramatically mobilize Hox11+ splenic stem cells (p=0.000013) into the peripheral blood. (fliphtml5.com)
Stem cell transplant - also called bone marrow transplant, in this procedure a donor's stem cells are transfused into your blood. (bidmc.org)
The transplanted stem cells go from your blood to your bone marrow. (bidmc.org)
A key milestone in a patient's recovery, neutrophil engraftment is a measure of how quickly the stem cells a patient receives in a bone marrow transplant are established and begin to make healthy new cells. (biospace.com)
Hematopoietic stem cells (HSCs) are very rare cells, representing approximately one in 100,000 bone marrow (BM) cells in the adult. (longdom.org)
Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)

Acute lymphoblastic leukemia (ALL), also called acute lymphocytic leukemia, is a cancer of the white blood cells. (bidmc.org)
These leukemia cells do not fight infection well, and they crowd out the healthy blood cells and platelets. (bidmc.org)
Acute lymphoblastic leukemia is similar to acute myeloid leukemia (AML) , except that AML affects the myeloid white blood cells instead of lymphocytes. (bidmc.org)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
Although the disease can evolve toward acute leukemia, morbidity and mortality most frequently result from a marrow failure syndrome. (acgtfoundation.org)

Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (sagepub.com)
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)

Peripheral blood flow cytometry is the most valuable test to confirm a diagnosis of CLL. (medscape.com)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (msdmanuals.com)

In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy. (broadinstitute.org)
At BIDMC, we review all of your information with the full blood cancer treatment team in our weekly multidisciplinary conferences. (bidmc.org)
When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
Bob Fishman is a founding member of the Bone Marrow & Cancer Foundation's Board of Directors. (bonemarrow.org)
When not advocating for the Bone Marrow & Cancer Foundation, Bob is a producer and director at CBS Sports. (bonemarrow.org)
Charlotte is a Trustee of Thomas Jefferson BMCF at Monticello, the Bone Marrow & Cancer Foundation, American Corporate Partners, The Madoo Conservancy, a member of the International Council of Hillwood Estate, Museum and Gardens, and on the Advisory Board of The New York School of Interior Design where she holds an Honorary Doctorate Degree. (bonemarrow.org)
As Treasurer of the Board of Directors, Andy Robin plays an integral part in the efforts of the Bone Marrow & Cancer Foundation. (bonemarrow.org)
Christina Merrill is President and Chief Executive Officer of the Bone Marrow & Cancer Foundation. (bonemarrow.org)
Her passion for patient support and advocacy lead to founding the Bone Marrow & Cancer Foundation. (bonemarrow.org)
Pediatr Blood Cancer. (chop.edu)
Advances in cellular immunotherapy that spur genetically modified T cells to attack cancer cells have revolutionized the treatment of certain blood cancers. (wustl.edu)
Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)

Bone Marrow Transplantation (2000) 25, 807-813. (nature.com)

If one of the brothers and sisters is compatible, we speak about geno-identical allogeneic transplantation having the advantage of reducing the complications post-transplantation. (longdom.org)
Are other atypical white blood cells an asset to address complications? (cryostem.org)
Hare H, Tiwari P, Baluch A, Greene J. Infectious Complications of DiGeorge Syndrome in the Setting of Malignancy. (moffitt.org)

Allogeneic stem cell transplantation is the only known curative therapy. (medscape.com)

During the quarter, Gamida Cell continued to advance omidubicel, the first cell therapy for bone marrow transplant to receive Breakthrough Therapy Designation from the U.S. Food and Drug Administration (FDA). (biospace.com)

Samples of peripheral blood lymphocytes (PBLs) were obtained from ten normal untreateddonors and 18 normal donors treated with G-CSF. (fliphtml5.com)
In ALL, the bone marrow (the soft, spongy center of bones) produces too many lymphocytes, a type of white blood cells that do not mature as they should. (bidmc.org)
The development of normal lymphocytes is a well-orchestrated process, that begins in the bone marrow. (stanford.edu)
Morphologically, in the peripheral blood, these cells resemble mature lymphocytes. (medscape.com)

The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)
As stated above, the fine tuning of the allogeneic immune response by T-cell depletion or pharmacological means represents the second important pillar in the development of optimized transplantation protocols. (haematologica.org)
HSCs are characterized by their unique ability to self-renew and give rise to the entirety of the blood and immune system throughout the lifetime of an individual. (longdom.org)
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
Dana-Farber/Boston Children's offers internationally renowned care for children with cancers of the blood and immune system. (dana-farber.org)

From 1999 until 2002 he was the Director of the Allogeneic Stem Cell Transplantation program at the University of Nebraska. (wikipedia.org)

Anatomy27

Organisms13

Diseases56

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment79

Psychiatry and Psychology2

Phenomena and Processes39

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups5

Health Care16

HSCT17

Biol Blood Marrow Transplant1

Sibling donors1

Total body irradi4

Malignant6

Neoplasms2

Disorders4

GVHD12

Hematopoietic cell transplant2

Aspiration4

Undergoing a bone marrow tra1

Patients44

Autologous5

Hematological3

Biopsy3

Diseases3

Haploidentical1

Regimens2

Clinical9

Relapse2

Transplants1

Chemotherapy1

Hematology1

Acute Graft Versus1

Myeloproliferative1

Outcomes2

Severe1

20201

Stem cells8

Leukemia6

Nonmyeloablative2

Diagnosis2

Cancer13

20001

Complications3

Curative therapy1

Cell therapy for bone1

Lymphocytes4

Immune5

19991