AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Transplantation, HomologousGraft vs Host DiseaseBone Marrow TransplantationHematopoietic Stem Cell TransplantationTransplantation ConditioningIsoantigensLymphocyte Culture Test, MixedHematologic NeoplasmsTransplantation ChimeraGraft vs Tumor EffectT-LymphocytesGraft SurvivalTransplantation, IsogeneicWhole-Body IrradiationGraft vs Leukemia EffectStem Cell TransplantationTissue DonorsLeukemiaSkin TransplantationHistocompatibility TestingHistocompatibilityGraft vs Host ReactionTransplantation, AutologousLymphocyte ActivationBusulfanGraft RejectionTransplantation ImmunologyRecurrenceCytotoxicity, ImmunologicMice, Inbred BALB CMice, Inbred C57BLLymphocyte DepletionTreatment OutcomeImmunosuppressionRemission InductionImmunosuppressive AgentsSpleenLeukemia, Myeloid, AcuteMyeloablative AgonistsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveRadiation ChimeraLeukocyte TransfusionPeripheral Blood Stem Cell TransplantationDendritic CellsVidarabineBlood Transfusion, AutologousImmune TolerancePrecursor Cell Lymphoblastic Leukemia-LymphomaAnemia, AplasticHLA AntigensLymphocytesAcute DiseaseChimerismT-Lymphocytes, CytotoxicTransplantation ToleranceHistocompatibility AntigensMyelodysplastic SyndromesMice, Inbred StrainsTime FactorsCytomegalovirus InfectionsRetrospective StudiesMice, Inbred C3HH-2 AntigensSurvival AnalysisCytotoxicity Tests, ImmunologicBlood TransfusionCD4-Positive T-LymphocytesImmunotherapy, AdoptiveKiller Cells, NaturalAllograftsMinor Histocompatibility AntigensFlow CytometryHematologic DiseasesCD8-Positive T-LymphocytesCells, CulturedSurvival RateCyclophosphamideAntilymphocyte SerumHepatic Veno-Occlusive DiseaseT-Lymphocytes, RegulatoryGraft Enhancement, ImmunologicAntigens, CDMajor Histocompatibility ComplexCyclosporineChimeraCombined Modality TherapyBone Marrow CellsImmunophenotypingLeukemia, MyeloidSiblingsImmunity, CellularInterleukin-2IsoantibodiesIslets of Langerhans TransplantationAntibodies, MonoclonalThymus GlandHost vs Graft ReactionBone MarrowSalvage TherapyMultiple Myeloma
TransplantAdministration of allogenAutologous stem cellTRANSPLANTATION OF ORGANSGVHDRethymicMSCsRegenerationTherapiesRecipientAllograftRegenerative medicineHSCTAntigensDonorsTransplantsReceives bone marrowGraftEfficacyIPSCCellChronicAdiposeDiseaseTreatmentsProcedureCongenital athymiaImmuneClinicalPerson'sPatientsXenogeneicThymus tissueScaffoldHumanRecipientsPerfusionTreatmentAdequate
Transplant16
  • GVHD may occur after a bone marrow, or stem cell, transplant in which someone receives bone marrow tissue or cells from a donor. (medlineplus.gov)
  • This type of transplant is called allogeneic. (medlineplus.gov)
  • Before a transplant, tissue and cells from possible donors are checked to see how closely they match the recipient. (medlineplus.gov)
  • It may be performed using cells from the patient's own body (autologous transplant) or cells from a donor (allogeneic transplant). (mayo.edu)
  • An allogeneic bone marrow transplant uses marrow from a donor whose tissue type closely matches the patient's. (imaginis.com)
  • A team of hematology marrow transplant department of the Saint-Louis Hospital AP-HP, the Paris University and INSERM (U976 unit) in collaboration with the Pasteur Institute, led the work on graft against host disease (GVHD) using liquid chromatography coupled with mass spectrometry to study the metabolome of allogeneic patients at Saint-Louis hospital AP-HP. (pasteur.fr)
  • In this project, the team of Dr. David Michonneau and Professor Gérard Socié (INSERM U976 / Saint Louis Hospital AP-HP / University of Paris) was interested in the study of the metabolome of allogeneic patients in the hospital Saint- Louis AP-HP in the hematology-transplant adult service. (pasteur.fr)
  • 42 A source establishment that distributes a cell, tissue or organ under section 40 before the donor suitability assessment is complete must, after the distribution, complete the assessment, carry out any other appropriate follow-up testing and notify the relevant transplant establishment of the results. (gc.ca)
  • the disease is a side effect that is common after an allogeneic bone marrow transplant. (researchandmarkets.com)
  • Before undergoing an allogeneic stem cell transplant, the patient will receive high doses of chemotherapy or radiation to destroy the diseased cells and prepare the body for the donor cells. (researchandmarkets.com)
  • As an allogeneic transplant recipient, the patient might experience either form of Graft vs. Host Disease, either form, or neither. (researchandmarkets.com)
  • Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML. (cdc.gov)
  • Is a matched unrelated donor search needed for all allogeneic transplant candidates? (cdc.gov)
  • The risk for infections caused by pathogens transmitted through solid organ or tissue transplants, referred to here as donor-derived or transplant-transmitted infections, has been recognized for decades and remains a worldwide public health problem. (cdc.gov)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • Subjects who have undergone allogeneic SCT will be eligible if, in addition to meeting other eligibility criteria, they are at least 100 days post-transplant, they have no evidence of active GVHD and have been without immunosuppressive agents for at least 30 days. (who.int)
Administration of allogen1
  • The safety and efficacy of allogeneic processed thymus tissue were established in clinical studies that included 105 participants, with ages from one month to 16 years, who each received a single administration of allogeneic processed thymus tissue, from 1993 to 2020. (wikipedia.org)
Autologous stem cell2
  • What's the difference between allogeneic and autologous stem cell transplantations? (clevelandclinic.org)
  • The stem cell therapy market is segmented into allogeneic and autologous stem cell therapies based on type. (marketsandmarkets.com)
TRANSPLANTATION OF ORGANS5
  • The transplantation of organs, cells and tissues has become the treatment of choice for a wide range of both fatal and non-fatal diseases, resulting in high levels of demand for transplantation services, particularly in high- and middle-income countries. (who.int)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
GVHD5
  • Testosterone levels CELL SB 239063 Account activation Testosterone levels cells are a vital element of the resistant response to allogeneic tissue, straight mediating being rejected and graft-versus-host disease (GVHD) [12]. (molecularcircuit.com)
  • Substantial blood vessel loss may lead to impaired blood perfusion and tissue fibrosis, the hallmark lesion of chronic GVHD. (nih.gov)
  • Graft against the host (GVHD) is a major complication that may occur after a allograft, and is characterized by tissue damage induced by donor immune cells which react against those of the recipient. (pasteur.fr)
  • Recent advances in the understanding of immunological mechanisms of GVHD have shown that activation of donor immune cells is tightly regulated by the microenvironment tissue or digestive microbiota changes after transplantation. (pasteur.fr)
  • Indoles derivatives are ligands of the receptor Aryl Hydrocarbon (AhR), which regulates the activation and differentiation of immune cells and could therefore contribute to limiting the risk of immune reaction to allogeneic origin of GVHD. (pasteur.fr)
Rethymic6
  • Allogeneic processed thymus tissue, sold under the brand name Rethymic, is a thymus tissue medical therapy used for the treatment of children with congenital athymia. (wikipedia.org)
  • The U.S. Food and Drug Administration (FDA) granted the application for allogeneic processed thymus tissue a rare pediatric disease voucher and granted approval of Rethymic to Enzyvant Therapeutics, Inc. "Enzyvant Resubmits Biologics Licensing Application (BLA) to FDA for RVT-802 for Pediatric Congenital Athymia" (Press release). (wikipedia.org)
  • Enzyvant Receives FDA Approval for Rethymic (allogeneic processed thymus tissue-agdc), a One-Time Regenerative Tissue-Based Therapy for Pediatric Congenital Athymia" (Press release). (wikipedia.org)
  • Our Rethymic (allogeneic processed thymus tissue-agdc) for Surgical Implantation Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • RETHYMIC consists of yellow to brown slices of allogeneic processed thymus tissue for administration by surgical implantation. (rxlist.com)
  • This thymus tissue is aseptically processed and cultured for 12 to 21 days to produce RETHYMIC slices. (rxlist.com)
MSCs14
  • Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
  • Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
  • MSCs were initially isolated from bone marrow but are now known to exist in a wide range of tissues in the human adult, including brain, thymus, lung, liver, spleen, kidney, and dental pulp [ 11 , 12 ]. (hindawi.com)
  • MSCs have also been derived from embryonic tissues, such as Wharton's jelly and umbilical cord blood [ 13 , 14 ]. (hindawi.com)
  • Based on cell source, the stem cell therapy market is segmented into adipose tissue-derived MSCs (mesenchymal stem cells), placental/umbilical cord-derived MSCs, bone marrow-derived MSCs, and other sources. (marketsandmarkets.com)
  • In 2021, the adipose tissue-derived stem cells segment dominated stem cell therapy with the highest revenue share, which was attributed to the growing adoption of these MSCs across different therapeutic indications. (marketsandmarkets.com)
  • Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
  • Clinical preliminaries have shown that allogeneic bone marrow-inferred MSCs might be securely managed to people without evoking clinically applicable insusceptible responses. (alliedacademies.org)
  • In the primary clinical preliminary of allogeneic MSC treatment for intense MI4, intravenous mixture of MSCs didn't create a resistant response and prompted better results as to cardiovascular arrhythmias, pneumonic capability, left ventricular capability, and suggestive worldwide appraisal. (alliedacademies.org)
  • Ensuing to this intense MI preliminary, we played out a randomized clinical preliminary in patients with ongoing ischemic cardiomyopathy, which had as its fundamental objective the examination of transendocardial infusion of autologous and allogeneic bone marrow-determined MSCs. (alliedacademies.org)
  • Significantly, just two patients getting allogeneic MSCs created sharpening as estimated by the board receptive antigen (PRA). (alliedacademies.org)
  • a promising source of MSCs is adipose tissue (AT). (biomedcentral.com)
  • These characteristics make MSCs interesting tools for tissue engineering and regeneration in human clinical trials. (biomedcentral.com)
  • In preclinical animal studies, a promising source of MSCs has been found to be adipose tissue (AT). (biomedcentral.com)
Regeneration6
  • Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. (healthpartners.com)
  • CONCLUSIONS: There was evidence of meniscus regeneration and improvement in knee pain following treatment with allogeneic human mesenchymal stem cells. (healthpartners.com)
  • These results support the study of human mesenchymal stem cells for the apparent knee-tissue regeneration and protective effects. (healthpartners.com)
  • Their idea is that, for a heart that is potentially weak, an inserted cardiac membrane could support regeneration of heart tissue. (tgen.org)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
Therapies5
  • Comparatively fewer complications are associated with the development and manufacturing of allogeneic stem cell therapies, which is the key attributive reason for their largest share in the market. (marketsandmarkets.com)
  • This has also led to an increase in the number of clinical trials regarding the development of allogeneic stem cell therapies, making it the fastest growing segment during the forecast period. (marketsandmarkets.com)
  • Allogeneic therapy increases the risk of bringing out an immune response from the patient, and immunosuppressive therapies along with some combinational therapies for providing allogeneic processes. (vedantu.com)
  • IN8bio's DeltEx platform employs allogeneic, autologous, iPSC and genetically modified approaches to develop cell therapies, designed to effectively identify and eradicate tumor cells. (itbusinessnet.com)
  • Evotec's industry leading iPSC platform has been developed over the last years to industrialise the use of iPSC technology in terms of throughput, reproducibility and robustness for applications both in drug screening as well as in next generation off-the-shelf allogeneic cell therapies. (evotec.com)
Recipient3
  • Vascular endothelial cells form the interface between recipient tissues and circulating alloreactive donor T cells after allogeneic stem cell transplantation. (nih.gov)
  • The soft-tissue margins of the maxillary recipient bed were sharply de-epithelized. (allenpress.com)
  • For these infections, the initial link to the transplanted organ was made by histopathologic evaluation and immunohistochemical testing of tissue from an organ recipient who died 4 weeks after undergoing transplantation. (cdc.gov)
Allograft2
  • Allograft meaning allogeneic transplantation or homograft. (vedantu.com)
  • Allograft definition termed as the tissues or bones is transplanted between the genetically non identical individuals of the same species. (vedantu.com)
Regenerative medicine1
  • Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
HSCT2
Antigens4
  • For the indirect path, antigens from allogeneic cells are presented and processed in the circumstance of personal MHC elements. (molecularcircuit.com)
  • Stream kilometric crosscoordinate with serum from the second understanding to new contributor T cells showed a powerless positive response, demonstrating low titer, once more allogeneic refinement with class I benefactor antigens. (alliedacademies.org)
  • Tissue antigens 2004 Apr 63 (4): 293-325. (cdc.gov)
  • Tissue antigens 2006 Jan 67 (1): 30-7. (cdc.gov)
Donors7
  • Thymus tissue is obtained from donors less than or equal to 9 months of age undergoing cardiac surgery. (rxlist.com)
  • Health Canada proposes to make NAT a requirement instead of a recommendation for the detection of human immunodeficiency virus type 1 ( HIV -1) and Hepatitis C ( HCV ) for tissue donation from deceased donors, as well as for cord blood donation. (canada.ca)
  • and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • This is mainly because very close tissues in the umbilical cord match the patients and newborn donors. (vedantu.com)
  • The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
  • Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
Transplants2
  • Transplantation of allogeneic or nonself tissue stimulates a robust defense response leading to graft being rejected, and therefore most recipients of allogeneic body organ transplants require the lifelong make use of of defense suppressive realtors. (molecularcircuit.com)
  • Identical twin allogeneic transplants are called syngeneic transplants. (ucsfhealth.org)
Receives bone marrow1
  • For allogeneic transplantation, the patient receives bone marrow or blood stem cells from a tissue-matched (HLA-matched) donor who may or may not be a relative. (ucsfhealth.org)
Graft3
  • Receiver APC can acquire these allogeneic peptides from coloring donor APCs present within depleting supplementary lymphoid tissue or from donor cells straight at the graft site [30]. (molecularcircuit.com)
  • Developed for decision-makers, this Graft vs. Host Disease - Epidemiology Forecast - 2032 report provides a detailed panorama on the incidence and prevalence of this severe complication of allogeneic stem cell transplantation in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. (researchandmarkets.com)
  • Graft-versus-host disease is a potentially serious complication of allogeneic stem cell transplantation. (researchandmarkets.com)
Efficacy1
  • The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
IPSC1
  • ReNeuron uses its conditionally immortalized induced pluripotent stem cell (iPSC) platform to make allogeneic tissue cells of choice. (reneuron.com)
Cell33
Chronic1
  • In this article, we describe use of a tongue flap in the closure of a chronic anterior maxillary dehiscence and to provide keratinized soft tissue coverage for anterior dental implants. (allenpress.com)
Adipose1
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
Disease8
  • Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
  • A disease that causes tissues or organs to deteriorate in structure or function over time. (mayo.edu)
  • Mandatory and recommended tests are described in the CTO Guidance document, and Health Canada has taken this opportunity to propose new transmissible disease testing requirements that would be considered mandatory for tissue donation and cord blood donation. (canada.ca)
  • 1 By contrast, cellular therapy uses healthy transplanted human cells to grow, replace, or repair damaged tissue that causes disease. (pharmaceuticalcommerce.com)
  • PHOENIX and TUCSON, Ariz. - Oct. 5, 2020 - Avery Therapeutics Inc. of Tucson has developed an engineered heart tissue, a lab-grown cardiac membrane that can help heal the heart, either following a heart attack or as a result of progressive heart disease. (tgen.org)
  • The heart tissue, called MyCardia™, could revolutionize the treatment of cardiovascular disease, and someday might be applied to other failing organs. (tgen.org)
  • Avery licensed the technology for MyCardia from the University of Arizona, where Avery scientists had worked on developing engineered regenerative tissues to treat cardiovascular disease. (tgen.org)
  • 39 An establishment that stores cells, tissues or organs must ensure that any of them that are untested or for which the results of tests on donor blood samples are positive or reactive for transmissible disease agents or markers or are unavailable are segregated from all other cells, tissues and organs. (gc.ca)
Treatments1
  • But with growing momentum to develop treatments for solid tumors and other tissues, more products with different requirements are likely to emerge. (pharmaceuticalcommerce.com)
Procedure3
  • A procedure in which tissue samples are removed from the body for examination of their appearance under a microscope to find out whether cancer or other abnormal cells are present. (imaginis.com)
  • This technique was used as a salvage procedure for an anterior maxillary soft tissue defect after multiple local soft tissue procedures were attempted and failed. (allenpress.com)
  • Blood supply to the transplanted tissues is maintained throughout the transplantation procedure with minimal ischemia. (bvsalud.org)
Congenital athymia2
  • Allogeneic processed thymus tissue is indicated for immune reconstitution in children with congenital athymia. (wikipedia.org)
  • Allogeneic processed thymus tissue improved survival of people with congenital athymia, and most people treated with this product survived at least two years. (wikipedia.org)
Immune2
  • Allogeneic processed thymus tissue is composed of human allogeneic (donor-derived) thymus tissue that is processed and cultured, and then implanted into people to help reconstitute immunity (improve immune function) in people who are athymic. (wikipedia.org)
  • This is an immune disorder that causes deep tissue infections. (clevelandclinic.org)
Clinical1
  • Likewise, in another clinical preliminary where allogeneic mesenchyme antecedent cells (MPCs) were conveyed to patients with left ventricular help gadgets, contributor explicit HLA refinement created after randomization in two MPC and three control patients, which were all settled by 1 year. (alliedacademies.org)
Person's2
  • Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)
  • During the allogeneic transplantation, a person's stem cells are replaced with the new healthy stem cells. (vedantu.com)
Patients3
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
  • The allogeneic means that the single source of cells is used to treat many patients. (vedantu.com)
Xenogeneic1
  • This report outlines the main concerns about allogeneic and xenogeneic transplantation identified during the consultation process, and highlights points of consensus. (who.int)
Thymus tissue2
  • Allogeneic processed thymus tissue is the first thymus tissue product approved by the U.S. Food and Drug Administration (FDA). (wikipedia.org)
  • Dosing is patient customized, determined by the surface area of the allogeneic processed thymus tissue slices and the body surface area of the patient. (wikipedia.org)
Scaffold1
  • The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
Human3
  • The consultations highlighted, however, the facts that allogeneic (human-to-human) transplantation poses major challenges and that xenotransplantation, which offers a potential alternative to allogeneic transplantation in certain conditions, requires better oversight and management in view of its specific potential risks and related problems. (who.int)
  • This CTO Guidance document provides clarification and interpretation of the regulatory requirements contained in the Safety of Human Cells, Tissues and Organs for Transplantation Regulations ( CTO Regulations). (canada.ca)
  • Bauer investigated the preservation and storage of canine allografts in 1910, and in the 1940s, the storage of autogeneic and allogeneic human bone was reported. (medscape.com)
Recipients1
  • A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
Perfusion1
  • In recent years, research has shown that it is possible to improve tissue perfusion through therapeutic angiogenesis. (unav.edu)
Treatment4
  • BACKGROUND: There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee. (healthpartners.com)
  • An open door that extraordinarily upgrades the capacity to foster such an item is the utilization of allogeneic treatment, which offers a proficient method for accomplishing both quick accessibility of item and the proper number of cells [ 1 ]. (alliedacademies.org)
  • Allogeneic treatment is obviously a problematic idea in science. (alliedacademies.org)
  • MSC treatment further developed files of actual useful limit and personal satisfaction (6-minute walk test and the Minnesota Living with Heart Failure Questionnaire score, separately) and decreased scar tissue and left-ventricular sphericity record, markers of ventricular rebuilding. (alliedacademies.org)
Adequate1
  • All of these techniques failed to provide adequate soft-tissue coverage. (allenpress.com)