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  • GvHD
  • However, it has been shown that genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle are differentially expressed in patients with fatal GvHD versus "indolent" GvHD. (wikipedia.org)
  • Currently, he is the Head of the Graft-versus-host disease (GVHD) and Autoimmunity Unit and Senior Clinician at the Experimental Transplantation and Immunology Branch of the National Cancer Institute's (NCI) Center for Cancer Research at the U.S. National Institutes of Health (NIH). (wikipedia.org)
  • He is presently also an Adjunct Professor of Medicine and Oncology at Lombardi Cancer Center, Georgetown University, Washington, D.C. Pavletic's main area of research is in the field of hematopoietic stem cell transplantation for hematologic malignancies, chronic Graft-versus-host disease (GVHD) and transplantation for autoimmune disease, with a particular interest in addressing late effects in cancer therapy survivors. (wikipedia.org)
  • He is best known for his research on chronic GVHD, the most common late effect in cancer survivors who underwent allogeneic stem cell transplantations as a form of treatment. (wikipedia.org)
  • The United States Embassy in Zagreb, Croatia, granted Pavletic a United States Government stipend to spend six weeks at the University Hospital Centre Zagreb, Croatia, in 2013, to assist in the establishment of a multidisciplinary center for the treatment of chronic GVHD resulting from allogeneic stem cell transplantations. (wikipedia.org)
  • regimen
  • Safety and feasibility of allogeneic transplantations between individuals without need of immunosuppressive drug regimen are proven. (clinicaltrials.gov)
  • In the FLAG-IDA regimen (also called FLAG-Ida, IDA-FLAG, or Ida-FLAG), idarubicin-an anthracycline antibiotic that is able to intercalate DNA and prevent cell division (mitosis)-is added to the standard FLAG regimen. (wikipedia.org)
  • syngeneic
  • It is contrasted with autotransplantation (from one part of the body to another in the same person), syngeneic transplantation (grafts transplanted between two genetically identical individuals of the same species) and xenotransplantation (from other species). (wikipedia.org)
  • lung
  • Carsten Bokemeyer has a unique experience in the diagnosis and treatment of blood cancer (leukemia), malignant lymphoma, tumors of germ cells (testicular cancer), gastrointestinal malignancies, including cancer of the esophagus, stomach, intestines, oncological diseases of the respiratory tracts (lung cancer), connective tissue (sarcomas), head and neck as well as blood clotting disorders. (bookinghealth.com)
  • Examples of surgical procedures for cancer include mastectomy for breast cancer, prostatectomy for prostate cancer, and lung cancer surgery for non-small cell lung cancer. (wikipedia.org)
  • Most recently Dr Moore has been studying the cancer stem cell in lung cancer and ovarian cancer and has developed some novel methods for growing human cancer stem cells in vitro allowing extensive molecular analysis and identification of targets for therapy designed to eliminate this rare cell population that is responsible for aggressive tumor growth and relapse. (wikipedia.org)
  • tissues
  • Stem cells have the potential of multi-directional differentiations, and they can differentiate into specialized cells to repair injured tissues under certain conditions [ 1 ]. (medsci.org)
  • Animal experiments have demonstrated that in anoxic environment, implanted stem cells can differentiate and promote neovascularization which effectively increase the blood perfusion in ischemic tissues, and thus inhibit further necrosis of tissues [ 2 , 3 ]. (medsci.org)
  • Researchers have transplanted the bone marrow stem cells into the necrotic femoral heads, and results show bone marrow stem cells can remove vascular lesions and promote angiogenesis in necrotic femoral heads, accompanied by significant improvement of blood circulation in the necrotic femoral head and surrounding tissues [ 4 ]. (medsci.org)
  • The main focuses of research, diagnosis and treatment are on leukemia and lymphomas, malignancies of the gastrointestinal tract, tumors of germ cells (e.g. testicles) and malignancies of bone and connective tissues. (bookinghealth.com)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Allotransplant (allo- from the Greek meaning "other") is the transplantation of cells, tissues, or organs, to a recipient from a genetically non-identical donor of the same species. (wikipedia.org)
  • In order to ensure the quality of donor tissue and reduce contamination and disease transmission risks, three regulations addressing manufacturing activities associated with human cells, tissues, and cellular and tissue-based products (HCT/Ps) were promulgated in May 2005: The first requires companies producing and distributing HCT/Ps to register with the FDA. (wikipedia.org)
  • mortality
  • However, for other cancers such as acute myeloid leukemia, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, and therefore the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
  • hematologic
  • Because of the failure of hematologic components to develop-white blood cells, red blood cells, and platelets-the body's capabilities to fight infection, deliver oxygen, and form clots are all diminished. (wikipedia.org)
  • lymph
  • CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
  • Less commonly, CLL may present with enlarged lymph nodes without a high white blood cell count or no evidence of the disease in the blood. (wikipedia.org)
  • 2000
  • Because of the genetic defect in DNA repair, cells from people with FA are sensitive to drugs that treat cancer by DNA crosslinking, such as mitomycin C. The typical age of death was 30 years in 2000. (wikipedia.org)
  • individual's
  • Evans syndrome is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets. (wikipedia.org)
  • severe
  • Unfortunately, these medications may cause severe side-effects such as hypersensitivity reactions, bone marrow suppression, auto-immune disease and sideroblastic anemia. (clinicaltrials.gov)
  • organ
  • The first attempt, an unsuccessful one, at gene therapy (as well as the first case of medical transfer of foreign genes into humans not counting organ transplantation) was performed by Martin Cline on 10 July 1980. (wikipedia.org)
  • genetically
  • In addition, all the CLL cells within one individual are clonal, that is, genetically identical. (wikipedia.org)
  • In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23. (wikipedia.org)
  • immune system
  • In his early career Dr Moore discovered that all stem cells of the blood and lymphoid system developed in the yolk sac at an early stage of embryo development and migrated via the blood stream to colonize the bone marrow and immune system. (wikipedia.org)
  • isolation
  • In the field of cell transplantation, MSCs have many advantages over other cell types such as easy isolation and culture, rapid in vitro amplification, differentiation potential, and easy collection [ 2 ]. (medsci.org)
  • anemia
  • Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are destroyed by an autoimmune process. (wikipedia.org)
  • Autoantibodies targeted at different antigenic determinants on red cells and platelets are assumed to cause isolated episodes of hemolytic anemia and thrombocytopenia, respectively. (wikipedia.org)
  • In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
  • While at birth, blood count is usually normal, macrocytosis/megaloblastic anemia, defined as unusually large red blood cells, is the first detected abnormality, often within the first decade of life (median age of onset is 7 years). (wikipedia.org)
  • autoimmune
  • citation needed] It has been observed that there is a risk of developing other autoimmune problems and hypogammaglobulinemia, with recent research finding that 58% of children with Evans syndrome have CD4-/CD8- T cells which is a strong predictor for having autoimmune lymphoproliferative syndrome. (wikipedia.org)