AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
Graft vs Leukemia EffectTransplantation, HomologousHematopoietic Stem Cell TransplantationStem Cell TransplantationGraft vs Host DiseaseTransplantation ConditioningGraft vs Host ReactionTransplantation, AutologousPeripheral Blood Stem Cell TransplantationHematologic NeoplasmsLeukemiaTransplantation ChimeraStem CellsGraft vs Tumor EffectLeukemia, Myeloid, AcuteBone Marrow TransplantationGraft SurvivalTreatment OutcomeMyeloablative AgonistsBusulfanTissue DonorsRemission InductionVidarabineRecurrenceLeukemia, Myelogenous, Chronic, BCR-ABL PositiveHistocompatibility TestingLymphocyte TransfusionImmunosuppressive AgentsRetrospective StudiesMultiple MyelomaPrecursor Cell Lymphoblastic Leukemia-LymphomaHematopoietic Stem CellsCombined Modality TherapySiblingsCord Blood Stem Cell TransplantationCytomegalovirus InfectionsLiver TransplantationMinor Histocompatibility AntigensDisease-Free SurvivalSalvage TherapyWhole-Body IrradiationSurvival AnalysisLymphocyte DepletionNeoplasm, ResidualSurvival RateAntilymphocyte SerumMyelodysplastic SyndromesVirus ActivationHistocompatibilityTime FactorsMelphalanLeukemia, Lymphocytic, Chronic, B-CellChimerismHepatic Veno-Occlusive DiseaseAntineoplastic Combined Chemotherapy ProtocolsAcute DiseaseCyclophosphamideT-LymphocytesMesenchymal Stem Cell TransplantationKidney TransplantationCytomegalovirusHematopoietic Stem Cell MobilizationFollow-Up StudiesLeukemia, Myeloid, Accelerated PhasePrimary MyelofibrosisCell TransplantationAnemia, AplasticPrognosisHLA AntigensCytarabineEmbryonic Stem CellsHematologic DiseasesAntigens, CD34Fusion Proteins, bcr-ablAntineoplastic AgentsTransplantation ImmunologyAntibodies, NeoplasmImmunosuppressionRoseolovirus InfectionsLymphoproliferative DisordersBenzamidesAdult Stem CellsImmunocompromised HostLeukemia, MyeloidHodgkin DiseaseReceptors, Purinergic P2X5PyrimidinesNuclear FamilyGranulocyte Colony-Stimulating FactorCyclosporineLymphoma, Non-HodgkinInfectionCell DifferentiationFatal OutcomeGraft RejectionHeart TransplantationGanciclovirLiving DonorsFlow CytometryImmunotherapy, Adoptive
GvHDTransplantHSCTChemotherapyMarrow TransplantationDiseaseRelapseBoneTumorHaematopoietic stem cell transplantNonmyeloablativePeripheral-bloodHematopoietic cellsImmuneTransplantsLymphomaAplastic AnemiaBackground AllogeneicMalignanciesIntensity allogeneicCancersSurvivalCurativeAutologous stemTherapyEngraftmentClinicalOutcomesCyclophosphamideSevereFollowed by hematopoieticRecipientsTherapeuticAdultsLymphocytesMyeloidPatient's own cellsLeukemic2020Versus leukemiaDonorsInfectionSuppressTreatment
GvHD34
  • It is closely linked with graft-versus-host disease (GvHD), as the underlying principle of alloimmunity is the same. (wikipedia.org)
  • CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
  • Whereas graft-versus-host-disease (GvHD) has a negative impact on the host, GvL is beneficial for patients with hematopeietic malignancies. (wikipedia.org)
  • After HSC transplantation both GvL and GvHD develop. (wikipedia.org)
  • The interconnection of those two effects can be seen by comparison of leukemia relapse after HSC transplantation with development of GvHD. (wikipedia.org)
  • Patients who develop chronic or acute GvHD have lower chance of leukemia relapse. (wikipedia.org)
  • When transplanting T-cell depleted stem cell transplant, GvHD can be partially prevented, but in the same time the GvL effect is also reduced, because T-cells play an important role in both of those effects. (wikipedia.org)
  • The possibilities of GvL effect in the treatment of hematopoietic malignancies are limited by GvHD. (wikipedia.org)
  • There are some strategies to suppress the GvHD after transplantation or to enhance GvL but none of them provide an ideal solution to this problem. (wikipedia.org)
  • When transplanting HSC during AML, T-cells are usually selectively depleted to prevent GvHD while NK cells help with the GvL effect which prevent leukemia relapse. (wikipedia.org)
  • When using non-depleted T-cell transplant, cyclophosphamide is used after transplantation to prevent GvHD or transplant rejection. (wikipedia.org)
  • Other strategies currently clinically used for suppressing GvHD and enhancing GvL are for example optimization of transplant condition or donor lymphocyte infusion (DLI) after transplantation. (wikipedia.org)
  • G-CSF can help to enhance GvL effect and suppress GvHD by reducing levels of LPS and TNF-α. (wikipedia.org)
  • Winship study: Can engineered T cell prevent GvHD and relapse in blood cancer? (emory.edu)
  • A new Phase 3 clinical trial at Winship is enrolling participants after extremely encouraging results in the study's first two phases indicate the first-in-class high-precision cell therapy retains the benefits of stem cell transplant without such serious complications as graft versus host disease (GvHD) and disease relapse in patients with certain blood cancers. (emory.edu)
  • GvHD is an immune reaction of donor T cells against normal tissues in the transplant recipient," he says. (emory.edu)
  • Orca-T combines purified cells from a matched donor to replace a patient's diseased blood and immune system with a healthy one while lowering their risk of developing GvHD and other life-threatening transplant-related side effects. (emory.edu)
  • These cells expand and help prevent both rejection of the graft and GvHD. (emory.edu)
  • [ 1 ] The number continues to increase by 10-20% annually, and reductions in organ damage, infection, and severe, acute graft versus host disease (GVHD) seem to be contributing to improved outcomes. (medscape.com)
  • The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
  • At the same time, the so-called graft versus host disease (GvHD) often develops when the donor's lymphocytes are transplanted. (uni-mainz.de)
  • This article is a summary of the European Society for Blood and Marrow Transplantation (EBMT) webinar entitled 'Pathophysiology of acute and chronic GvHD, novel therapeutic strategies in the preclinical phase' delivered by Ernst Holler on May 5th, 2020. (gvhdhub.com)
  • The restoration of hematopoiesis together with the donor's immune system can lead to a major immune reaction, graft- versus -host disease (GvHD). (gvhdhub.com)
  • The most commonly affected organs in GvHD are presented in Table 1 . (gvhdhub.com)
  • Fludarabine-melphalan conditioning for AML and MDS: alemtuzumab reduces acute and chronic GVHD without affecting long-term outcomes. (uchicago.edu)
  • Patterns and kinetics of T-cell chimerism after allo transplant with alemtuzumab-based conditioning: mixed chimerism protects from GVHD, but does not portend disease recurrence. (uchicago.edu)
  • Common time-to-event efficacy endpoints in randomized clinical trials including leukemia patients after allogeneic stem-cell transplantation (ASCT) are, for instance, overall-survival or the incidence of graft-versus-host-disease (GvHD). (psiweb.org)
  • Graft-versus-host disease (GVHD) is one of the major obstacles for the success of allogeneic hematopoietic stem cell transplantation. (aai.org)
  • In this article, we report that the interaction between OX40L and OX40 is of critical importance for both induction and progression of acute GVHD (aGVHD) driven by human T cells. (aai.org)
  • However, graft-versus-host disease (GVHD) is one of the major causes of HSCT failure. (aai.org)
  • Graft-versus-host disease (GVHD) is a life-threatening complication that can occur after certain stem cell or bone marrow transplants . (medlineplus.gov)
  • GVHD may occur after a bone marrow, or stem cell, transplant in which someone receives bone marrow tissue or cells from a donor. (medlineplus.gov)
  • GVHD does not occur when people receive their own cells. (medlineplus.gov)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Transplant47
  • NK cells are within the first cells to repopulate host's bone marrow which means they play important role in the transplant engraftment. (wikipedia.org)
  • Principal investigator Edmund K. Waller, MD, PhD, FACP, says the net result of giving the patient a precise number of donor T cells with specific functions "leads to better elimination of cancer with less graft versus host disease and less toxicity from the transplant. (emory.edu)
  • It can occur in any transplant of blood cells from a donor to a patient and can be very dangerous. (emory.edu)
  • Transplantation & Cellular Therapy Meetings of the American Society of Transplantation and Cellular Therapy (ASTCT) and Center for International Blood and Marrow Transplant Research (CIBMTR), and the American Society of Hematology (ASH) annual meeting. (emory.edu)
  • To create the precision-engineered donor graft, Waller explains that different cellular subsets in the graft are selectively purified and then infused into the transplant recipient in a timed fashion. (emory.edu)
  • Although T-cell depletion is increasingly used to reduce the risk of graft-versus-host disease its impact on the graft-versus-leukemia effect and long-term outcome post-transplant is unknown. (ox.ac.uk)
  • DESIGN AND METHODS: We have characterized pre- and post-transplant factors determining overall survival in 168 patients with acute myeloid leukemia transplanted using an alemtuzumab based reduced intensity conditioning regimen with a median duration of follow-up of 37 months. (ox.ac.uk)
  • CONCLUSIONS: Disease stage, presentation karyotype and post-transplant CsA exposure are important predictors of outcome in patients undergoing a T-cell depleted reduced intensity conditioning allograft for acute myeloid leukemia. (ox.ac.uk)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • Currently, there is little information about the effects of MRD on transplant outcomes in haplo-SCT settings. (biomedcentral.com)
  • There may be differences in the anti-leukemia effects of haplo-SCT vs. MSDT [ 21 ], so this study investigated both the asso ciation of MRD status with outcomes in haplo-SCT and MDST settings and also possible differences in the transplant outcomes of patients with positive pre-MRD (as determined by MFC) who underwent haplo-SCT versus MDST. (biomedcentral.com)
  • A woman with human immunodeficiency virus (HIV) who received a cord blood stem cell transplant to treat acute myeloid leukemia has had no detectable levels of HIV for 14 months, despite cessation of antiretroviral therapy, according to research presented at the Conference on Retroviruses and. (ascopost.com)
  • Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
  • Doctors transplant the donor's stem cells into the individual after chemotherapy or radiation therapy to replace their diseased or damaged stem cells. (medicalnewstoday.com)
  • Dr Roger Owen (Leeds General Infirmary) gives his opinion on the place of allogeneic transplant in myeloma following the debate. (medicalupdateonline.com)
  • This phase II trial studies the side effect of busulfan, fludarabine phosphate, and post-transplant cyclophosphamide in treating patients with blood cancer undergoing donor stem cell transplant. (mdanderson.org)
  • Giving chemotherapy such as busulfan and fludarabine phosphate before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (mdanderson.org)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) involves the infusion of stem cells following administration of high-dose chemotherapy or total body irradiation for either tumor control or to prevent solid transplant rejection. (gvhdhub.com)
  • Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
  • Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
  • Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease. (uchicago.edu)
  • Feasibility of clofarabine cytoreduction before allogeneic transplant conditioning for refractory AML. (uchicago.edu)
  • Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant. (uchicago.edu)
  • Allogeneic stem cell transplant in renal failure: engraftment and prolonged survival, but high incidence of neurologic toxicity. (uchicago.edu)
  • Clinicopathologic features of late-onset veno-occlusive disease/sinusoidal obstruction syndrome after high dose intravenous busulfan and hematopoietic cell transplant. (uchicago.edu)
  • Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas. (uchicago.edu)
  • T-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. (uchicago.edu)
  • Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
  • Pilot study of comprehensive geriatric assessment (CGA) in allogeneic transplant: CGA captures a high prevalence of vulnerabilities in older transplant recipients. (uchicago.edu)
  • Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
  • Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)
  • HR=2.64, 95%CI: 1.05-6.63, P =0.04, respectively), while a CR status at transplant was associated with improved leukemia-free survival (HR=0.44, 95%CI: 0.22-0.88, P =0.02). (haematologica.org)
  • Although it is proving to be a heterogeneous disease process, the only treatment with proven survival benefit for poor risk AML remains allogeneic hematopoietic cell transplant. (sagepub.com)
  • The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
  • The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
  • They also appear to affect the risk of dying after a hematopoietic stem cell transplant. (cancer.gov)
  • In a new NCI-funded study, researchers found that, in people with blood cancers who had received an allogeneic hematopoietic stem cell transplant, the health of their gut bacteria was linked with their survival. (cancer.gov)
  • In an allogeneic stem cell transplant, the blood-forming stem cells in a patient's bone marrow are destroyed using high doses of chemotherapy or radiation therapy. (cancer.gov)
  • It also carries risks of potential harms, including infection, graft-versus-host disease (where certain immune cells from the donor attack the normal tissue of the transplant recipient), and death. (cancer.gov)
  • And antibiotic use after transplant, which can disrupt the microbiome, is associated with a higher risk of death from any cause and specifically from graft-versus-host disease. (cancer.gov)
  • There are so many variables in play locally, including how we treat our patients, and environmental and genetic influences on the microbiome that vary across geographical regions," said Steven Pavletic, M.D., a stem-cell transplant specialist at NCI's Center for Cancer Research , who was not involved in the study. (cancer.gov)
  • The NEPHRO-LEA study will allow a good evaluation of the long-term renal function of patients treated in childhood for acute leukemia, whether or not they received an allogeneic bone marrow transplant. (plateforme-lea.fr)
  • There's an "incredibly exciting" amount of research and development in the transplant and cellular therapy space that could result in gamechanging treatments for patients facing blood cancers such as leukemia and lymphoma. (managedhealthcareexecutive.com)
  • Ronneberg and Steven Devine, MD, stem cell transplant physician and medical director at Be The Match BioTherapies, recently spoke with Managed Healthcare Executive to discuss developments in the transplant and cellular therapy space. (managedhealthcareexecutive.com)
  • Bone marrow transplant is becoming a safer choice for elderly patients with lymphoma, myeloma, acute leukemia, and myeloid dysplastic syndrome, says Devine. (managedhealthcareexecutive.com)
  • This type of transplant is called allogeneic. (medlineplus.gov)
  • Before a transplant, tissue and cells from possible donors are checked to see how closely they match the recipient. (medlineplus.gov)
HSCT27
  • Graft-versus-tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). (wikipedia.org)
  • This response is mediated largely by cytotoxic T lymphocytes (CTL) but it can be employed by natural killers (NK cells) as separate effectors, particularly in T-cell-depleted HLA-haploidentical HSCT. (wikipedia.org)
  • For some forms of hematopoietic malignancies, for example acute myeloid leukemia (AML), the essential cells during HSCT are, beside the donor's T cells, the NK cells, which interact with KIR receptors. (wikipedia.org)
  • Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. (emory.edu)
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
  • Here, we present a case of an over 60-years old male patient with AML, and the possibility for him to receive an allogeneic hematopoietic stem cell transplantation (allo-HSCT). (pensoft.net)
  • However, very limited research has been done to investigate how AA secondary to nivolumab therapy may affect the outcome of HSCT. (pensoft.net)
  • Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)
  • Modern medicine uses healthy stem cells from a donor in the technique known as allogeneic hematopoietic stem cell transplantation (HSCT). (uni-mainz.de)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
  • We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
  • Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
  • In the future, prospective studies should evaluate whether acute myeloid leukemia patients with high pre-HSCT BAALC / ABL1 copy numbers benefit from additional treatment before or early intervention after HSCT. (oncotarget.com)
  • Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
  • Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for patients with non-malignant diseases as well as high-risk and refractory hematopoietic malignancies. (haematologica.org)
  • As a result, HSCT is often attributed to an increased risk of health complications, the most severe being chronic graft- versus -host disease (cGvHD). (haematologica.org)
  • Allo-HSCT is an important treatment strategy, which allows administration of myeloablative therapy and the elimination of cancer cells by the transplanted donor T and natural killer (NK) cells in a phenomenon known as the graft- versus -leukemia (GvL) effect. (gvhdhub.com)
  • Recently, we and others have shown that allogeneic hematopoietic stem cell transplantation (allo-HSCT) may represent a valid treatment option in leukemic myeloid sarcoma. (haematologica.org)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) offers great opportunities for curing hematologic malignancies. (aai.org)
  • The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • In the section on aspergillosis, the revised recommendations include the use of a room with high-efficiency particulate air filters rather than laminar airflow as the protective environment for allogeneic HSCT recipients and the use of high-efficiency respiratory-protection devices (e.g. (cdc.gov)
Chemotherapy23
  • For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
  • For conditioning for transplantation, patients were given a reduced dosage of chemotherapy so that the acute tolerance of the transplantation was very good. (disabled-world.com)
  • Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • The superior clinical outcomes of allogeneic SCT versus chemotherapy alone as post-remission treatment could be related to the graft-versus-leukemia (GVL) effects of recovered donor T cells. (biomedcentral.com)
  • Laboratory investigations revealed white blood cell count (WBC) 44×109/L with 86% blasts, hemoglobin 8.1 g/dL and a platelet count of 37×109/L. After obtaining an informed consent, the patient was treated with an induction chemotherapy with IA regimen (cytarabine 1.5 g/m2 by vein daily on days 1-3, with idarubicin 12 mg/m2 by vein daily on days 1-3). (pensoft.net)
  • It reveals the patient reported no other adverse reaction besides common side effects of IA regimen from the chemotherapy.On day 8, the first dose of nivolumab (1 mg/kg by vein) was started without induction chemotherapy and continued every two weeks for 10 cycles. (pensoft.net)
  • See Chemotherapy Regimens, below, and Chronic Lymphocytic Leukemia Treatment Protocols . (medscape.com)
  • In patients with newly diagnosed acute myeloid leukemia (AML) with an IDH1 mutation who were ineligible for intensive chemotherapy, the addition of the IDH1 inhibitor ivosidenib to azacitidine significantly improved survival vs azacitidine alone, according to data presented at the 2021 American. (ascopost.com)
  • Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
  • Chemotherapy uses drugs to kill cancer cells and slow or stop their growth. (medicalnewstoday.com)
  • Chemotherapy for leukemia can cause various side effects, depending on the specific drugs, the dosage, and the person. (medicalnewstoday.com)
  • Some supportive therapies, such as anti-nausea medications or growth factors to boost blood cell production, may help manage side effects and improve quality of life during chemotherapy. (medicalnewstoday.com)
  • Learn more about chemotherapy side effects here. (medicalnewstoday.com)
  • Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
  • Allogeneic hematopoietic stem cell transplantation is currently the only available treatment that offers patients a realistic chance of recovery from chemotherapy-resistant leukemias. (uni-mainz.de)
  • In the allogeneic stem cell technique, what happens is that the leukemia patient's own hematopoietic cells are first destroyed by chemotherapy and radiation therapy. (uni-mainz.de)
  • Drugs used in chemotherapy, such as busulfan, fludarabine phosphate and cyclophosphamide work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mdanderson.org)
  • Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
  • Acute leukemia chemotherapy contains many potentially nephrotoxic molecules, especially when combined with other nephrotoxic treatments to which patients are regularly exposed. (plateforme-lea.fr)
  • Children with Down's syndrome have a higher risk of developing acute leukemia in the first years of life and are more prone to acute toxicities from chemotherapy treatments, despite reduced intensity protocols. (plateforme-lea.fr)
  • Therapy often involves several cycles of chemotherapy, targeted biological treatment, immunological, immunosuppressive and instrument treatment (TPE and depletion procedures performed in cooperation with the IHBT Apheresis Department ), as well as different forms of hematopoietic stem cell transplantation . (uhkt.cz)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Marrow Transplantation15
Disease38
  • Graft-versus-host disease Hematopoietic stem cell transplantation Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R (January 2013). (wikipedia.org)
  • The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
  • Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the GCLLSG CLL3X Trial. (disabled-world.com)
  • Graft versus host disease can cause severe damage to the skin, liver, intestines and lungs," Waller says. (emory.edu)
  • ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
  • Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. (scielo.br)
  • However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. (scielo.br)
  • This study compared the effects of pre-transplantation minimal residual disease (pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched sibling donor transplantation (MSDT) or who received unmanipulated haploidentical allografts. (biomedcentral.com)
  • Joshua Brody, MD, Director of the CLL/Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai, New York, who was not involved in these trials, commented: "CLL is an extremely prevalent disease affecting nearly 200,000 patients in the United States. (ascopost.com)
  • Four patients developed acute, grade 2 to 3, graft- versus -host disease and four patients developed extensive chronic graft- versus -host disease. (aacrjournals.org)
  • Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
  • Leukemia remission is when there is no evidence of the disease during treatment. (medicalnewstoday.com)
  • In other words, it is a period when leukemia is in a state of minimal or undetectable disease activity. (medicalnewstoday.com)
  • However, it does not mean a complete cure, as some cancer cells may remain in the body and can cause the disease to return. (medicalnewstoday.com)
  • Refractory ALL is a type of leukemia characterized by the failure to achieve complete remission or the recurrence of the disease after initial treatment. (medicalnewstoday.com)
  • Humanigen believes that GM-CSF neutralization with lenzilumab also has the potential to reduce the hyper-inflammatory cascade known as cytokine release syndrome common to chimeric antigen receptor T-cell (CAR-T) therapy and acute Graft versus Host Disease (aGvHD). (businesswire.com)
  • 7 In the recently completed LenaRIC study patients undergoing allo-SCT with reduced-intensity conditioning received lenalidomide for 12 months from day 35 post-transplantation, with DLI for mixed chimerism or persistent disease. (medicalupdateonline.com)
  • Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). (mdanderson.org)
  • Recent data indicate that high BAALC expression levels may also be used as marker for residual disease following acute myeloid leukemia treatment. (oncotarget.com)
  • Graft vs leukemia (GVL) effects independent of graft vs host disease were investigated in allogeneic bone marrow chimeras tolerant of host and donor alloantigens. (ox.ac.uk)
  • The data suggest that T cells may mediate GVL effects in the absence of graft vs host disease and in circumstances where tolerance to conventional alloantigens is elicited. (ox.ac.uk)
  • Induction of GVL effects by allogeneic cells tolerant of host MHC suggests that these effects may be independent of graft vs host disease. (ox.ac.uk)
  • Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes. (uchicago.edu)
  • Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance. (uchicago.edu)
  • High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. (cdc.gov)
  • Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
  • Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)
  • Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation. (cdc.gov)
  • Study end points were the probabilities of overall survival, leukemia-free survival (LFS), relapse incidence (RI), non-relapse mortality (NRM) and chronic graft- versus -host disease. (haematologica.org)
  • People who lost diversity in their gut microbiome also had a higher likelihood of dying from graft-versus-host disease. (cancer.gov)
  • Previous studies from single hospitals have shown that people undergoing allogeneic stem-cell transplantation often have disruptions in their gut microbiome, including an increase in numbers of potentially disease-causing species of bacteria and an overall loss of diversity. (cancer.gov)
  • They then looked for associations between diversity of the gut microbiome and survival following transplantation, as well as the incidence of graft-versus-host disease. (cancer.gov)
  • The precise identification of patients with each of these late effects in the LEA cohort, as well as their detailed description in terms of variables associated with the patient, disease and treatment will greatly facilitate the study at the genome level. (plateforme-lea.fr)
  • We've managed to be able to reduce the rates of severe graft-versus-host disease-that's the major complication of transplants," says Devine. (managedhealthcareexecutive.com)
  • 3. Cancer is not the only disease benefited by transplantation. (managedhealthcareexecutive.com)
  • There are increasing indications not only for patients with cancer, but also for nonmalignant conditions like sickle cell disease and even potentially down the road, autoimmune diseases like multiple sclerosis," says Devine. (managedhealthcareexecutive.com)
  • Graft-versus-host disease and graft-versus-leukemia responses. (medlineplus.gov)
  • This disease is characterized by the malfunctioning of the DNA repair mechanism, which present an increase in the rate of spontaneous damage, among these spontaneous chromosomal instability, and hypersensitivity of cells to the chromosomal breaking effect induced by clastogenic agents 2-3 . (bvsalud.org)
Relapse9
  • The results indicated that, for pre-MRD-positive AML patients, haplo-SCT was associated with lower incidence of relapse and better survival, suggesting a stronger anti-leukemia effect. (biomedcentral.com)
  • 15 ] reported that peri-SCT MRD dynamics, as determined by MFC, are associated with a high risk of leukemia relapse and poor outcomes. (biomedcentral.com)
  • Our earlier work indicated that patients with refractory/relapsed leukemia who received haplo-SCT experienced a significantly lower cumulative incidence of relapse compared to those who underwent MSDT (26% vs. 49%, P = 0.008) [ 21 ]. (biomedcentral.com)
  • Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
  • National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
  • Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)
  • Most cases of myeloid sarcoma will develop within the first year preceding the occurrence of acute myeloid leukemia (AML), or concomitantly to AML, or at relapse of AML. (haematologica.org)
  • NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. (sagepub.com)
  • The biggest problem that remains for patients transplanted for hematological malignancies such as leukemia, lymphoma, or multiple myeloma, is relapse, says Devine. (managedhealthcareexecutive.com)
Bone24
  • While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
  • First are the bone-marrow-reconstituting stem cells and a population of regulatory T cells. (emory.edu)
  • AML is a type of blood cancer with excess immature white blood cells in bone marrow. (pensoft.net)
  • The efficacy of allo-SCT in MM relies on the transplanted immune system having an anti-tumour effect on the host bone marrow, the so-called graft-versus-myeloma (GvM) effect. (medicalupdateonline.com)
  • The binding of Campath stimulates destruction of the malignant lymphocytes and reduction or elimination of cancerous cells throughout the bone marrow, blood and lymph system. (broomeoncology.com)
  • Myelodysplastic syndromes (MDS) are a group of blood cancers in which your bone marrow doesn't make enough healthy blood cells. (healthline.com)
  • Instead, many of the cells made in the bone marrow are irregular. (healthline.com)
  • In MDS, many of the blood cells made in the bone marrow are irregular (dysplastic). (healthline.com)
  • Although a small number of blasts can be found in healthy people, they can make up 5 to 19 percent of cells in the bone marrow of individuals with MDS. (healthline.com)
  • The genetic or chromosomal changes in MDS stop the stem cells in the bone marrow from developing as they should. (healthline.com)
  • Lenalidomide is an immunomodulator that helps your body target irregular bone marrow cells and produce healthy ones. (healthline.com)
  • It is now widely accepted that immunocompetent lymphocytes in allogeneic bone marrow grafts exert an antileukemic effect that contributes to the cure of leukemia. (ox.ac.uk)
  • Mice were reconstituted with C57BL/6 bone marrow cells depleted of well-defined T-cell subsets or enriched for stem cells by the soybean agglutination method. (ox.ac.uk)
  • This process can potentially eliminate some cancers derived from cells in the bone marrow, such as leukemia and lymphoma. (cancer.gov)
  • Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
  • Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
  • Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
  • Acute lymphoblastic leukemia (ALL) is an aggressive leukemia characterized by a proliferation of lymphoblasts or lymphocytes in the blood and bone marrow. (amgenoncology.com)
  • Acute myeloid leukemia (AML) is an aggressive leukemia where an excess of myeloblasts are found in the blood and bone marrow. (amgenoncology.com)
  • There are many clinical trials in the cellular therapies space outside of bone marrow transplants, such as CAR-T cell therapy and the use of NK cells, says Ronneberg, noting that a few CAR-T therapies have already received FDA approval. (managedhealthcareexecutive.com)
  • People who receive closely matched bone marrow tissue and cells usually do better. (medlineplus.gov)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
  • Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
Tumor11
  • The biology of GvT response is still not fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved. (wikipedia.org)
  • Healthcare providers call this "graft-versus-tumor" effect (GVT). (clevelandclinic.org)
  • New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
  • Effect of anticoagulant/antifibrinolytic combination therapy on enhanced-fibrinolytic-type DIC in end-of-life stage solid tumor patients. (kanazawa-u.ac.jp)
  • Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
  • CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
  • Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
  • Moreover, according to Urban, the trail-blazing efforts of the Clinical Research Unit 183 are also relevant to other fields of transplantation and tumor immunology. (uni-mainz.de)
  • Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a rare extramedullary tumor composed of immature myeloid cells at different stages of differentiation which can involve any site of the body. (haematologica.org)
  • Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (sagepub.com)
  • Thus, our care covers congenital or acquired non-tumor diseases (anemias, coagulation disorders, etc.), as well as tumor diseases such as leukemia or myelodysplastic syndrome. (uhkt.cz)
Haematopoietic stem cell transplant2
Nonmyeloablative2
Peripheral-blood2
Hematopoietic cells1
  • The graft usually comes from a human leukocyte antigen (HLA)-matched donor and contains hematopoietic cells as well as immune cells, including T lymphocytes. (gvhdhub.com)
Immune12
  • This is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. (clevelandclinic.org)
  • It is crucial to control the transplanted donor immune cells so that the effect is strong enough to eliminate the leukemia cells but not strong enough to lead to complications in other tissues and organs. (disabled-world.com)
  • With their ability to detect and directly destroy virally infected or malignant cells, natural killer (NK) cells form an important part of the first line defense of the immune system. (frontiersin.org)
  • As an Immune checkpoint blockade therapy (ICB), nivolumab has demonstrated efficacy in Acute Myeloid Leukemia (AML) and various other malignancies. (pensoft.net)
  • Over-activated T-cells will cause immune-related adverse events such as Aplastic Anemia (AA). (pensoft.net)
  • The lymphocytes produced by the donor's immune system then recognize and destroy the leukemia cells still present in the patient's body. (uni-mainz.de)
  • Once the donated stem cells begin working, the patient's immune system may see the remaining cancer cells as not belonging in the patient's body and destroy them. (mdanderson.org)
  • 2 cGvHD is a multisystemic disorder that occurs due to foreign donor immune cells attacking the recipient's tissues. (haematologica.org)
  • Various immune-suppressive cell populations appear to associate with suppression of cGvHD, including T reg cells, B reg cells, M2 macrophages, dendritic cells, and CD56 bright natural killer (NK) cells. (haematologica.org)
  • The NIMA-complementary BMT preserved the graft-versus- leukemia effects and favored the immune reconstitution, thus resulting in a marked improvement of the outcome after BMT. (elsevierpure.com)
  • Stem cells from a donor, called a graft , are then infused to replace the destroyed cells, produce new marrow, and rebuild the recipient's immune system. (cancer.gov)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Transplants7
Lymphoma2
Aplastic Anemia1
Background Allogeneic1
Malignancies1
  • The GEN-LEA study focused on four side effects: metabolic syndrome, anthracycline-induced cardiomyopathy, second malignancies, and symptomatic osteonecrosis. (plateforme-lea.fr)
Intensity allogeneic2
Cancers3
Survival8
  • Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response and the development of a graft versus leukemia effect. (emory.edu)
  • The platform technology used in this study can be applied to include additional populations of cells that may further improve survival and decrease complications for patients with leukemia and MDS undergoing allogeneic stem cell transplantation," he says. (emory.edu)
  • Here, we show that well-tolerated doses of canagliflozin suppress proliferation and survival of androgen-sensitive and insensitive human PC cells and tumors and sensitize them to radiotherapy. (bvsalud.org)
  • In vivo development and survival of NK cells require cytokines ( 6 - 8 ). (frontiersin.org)
  • Hokkaido Hematology Study Group: Effects of the mean daily doses of imatinib during the first year on survival of patients with chronic myeloid leukemia in Japan: a study of the Hokkaido Hematology Study Group. (hokudai-hematology.jp)
  • Overall survival was not significantly affected either, although it was 46 months with fludarabine compared with 64 months for chlorambucil. (medscape.com)
  • Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
  • Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)
Curative2
  • BACKGROUND: Reduced intensity conditioning regimens permit the delivery of a potentially curative graft-versus-leukemia effect in older patients with acute myeloid leukemia. (ox.ac.uk)
  • Allogeneic stem cell transplantation is the only known curative therapy. (medscape.com)
Autologous stem2
Therapy20
  • Successful treatment of therapy-resistant chronic leukemia using allogeneic stem cell transplantation. (disabled-world.com)
  • Our study is the largest so far for this patient population and proved that allogeneic stem cell transplantation is a promising therapy option for high-risk CLL and has the potential to cure for this otherwise incurable kind of leukemia," says Professor Dreger, head of the study. (disabled-world.com)
  • Allogeneic stem cell transplantation is a very stressful and risky form of therapy, which could previously not be carried out on the generally older patients affected by CLL. (disabled-world.com)
  • Winship is one of several clinical trial sites for the Precision-T study evaluating the safety and efficacy of Orca-T, a cell therapy that combines purified cells from a matched donor, in patients with acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) and high-risk myelodysplastic sydromes (MDS). (emory.edu)
  • A main challenge of NK cell therapy is that it requires a high amount of functional NK cells. (frontiersin.org)
  • In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
  • In Section II, Dr. James Griffin reviews the mechanisms that lead to activation of tyrosine kinases by mutations in AML, the consequences of that activation for the cell, and the opportunities for targeted therapy and discusses some examples of developing novel drugs (tyrosine kinase inhibitors) and their effectiveness in AML (FLT3). (ashpublications.org)
  • The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
  • An experienced multidisciplinary team in close consultation with the primary transplantation centre should perform the rehabilitation therapy. (mdpi.com)
  • Radiation therapy is a cancer treatment that uses high-energy radiation to destroy cancer cells. (medicalnewstoday.com)
  • External radiation therapy involves delivering radiation to the cancer cells from outside the body using a linear accelerator. (medicalnewstoday.com)
  • Learn more about the side effects of radiation therapy here. (medicalnewstoday.com)
  • The German Research Foundation (DFG) will be providing funding for a further three years for a research association that has been in existence at the Mainz University Medical Center since 2007, the Clinical Research Unit 183 on Optimized Allogeneic Lymphocyte Therapy. (uni-mainz.de)
  • Other promising developments to improve outcomes in allo-SCT include conditioning with radiolabelled anti-CD66, as well as salvage therapy with daratumumab 8 or newer imids which suggest that allo-SCT has the potential to enhance the efficacy of other therapies that may have been less effective pre-transplantation. (medicalupdateonline.com)
  • 12 however, the finding in the Myeloma XI study that lenalidomide maintenance therapy was associated with a significant improvement in PFS but with little further improvement in depth of response 13 suggests that the graft is providing an adjunct to highly effective maintenance therapy rather than the other way around. (medicalupdateonline.com)
  • Chronic myeloid leukaemia is a hematopoietic stem cells disorder treated by tyrosine kinase inhibitors but often cause recurrence of the leukaemia after cessation of therapy, hence require alternative treatment. (bvsalud.org)
  • Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. (uchicago.edu)
  • Hematology, transfusion and cell therapy 2018 7 40 (2): 136-142. (cdc.gov)
  • These efforts involve every step of AML diagnostics and therapy, including the intricate processes of conditioning, graft manipulation and immunomodulation. (sagepub.com)
  • And before you go through a stressful therapy like allogeneic transplantation, [we] want to make sure that all of your organs are functioning well. (cancer.gov)
Engraftment1
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Clinical9
  • The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
  • The Precision-T study is funded by Orca Bio, a clinical-stage biotechnology company developing purified, high-precision cell therapies for the treatment of cancer, autoimmune diseases and genetic blood disorders. (emory.edu)
  • Many culturing strategies are based on the addition of feeder or accessory cells, which need to be removed prior to the clinical application of the final NK cell product. (frontiersin.org)
  • Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
  • In a study reported in the Journal of Clinical Oncology, Elsayed et al developed a risk score based on single nucleotide polymorphisms (SNPs) associated with cytarabine pharmacodynamics or clinical outcomes that identified pediatric patients with acute myeloid leukemia (AML) who could benefit from. (ascopost.com)
  • The Chief Scientific Director of the Mainz University Medical Center, Professor Reinhard Urban, is convinced that the team led by Professor Wolfgang Herr will be able to achieve significant progress in the field of leukemia treatment: 'I share the view of the German Research Foundation that it will be readily possible to apply the highly relevant research results to clinical practice. (uni-mainz.de)
  • The identification of cytogenetic, molecular, and clinical factors impacting on outcome at acute myeloid leukemia (AML) diagnosis improved risk stratification [ 1 , 2 ]. (oncotarget.com)
  • Constitution of a clinical-biological collection for the search for genetic susceptibility to late sequelae in a cohort of patients cured of childhood leukemia. (plateforme-lea.fr)
  • DOREMy: Harmonized clinical and biological database for research integrated into the management of pediatric acute myeloid leukemia. (plateforme-lea.fr)
Outcomes2
  • This study indicates that transplantation of defined populations of cells can lead to improved patient outcomes," he says, pointing out that it could also have even wider implications. (emory.edu)
  • High BAALC expression levels at acute myeloid leukemia diagnosis have been linked to adverse outcomes. (oncotarget.com)
Cyclophosphamide1
  • The role of Thy1.2, L3T4 and Lyt2 T lymphocytes as effector cells of GVL were investigated in (BALB/c x C57BL/6)F1 mice inoculated with murine B-cell leukemia and subsequently conditioned with total lymphoid irradiation and cyclophosphamide (200 mg/kg). (ox.ac.uk)
Severe2
  • Providers may use allogeneic stem cell transplantation to treat severe forms of thalassemia. (clevelandclinic.org)
  • However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)
Followed by hematopoietic1
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Recipients2
  • Treatment of the primary marrow inoculum with monoclonal anti-Thy1.2 or anti-Lyt2 abolished the GVL effects and all secondary BALB/c recipients developed leukemia within 60 days. (ox.ac.uk)
  • On the other hand, the treatment with monoclonal anti-L3T4 did not influence the effect of GVL and all treated recipients remained without leukemia. (ox.ac.uk)
Therapeutic2
  • The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. (ashpublications.org)
  • In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)
Adults2
Lymphocytes6
Myeloid7
Patient's own cells2
  • The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)
  • Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Leukemic3
  • As the name of this effect indicates, GvL is a reaction against leukemic cells of the host. (wikipedia.org)
  • Additionally, NK reg cells do not kill leukemic cells. (haematologica.org)
  • This study was conducted to investigate the effect of magnetite nanoparticles (MNPs) and magnetite folate core shell (MFCS) on leukemic and hepatocarcinoma cell cultures as well as their effect on the animal model of acute myelocytic leukemia (AML). (bvsalud.org)
20201
Versus leukemia2
  • Graft-versus-leukemia (GvL) is a specific type of GvT effect. (wikipedia.org)
  • The conventional T cells help eliminate the cancer in the patient through a process called "graft-versus-leukemia. (emory.edu)
Donors3
Infection4
  • The mucosa-associated invariant T (MAIT) cells are innate-like T cells with restricted T cell receptor (TCR) usage, which are preferentially localized in mucosal tissues (liver, lung and gut) and respond to microbial infection by rapidly producing cytokines and cytotoxic effectors. (cryostem.org)
  • In addition, we want to improve the patient's immunity to infection through the graft versus infection (GvI) effect,' emphasized Herr. (uni-mainz.de)
  • Successful allogeneic transplantation of patients with suspected prior invasive mold infection. (uchicago.edu)
  • In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
Suppress2
  • In large patient populations, we have shown a CD56 bright natural killer (NK) population to strongly associate with a lack of cGvHD and we hypothesize that these cells function to suppress cGvHD. (haematologica.org)
  • We also found that viable NK reg cells may be isolated by sorting on CD56 + and CD16 - NK cells, and this population can suppress allogeneic CD4 + T cells, but not T reg cells or CD8+ T cells through a non-cytolytic, cell-cell contact dependent mechanism. (haematologica.org)
Treatment11
  • Cancer Care provides free, professional support services for people affected by myeloproliferative neoplasms, as well as treatment information and financial help with cancer-related costs and treatment co-pays. (cancercare.org)
  • In summary, this two-phased feeder cell-free ex vivo culturing protocol combined efficient expansion and high cytolytic functionality of NK cells for treatment of radiation-resistant RMS. (frontiersin.org)
  • We identified marked variation in the T cell components across AML patients at pre- and post- treatment, demonstrating significant dynamic changes in CD4, CD8 and non-classical T cells populations, including MAIT ( figure 3 A-B). Among CD8 cells, we identified a unique GZMK-enriched population that was highest at pretreatment in responders. (bmj.com)
  • After the first week of treatment, the patient's WBC count fell to 36×109/L with a significant decrease in blast cell count. (pensoft.net)
  • Each treatment option can have side effects that vary for different people. (medicalnewstoday.com)
  • The healthcare team will work closely with the person to manage side effects and provide supportive care throughout treatment. (medicalnewstoday.com)
  • The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
  • The sample size and the low event rate, in a time-to-event context, lead to the choice of composite endpoints as primary endpoints and it is likely that the effect of treatment is not uniform across all components. (psiweb.org)
  • https://www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq. (amgenoncology.com)
  • https://www.cancer.gov/types/leukemia/patient/adult-aml-treatment-pdq. (amgenoncology.com)
  • In this context, the identification of genetic susceptibilities to a specific late effect associated with treatment is a very promising approach. (plateforme-lea.fr)